BGC0001341 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001341 (Rothia nasimurium)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS	1	20,822	valinomycin	NRPS:Type I	100%

BGC0001341 - Region 1 - NRPS

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Location: 1 - 20,822 nt. (total: 20,822 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 20,823
Label		BGC0001341

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001341	1.00	NRP	valinomycin	Rothia nasimurium
BGC0001133	0.36	NRP	taxlllaid A	Xenorhabdus bovienii SS-2004
BGC0002071	0.32	NRP	virginiafactin A, virginiafactin B, virginiafactin C, virginiafactin D	Pseudomonas sp. QS1027
BGC0000351	0.26	NRP	exochelin	Mycolicibacterium smegmatis MC2 155
BGC0001825	0.26	NRP	xenematide	Xenorhabdus nematophila AN6/1
BGC0001132	0.24	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0000320	0.24	NRP	cereulide	Bacillus cereus
BGC0001833	0.24	NRP	icosalide A, icosalide B	Burkholderia gladioli
BGC0001846	0.24	Saccharide, NRP	valinomycin, montanastatin	Streptomyces sp. CBMAI 2042
BGC0000426	0.24	NRP	sevadicin	Paenibacillus larvae

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001341	1.00	NRP	valinomycin	Rothia nasimurium
BGC0001133	0.69	NRP	taxlllaid A	Xenorhabdus bovienii SS-2004
BGC0002071	0.65	NRP	virginiafactin A, virginiafactin B, virginiafactin C, virginiafactin D	Pseudomonas sp. QS1027
BGC0000351	0.59	NRP	exochelin	Mycolicibacterium smegmatis MC2 155
BGC0001825	0.59	NRP	xenematide	Xenorhabdus nematophila AN6/1
BGC0001132	0.57	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0000320	0.57	NRP	cereulide	Bacillus cereus
BGC0001833	0.57	NRP	icosalide A, icosalide B	Burkholderia gladioli
BGC0001846	0.57	Saccharide, NRP	valinomycin, montanastatin	Streptomyces sp. CBMAI 2042
BGC0000426	0.57	NRP	sevadicin	Paenibacillus larvae

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 20822:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X - D-Val) + (X - Val)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

A7979_04520

Search NORINE for peptide: strict or relaxed

AMP-binding (202..623): X

nrpys: Pyv

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: GLSWIAENMK
Nearest Stachelhaus code(s):: Pyv GLSWIAENMK (100% 8Å match); Pyv or Lac GLSWIAENMK (91% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1811..2194): Val

nrpys: Val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: val (Val)

Stachelhaus prediction details:

Stachelhaus sequence:: DAFWVGGTFK
Nearest Stachelhaus code(s):: Val DAFWVGGTFK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

A7979_04525

Search NORINE for peptide: strict or relaxed

AMP-binding (16..422): X

nrpys: Kiv

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: AALWIAASGK
Nearest Stachelhaus code(s):: Kiv AALWIAASGK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1790..2177): Val

nrpys: Val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: val (Val)

Stachelhaus prediction details:

Stachelhaus sequence:: DAFWLGGTFK
Nearest Stachelhaus code(s):: Val DAFWLGGTFK (100% 8Å match)
Stachelhaus code match:: 100% (strong)