LOCUS       BGC0001343             19349 bp    DNA     linear   BCT 16-AUG-2011
DEFINITION  Stigmatella aurantiaca aurachin biosynthetic gene cluster, locus 1,
            strain Sg a15.
ACCESSION   BGC0001343
VERSION     BGC0001343
KEYWORDS    .
SOURCE      Stigmatella aurantiaca Sg a15
  ORGANISM  Stigmatella aurantiaca Sg a15
            Bacteria; Myxococcota; Myxococcia; Myxococcales; Cystobacterineae;
            Archangiaceae; Stigmatella.
COMMENT     On May 3, 2011 this sequence version replaced AM404078.1.
            ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-10-17 15:22:16
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     source          1..19349
                     /db_xref="taxon:675526"
                     /mol_type="genomic DNA"
                     /organism="Stigmatella aurantiaca Sg a15"
                     /strain="Sg a15"
     protocluster    1..19349
                     /aStool="rule-based-clusters"
                     /category="PKS"
                     /contig_edge="True"
                     /core_location="[12818:15276]"
                     /cutoff="5000"
                     /detection_rule="(hr-t2pks-ksa and (t2fas or APE_KS2 or
                     ketoacyl-synt))"
                     /neighbourhood="20000"
                     /product="HR-T2PKS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      12819..15276
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="5000"
                     /detection_rule="(hr-t2pks-ksa and (t2fas or APE_KS2 or
                     ketoacyl-synt))"
                     /neighbourhood="20000"
                     /product="HR-T2PKS"
                     /protocluster_number="1"
     cand_cluster    1..19349
                     /SMILES=""
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(hr-t2pks-ksa and (t2fas or APE_KS2 or
                     ketoacyl-synt))"
                     /kind="single"
                     /product="HR-T2PKS"
                     /protoclusters="1"
                     /tool="antismash"
     subregion       1..19349
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0001343"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..19349
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="HR-T2PKS"
                     /region_number="1"
                     /rules="(hr-t2pks-ksa and (t2fas or APE_KS2 or
                     ketoacyl-synt))"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            62..1555
                     /gene="orf12"
     CDS             62..1555
                     /codon_start=1
                     /gene="orf12"
                     /product="hypothetical protein"
                     /protein_id="CCA65701.1"
                     /transl_table=11
                     /translation="MAGFSGVEDYARLTLSPPMIRLLLLMPLLTVCACATLQGRADELA
                     SRGQYIEAAEIYDQLVHEKPGEKPLVDARDDLRWKGLEQLLGRARRLRFEGHDDEAERF
                     LESFLSYRTQWNTKLNGGMESSLVDEFDGTYLHFQKIILEPAQQGLALTAEAALDPKRK
                     LLSYAVLNKVRQEMETAVVQGGQATCDRVKQLPAEGLPHWNELVARYCLRYQARGPEPL
                     FIPEVLAAPSWSVSLSGVSLAQQESLVARLSRAFEASAWYSPVAERRPVFSLRGQFTED
                     WAQRTVQLTAPWTDREPYTDHEERTEVTEEPFEDEEEYTDEQGNKKTRKVTRYRKKTRE
                     YTVPVTKYRDVPKSFEYFAQRHSVDYGFSVSATGILSEAHSALSVAVTDRYSAYGFEHD
                     VSFSPGNVYPQRPRLLLPHDWFEQHARGLEQAFAGQLQEHWRQYYCSEPSLSLDAAARC
                     ARAGAALPPQARQVLSDVLGTDGSYTPRLFLSGGGALSP"
     gene            complement(1564..2367)
                     /gene="orf11"
     CDS             complement(1564..2367)
                     /codon_start=1
                     /gene="orf11"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1262:haloalkane dehalogenase (Score: 103.3; E-value:
                     2.3e-31)"
                     /gene_kind="biosynthetic-additional"
                     /product="predicted alpha/beta superfamily hydrolase"
                     /protein_id="CCA65702.1"
                     /sec_met_domain="PF00561 (E-value: 4.6e-20, bitscore: 62.5,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 9.2e-24, bitscore:
                     75.5, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPLHVTARGEGEPVLLLHSGGMSARQWRKLGDALAPTHQVLAPDF
                     LGSGENPPWPAGEPFHFQQDVEAVSELLSGLGDPAHLVGHSYGGFIALMLARKAPAQVR
                     SLAVYEPVAFGVLHDAQDAEGLENLARAGAHPTFNDASQGGSDAWLELFIDYWNGPGSW
                     RAMAPPARQAFLRVGRKVYYEVSTLMEDRTPLAAYAAITAPSLLLFGAQSPAAARRLVT
                     LLGTAIPQATVQTLSGAGHMGPMTHAEAVNATITRHILAATTRSP"
     gene            complement(2377..3927)
                     /gene="auaEII"
     CDS             complement(2377..3927)
                     /NRPS_PKS="Domain: AMP-binding (22-420). E-value: 6.4e-86.
                     Score: 280.3. Matches aSDomain:
                     nrpspksdomains_auaEII_AMP-binding.1"
                     /codon_start=1
                     /gene="auaEII"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002:AMP-dependent synthetase and ligase (Score:
                     346.7; E-value: 3e-105)"
                     /gene_kind="biosynthetic-additional"
                     /product="anthranilate-CoA ligase"
                     /protein_id="CCA65703.1"
                     /sec_met_domain="AMP-binding (E-value: 1.8e-99, bitscore:
                     323.3, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKASDLPLYYNAVDILERNLPVRANKTALFTPDREMTFRQVSNEA
                     NQVGNALKGLGVRFGECVGLLTLDSAEWVTSFFGIVKLGAIAVGINTLLKPPEYEYILR
                     DCRARVLIVHQEFLPLIESIRGNLPMLEHIVVIGEGPQEGYLSFNDWIRPQPTTLEAAQ
                     SHREDICSLNYSSGTTGGPKGIPHAHKDYPLTAQLWGVNVLGLRESDRTFALAKLFFTF
                     GTGGNLIFPWYVGASCVLFPGAARVASNVLSTISRFKPTIFYNAPTGYAAALALKDFSQ
                     HDLSSLRLCVSASEALPAALWYAWKEATGVDIIDGIGCTENFHIFISNRPGDIRPGSSG
                     KPVEGYELKLVDDEGKTVPAGEIGNVLLRSETAALSYWHNFEKSRQTFQGEWLATGDKY
                     FVDADGYYWHAGRSDDMLKVGGIWVSPVEVESTLIQHPAVQECAVIGCPDQSRLIKPKA
                     FIILKPEQIPSEALIRQITDHCTEKMAAYKRPRWIEFVTELPKTATGKIQRFKLRSAA"
     CDS_motif       complement(2638..2700)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_auaEII_0002"
                     /evalue="3.50E-04"
                     /label="NRPS-A_a8"
                     /locus_tag="auaEII"
                     /protein_end="430"
                     /protein_start="409"
                     /score="13.4"
                     /tool="antismash"
                     /translation="AGRSDDMLKVGGIWVSPVEVE"
     aSDomain        complement(2668..3861)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_auaEII_AMP-binding.1"
                     /evalue="6.40E-86"
                     /label="auaEII_AMP-binding.1"
                     /locus_tag="auaEII"
                     /protein_end="420"
                     /protein_start="22"
                     /score="280.3"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="RANKTALFTPDREMTFRQVSNEANQVGNALKGLGVRFGECVGLLT
                     LDSAEWVTSFFGIVKLGAIAVGINTLLKPPEYEYILRDCRARVLIVHQEFLPLIESIRG
                     NLPMLEHIVVIGEGPQEGYLSFNDWIRPQPTTLEAAQSHREDICSLNYSSGTTGGPKGI
                     PHAHKDYPLTAQLWGVNVLGLRESDRTFALAKLFFTFGTGGNLIFPWYVGASCVLFPGA
                     ARVASNVLSTISRFKPTIFYNAPTGYAAALALKDFSQHDLSSLRLCVSASEALPAALWY
                     AWKEATGVDIIDGIGCTENFHIFISNRPGDIRPGSSGKPVEGYELKLVDDEGKTVPAGE
                     IGNVLLRSETAALSYWHNFEKSRQTFQGEWLATGDKYFVDADGYYWHAGRSDDMLKVG"
     CDS_motif       complement(3361..3411)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_auaEII_0001"
