LOCUS       BGC0001364             17590 bp    DNA     linear   CON 22-MAR-2023
DEFINITION  Actinomadura atramentaria DSM 43919 strain SF2197
            G339DRAFT_scaffold00004.4, whole genome shotgun sequence.
ACCESSION   BGC0001364
VERSION     BGC0001364
KEYWORDS    .
SOURCE      Actinomadura atramentaria DSM 43919
  ORGANISM  Actinomadura atramentaria DSM 43919
            Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
            Thermomonosporaceae; Actinomadura.
COMMENT     REFSEQ INFORMATION: The reference sequence is identical to
            KB907211.1.
            URL -- http://www.jgi.doe.gov
            JGI Project ID: 405907
            Source DNA and organism available from Hans-Peter Klenk at the
            German Collection of Microorganisms and Cell Cultures (DSMZ)
            (hans-peter.klenk@dsmz.de)
            Contacts: Nikos  Kyrpides (nckyrpides@lbl.gov)
            Tanja Woyke (microbe@cuba.jgi-psf.org)
            Whole genome sequencing and draft assembly at JGI-PGF
            Annotation by JGI-PGF and JGI-ORNL
            The JGI and collaborators endorse the principles for the
            distribution and use of large scale sequencing data adopted by the
            larger genome sequencing community and urge users of this data to
            follow them. It is our intention to publish the work of this
            project in a timely fashion and we welcome collaborative
            interaction on the project and analysis.
            (http://www.genome.gov/page.cfm?pageID=10506376)
            Full annotations are available from IMG.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-10-17 15:24:27
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 17590
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     subregion       1..17590
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0001364"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..17590
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="lanthipeptide-class-ii"
                     /region_number="1"
                     /rules="cds(LANC_like and DUF4135)"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            complement(4..417)
                     /locus_tag="G339_RS0111955"
     CDS             complement(4..417)
                     /GO_process="GO:0030638 - polyketide metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF07366"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF019013.2"
                     /locus_tag="G339_RS0111955"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ester cyclase"
                     /protein_id="WP_019631317.1"
                     /sec_met_domain="PF07366 (E-value: 7e-21, bitscore: 64.7,
                     seeds: 29, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPQGAEGTAHPGPGEVHRRVFEGYRESRFEDALELIDPDVVDHRE
                     GAHVDHRGRDAWRRKWERGRADSMFRDVSLTIEQNVVSGDTSVNRYTVRGTHTASGRRY
                     EVLSLDMVRVRDGRIIEHWALLDTDAMRDQLGL"
     gene            447..827
                     /locus_tag="G339_RS33370"
     CDS             447..827
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="G339_RS33370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_019631318.1"
                     /transl_table=11
                     /translation="MAALGARSQSLLAEGPLGDALFEWLRDFIAHVAAKRELALAITDD
                     RTGRRSALFDRWHHSMRTAASALLVRAQSAGAVRADLDASELLALANGIALTTTGAAQA
                     ERLVLLIRQGTDTPATPDVSNR"
     gene            999..2231
                     /locus_tag="G339_RS0111965"
     CDS             999..2231
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="G339_RS0111965"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_019631319.1"
                     /transl_table=11
                     /translation="MKYGTASAEARIDEASNVLIAPADLQNNELISGFSGSAVTPEALE
                     SKALDLAQKTVYLCGDVSEISARRLHGAARVFIIRELSDGYRADVDGTWPVVDVGRVPV
                     RVHGAGVYYRRFFDLGADHFGSIRAEHAFQSLTESTKPGAAHRSGIYLTPVARDGDELH
                     FRLLRCSTNLSGPTEGFRPTDTGIVDALNREAAFVFRDHAPLNHVLAQIYHNTPATTGR
                     KQAKAKISAHADKTKDMPVNGIMAFCTFYDRLDKLQPLADDAFDYGVKGVSGLTKLRFR
                     LKDPTAERDAVALPPQFTLTLYPGSVFFMPLSTNRLYTHEIRSSMLDAELLPTRLGYVV
                     RCSSAEAVHKHGDTFLKVDGDLVKLGPPTPEGMDRLRRLYAEENKTTSFIDYGDELLFS
                     MNEGDYVAPRP"
     protocluster    2027..17590
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[12026:15248]"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      12027..15248
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
     cand_cluster    2027..17590
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(LANC_like and DUF4135)"
                     /kind="single"
                     /product="lanthipeptide-class-ii"
                     /protoclusters="1"
                     /tool="antismash"
     gene            2317..2985
                     /locus_tag="G339_RS0111970"
     CDS             2317..2985
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="G339_RS0111970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_205625531.1"
                     /transl_table=11
                     /translation="MGKGRQGAVLARVDDAGGVPLVRTATRYVRPAQRFRAVHERLANQ
                     IQEHAAFPTAFNNALVECYTNAYRKMGGHSDQALDLADGSFIAVFSCYRHPDADPPRKL
                     IFEPKEPGGEKFDIPLAHNSVVAFSIDSNRRLKHKIVLDAPVQTPDNQWLGVTFRASKT
