BGC0001358: leucinostatin A biosynthetic gene cluster from Purpureocillium lilacinum
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Location: 1,034,990 - 1,134,564 nt. (total: 99,575 nt).
This entry is originally from NCBI GenBank LSBH01000002.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001358
Short description leucinostatin A biosynthetic gene cluster from Purpureocillium lilacinum
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Unknown)
Loci
LSBH01000002.1
1034990 - 1134564
via
Compounds
  • leucinostatin A
  • leucinostatin B
Species Purpureocillium lilacinum [taxonomy]
References
Chemical products information
leucinostatin A Evidence:
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C62H111N11O13
Chemical database entries
PubCHEM
leucinostatin B Evidence:
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C61H109N11O13
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • VFPBJ_02521
  • OAQ83753.1
 1034990 - 1036504 (+) sterigmatocystin 8-O-methyltransferase
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    • VFPBJ_02522
    • OAQ83754.1
    		 1036873 - 1042287 (-) ABC multidrug transporter
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      • VFPBJ_02523
      • OAQ83755.1
      		 1044084 - 1045854 (+) isotrichodermin C-15 hydroxylase
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        • VFPBJ_02524
        • OAQ83756.1
        		 1046050 - 1046979 (-) thioesterase-like superfamily domain-containing protein
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          • VFPBJ_02525
          • OAQ83757.1
          		 1048341 - 1050041 (+) cytochrome P450
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            • VFPBJ_11780
            • OAQ83758.1
            		 1051221 - 1051962 (-) bZIP transcription factor domain-containing protein
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              • VFPBJ_02526
              • OAQ83759.1
              		 1054377 - 1054625 (-) hypothetical protein
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                • VFPBJ_02527
                • OAQ83760.1
                		 1055948 - 1064232 (-) polyketide synthase
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                  • VFPBJ_02528
                  • OAQ83761.1
                  		 1065257 - 1066391 (-) cytochrome P450
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                    • VFPBJ_02529
                    • OAQ83762.1
                    		 1066860 - 1070185 (+) abc1 domain-containingprotein
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                      • VFPBJ_02530
                      • OAQ83763.1
                      		 1070389 - 1071750 (-) branched-chain amino acid aminotransferase
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                        • VFPBJ_02531
                        • OAQ83764.1
                        		 1072576 - 1074342 (+) basic-leucine zipper (bZIP) transcription factor
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                          • VFPBJ_02532
                          • OAQ83765.1
                          		 1075701 - 1083956 (+) KR domain-containing protein
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                            • VFPBJ_02533
                            • OAQ83766.1
                            		 1084230 - 1085491 (-) phenylacetyl- ligase protein
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                              • VFPBJ_11781
                              • OAQ83767.1
                              		 1088115 - 1089327 (+) hypothetical protein
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                                • VFPBJ_02534
                                • OAQ83768.1
                                		 1089695 - 1091155 (+) zn-dependent hydrolase oxidoreductase family protein
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                                  • VFPBJ_02535
                                  • OAQ83769.1
                                  		 1092705 - 1093707 (+) Amt4
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                                    • VFPBJ_02536
                                    • OAQ83770.1
                                    		 1093942 - 1094789 (-) signal transduction protein
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                                      • VFPBJ_02538
                                      • OAQ83771.1
                                      		 1096300 - 1097240 (+) nucleoside-diphosphate-sugar epimerase protein
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                                        • VFPBJ_02539
                                        • OAQ83772.1
                                        		 1098659 - 1134564 (+) nonribosomal peptide synthase
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                                          Biosynthesis information