                     /evalue="8.60E-04"
                     /label="NRPS-A_a3"
                     /locus_tag="auaEII"
                     /protein_end="189"
                     /protein_start="172"
                     /score="12.4"
                     /tool="antismash"
                     /translation="NYSSGTTGGPKGIPHAH"
     gene            complement(4078..5097)
                     /gene="orf10"
     CDS             complement(4078..5097)
                     /codon_start=1
                     /gene="orf10"
                     /product="predicted Rieske-[2Fe-2s]-domain protein"
                     /protein_id="CCA65704.1"
                     /transl_table=11
                     /translation="MKELDFWHPVIPSKELKDKPLAVTVAGKQIALFRTADGNVGALED
                     RCPHRRMKLSVGKVEGDRLVCPYHGWSIDRTGEVRAPIHNNEPMRSCATHYSATEQHGA
                     IWIKNASSEAPLPQLHKPDHRCAFVMRHRMEAPLEVVLDNFVELDHSVTTHLIFGYQNV
                     AQATAEMEVDGDVLRVNHRGPQKQVSLPLRLMFGVKEGDWVQVPTEIRFGPLSMISEQL
                     WTNDKEPGKVRSPGTQMVIFFTPVDENITDVLTFTFVSPTLDKTLGRMPFIGYKVLHTL
                     VNYETKLDQEMLKNLADKDPNLRGMKLGRLDKPLGQVRTMLNRIYRGQLQPVRVADSA"
     gene            complement(5156..5881)
                     /gene="orf9"
     CDS             complement(5156..5881)
                     /codon_start=1
                     /gene="orf9"
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 207.7; E-value:
                     3.2e-63)"
                     /gene_kind="transport"
                     /product="predicted ABC transporter ATP-binding protein"
                     /protein_id="CCA65705.1"
                     /transl_table=11
                     /translation="MTSQNLLDLKGITKDYLLGKTKVSALRGVDLTIAAGEFTVVTGPS
                     GSGKTTLLNIIGCLDRATDGSYKLDGEEVGNRDFDDLAEVRNRKIGFIFQNFNLIPVLD
                     VAENIEFPCVVRRGAEGKASLRKRVEALAEAVGLKPYLHHRPDELSGGQRQRVAIARAL
                     ITEPKLVLADEPTANLDSTTSEQIIDLMLKLNRDNGVTFLFSTHDPRVVSHARRALHIQ
                     DGKMLQGEFRGAAPHAQAS"
     gene            complement(5891..7324)
                     /gene="orf8"
     CDS             complement(5891..7324)
                     /codon_start=1
                     /gene="orf8"
                     /product="hypothetical protein"
                     /protein_id="CCA65706.1"
                     /transl_table=11
                     /translation="MRPHFLFSGLLSSTLLASTAMGAEVNGYVESRTQYTRSRVDGVLP
                     TSAQPEVQQLFEFNGQLRQDYRPGGTVSADLSLFLSMAGRYRSLNADQEEIGVTPSEEA
                     AAQPIASINELFLQHEFVPAFNVLAGKKRLIWGAGLAYNPTDLLNPPKDPTDPTFQRAG
                     AWMVRLEVPLEKYAFTLLASPAVVKQKSGLPQSILTYPSWDKQDDELHYVIAARAYALL
                     LDADLNLMLFHSNLYRNAFENKTQVGFSFSRYFFTDYELHVEALVGSGSPRLYASRDCV
                     ASPEAALGCAERGEAFLFPRRIDEKRIRPQILVGTRYMFSDESMVSLEYLYQADGLKKG
                     EAQDYLNGLALLRTGEQFGLDPSDINFGGTDPGLPQKFSFEPITRHYAFLSFQKPKIRD
                     DFTLSAVIVSSLQDLSGLVSPSLSWSATEWLTLTASAFIPFQGPSSLASKKPDTHEAVS
                     EFGLLPLKYRGLFQARLFY"
     gene            complement(7345..8070)
                     /gene="orf7"
     CDS             complement(7345..8070)
                     /codon_start=1
                     /gene="orf7"
                     /product="predicted outer membrane lipoprotein sorting
                     protein"
                     /protein_id="CCA65707.1"
                     /transl_table=11
                     /translation="MKTLILSLMTLLAAAPALAADPTADELIARYDAAMGPHTYESESE
                     MISYREDGSKRTYGMRMMKADDDKFRIWFTSPSSVKGQEVLRSGQNMWVYLPNLKRATR
                     IANRESFQGGDFNNADVLRVTYAKDYTAKLVPSDAPDTWALELKAKNADTAYDAIKLWL
                     RKSDSLPVKGHYFGTSGQLQRSAEFTDYTEFEKGFTRPARIIMQNELVKTRRSEMIFKV
                     MKRNVEIQAQRFTQADLGR"
     gene            complement(8101..9381)
                     /gene="orf6"
     CDS             complement(8101..9381)
                     /codon_start=1
                     /gene="orf6"
                     /product="predicted ABC-type lipoprotein release
                     transporter, permease component"
                     /protein_id="CCA65708.1"
                     /transl_table=11
                     /translation="MSSSLPSIAVRNVARNGRRSFITLAAVLLGVTAVIVLRGISDGFV
                     RLMEDEVVQGRTGALQIHRKGFVDSVEALPLEPNMPYDDEMRARIQSVPGVTGITGHIQ
                     FSGLVSNGVSQTMFVGRALDMKTEKQAIPRSGFDVREGGETLSEADYTHGIFGAELIKS
                     FGAVTQEAKKKALAAGTPGAQTLIEQVTLSSTSPKGRSNSYDVSIKGLSESNLPFENKR
                     VATVPLALAQDLLGLQGRVTEYAVAVDNLQNLDRIAAELRKKLGPEYEVHTWQELQPFV
                     RDVIVRLKVVLGFVSVVLGIIIITGIINVMLMSVFERVREIGTMLAVGVRRYQVLVLFL
                     TEAAFLGLLGSIGGALIGSALVRLLASKGIPMKSLGSGVESLLRPELHAPFMLGTLIFA
                     TLGAVVAASYPAWKASRMQPVDALRSV"
     gene            complement(9378..10268)
                     /gene="orf5"
     CDS             complement(9378..10268)
                     /codon_start=1
                     /gene="orf5"
                     /product="predicted ABC-type transport system"
                     /protein_id="CCA65709.1"
                     /transl_table=11
                     /translation="MTAFDPKLEAQVTPRRMDWLGTGSFLSSVDASEMMLNADMARSLG
                     TQVMNAQSPPPEDQWPALLASDRDGVLNGEGVKLSGTLVSATPGDRRLGYLPLATAQRL
                     LRMEGRVTEYALALNRLEDAPKVRDALKAQLGDEYEVHTWDEVQPYVAELLKQEDALFG
                     IIIFIFLFVVLLGVVNVMLMNVLERVREIGTMLAVGMRRRHIVSLFLMEGAVLGLLGGV
                     LGALLGWALTVWLNQKGIRIPAPGASVDSIIRPVIPLTYLVRATVLAIVGASLAALWPA
                     YRASRLRPVEALSTT"
     gene            complement(10694..11317)
                     /gene="orf4"
     CDS             complement(10694..11317)
                     /codon_start=1
                     /gene="orf4"
                     /gene_functions="regulatory (smcogs) SMCOG1057:TetR family
                     transcriptional regulator (Score: 99.8; E-value: 4.2e-30)"
                     /gene_kind="regulatory"
                     /product="predicted transcriptional regulator"
                     /protein_id="CCA65710.1"
                     /transl_table=11
                     /translation="MAQALRKDEVRNTRRAILDAALDLFSVHGYAGTSIRQIARAVEVR
                     ESALYHHFPSKAAIFEALLHEYGPGKTERLSQLDLDASLANGAQACLRTMAVELFEEWA
                     TPREQKFARLMMSEAPRLSTAGIVHPAAILGQSHTHIVRFMEELVRRQLIRPGDLDLYA
                     LEFMGPLIMLRQMYLMMSWGLTDMRVLKNQVEQHVHHFCQSVKL"
     gene            11507..12487
                     /gene="auaA"
     CDS             11507..12487
                     /codon_start=1
                     /db_xref="GOA:A4F5C0"
                     /db_xref="InterPro:IPR000537"
                     /db_xref="UniProtKB/TrEMBL:A4F5C0"
                     /gene="auaA"
                     /product="prenyltransferase"
                     /protein_id="CAL48953.1"
                     /transl_table=11
                     /translation="MTLLQVGSIRFTAFYLAAFSTAIAATGHDPVPWLALSVPLWMVKC
                     LAIELTNRYADRIEDAVNRQERTLLCEQVGYDTIRRAAIGLNALVLAFYLAWFVEWRRP
                     ELFAVQLVSWLVMWNYSVGLRFKGRRLGVLVALCGTFILPFLCGWMIYGQFKDVPLPIL
                     SMLVFVFSLSGIKDITDVEGDAKRGYRSFFVDVASRRSAARLLLLLGSPYLFIAGLVAF
                     GAAPPRFLALVAFAPVSLLFASLVRGAREPHERTTIREWTYHFWFVFLMGILLLVHPTV
                     QNAAVLGGCVAFWVVATRRLHWAVGLRADQVEDVSRILSRVFVAS"
     gene            12568..12822
                     /gene="auaB"
     CDS             12568..12822
                     /NRPS_PKS="Domain: PP-binding (8-74). E-value: 2.7e-10.
