BGC0001338 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001338 (Monascus ruber)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	42,813	citrinin	PKS:Iterative type I	100%

BGC0001338 - Region 1 - T1PKS

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Location: 1 - 42,813 nt. (total: 42,813 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 42,814
Label		BGC0001338

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001338	0.89	Polyketide	citrinin	Monascus ruber
BGC0000099	0.38	Polyketide	monascorubrin	Talaromyces marneffei
BGC0002429	0.30	Terpene, Polyketide	higginsianin B	Colletotrichum higginsianum IMI 349063
BGC0000894	0.28	Other	citrinin	Monascus aurantiacus
BGC0001264	0.27	Polyketide	betaenone A, betaenone B, betaenone C	Phoma betae
BGC0002427	0.26	Terpene, Polyketide	subglutinol A, subglutinol B	Metarhizium robertsii ARSEF 23
BGC0002483	0.26	Polyketide	usnic acid	Cladonia uncialis subsp. uncialis
BGC0002262	0.24	Polyketide	trienylfuranol A, sporothriolide, dihydrosporothriolide, deoxysporothric acid, dihydroisosporothric acid, sporothric acid, isosporothric acid, sporochartine B	Hypomontagnella monticulosa
BGC0002603	0.23	Polyketide	chevalone E	Aspergillus versicolor
BGC0001118	0.23	Polyketide	endocrocin	Aspergillus fumigatus Af293

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001338	1.00	Polyketide	citrinin	Monascus ruber
BGC0000894	0.74	Other	citrinin	Monascus aurantiacus
BGC0000099	0.70	Polyketide	monascorubrin	Talaromyces marneffei
BGC0002429	0.64	Terpene, Polyketide	higginsianin B	Colletotrichum higginsianum IMI 349063
BGC0001264	0.60	Polyketide	betaenone A, betaenone B, betaenone C	Phoma betae
BGC0002427	0.60	Terpene, Polyketide	subglutinol A, subglutinol B	Metarhizium robertsii ARSEF 23
BGC0002483	0.59	Polyketide	usnic acid	Cladonia uncialis subsp. uncialis
BGC0002476	0.59	NRP	enterobactin	Escherichia coli str. K-12 substr. MG1655
BGC0002262	0.57	Polyketide	trienylfuranol A, sporothriolide, dihydrosporothriolide, deoxysporothric acid, dihydroisosporothric acid, sporothric acid, isosporothric acid, sporochartine B	Hypomontagnella monticulosa
BGC0002603	0.56	Polyketide	chevalone E	Aspergillus versicolor

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 40651:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (pk)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

citS

PKS_AT (913..1210): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 66.7%; Ethylmalonyl-CoA: 58.3%; Methylmalonyl-CoA: 58.3%

minowa: Methoxymalonyl-CoA

Prediction, score:

Methoxymalonyl-CoA: 52.4
Malonyl-CoA: 52.0
inactive: 48.1
Methylmalonyl-CoA: 47.2
Propionyl-CoA: 31.7
Ethylmalonyl-CoA: 26.3
CHC-CoA: 24.3
2-Methylbutyryl-CoA: 20.8
fatty_acid: 19.6
trans-1,2-CPDA: 16.4
Acetyl-CoA: 14.3
Benzoyl-CoA: 11.0
Isobutyryl-CoA: 8.9
3-Methylbutyryl-CoA: 0.0

mrr8

AMP-binding (74..512): X

nrpys: Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: -AMLIFF-SK
Nearest Stachelhaus code(s):
Stachelhaus code match:: 0% (weak)