Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0001359.1:
Cluster 1Polyketide199360
The following clusters are from record BGC0001359.2:
Cluster 2Polyketide172144

BGC0001359, PM100117 / PM100118 biosynthetic gene cluster from Streptomyces caniferus. Locus 1. Partial MIBiG entry.

Chemical compounds

Compound: PM100117
SMILES string: Copy to clipboard
Molecular formula: C82H132O29
Average molecular mass: 1581.929 Da

Class-specific details

Biosynthetic class(es):
Polyketide
Polyketide synthase subclass:
Modular Type I

Gene cluster description

PM100117 / PM100118 (BGC0001359). Gene Cluster 1. Biosynthetic class = Polyketide. GenBank LN997801. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

Literature references

1. Perez M et al. (2016) PM100117 and PM100118, new antitumor macrolides produced by a marine Streptomyces caniferus GUA-06-05-006A. J Antibiot (Tokyo) 69(5):388-94. doi: 10.1038/ja.2015.121. Epub 2015
2. Salcedo RG et al. (2016) Characterization and engineering of the biosynthesis gene cluster for antitumor macrolides PM100117 and PM100118 from a marine actinobacteria: generation of a novel improved derivative. Microb Cell Fact 15:44. doi: 10.1186/s12934-016-0443-5.

BGC0001359, PM100117 / PM100118 biosynthetic gene cluster from Streptomyces caniferus. Locus 2. Partial MIBiG entry.

Chemical compounds

Compound: PM100117
SMILES string: Copy to clipboard
Molecular formula: C82H132O29
Average molecular mass: 1581.929 Da

Class-specific details

Biosynthetic class(es):
Polyketide
Polyketide synthase subclass:
Modular Type I

Gene cluster description

PM100117 / PM100118 (BGC0001359). Gene Cluster 2. Biosynthetic class = Polyketide. GenBank LN997802. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

Literature references

1. Perez M et al. (2016) PM100117 and PM100118, new antitumor macrolides produced by a marine Streptomyces caniferus GUA-06-05-006A. J Antibiot (Tokyo) 69(5):388-94. doi: 10.1038/ja.2015.121. Epub 2015
2. Salcedo RG et al. (2016) Characterization and engineering of the biosynthesis gene cluster for antitumor macrolides PM100117 and PM100118 from a marine actinobacteria: generation of a novel improved derivative. Microb Cell Fact 15:44. doi: 10.1186/s12934-016-0443-5.