                     Score: 32.6. Matches aSDomain:
                     nrpspksdomains_auaB_PP-binding.1"
                     /codon_start=1
                     /db_xref="GOA:A4F5C1"
                     /db_xref="InterPro:IPR006163"
                     /db_xref="InterPro:IPR009081"
                     /db_xref="UniProtKB/TrEMBL:A4F5C1"
                     /gene="auaB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_kind="biosynthetic-additional"
                     /product="acyl carrier protein"
                     /protein_id="CAL48954.1"
                     /sec_met_domain="PP-binding (E-value: 8.7e-11, bitscore:
                     32.6, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTRDEIRSKVMQIAAEIFELEPEALLGDKHIVDELGATSVLRLEF
                     IVMLERGFKFQFNPEEIEVAQNLNEVVDVVEKLLRGKGS"
     aSDomain        12592..12789
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_auaB_PP-binding.1"
                     /evalue="2.70E-10"
                     /label="auaB_PP-binding.1"
                     /locus_tag="auaB"
                     /protein_end="74"
                     /protein_start="8"
                     /score="32.6"
                     /tool="antismash"
                     /translation="KVMQIAAEIFELEPEALLGDKHIVDELGATSVLRLEFIVMLERGF
                     KFQFNPEEIEVAQNLNEVVDV"
     gene            12819..14039
                     /gene="auaC"
     CDS             12819..14039
                     /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (74-404). E-value:
                     6.9e-57. Score: 185.1. Matches aSDomain:
                     nrpspksdomains_auaC_PKS_KS.1"
                     /codon_start=1
                     /db_xref="GOA:A4F5C2"
                     /db_xref="InterPro:IPR000794"
                     /db_xref="InterPro:IPR014030"
                     /db_xref="InterPro:IPR014031"
                     /db_xref="InterPro:IPR016038"
                     /db_xref="InterPro:IPR016039"
                     /db_xref="InterPro:IPR018201"
                     /db_xref="UniProtKB/TrEMBL:A4F5C2"
                     /gene="auaC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     HR-T2PKS: hr-t2pks-ksa"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022:Beta-ketoacyl synthase (Score: 363.8; E-value:
                     2.1e-110)"
                     /gene_kind="biosynthetic"
                     /product="beta-ketoacyl-ACP synthase II"
                     /protein_id="CAL48955.1"
                     /sec_met_domain="hr-t2pks-ksa (E-value: 2.7e-117, bitscore:
                     382.3, seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKRNVVVTGVSVITSVGVGVDAFWSAVRRGEVGTGPLTRFSPEG
                     LRSDRAGEIKNFDDTKAFHHLDPTPHQRGTRLALSASRMAVEDAKLSVGMLEGASERAG
                     VVMGVVVANRPGLESPYGQTHLKPEGRKHVSLRAHDVALVSEVPASELGLRGPSLVIPT
                     ACAAGNSAIGCAMDLIQDGHADLMLAGGVDELSPAMLMMFSMFDAMSKDVVRPFDKNRR
                     GLILSEGAAVLVLEAEEHARARGAHIYGRVLGHGNFADAHDMTHPHPEGLGARLAMESA
                     LRESGLSPQDVHYVSAHGTGTPTNDPTEARAIRDLFGKHTDSLPVSSIKSMLGHSQGAA
                     SAIESVACLLAIRDGVVPPTVNFTEADPECLALDVVPNQARKHRVQVAMNNAFGFGGNI
                     SCVVFGQ"
     aSDomain        13041..14030
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_auaC_PKS_KS.1"
                     /domain_subtypes="Iterative-KS"
                     /evalue="6.90E-57"
                     /label="auaC_PKS_KS.1"
                     /locus_tag="auaC"
                     /protein_end="404"
                     /protein_start="74"
                     /score="185.1"
                     /tool="antismash"
                     /translation="TRLALSASRMAVEDAKLSVGMLEGASERAGVVMGVVVANRPGLES
                     PYGQTHLKPEGRKHVSLRAHDVALVSEVPASELGLRGPSLVIPTACAAGNSAIGCAMDL
                     IQDGHADLMLAGGVDELSPAMLMMFSMFDAMSKDVVRPFDKNRRGLILSEGAAVLVLEA
                     EEHARARGAHIYGRVLGHGNFADAHDMTHPHPEGLGARLAMESALRESGLSPQDVHYVS
                     AHGTGTPTNDPTEARAIRDLFGKHTDSLPVSSIKSMLGHSQGAASAIESVACLLAIRDG
                     VVPPTVNFTEADPECLALDVVPNQARKHRVQVAMNNAFGFGGNISCVVF"
     CDS_motif       13698..13745
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_auaC_0001"
                     /evalue="6.10E-03"
                     /label="PKSI-KS_m5"
                     /locus_tag="auaC"
                     /protein_end="309"
                     /protein_start="293"
                     /score="9.4"
                     /tool="antismash"
                     /translation="YVSAHGTGTPTNDPTE"
     gene            14053..15276
                     /gene="auaD"
     CDS             14053..15276
                     /NRPS_PKS="Domain: PKS_KS(Trans-AT-KS) (70-370). E-value:
                     1e-24. Score: 79.0. Matches aSDomain:
                     nrpspksdomains_auaD_PKS_KS.1"
                     /codon_start=1
                     /db_xref="GOA:A4F5C3"
                     /db_xref="InterPro:IPR000794"
                     /db_xref="InterPro:IPR014030"
                     /db_xref="InterPro:IPR014031"
                     /db_xref="InterPro:IPR016038"
                     /db_xref="InterPro:IPR016039"
                     /db_xref="UniProtKB/TrEMBL:A4F5C3"
                     /gene="auaD"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     HR-T2PKS: t2fas"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1093:Beta-ketoacyl synthase (Score: 179.4; E-value:
                     1.5e-54)"
                     /gene_kind="biosynthetic"
                     /product="beta-ketoacyl-CLF synthase II"
                     /protein_id="CAL48956.1"
                     /sec_met_domain="t2fas (E-value: 5.1e-55, bitscore: 177.0,
                     seeds: 8, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSGSDVVITGLGAITPFGVGAAAVRQALLERRTAFASTAPTMDAM
                     PPLEPVLSARVAESAASTVLGKKGLRAVNPESQLFIAAAQLALREAGLESANVEPTHIG
                     LFAGTVRGGLDEYLRYHIESLVWGMHRVSATRGPNTGFNAPASHGSIRLRLQAANMTLS
                     SRTAASLDAISQGADFIRRGRARYILAGGIETFSYAAADSLQADGQVPSEPPRPYDTQR
                     QRPVPGEGAVVLLLETRENAQARGAKILATVGAWSTSFEPAIRGANVAAAGVRSLRGAL
                     SREGIDAKGIGAIFSSASGSVETDAAEARALGEVFGPALSETPLCAVKGTAGEWDGASG
                     ALQALAAVQSLAEGVIPPTGGTESVDPALPRMLIPKEPLQGSWKRALVHVLDPSGRSST
                     LILRGAEG"
     aSDomain        14263..15162
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_auaD_PKS_KS.1"
                     /domain_subtypes="Trans-AT-KS"
                     /evalue="1.00E-24"
                     /label="auaD_PKS_KS.1"
                     /locus_tag="auaD"
                     /protein_end="370"
                     /protein_start="70"
                     /score="79.0"
                     /specificity="transATor: (unknown)"
                     /tool="antismash"
                     /translation="RAVNPESQLFIAAAQLALREAGLESANVEPTHIGLFAGTVRGGLD
                     EYLRYHIESLVWGMHRVSATRGPNTGFNAPASHGSIRLRLQAANMTLSSRTAASLDAIS
                     QGADFIRRGRARYILAGGIETFSYAAADSLQADGQVPSEPPRPYDTQRQRPVPGEGAVV
                     LLLETRENAQARGAKILATVGAWSTSFEPAIRGANVAAAGVRSLRGALSREGIDAKGIG
                     AIFSSASGSVETDAAEARALGEVFGPALSETPLCAVKGTAGEWDGASGALQALAAVQSL
                     AEGVIPPTGGTESVDPALP"
     gene            15273..16766
                     /gene="auaE"
     CDS             15273..16766
                     /NRPS_PKS="Domain: AMP-binding (18-415). E-value: 8.6e-82.
