BGC0001339: squalestatin S1 biosynthetic gene cluster from Phoma sp. MF5453
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Location: 1 - 69,700 nt. (total: 69,700 nt).
This entry is originally from NCBI GenBank KU946987.1.

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core biosynthetic genes
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Gene details
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General
Compounds
Genes
Polyketide
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001339
Short description squalestatin S1 biosynthetic gene cluster from Phoma sp. MF5453
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Polyketide (Other)
Loci NCBI GenBank: KU946987.1
Compounds
  • squalestatin S1
Species Phoma sp. MF5453 [taxonomy]
References
Chemical products information
squalestatin S1 [synonyms: zaragozic acid a]
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C35H46O13
Chemical database entries
NPAtlas
ChemSpider
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AMY15054.1
  • mfL3
 46 - 4089 (-) transcription factor
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  • AMY15055.1
  • mfL2
 5098 - 6941 (+) MFS transporter
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  • AMY15056.1
  • mfL1
 8714 - 12825 (+) hypothetical protein
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  • AMY15057.1
  • mfpks1
 15080 - 23393 (-) tetraketide synthase MF-SQTKS
  • Scaffold biosynthesis
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  • AMY15058.1
  • mfM1
 23904 - 25116 (+) copper dependent oxygenase
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  • AMY15059.1
  • mfM2
 25936 - 27732 (+) MFS transporter
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  • AMY15060.1
  • mfM3
 28231 - 29304 (-) NADP dependent dehydrogenase
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  • AMY15061.1
  • mfM4
 30144 - 31634 (+) acyltransferase AT1
  • Tailoring (Acylation)
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  • AMY15062.1
  • mfM5
 34454 - 34834 (-) mfM5 protein
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  • AMY15063.1
  • mfM6
 37170 - 39091 (+) MFS transporter
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  • AMY15064.1
  • mfM7
 40066 - 42358 (+) phenylalanine ammonia-lyase
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  • AMY15065.1
  • mfM8
 42512 - 43583 (-) esterase/lipase
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  • AMY15066.1
  • mfM9
 44065 - 45803 (-) acyl-CoA synthetase/ligase
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  • AMY15067.1
  • mfM10
 46182 - 48142 (+) hydrolase
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  • AMY15068.1
  • mfpks2
 48806 - 56980 (+) hexaketide synthase MF-SQHKS
  • Scaffold biosynthesis
Sequence-based prediction
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  • AMY15069.1
  • mfR1
 57584 - 58709 (-) putative non-heme iron dependent
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  • AMY15070.1
  • mfR2
 59112 - 59993 (+) putative non-heme iron dependent
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  • AMY15071.1
  • mfR3
 60271 - 61886 (-) citrate synthase
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  • AMY15072.1
  • mfR4
 62500 - 63906 (+) acyltransferase-3 superfamily AT2
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  • AMY15073.1
  • mfR5
 64258 - 66006 (-) MFS transporter
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  • AMY15074.1
  • mfR6
 66436 - 67748 (+) squalene synthase
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  • AMY15075.1
  • mfR7
 68574 - 69577 (+) ab hydrolase
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Polyketide-specific information
Subclass Other
Starter unit Benzoyl-CoA
Cyclic? no
Polyketide-synthases
Genes Properties Modules
mfpks1
+
mfpks2 		Synthase subclass: Iterative type I
Iterative PKS type: Highly reducing, Unknown
Iteration counts: 5
Annotation changelog
MIBiG version Submitter Notes
1.3
  • Hidden contributor (ID: 3XTF2R3BHL5LPPSMGJ2QHJQC, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Corrected gene identifiers
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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