BGC0001340: byssochlamic acid biosynthetic gene cluster from Byssochlamys fulva
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
View antiSMASH-generated output
Download Cluster GenBank file
Download region SVG
Location: 1 - 52,546 nt. (total: 52,546 nt).
This entry is originally from NCBI GenBank KU928136.1.

Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset zoomreset view
zoomzoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001340
Short description byssochlamic acid biosynthetic gene cluster from Byssochlamys fulva
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Type I)
Loci
KU928136.1
via Knock-out studies, Heterologous expression, Gene expression correlated with compound production
Compounds
  • byssochlamic acid
  • agnestadride A
  • agnestadride B
  • Triketide maleidride monomer type A
Species Byssochlamys fulva [taxonomy]
References
Chemical products information
byssochlamic acid Evidence: X-ray crystallography [1]
Copy SMILES
C18H20O6
Chemical database entries
PubCHEM
ChEMBL
NPAtlas
agnestadride A Evidence: NMR [2]
Copy SMILES
C18H20O6
Chemical database entries
ChEBI
NPAtlas
PubCHEM
agnestadride B Evidence: NMR [2]
Copy SMILES
C18H18O5
Chemical database entries
PubCHEM
ChEBI
NPAtlas
Triketide maleidride monomer type A Evidence: Total synthesis [2]
Copy SMILES
C10H10O5
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ANF07276.1
  • bfL12
 1841 - 3812 (+) MFS transporter
  • Transport
copy AA seq
copy Nt seq
  • ANF07277.1
  • bfL11
 4760 - 5585 (+) enoyl-CoA hydratase/isomerase family protein
    copy AA seq
    copy Nt seq
    • ANF07278.1
    • bfL10
    		 6336 - 7122 (+) ketosteroid isomerase-like protein
    • Tailoring
    • Other in vivo study
    copy AA seq
    copy Nt seq
    • ANF07279.1
    • bfL9
    		 7905 - 8537 (+) phosphatidylethanolamine-binding protein-like protein
    • Activation / processing
    • Other in vivo study
    copy AA seq
    copy Nt seq
    • ANF07280.1
    • bfL8
    		 9232 - 9901 (-) putative regulatory protein
      copy AA seq
      copy Nt seq
      • ANF07281.1
      • bfL7
      		 11833 - 13376 (-) C6 transcription factor
      • Regulation
      copy AA seq
      copy Nt seq
      • ANF07282.1
      • bfL6
      		 14721 - 15503 (-) ketosteroid isomerase-like protein
      • Tailoring
      • Other in vivo study
      copy AA seq
      copy Nt seq
      • ANF07283.1
      • bfL5
      		 16375 - 17067 (-) phosphatidylethanolamine-binding protein-like protein
      • Activation / processing
      • Other in vivo study
      copy AA seq
      copy Nt seq
      • ANF07284.1
      • bfL4
      		 18310 - 20034 (-) MFS
      • Transport
      copy AA seq
      copy Nt seq
      • ANF07285.1
      • bfL3
      		 20610 - 22126 (-) 2-methylcitrate dehydratase
      • Tailoring
      • Other in vivo study
      copy AA seq
      copy Nt seq
      • ANF07286.1
      • bfL2
      		 22865 - 24492 (-) citrate synthase-like protein
      • Tailoring
      • Other in vivo study
      copy AA seq
      copy Nt seq
      • ANF07287.1
      • bfL1
      		 25045 - 25830 (-) hydrolase 341
      • Tailoring
      • Other in vivo study
      copy AA seq
      copy Nt seq
      • ANF07288.1
      • bfpks1
      		 26350 - 34624 (+) hrPKS
      • Scaffold biosynthesis
      • Knock-out Other in vivo study
      copy AA seq
      copy Nt seq
      • ANF07289.1
      • bfR1
      		 34976 - 35495 (-) DUF636 domain-containing protein
        copy AA seq
        copy Nt seq
        • ANF07290.1
        • bfR2
        		 36349 - 37008 (-) sodium/solute symporter
        • Transport
        copy AA seq
        copy Nt seq
        • ANF07291.1
        • bfR3
        		 38074 - 38803 (-) seed maturation-like protein
          copy AA seq
          copy Nt seq
          • ANF07292.1
          • bfR4
          		 41331 - 43675 (+) C6 transcription factor 2
          • Regulation
          copy AA seq
          copy Nt seq
          • ANF07293.1
          • bfR5
          		 45381 - 47802 (+) small oligopeptide transporter
          • Transport
          copy AA seq
          copy Nt seq
          • ANF07294.1
          • bfR6
          		 49811 - 50381 (-) YCII-related domain protein
            copy AA seq
            copy Nt seq
            • ANF07295.1
            • bfR7
            		 50918 - 51432 (+) YCII-related domain protein
              copy AA seq
              copy Nt seq
              Biosynthesis information

              Biosynthetic paths

              byssochlamic acid
              Show structure
              Pathway: hrPKS+bfL1 > bfL2 > bfL3 > bfL6|bfL10 [3], [5]
              Comment: Main product of the pathway
              agnestadride A
              Show structure
              Pathway: hrPKS+bfL1 > bfL2 > bfL3 > bfL6|bfL10 [3], [5]
              agnestadride B
              Show structure
              Pathway: hrPKS+bfL1 > bfL2 > bfL3 > bfL6|bfL10 [3], [5]
              Triketide maleidride monomer type A
              Show structure
              Pathway: hrPKS+bfL1 > bfL2 > bfL3 [3], [5]
              Comment: This product spontaneously decarboxylates to produce the decarboxylated triketide monomer
              Subcluster
              Precursor
              decarboxylated triketide monomer
              Show structure
              Pathway: hrPKS+bfL1 > bfL2 > bfL3 [3], [5]
              Subcluster
              Precursor
              Annotation changelog

              Entry version: next

              Date
              Changes
              Submitters
              Reviewers
              2024-04-23
              MIBiG v4 annotathon
              • (ID: HDJ3EC3TGIV3UPD32FQLYIFP)
              • (ID: IEZIYZ7653O6LRHFKMRXEA7B)
              • (ID: XBXL5Y5CH4BE3EYSVTFNOISJ)
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

              Entry version: 2

              Date
              Changes
              Submitters
              Reviewers
              2019-10-16
              Migrated from v1.4
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              2019-10-16
              Updated compound(s) information (NPAtlas curation)
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

              Entry version: 1

              Date
              Changes
              Submitters
              Reviewers
              2016-09-03
              Submitted
              • (ID: HDJ3EC3TGIV3UPD32FQLYIFP)
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              Detailed domain annotation
              Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
              A domain glossary is available here, and an explanation of the visualisation is available here.
              Selected features only
              Show module domains
              Similar known gene clusters from MIBiG 4.0
              Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
              Click on reference genes to show details of similarities to genes within the current region.
              Click on an accession to open that entry in the MiBIG database.