                     Score: 266.7. Matches aSDomain:
                     nrpspksdomains_auaE_AMP-binding.1"
                     /codon_start=1
                     /db_xref="GOA:A4F5C4"
                     /db_xref="InterPro:IPR000873"
                     /db_xref="UniProtKB/TrEMBL:A4F5C4"
                     /gene="auaE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002:AMP-dependent synthetase and ligase (Score:
                     308.8; E-value: 9.3e-94)"
                     /gene_kind="biosynthetic-additional"
                     /product="anthranilate-CoA-ACP transferase"
                     /protein_id="CAL48957.1"
                     /sec_met_domain="AMP-binding (E-value: 1.5e-83, bitscore:
                     270.8, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSGANVFATLVTRHLEAGKGERPAYRQTGRTYTYAELERLSARAA
                     GLLHEAGLRRGDRVLCLAGDSVEIIALVLGAFRLGAVAVVANQLSPAAKLRFLCEDTAA
                     QVVIVSSVSASALASWTERPASLRSIWFQGEGEAGSFPRLEESIAAMPPRESVEPVEGT
                     HPACWQYTHGADGTELAVVHSHQGLAAAVEPFARAKLGLCESDVVFSIAKLYFGYGFAN
                     SLVFPLAAGACTLLHPGRSDVLTVMELVRREHPTVFFGVPTFYSGILKVPSAAQRFDVS
                     SVRAFVSAGEELSASLARKFKDTFGSLPVNGLGSTEMFHIYIATELRGDSPGSLGTLTP
                     GHEVRLLSASGQPVADGEVGELWVRGPHIGVGYAHHPEHTRRVFVEGWVRTGDLVTRDA
                     SGAYVFRGRTDALLKVAGQKTLLFEVEQCLRSHEAVVEAEVQVVVDEDGIRDLLAKVRL
                     REGVAPGNATVRVLRTFMRERLLPHSCPSKIEVLSGSAS"
     aSDomain        15327..16517
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_auaE_AMP-binding.1"
                     /evalue="8.60E-82"
                     /label="auaE_AMP-binding.1"
                     /locus_tag="auaE"
                     /protein_end="415"
                     /protein_start="18"
                     /score="266.7"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="KGERPAYRQTGRTYTYAELERLSARAAGLLHEAGLRRGDRVLCLA
                     GDSVEIIALVLGAFRLGAVAVVANQLSPAAKLRFLCEDTAAQVVIVSSVSASALASWTE
                     RPASLRSIWFQGEGEAGSFPRLEESIAAMPPRESVEPVEGTHPACWQYTHGADGTELAV
                     VHSHQGLAAAVEPFARAKLGLCESDVVFSIAKLYFGYGFANSLVFPLAAGACTLLHPGR
                     SDVLTVMELVRREHPTVFFGVPTFYSGILKVPSAAQRFDVSSVRAFVSAGEELSASLAR
                     KFKDTFGSLPVNGLGSTEMFHIYIATELRGDSPGSLGTLTPGHEVRLLSASGQPVADGE
                     VGELWVRGPHIGVGYAHHPEHTRRVFVEGWVRTGDLVTRDASGAYVFRGRTDALLKV"
     CDS_motif       16338..16424
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_auaE_0001"
                     /evalue="8.70E-08"
                     /label="NRPS-A_a6"
                     /locus_tag="auaE"
                     /protein_end="384"
                     /protein_start="355"
                     /score="24.5"
                     /tool="antismash"
                     /translation="DGEVGELWVRGPHIGVGYAHHPEHTRRVF"
     gene            complement(16755..17429)
                     /gene="orf1"
     CDS             complement(16755..17429)
                     /codon_start=1
                     /gene="orf1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_kind="biosynthetic-additional"
                     /product="predicted carboxymethylenebutenolidase"
                     /protein_id="CCA65711.1"
                     /sec_met_domain="Abhydrolase_6 (E-value: 3.1e-09, bitscore:
                     28.0, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTPIHFPRPDGGEAMGSLALPTSGTGGPSVVVLHEWWGLTDTVK
                     QVADRLAASGYRALAVDYYRGYVASSKLEAMRKRMSMDVMDVVTQDVRGAAQYLKASGG
                     KTAVLGFSLGGAVATIAACHVPEFDAGISFYGIPPGKNADPGLIRIPFQAHYALSDDWY
                     PVPQIDALEARMRQGNVDLDFHRYEAKHGFFSTHWPEEYDATAAEKAWENLLKFLSARL
                     GS"
     gene            complement(17505..18167)
                     /gene="orf2"
     CDS             complement(17505..18167)
                     /codon_start=1
                     /gene="orf2"
                     /product="hypothetical protein"
                     /protein_id="CCA65712.1"
                     /transl_table=11
                     /translation="MRPIQKDGAWHVELGGATYPWNDGKTKPFAEALESPDLEDTLSIP
                     YTPGPITPVTRENEDPGRIRFEPLFHAAYGASEAQVDVVSIVFLGQTLKVHRKAAPAFE
                     RVATRLEATVKQEPSLKPYLKNLGGTFVWRKIAHTNRQSAHSYGVSIDVNVKHAHYWEW
                     ARPKAPVRWRNQIPQAIVDAFEAEGFIWGGRWYHYDTMHFEYRPELLDPACASSPSR"
     gene            complement(18332..19132)
                     /gene="orf3"
     CDS             complement(18332..19132)
                     /codon_start=1
                     /gene="orf3"
                     /product="predicted secreted hydrolase"
                     /protein_id="CCA65713.1"
                     /transl_table=11
                     /translation="MWAPQLIKSGSTYYIYFTAGAGNAHRMYVIQSQSPNSGYSAAAPL
                     ALPDNKWAIDGTAFVYKGQWYFVWSGWVGDSNGEQTLFIARMSSPTQVTGARYVISQPR
                     EWWEKVDVNPPTRVNEGPEPIIDPNGQLHIVYSANGSWDVNYCLADLRLRAGGDPTYVW
                     DWFKANGCFFSANGGIMMQGWHPTLYAKGVGHHSFVLLNGDPNTSPPAGPTFPLAYHGV
                     PKNDYPNPFWGGRYWYSGTFQWWGNITYTRGSESNTGWSLKFYE"
ORIGIN
        1 tatggaaagt ttccgcaggg gtcaattcag atgattcatg tgtcgagggc gtggtgagcg
       61 attggctggg ttctcgggtg ttgaagatta tgctagactg acattgtctc cgcccatgat
      121 ccgacttctc ctgttgatgc ccctgttgac cgtctgtgcc tgcgccaccc ttcaaggccg
      181 ggccgatgaa ctcgcctcgc gaggccaata catcgaagcg gccgagatct acgaccagct
      241 cgttcacgag aagccgggag agaagccgct cgtcgacgcc cgggatgatt tgcggtggaa
      301 gggattggag caattgctgg ggcgcgccag gcggctgcgc ttcgagggac acgacgacga
      361 ggcggagcgc ttcctcgagt cttttctctc ctaccgcacc cagtggaaca cgaagctgaa
      421 cggcggcatg gaaagctcgc tggtggatga gtttgacggg acatacctgc acttccagaa
      481 aatcatcctg gaacccgccc aacaggggct ggcgttgacg gcggaggcgg ccctggaccc
      541 gaagcgaaag ctgctgagtt acgcggtgct gaacaaggtc cgccaggaaa tggagaccgc
      601 ggttgttcaa ggcgggcagg ccacgtgtga ccgggtgaag cagcttcccg cggaggggct
