Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0001348.1:
Cluster 1Polyketide170801

BGC0001348, JBIR-100 biosynthetic gene cluster from Streptomyces varsoviensis. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: JBIR-100
PubChem ID: 102518265
SMILES string: Copy to clipboard
Molecular formula: C38H58O10
Average molecular mass: 674.872 Da
Molecular activity: Antibacterial, Antifungal, Cytotoxic

Class-specific details

Biosynthetic class(es):
Polyketide
Polyketide subclass:
Macrolide (cyclic)
Polyketide synthase subclass:
Modular type I
Starter unit:
Isobutyryl-CoA
Thioesterase type:
Type II
Release / cyclization type:
Macrolactonization

Gene cluster description

JBIR-100 (BGC0001348). Gene Cluster 1. Biosynthetic class = Polyketide. GenBank NZ_JOBF01000033, positions 93200-164000. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Sequence-based prediction
MIxS-compliance:Unknown
Contact for this cluster:Douglas Mitchell (University of Illinois)

Literature references

1. Molloy EM et al. (2016) Biological characterization of the hygrobafilomycin antibiotic JBIR-100 and bioinformatic insights into the hygrolide family of natural products. Bioorg Med Chem 24(24):6276-6290. doi: 10.1016/j.bmc.2016.05.021.
2. Ueda JY et al. (2010) A new 16-membered tetraene macrolide JBIR-100 from a newly identified Streptomyces species. J Antibiot (Tokyo) 63(10):627-9. doi: 10.1038/ja.2010.104. Epub 2010