Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0001344.1:
Cluster 1NRP / Polyketide151513

BGC0001344, tubulysin biosynthetic gene cluster from Cystobacter sp. SBCb004. Locus 1. Partial MIBiG entry.

Chemical compounds

Compound: tubulysin A
PubChem ID: 12134544
SMILES string: Copy to clipboard
Molecular formula: C43H65N5O10S
Average molecular mass: 844.078 Da

Class-specific details

Biosynthetic class(es):
NRP / Polyketide
Polyketide synthase subclass:
Modular Type I

Gene cluster description

tubulysin (BGC0001344). Gene Cluster 1. Biosynthetic class = NRP/Polyketide. GenBank GU002154. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

Literature references

1. Chai Y et al. (2010) Discovery of 23 natural tubulysins from Angiococcus disciformis An d48 and Cystobacter SBCb004. Chem Biol 17(3):296-309. doi: 10.1016/j.chembiol.2010.01.016.
2. Chai Y et al. (2012) Heterologous expression and genetic engineering of the tubulysin biosynthetic gene cluster using Red/ET recombineering and inactivation mutagenesis. Chem Biol 19(3):361-71. doi: 10.1016/j.chembiol.2012.01.007.