      661 cccccattgg aatgagctgg tggcccgcta ctgcctgcgc taccaggccc gtgggccgga
      721 gcccctgttc attcccgagg tgctggcggc gccttcctgg tcggtgtcgc tctcaggagt
      781 gagccttgcc cagcaggagt ccctcgtggc gcggctctct cgggccttcg aggcatcggc
      841 ttggtattcg cccgtggccg agcggaggcc cgtcttctcc ctgcgagggc agttcaccga
      901 ggattgggcg cagcgcacgg tgcagttgac ggccccctgg accgacagag agccgtacac
      961 cgatcatgaa gagcggaccg aagtcaccga agagcccttc gaggacgagg aggagtacac
     1021 cgacgaacag gggaacaaga agacgcgaaa ggtcacccgg taccgcaaga aaacacgcga
     1081 atacacggtt cccgtgacca agtaccgcga tgtacccaag agctttgagt acttcgcgca
     1141 gcgccactcg gtggactatg ggttttccgt gtccgccacg ggcatcttgt ccgaggcaca
     1201 cagtgccctc tccgtggcgg tgacggatcg gtactccgcc tacggtttcg agcacgatgt
     1261 gtccttctcg cccggcaatg tctatcctca gcgcccgcgc cttttgctcc ctcatgactg
     1321 gttcgagcag cacgctcgcg ggttggagca ggctttcgcg ggacaacttc aggagcattg
     1381 gcgccagtac tattgctccg agccctcgtt gtcgctggat gcggctgccc gctgcgcccg
     1441 cgctggagcc gcgttgccgc cgcaggcccg tcaggtgctc tcggatgtgc tcggcacgga
     1501 tggctcctac acgccgcgcc tcttcttgtc tggtggggga gcgctgtccc cgtaatgcgc
     1561 aggtcagggg ctccgggtcg tggcggcgag gatgtgccga gtgatggtcg cgttcacggc
     1621 ctcggcgtgg gtcatcggcc ccatgtggcc cgcgccggag agggtttgga ccgttgcctg
     1681 gggaatcgct gttccgagca aggtgacgag gcggcgcgcg gccgccgggg attgcgcccc
     1741 gaagagcagg agggagggcg cggtgatcgc ggcataggcc gccaggggcg tccggtcctc
     1801 catcagggtg ctgacctcgt agtagacctt tctgcccacg cgcaagaacg cctgccgggc
     1861 gggcggcgcc atggcgcgcc agctcccggg gccgttccaa tagtcgatga acagctccag
     1921 ccatgcgtcg gagccgccct gtgacgcgtc gttgaaggtg ggatgggctc ctgcgcgcgc
     1981 gaggttttcg aggccctcgg cgtcctgcgc gtcgtggagg accccgaagg ccacgggctc
     2041 atacacggcg agcgaacgga cctgggcggg ggccttccgc gcgagcatca gcgcgatgaa
     2101 gccgccatag gaatggccca cgaggtgagc tgggtccccc agccccgaga ggagttcgct
     2161 gactgcctcg acgtcttgct ggaagtggaa gggctctccg gcgggccagg gcgggttctc
     2221 gccggagccg aggaagtccg gggcgagcac ctggtgggtg ggggcgagcg catcgccgag
     2281 tttgcgccac tggcgggccg acattcctcc actgtggaga agaaggacgg gctcgccctc
     2341 acctcgggcc gtgacatgca ggggcatggc gccggattat gcggcgcttc gcagcttgaa
     2401 gcgttggatc tttcccgtgg cggtcttcgg cagctcggtg acgaattcaa tccagcgcgg
     2461 ccgcttgtaa gccgccatct tctccgtgca gtgatcggtg atctggcgga tcaacgcctc
     2521 ggacggaatc tgctcgggtt tgaggatgat gaaggccttg ggcttgatga gtcggctctg
     2581 gtccgggcag ccgatgacgg cgcattcctg cacagccggg tgctggatga gggtgctctc
     2641 gacttccacg ggggacaccc agatgccgcc caccttcagc atgtcgtccg agcggcccgc
     2701 gtgccagtag tacccgtccg cgtcgacgaa gtacttgtcg cccgtggcca gccactcgcc
     2761 ctggaaggtt tgtcggctct tctcgaagtt gtgccagtag gagagcgccg ccgtctcgct
     2821 gcgcagcagc acgttgccga tctctccggc cggtaccgtc ttgccctcgt cgtcgaccag
     2881 cttgagctcg tagccctcga cgggcttgcc actgctgccg gggcggatgt ccccaggccg
     2941 gttcgagatg aagatgtgga agttctcggt gcagccaatg ccgtcgatga tgtccacccc
     3001 ggtggcttcc ttccaggcgt accagagcgc cgcgggaagg gcctcgctgg cggacacgca
     3061 cagccgcagc gacgacaagt cgtgctggga gaagtccttc aacgccagcg ccgccgcgta
     3121 gccggtgggg gcgttgtaga agatggtggg cttgaagcgg gagatggtgc tcagcacgtt
     3181 cgaggcgacc cgggccgctc ccgggaagag cacgcaactg gcgcccacgt accacgggaa
     3241 gatgaggttg ccgccggttc cgaaggtgaa gaacagcttg gccagggcaa aggtgcgatc
     3301 gctctcgcgc aggcccagga cgttcacgcc ccagagctgt gcggtgagcg ggtagtcctt
     3361 gtgcgcgtgg ggaatgccct tcggtccgcc cgtggtgccg ctggagtagt tcagcgagca
     3421 gatgtcctcg cggtggctct gcgccgcctc gagggtggtg ggctggggcc ggatccagtc
     3481 gttgaatgag aggtagccct cctgcgggcc ctctccgatg acaacgatgt gctccagcat
     3541 gggcaggttc ccacgaatgg attcgatgag cgggaggaac tcctggtgga cgatcaggac
     3601 gcgggccctg cagtcacgca ggatgtactc gtactcaggt ggcttgagca gcgtgttgat
     3661 gcccacggcg atcgcgccca gcttcacgat gccgaagaac gacgtgaccc actcggcgct
     3721 gtcgagtgtg agcaggccca cgcactcgcc gaatcggacg cccagcccct tgagcgcgtt
     3781 gcccacctgg ttggcttcgt tggacacctg ccggaaggtc atctcccggt ccggcgtgaa
     3841 gagggccgtc ttgttcgcgc gaacagggag gttgcgctcc aggatgtcca cggcgttgta
     3901 gtacagcggc agatcggaag ccttcatcca caaccctcgt cgcaagcagt cagcagaatc
     3961 gcctctaagt ggaataatgc acttttggcg gctaacaggg aagtaggggg atggcgcggc
     4021 ttgtcaacgc ccctcatccc tggggagggg aaggtagggg cgtgtcggtc tcctggctca
     4081 ggcggagtcg gcgacgcgga ccggctggag ctgaccgcgg tagatgcggt tgagcatggt
     4141 gcgaacttga cccaggggct tgtcgaggcg ccccagcttc atgccccgga ggttcgggtc
     4201 cttgtcggcc aggttcttga gcatctcctg gtcgagcttg gtctcgtagt tgacgagggt
     4261 gtggagcacc ttgtagccga tgaaaggcat gcgccccagc gtcttgtcca gcgtggggga
     4321 gacgaaggtg aaggtcagca cgtcggtgat gttctcatcc accggggtga agaagatgac
     4381 catctgggtg ccgggggagc ggaccttgcc gggctccttg tcgttggtcc agagctgctc
     4441 ggagatcatg ctgaggggcc cgaagcggat ctccgtgggg acctggaccc agtccccctc
     4501 cttgacgccg aacatgagcc gcaggggcag ggacacctgc ttctgggggc cgcggtggtt
     4561 gacgcggagg acatccccgt ccacctccat ttcggcggtg gcctgggcca cgttctggta
     4621 gccgaagatg aggtgagtcg tgacgctgtg gtccagctcg acgaagttgt cgagcaccac
     4681 ttccagcggg gcctccatcc ggtggcgcat cacgaaggcg cagcggtggt cgggcttgtg
     4741 gagctggggc aggggcgcct ccgagctcgc gttcttgatc cagatggccc cgtgctgctc
     4801 tgtggccgag tagtgggtgg cgcatgagcg catgggctca ttgttgtgga tgggggcccg
     4861 gacttcgccc gtccggtcga tgctccaccc gtggtagggg cacaccaacc ggtccccctc
     4921 gaccttgccg acgctgagct tcatccggcg gtgggggcag cgatcctcca gcgctccgac
     4981 gttgccgtcg gcggtgcgga acagggcgat ctgcttgccc gcgacggtga cggccagggg
     5041 cttgtccttc agttccttgc tcggaatgac ggggtgccag aagtcgagtt ctttcatgac
     5101 gtcctcccag gtgaatcagg caatgcggtc tgcgctgtga agaaaaggtc tcggttcaag
     5161 aggcctgggc gtgcggcgcg gcgccccgga actcgccctg caacatcttg ccatcttgga
     5221 tgtggagggc gcgacgggca tggctcacca cccgtgggtc gtgggtggag aagaggaacg
     5281 tcaccccatt gtcccggttg agcttgagca tgaggtcgat gatctgctcg ctggtcgtgg
