Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0001340.1:
Cluster 1Polyketide152546

BGC0001340, byssochlamic acid biosynthetic gene cluster from Byssochlamys fulva. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: byssochlamic acid
PubChem ID: 164723
ChEMBL ID: 3039421
SMILES string: Copy to clipboard
Molecular formula: C18H20O6
Average molecular mass: 332.352 Da
Molecular activity: Unknown

Class-specific details

Biosynthetic class(es):
Polyketide
Polyketide subclass:
Other (linear)
Polyketide synthase subclass:
Iterative type I
Starter unit:
Acetyl-CoA
Polyketide synthase / ketosynthase-encoding genes:
ANF07288.1
Iterative PKS subtype:
Highly reducing
3
Thioesterase type:
Unknown
Release / cyclization type:
Unknown

Modular polyketide synthases:
bfpks1 (ANF07288.1)
Module 1
AT specificity: Acetyl-CoA
Evidence for specificity: Structure-based inference
KR stereochemistry: Unknown
Scaffold-modifying domain: None
Module is iterated
Evidence for iteration: Unknown

Gene cluster description

byssochlamic acid (BGC0001340). Gene Cluster 1. Biosynthetic class = Polyketide. GenBank KU928136. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Knock-out studies, Heterologous expression, Gene expression correlated with compound production, Sequence-based prediction
MIxS-compliance:Unknown
Contact for this cluster:Katherine Williams (Cardiff University)

Literature references

1. Williams K et al. (2016) Heterologous Production of Fungal Maleidrides Reveals the Cryptic Cyclization Involved in their Biosynthesis. Angew Chem Int Ed Engl 55(23):6784-8. doi: 10.1002/anie.201511882.
2. Szwalbe AJ et al. (2015) Novel nonadride, heptadride and maleic acid metabolites from the byssochlamic acid producer Byssochlamys fulva IMI 40021 - an insight into the biosynthesis of maleidrides. Chem Commun (Camb) 51(96):17088-91. doi: 10.1039/c5cc06988b.