                                          Biosynthetic modules

                                          Name
                                          Unk01
                                          Type
                                          nrps-type1
                                          Genes
                                          VFPBJ_02533
                                          Substrates
                                          (E)-4-methylhex-2-enoic acid (evidence: Structure-based inference, Sequence-based prediction)
                                          Integrated Monomers
                                          Domains
                                          adenylation
                                          Name
                                          Unk02
                                          Type
                                          nrps-type1
                                          Genes
                                          VFPBJ_02539
                                          Substrates
                                          4-methylproline (evidence: Structure-based inference, Sequence-based prediction)
                                          Integrated Monomers
                                          Domains
                                          adenylation
                                          Name
                                          Unk03
                                          Type
                                          nrps-type1
                                          Genes
                                          VFPBJ_02539
                                          Substrates
                                          2-amino-6-hydroxy-4-methyl-8-oxodecanoic acid (evidence: Structure-based inference [1])
                                          Integrated Monomers
                                          Domains
                                          adenylation
                                          Name
                                          Unk04
                                          Type
                                          nrps-type1
                                          Genes
                                          VFPBJ_02539
                                          Substrates
                                          3-hydroxyleucine (evidence: Structure-based inference, Sequence-based prediction)
                                          Integrated Monomers
                                          Domains
                                          adenylation
                                          Name
                                          Unk05
                                          Type
                                          nrps-type1
                                          Genes
                                          VFPBJ_02539
                                          Substrates
                                          2-aminoisobutyric acid (evidence: Structure-based inference [1])
                                          Integrated Monomers
                                          Domains
                                          adenylation
                                          Name
                                          Unk06
                                          Type
                                          nrps-type1
                                          Genes
                                          VFPBJ_02539
                                          Substrates
                                          leucine (evidence: Structure-based inference [1])
                                          Integrated Monomers
                                          Domains
                                          adenylation
                                          Name
                                          Unk07
                                          Type
                                          nrps-type1
                                          Genes
                                          VFPBJ_02539
                                          Substrates
                                          leucine (evidence: Structure-based inference [1])
                                          Integrated Monomers
                                          Domains
                                          adenylation
                                          Name
                                          Unk08
                                          Type
                                          nrps-type1
                                          Genes
                                          VFPBJ_02539
                                          Substrates
                                          2-aminoisobutyric acid (evidence: Structure-based inference [1])
                                          Integrated Monomers
                                          Domains
                                          adenylation
                                          Name
                                          Unk09
                                          Type
                                          nrps-type1
                                          Genes
                                          VFPBJ_02539
                                          Substrates
                                          2-aminoisobutyric acid (evidence: Structure-based inference [1])
                                          Integrated Monomers
                                          Domains
                                          adenylation
                                          Name
                                          Unk10
                                          Type
                                          nrps-type1
                                          Genes
                                          VFPBJ_02539
                                          Substrates
                                          beta-alanine (evidence: Structure-based inference [1])
                                          Integrated Monomers
                                          Domains
                                          adenylation
                                          Name
                                          Unk11
                                          Type
                                          nrps-type1
                                          Genes
                                          VFPBJ_02539
                                          Substrates
                                          alanine (evidence: Structure-based inference [1])
                                          Integrated Monomers
                                          Domains
                                          adenylation
                                          Annotation changelog

                                          Entry version: next

                                          Date
                                          Changes
                                          Submitters
                                          Reviewers
                                          2024-07-28
                                          MIBiG v4 annotathon
                                          • (ID: 2U5WMR7MBJ4KI76XQF5437F7)
                                          • (ID: 4CEPXXFDQQ46VQJXBT4B4AUO)
                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                          Entry version: 3

                                          Date
                                          Changes
                                          Submitters
                                          Reviewers
                                          2022-09-15
                                          Added NRP substrate specificities
                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                          2022-09-15
                                          Fixed biosynthetic classes
                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                          Entry version: 2

                                          Date
                                          Changes
                                          Submitters
                                          Reviewers
                                          2019-10-16
                                          Migrated from v1.4
                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                          Entry version: 1

                                          Date
                                          Changes
                                          Submitters
                                          Reviewers
                                          2016-09-03
                                          Submitted
                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                          Detailed domain annotation
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