     5341 agtccaggtt ggcggtaggc tcgtcggcga gcaccagctt cggctcggtg atgagcgcgc
     5401 gggcgatggc cacgcgctgg cgctggccac ccgacagctc gtcgggccga tggtgcaggt
     5461 agggcttgag gcccacggct tccgcgagtg cctcgacgcg cttgcgcagg gaggccttgc
     5521 cctcggcgcc gcggcgcacg acgcagggga actcgatgtt ctccgccacg tcgaggaccg
     5581 ggatgaggtt gaagttctgg aagatgaagc cgatcttccg gttgcgcacc tcggccaggt
     5641 cgtcgaagtc gcggttgccg acctcttccc cgtcgagctt gtaggagccg tccgtggctc
     5701 ggtccaggca gccgatgatg ttgagcagcg tcgtcttgcc actgcccgag gggcccgtga
     5761 cgacggtgaa ctcgccggcc gcgatggtca ggtcgacgcc gcgcagggcg ctgactttcg
     5821 tcttgcccaa caggtagtcc ttggtgatgc ccttgaggtc gaggaggttc tgagaggtca
     5881 tggtcgtctt tcagtagaag aggcgagcct ggaagaggcc gcgatacttg aggggcagca
     5941 ggccaaactc gctcaccgcc tcgtgggtgt cgggcttctt ggaggcaagg gaagagggcc
     6001 cctggaaggg gatgaaggcg gaggcggtga gcgtcagcca ctcggtggcg gaccaggaca
     6061 ggctggggct caccagtccg gaaaggtcct ggaggctgga gacgatcacc gccgagaggg
     6121 tgaagtcatc ccggatcttc ggtttctgga aggagaggaa ggcgtagtgc cgggtgatgg
     6181 gctcgaagct gaacttctgg ggcagccccg ggtccgtgcc gccgaagttg atgtccgatg
     6241 ggtccaggcc gaactgctcg cccgtgcgca gcagggcaag cccgttcagg tagtcctggg
     6301 cctcgccctt cttcagccca tcggcttggt agaggtactc cagggacacc atcgactcgt
     6361 cgctgaacat gtagcgcgtg cccacgagaa tctgaggccg gatccgcttc tcgtcgatgc
     6421 gccggggaaa gagaaaggcc tcgccgcgct ccgcgcagcc gagcgccgcc tccggggagg
     6481 ccacgcagtc gcgcgaggca tagagcctgg gggagccaga gcccaccagc gcttccacgt
     6541 gcagttcgta gtcggtgaag aagtagcgcg agaaggagaa gcccacctgc gtcttgttct
     6601 cgaaggcgtt gcggtacagg ttcgagtgga agagcatcag gttgaggtcc gcgtcgagca
     6661 gcagcgcgta cgctcgggcg gcaatcacgt agtgcagttc gtcgtcctgc ttgtcccagg
     6721 aggggtaggt gaggatcgac tggggcaggc cgctcttttg tttgaccacc gcggggctgg
     6781 ccagcagcgt gaaggcgtac ttctccaacg gcacctccag gcgcaccatc catgccccgg
     6841 cgcgctggaa ggtggggtcc gtcggatcct tgggcgggtt gagcaggtcg gtggggttgt
     6901 aggccaggcc cgcgccccag atgaggcgct tcttgcccgc cagcacgttg aaggcgggga
     6961 cgaactcgtg ctggagaaac agctcgttga tggaggcgat gggctgggcc gcggcctcct
     7021 cgctgggggt gacgccgatt tcttcctggt ccgcgttcag gctgcggtag cgccccgcca
     7081 tggacaggaa gagggacagg tcggccgaga cggtgccccc cggccggtag tcctggcgga
     7141 gctggccatt gaactcgaag agctgctgca cttcgggctg cgcgctggtc ggcagcaccc
     7201 cgtccacccg ggagcgggtg tactgggtgc ggctctccac gtagccgttc acctcggccc
     7261 ccatggcggt ggaggccagc agcgtggacg acagcagccc ggagaagagg aagtgggggc
     7321 gcatagaggc cagaggcagg ggggttagcg gccgaggtcc gcctgggtga agcgctgggc
     7381 ttggatttcc acgttgcgct tcatgacctt gaagatcatc tccgagcggc gggtcttcac
     7441 cagctcgttc tgcatgatga tgcgggccgg ccgcgtgaag cccttctcga actcggtgta
     7501 gtcggtgaac tccgcgctgc gctgcagttg cccgctggtg ccgaagtagt gccccttcac
     7561 cgggaggctg tcggacttgc gcagccacag cttgatggcg tcataggccg tgtccgcgtt
     7621 cttcgccttg agctccagcg cccaggtgtc gggcgcgtcc gagggcacca gcttggcggt
     7681 gtagtccttg gcgtaggtga cgcgcagcac gtcggcgttg ttgaagtcgc cgccctggaa
     7741 gctctcgcgg ttggcgatgc gcgtggcgcg cttgaggttg ggcaggtaga cccacatgtt
     7801 ctgcccggag cggagcactt cctggccctt cacgctcgag ggggaggtga accagatgcg
     7861 gaacttgtca tcgtccgcct tcatcatgcg catcccgtag gttcgtttgc tgccgtcctc
     7921 ccggtacgag atcatctcgg actcgctctc gtaggtgtgc ggccccatgg ccgcgtcata
     7981 ccgggcaatc agctcatccg cagtggggtc cgcggcgagc gctggggcgg ccgccaggag
     8041 ggtcatcaag ctgaggatca aggtcttcat gggttcctct gggttggaaa gagacagggc
     8101 ctacacggag cggagggcat ccacgggctg catgcggctg gctttccacg ccgggtagct
     8161 ggccgcgacc accgcgccca gcgtggcgaa gatgagggtg ccgagcatga agggggcgtg
     8221 cagctcgggc cggagcaacg actcgacgcc gctgcccagg ctcttcatgg ggatgccctt
     8281 ggaggccagc aggcgcacca gcgcgctgcc gatcaaggct cccccgatgc tgcccagcag
     8341 ccccaggaag gccgcttccg tcaggaaaag gacgagcacc tggtagcggc gcactcccac
     8401 cgcgagcatg gtgccgatct cccgcacccg ctcgaacacg ctcatcagca tcacgttgat
     8461 gatgccggtg atgatgatga tgccgagcac cacggacacg aagcccagca cgactttcag
     8521 gcggacgatg acatcgcgca cgaacggctg gagctcttgc caggtgtgca cctcgtactc
     8581 ggggccgagc ttcttgcgca attccgccgc gatgcggtcc aggttctgga ggttgtccac
     8641 ggccaccgcg tactcggtga cgcgtccctg aaggcccaag agatcctgcg cgagcgccag
     8701 cggcaccgtg gccacgcgct tgttctcgaa aggcaggttg gactcgctca gccccttgat
     8761 ggacacgtcg taggagttgg agcggccctt ggggctggtg gacgagagcg tcacctgctc
     8821 gatgagtgtc tgcgcgccgg gggtccccgc cgccagggcc ttcttcttgg cctcctgggt
     8881 caccgcgcca aaggacttga tgagctcagc gccgaagatg ccgtgggtgt agtccgcctc
     8941 ggacagcgtc tcgccaccct cgcgcacgtc gaagcccgag cggggaatgg cctgcttctc
     9001 ggtcttcatg tccagggccc ggccgacgaa cattgtctgg gagacgccgt tgctcaccag
     9061 ccccgagaac tggatgtggc cggtgatgcc cgtgacgccc ggaacgctct ggattcgcgc
     9121 ccgcatctcg tcgtcgtagg gcatgttggg ctccagtggg agcgcctcca cgctgtcgac
     9181 gaagcccttg cggtggatct gcagggcacc cgtgcggcct tgaacgactt cgtcctccat
     9241 gaggcggacg aagccgtcgg aaattcctcg cagcacgatg acggcggtga cgcccagcag
     9301 gacggcggcg agggtgatga agctgcggcg cccattgcgc gccacgttgc ggacggcgat
     9361 cgaaggaaga gaggagctca tgtggtggac aacgcctcca cgggacggag tcgggaagcg
     9421 cggtaggcgg gccacagggc ggcaagcgac gctcccacga tggccagcac ggtcgcgcgg
     9481 acgaggtagg tcaagggaat gacgggccgg atgatgctgt cgacgctggc gcccggcgcg
     9541 gggatgcgga tgcccttctg gttcagccag acggtgaggg cccaccccag cagcgcgccc
     9601 agcacaccgc ccagcagccc cagcaccgcg ccctccatca ggaagagcga gacgatgtgg
     9661 cgccgccgca tgcccaccgc gagcatggtg ccgatttccc gcacccgctc gagcacgttc
     9721 atcagcatca cgttgacgac gcccagcagc accacgaaga ggaagatgaa gatgatgatg
     9781 ccgaagaggg cgtcctcctg cttgagcaac tccgccacgt agggctgcac ctcatcccag
     9841 gtgtggacct cgtactcgtc gccgagttgg gccttgagcg catcacgcac cttgggggca
     9901 tcctccagcc ggttcagggc cagggcgtac tccgtcacac gcccctccat ccggagcagg
     9961 cgctgcgcgg tggccagcgg cagatagccc aggcggcggt ctcccggggt ggcgctcacc
