BGC0001348: JBIR-100 biosynthetic gene cluster from Streptomyces varsoviensis
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Location: 93,200 - 164,000 nt. (total: 70,801 nt).
This entry is originally from NCBI GenBank NZ_JOBF01000033.1, but has been modified (see Modifications tab for details).

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
Modifications
General information about the BGC
MIBiG accession BGC0001348
Short description JBIR-100 biosynthetic gene cluster from Streptomyces varsoviensis
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Type I)
Loci
NZ_JOBF01000033.1
93200 - 164000
via
Compounds
  • JBIR-100
Species Streptomyces varsoviensis [taxonomy]
References
Chemical products information
JBIR-100 Evidence: NMR, Mass spectrometry
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C38H58O10
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Comment Extra
  • IF55_RS40995
 94019 - >97296 (+) beta-ketoacyl synthase N-terminal-like domain-containing protein
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    • IF55_RS32365
    • WP_157857240.1
    		 97365 - 109040 (+) hypothetical protein
    • Scaffold biosynthesis
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    • IF55_RS32370
    • WP_048832936.1
    		 109077 - 124394 (+) polyketide synthase
    • Scaffold biosynthesis
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    • IF55_RS32375
    		 124452 - 136256 (+) beta-ketoacyl synthase
    • Scaffold biosynthesis
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    • IF55_RS41000
    • WP_245661582.1
    		 136405 - 146841 (+) polyketide synthase
    • Scaffold biosynthesis
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    • IF55_RS36525
    		 136420 - 142485 (+) polyketide synthase
      incomplete; partial in the middle of a contig; missing stop; Derived by automated computational analysis using gene prediction method: Protein Homology.
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      • IF55_RS32385
      • WP_063764078.1
      		 146912 - 153361 (+) polyketide synthase
      • Scaffold biosynthesis
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      • IF55_RS32390
      • WP_048832937.1
      		 153358 - 154242 (+) 3-hydroxyacyl-CoA dehydrogenase
      • Precursor biosynthesis
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      • IF55_RS32395
      • WP_048832938.1
      		 154316 - 154618 (+) methoxymalonate biosynthesis protein
      • Precursor biosynthesis
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      • IF55_RS32400
      • WP_078645621.1
      		 154611 - 155846 (+) acyl-CoA dehydrogenase
      • Precursor biosynthesis
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      • IF55_RS32405
      • WP_048832952.1
      		 155903 - 157027 (+) FkbH
      • Precursor biosynthesis
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      • IF55_RS32410
      • WP_030890472.1
      		 157127 - 157789 (-) SAM-dependent methyltransferase
      • Precursor biosynthesis
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      • IF55_RS32415
      • WP_030890475.1
      		 157866 - 159779 (-) AfsR family transcriptional regulator
      • Regulation
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      • IF55_RS32420
      • WP_030890478.1
      		 160255 - 161004 (+) oleoyl-ACP hydrolase
      • Activation / processing
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      • IF55_RS37870
      • WP_245661583.1
      		 161192 - 161602 (+) LuxR C-terminal-related transcriptional regulator
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        • IF55_RS32425
        		 161384 - 161602 (+) transcriptional regulator
          Derived by automated computational analysis using gene prediction method: Protein Homology.
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          • IF55_RS32430
          • WP_030890486.1
          		 161943 - 162902 (+) malonyl transferase
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            • IF55_RS32435
            • WP_048832939.1
            		 162899 - 163999 (+) arylcarboxylate reductase
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              Biosynthesis information
              Annotation changelog

              Entry version: 4

              Date
              Changes
              Submitters
              Reviewers
              2022-10-07
              Update chemical activity to schema version 2.11
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

              Entry version: 3

              Date
              Changes
              Submitters
              Reviewers
              2022-09-15
              Fixed missing and incorrect gene identifiers
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              2022-09-15
              Updated bioactivity data
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

              Entry version: 2

              Date
              Changes
              Submitters
              Reviewers
              2019-10-16
              Migrated from v1.4
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

              Entry version: 1

              Date
              Changes
              Submitters
              Reviewers
              2016-09-03
              Submitted
              • (ID: FTVL3IN3CWSJUJDTYVJJVU23)
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              Detailed domain annotation
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              Modifications to original record
              • IF55_RS36525 was added
              • IF55_RS32425 was added