    10021 agcgtgccgg agagtttcac gccctcgccg ttgagcacgc cgtcgcggtc gctggccagc
    10081 agcgcgggcc actggtcctc gggcggtggc gactgggcat tcatcacctg cgtgcccagg
    10141 ctccgcgcca tgtccgcgtt gagcatcatc tcggaggcgt ccacgctcga caggaagctg
    10201 cccgtgccca gccagtccat ccggcgaggc gtcacctgcg cctcgagctt cggatcgaac
    10261 gccgtcatat aaaggaaggt cgtcttgccc gcttcgtcct cggacggggc ctcctggccc
    10321 gggggccacc gggtccggca tggagagcat ggcgccgaag gcgatgcgcg cggtgagggc
    10381 tttgaccccc tccacggagg cgatgcgctg gcgcagctcc tcggagtccg ccatgtccag
    10441 cgtcagcggc gagctctgga cgttggcttg gtagcccttc ttgttcacca cgacggcccc
    10501 caggttgccc tcgaccaccc catcctgggt gacgcgctgc tggccgttga tgtagccgcg
    10561 caggaccacc atcacacaca cgccgaggat caaggcgacg agcgaaatca gggtccggcg
    10621 ccggttgcgc gtgaggttgc gagcggcgag tgtgatgagc ttcaccggcc cctccactga
    10681 gtgaacgttc gtttcatagt ttcaccgact gacagaaatg gtggacgtgt tgttcaacct
    10741 gatttttcag gacccgcatg tccgtgaggc cccaggacat catcaggtac atctggcgca
    10801 gcatgatgag cggccccatg aactccaggg cgtagaggtc caggtccccg gggcggatga
    10861 gctggcggcg caccagctct tccatgaatc gcacgatgtg ggtgtgggac tggcccagga
    10921 tggccgcggg gtggacgatg cccgcggtgc tcagccgggg ggcttcggac atcatcagcc
    10981 gcgcgaattt ctgctcccga ggggtggccc actcctcgaa gagttccacg gccatggtgc
    11041 gcaggcaggc ctgagcgccg ttggccagcg aggcgtccag gtccagttgg ctcaggcgct
    11101 cggtttttcc cgggccgtac tcgtgcagca gtgcctcgaa gatggcggcc ttggagggga
    11161 agtggtggta gagcgcgctc tcgcgcacct cgacggcgcg ggcgatctgc cggatggacg
    11221 ttcccgcgta gccatgcacc gagaagaggt ccagggccgc gtcgagaatg gcgcggcggg
    11281 tattgcggac ttcatctttt ctcagggctt gcgccatgga ttgctgtcta ccgagcgaac
    11341 gttcagttca caagccaccc cgaaagtcgc tgatggaaga aaatttaatg ggtgcgattc
    11401 agtctgagag aaaaggggct gccgggagtg gtgcccgttt gaacgcagag ggaattttcc
    11461 gtattgtacg ggttttgtgc aatcagcgac attccctaga cgcgttgtga cgctgcttca
    11521 agtcggcagc atccggttca cagccttcta tctggcggct ttttcaacgg ccatcgcggc
    11581 cacgggacat gaccccgtcc cctggctggc gctctcggtg cccttgtgga tggtgaagtg
    11641 cctcgccatc gaattgacca atcgctacgc cgatcgcatc gaagacgcgg tgaatcgcca
    11701 ggagcggacg ctgctgtgcg agcaggtagg atatgacacc atccgtcggg ccgccattgg
    11761 gctgaacgcg ctggtgctgg ccttctacct ggcgtggttc gtggagtggc ggcgccccga
    11821 gctgttcgcg gtccagctcg tgtcgtggct ggtgatgtgg aactactcgg tggggctgcg
    11881 gttcaagggg cggcggcttg gggtgctggt ggccctctgc gggacgttca tcctgccctt
    11941 cctctgcggg tggatgatct acggccagtt caaggatgtg ccgctgccca tcctgtcgat
    12001 gctggtcttc gtcttctcgc tgtcgggcat caaggacatc accgacgtgg agggggacgc
    12061 gaagcgcggc taccggagct tcttcgtgga tgtggccagc cgccgctcgg ccgcccggct
    12121 cctgctgctg ctgggcagcc cctacctctt catcgccgga ctggtggcct ttggcgcggc
    12181 gccgccccgg ttcctggcgc tggtggcgtt cgccccggtg tcgctcctct tcgcctcgct
    12241 ggtgcggggg gcgcgcgagc ctcacgagcg gacgacgatc cgcgagtgga cgtaccattt
    12301 ctggttcgtc ttcctgatgg gcatcctcct gctcgtgcac cccaccgtcc agaacgcggc
    12361 ggtgctcggg ggctgcgtgg ccttttgggt ggtggccacc cgccgtctgc actgggccgt
    12421 ggggttgagg gcggatcagg tggaggatgt aagccggatc ctctcgcggg tcttcgtcgc
    12481 ctcgtgacac actgaagcat ctgacggcgg ctcacgcggc ggggtcgccg actgttccat
    12541 caagccaaag agaaggcgta cttcgtcatg acacgcgatg agattcgttc caaggtgatg
    12601 cagatcgctg ctgagatctt cgagttggaa cccgaggcac tcttgggtga caagcacatc
    12661 gtcgatgagt tgggggccac ctcggtcctg cggctggagt tcatcgtgat gctcgagcgc
    12721 ggcttcaagt tccagttcaa tcccgaagag atcgaagtgg cgcagaacct gaacgaggtg
    12781 gtggacgtgg tggagaagct ccttcgcggg aagggttcat gagcaagcgg aacgtcgtcg
    12841 tcacgggagt gagcgtcatc acttccgtgg gggtgggagt cgacgccttt tggtccgctg
    12901 tccgtcgggg cgaagtaggc acgggtccgc tcacccgttt ctcccccgag gggctgcgca
    12961 gcgaccgcgc cggagagatc aaaaactttg atgatacgaa ggccttccat cacctggatc
    13021 ccaccccgca ccagcgggga acgcggctgg ccctgtcggc ctctcggatg gctgtcgagg
    13081 acgccaagct gagcgttggg atgctggagg gggcttccga gcgggccggt gtggtgatgg
    13141 gtgtcgtggt ggccaaccgg ccgggtctgg agtctcccta tgggcaaacg cacctgaagc
    13201 ccgaagggcg caagcatgtc tcgttgcgcg cccatgacgt ggcgctggtg agcgaggtgc
    13261 ccgcaagcga gctggggctc cgggggccgt cgctggtgat tcccaccgcc tgcgccgcgg
    13321 gcaacagcgc catcggctgt gcgatggatc tcattcagga cggccatgcc gacctgatgc
    13381 tcgcgggggg cgtggatgag ctgtcgcccg cgatgctcat gatgttctcg atgttcgacg
    13441 ccatgtcgaa ggacgtggtg cgcccgttcg acaagaaccg gcgggggctg atcctctccg
    13501 agggggcggc ggtcctggtg ctcgaggcgg aggagcatgc ccgggctcga ggcgctcaca
    13561 tttatgggcg cgtgctgggg cacggaaact tcgcggatgc ccacgacatg actcacccgc
    13621 acccggaagg gttgggcgcg cggctggcca tggaatcggc tctgcgtgag agcggactgt
    13681 cgccgcagga cgtccactac gtctccgcgc acgggacggg gacgccgacc aatgatccga
    13741 ccgaggcccg tgccatccgg gacttgttcg gcaaacacac cgattcgctc cccgtctcgt
    13801 cgatcaagtc gatgttgggc cactcccagg gggcggccag cgccatcgag tccgtggcct
    13861 gcttgctggc gattcgggat ggcgtggtgc cgccgaccgt gaacttcacg gaggcggatc
    13921 ccgagtgcct ggcgctcgat gtggtgccca atcaggcgcg gaagcaccgc gtgcaggtgg
    13981 cgatgaacaa cgccttcggc ttcggcggaa acatttcctg tgtcgttttc ggccagtgag
    14041 ggatcagtga ctgtgagcgg atcagacgtg gtcatcacgg gcctgggggc catcacgccg
    14101 ttcggggtcg gggcggcggc ggtgcgtcag gcgcttctgg agcgccggac cgcctttgcc
    14161 tcaacggctc ctacgatgga tgcgatgcct ccgctggagc ctgtcctctc ggctcgggtg
    14221 gccgagagcg cggcctcgac ggtgttgggg aagaagggcc tgcgggcggt caatcccgag
    14281 tctcagctct tcatcgccgc ggcccagctc gccctgcgcg aggcgggcct cgagtccgcg
    14341 aatgtggaac cgactcacat cgggctgttc gctgggaccg tgcggggtgg gcttgatgag
    14401 tacctgcgct accacatcga gagcttggtg tggggtatgc accgagtgag cgcgacgcga
    14461 ggcccgaaca ccggcttcaa cgcgcccgcc tctcacggct ccatccggct ccggttgcag
    14521 gccgccaaca tgacactgtc cagccggacc gcggcctcgc tggatgcgat ctcccagggc
    14581 gcggacttca ttcgcagggg ccgggcgagg tacatcctcg cgggcggcat cgaaaccttc
    14641 agctatgctg cggccgattc gctccaggcc gatgggcagg tcccttcgga gcctccccgg
    14701 ccttacgaca ctcagcgcca gcggcccgtg cccggcgagg gggcggtggt gttgctgctg
    14761 gagacgcggg agaacgccca ggcgcggggg gcgaagatcc tggccacggt gggggcttgg
    14821 tccacctcgt tcgagcccgc gatccggggc gcgaacgtgg ccgccgccgg cgttcgttct
    14881 cttcgcgggg cactctcccg ggaggggatc gacgccaagg gcatcggcgc gatcttctcc
    14941 tctgcctcgg gcagtgtgga gacggatgcc gcggaggcac gggccctggg tgaagtcttc
    15001 ggccccgcct tgagcgagac ccccctgtgc gcggtcaagg gcaccgcggg cgagtgggat
    15061 ggggccagcg gtgcgcttca ggcgctcgcg gccgtgcagt ccctggccga gggggtcatt
    15121 ccgcccaccg gcggcaccga gagtgtagac cccgcgctgc cccgcatgct gattcccaag
    15181 gagcctctcc agggctcgtg gaagcgtgcc ctggtgcacg tgttggatcc gtcgggccgg
    15241 tcctcgacct tgatcctccg gggggcggag gggtgagcgg agccaacgtc ttcgcgaccc
    15301 tggtgacccg tcatctcgag gcgggcaaag gggaacggcc cgcataccgc cagacgggac
    15361 ggacctatac ctacgctgag ttggagcgcc tctccgcccg tgccgccgga ctactgcacg
    15421 aggcggggct tcgccgggga gaccgcgtgc tctgcctggc gggggacagc gtggagatca
    15481 tcgcgctggt gctcggggcg ttccggttgg gcgcggtggc ggtcgtggcc aaccagcttt
    15541 cgcccgcggc caagctgcgc ttcctgtgcg aggacacggc ggcgcaggtg gtgatcgtat
    15601 cctctgtcag cgcgtcggcg ctggcgtctt ggacggagcg gcctgcctcg ctgcgcagca
    15661 tctggtttca gggagaaggc gaggcgggct ccttcccgag gctggaagag tcgattgccg
    15721 ccatgcctcc gcgcgagtcc gtggagcctg tcgaggggac gcaccccgcg tgctggcagt
    15781 acacccatgg ggcggacggc acggagttgg cggtggtgca ctcccaccag gggttggccg
    15841 cggccgtgga gcccttcgcg cgcgcgaagt tgggcctgtg cgagagcgac gtcgtctttt
    15901 cgatcgccaa gctgtacttc ggctacggct tcgccaattc actggtgttc ccgctggcgg
    15961 caggggcgtg cacgttgctg cacccgggtc gctcggatgt gctgacggtg atggagttgg
    16021 tccggcggga gcaccccacg gtcttcttcg gcgtgcccac cttctattcg ggcatcctga
    16081 aggtgccctc ggccgcccag cgcttcgatg tctcgagcgt gcgtgccttc gtctccgcgg
    16141 gagaggagct gagcgcctcg ctggcccgca agttcaagga caccttcggc tccctgcccg
    16201 tcaacggact gggctcgacg gagatgttcc acatctatat cgcgacggag ttgaggggag
    16261 actctcccgg ctccctgggc acgctgaccc ctggacacga ggtgcgtctg ctctcggcca
    16321 gcggccagcc ggtggcggac ggagaggtgg gcgagttgtg ggtgcgaggc cctcacatag
    16381 gggtgggcta cgcgcaccat cccgagcaca cccgccgagt cttcgtggag gggtgggtgc
    16441 ggacaggcga tctggtcacc cgtgatgcga gcggcgccta tgtcttccgg ggccggacgg
    16501 atgccctgct gaaggtggcg ggacagaaga cgttgctctt cgaggtggag cagtgcctgc
    16561 gctcgcacga ggcggtcgtg gaggccgagg tccaggtggt ggtggacgag gacggcatcc
    16621 gggatctgct ggcgaaggtc cgcttgcgtg aaggcgtggc cccaggaaac gccacggtcc
    16681 gggtgcttcg cacgttcatg cgagagcgtc tcctgccgca ctcctgcccc tcgaagatcg
    16741 aggtgctgtc cgggtcagct tcctagccgc gccgagagga acttcagcag gttctcccag
    16801 gccttctcgg ccgcagtcgc gtcgtattcc tcgggccagt gcgtgctgaa gaagccgtgc
    16861 ttggcctcgt agcggtggaa gtccaggtcg acgttgccct ggcgcatgcg tgcctccagc
    16921 gcgtcgatct gtggcacggg gtaccagtcg tccgagagtg cgtagtgggc ctggaagggg
    16981 atgcggatga gccctgggtc cgcgttcttg ccgggaggga tgccgtagaa agagatcccc
    17041 gcgtcgaact cggggacatg gcaggcggcg atggtggcca ccgccccacc cagggagaag
    17101 ccgagcacgg cggtcttgcc cccagaggcc ttgaggtact gggccgcccc gcggacatcc
    17161 tgggtcacga cgtccatgac gtccatggac atccgcttgc gcatcgcctc cagcttggag
    17221 ctggcgacgt acccccggta gtagtccacc gcgagggcgc ggtagcccga ggccgccagt
    17281 cggtccgcca cctgcttcac ggtgtcggtg agcccccacc actcgtgcag caccaccacc
    17341 gaggggccgc cggtgccgga ggtgggcagg gccaggctgc ccatggcctc accgccgtct
    17401 gggcgtggga agtgaatcgg ggtgctcatg gggtgtctct cgtgggcgca cgttggcgcc
    17461 agcaaagggt caggccgact ccgacgggac cttcgtacac atcctcagcg tgagggggaa
    17521 gaggcgcacg cggggtccag cagctctggc cggtactcga agtgcatggt gtcgtagtgg
    17581 taccagcggc ccccccagat gaagccctcg gcctcgaagg cgtccacgat ggcttgtgga
    17641 atctgattcc tccagcgcac cggtgccttc ggccgggccc actcccaata gtgggcatgc
    17701 ttcacgttca cgtcgatgga caccccatag gagtgggcgc tctggcggtt cgtgtgggca
    17761 atcttccgcc acacgaaggt gccgcccagg ttcttcaggt acggcttcag tgagggctcc
    17821 tgcttcaccg tggcctcgag ccgtgtcgcc acgcgttcaa aggctggtgc cgccttgcgg
    17881 tgcaccttca gtgtttgtcc caggaagacg atgctcacca cgtcgacctg ggcttcggac
    17941 gcgccatagg ctgcgtggaa gagcggctcg aagcggatgc gccctgggtc ctcgttctcg
    18001 cgtgtcaccg gggtgatggg acctggggtg tacggaatcg agagcgtgtc ctccaggtcc
    18061 ggtgactcca gtgcctccgc gaacggcttc gtcttcccgt cattccatgg gtacgtggct
    18121 ccgcccaact cgacgtgcca cgccccgtcc ttctggatcg gcctcaccgg ataccatttg
    18181 gaaaggcacg ccagcgcacg gggaagggct tccggggaag gggcctcggg cgctgggccg
    18241 gtggctcggg cggagcttcc gagtgtgagg gcgagcagaa ggagcaggga cttgttcagg
    18301 cgaagcctcg gggagcgcgg tctggacgag gctactcgta gaacttcagg ctccagcccg
    18361 tgttgctctc ggagccgcgg gtataggtga tgttgcccca ccactggaac gtccccgagt
    18421 accagtaccg tccgccccag aaggggttgg ggtaatcgtt cttgggcacc ccgtggtacg
    18481 ccagggggaa ggtggggccc gcgggcgggc tggtattggg gtctccgttg agcagcacga
    18541 aggagtggtg ccccacgccc ttggcgtaca gcgtcggatg ccacccctgc atcatgatgc
    18601 cgccgttggc gctgaagaag cagccgttgg ccttgaacca gtcccagaca taggtgggat
    18661 ctcctcccgc ccggagccgc agatccgcca ggcagtagtt gacgtcccaa ctgccgttcg
    18721 ccgagtacac gatgtgcagt tgcccgttgg gatcgatgat gggctcgggc ccctcgttga
    18781 cgcgggtggg cgggttgacg tcgaccttct cccaccactc ccggggctgg gagatgacgt
    18841 accgggcgcc cgtgacttgg gtcgggctcg acatccgcgc gatgaacagg gtctgctccc
    18901 cgttggagtc gcccacccag ccggaccaga cgaagtacca ctggcccttg tagacgaagg
    18961 ccgtgccgtc gatggcccac ttgttgtcgg gcagggccag gggggccgcc gccgagtagc
    19021 ccgagttggg ggactgcgac tggatgacgt acatgcggtg ggcattgcct gcccccgccg
    19081 tgaagtagat gtagtaggtg ctgccgctct tgatgagctg gggagcccac acctcggccc
    19141 agttgctggg gttgctccag atgagcgagc ggggagctcc agccagggca tccacggagg
    19201 aggccgttcg cacatacagg cggccgccct ccgtctccgc ggagatgtag gtgctgtcga
    19261 cccggatgac gctggggtcg gcattcttga tggaaagccg cccgacggct tgctcctggg
    19321 tcgcgacagg ctcggagacg gattcgggg
//