                     LVQFHDGNAYLPQGARLTLADDEQKGEFYQLRRRENNETDFVYPPLAYTISESDLIPPV
                     "
     gene            3177..3605
                     /locus_tag="G339_RS0111975"
     CDS             3177..3605
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017586433.1"
                     /locus_tag="G339_RS0111975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_026341366.1"
                     /transl_table=11
                     /translation="MDNKLYSVEDVAELLGLHVRTVRGYIRSGRLRAVRIGKQYRIARA
                     DLDELIGKPEPASTAASAEVSSIVQLDGVDRRTADRLSTLVLAAVNGGSDPGRPLRVQV
                     VHDEERQRMKIVILGGVAETADVLQLIDAMFGEEARDG"
     gene            3598..3969
                     /locus_tag="G339_RS0111980"
     CDS             3598..3969
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012854402.1"
                     /locus_tag="G339_RS0111980"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF4180 domain-containing protein"
                     /protein_id="WP_019631322.1"
                     /transl_table=11
                     /translation="MADAVQTRAGVAVLVCDPDGPPIATMDDALDLIGATYLGAEAVAV
                     PAARLDERFFSLGTRFAGEIMQKFANYRLTLAVVGDISEHLAASSALRALVRESDRSGH
                     VWFVPDLDALDARLAGRRP"
     gene            4175..4516
                     /locus_tag="G339_RS0111985"
     CDS             4175..4516
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017600433.1"
                     /locus_tag="G339_RS0111985"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF5713 family protein"
                     /protein_id="WP_026341367.1"
                     /transl_table=11
                     /translation="MAITNEQVSEHRFLEEMFGDTYFPDHLVERGKQILLRFCERIEAE
                     RPADLPALYALSAAATAEFNELQEDFWAAGSEIETAARDCIAVDFGFVATAYGFPNADL
                     EELVADRDW"
     gene            complement(4534..5367)
                     /locus_tag="G339_RS0111990"
     CDS             complement(4534..5367)
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1199:NmrA family
                     protein (Score: 238.8; E-value: 1.5e-72)"
                     /gene_kind="other"
                     /inference="COORDINATES: protein motif:HMM:NF017206.2"
                     /locus_tag="G339_RS0111990"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="NAD(P)H-binding protein"
                     /protein_id="WP_019631324.1"
                     /transl_table=11
                     /translation="MTILITGARGTVARSLVRQLHDAGHRVRAGGRVPAEVDAPAGVEV
                     VAADPTRPGDLGPALAGVEKVFVYAERSGLGGFLAAAGAAGVRHVVLLSALGASPHAAD
                     AITRAHGEAERAVLDSGLEWSFVRPGGFATNRLMWAPMTRAGGPVLDPFPESQSALVHE
                     ADVAAVALAALTLPGQAGAIHSVTGPESQTARRHAELIGEAIGRPVEVAAQSLDDYQAS
                     LADRLPPDLLEARIARLAALVGRAQPTTDTVRTVTGRPARTFARWAADHAADFTG"
     gene            5461..5871
                     /locus_tag="G339_RS40365"
     CDS             5461..5871
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024949.2"
                     /locus_tag="G339_RS40365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_033322849.1"
                     /transl_table=11
                     /translation="MDGSELGGFLRSRRARVRPADAGFADGGRRRTPGLRRAEVALLAG
                     ISVDYYVRLEQGRGPRPSAQVLTALGRALRLTADERDYLLRLGAPPPPERAAAGPTSPR
                     PCGGSSTGSTTSPPSPSTPATTWSPGTRCSSR"
     gene            5775..6323
                     /locus_tag="G339_RS40370"
     CDS             5775..6323
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF037627.2"
                     /locus_tag="G339_RS40370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_019631325.1"
                     /transl_table=11
                     /translation="MRRLLDRLDDVPALAIDARYDLVAWNAMLVALIGDPAELPPARRN
                     RLRLLFDGPSPAAARLPDLAAQVVADVRASGRYPADPGLRDLVDGLRARSPGFAELWER
                     REVEARRSITKRTVHPVVGELELDCEILAVPGGEHRVLIYTAEPGTASAEALRRLARQV
                     PVRSEPPGEGRGPGLGNTG"
     gene            complement(6320..6532)
                     /locus_tag="G339_RS0112000"
     CDS             complement(6320..6532)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (lanthipeptides)
                     predicted lanthipeptide"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="G339_RS0112000"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_019631326.1"
                     /transl_table=11
                     /translation="MKRTLAVIVAAAAAVGCVVAARVALASADRPGGKEPAKSSTSPVQ
                     PPNTGYWTPERMQSAKPAPMPDPDD"
     CDS_motif       complement(6500..6532)
                     /prepeptide="leader"
                     /note="peptide class: {self.peptide_class}"
                     /note="predicted sequence: MKRTLAVIVAA"
                     /locus_tag="G339_RS0112000_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(6320..6499)
                     /prepeptide="core"
                     /locus_tag="G339_RS0112000_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-3.30"
                     /molecular_weight="5859.5"
                     /monoisotopic_mass="5855.9"
                     /core_sequence="AAAVGCVVAARVALASADRPGGKEPAKSSTSPVQPPNTGYWTP
                     ERMQSAKPAPMPDPDD"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MKRTLAVIVAA"
                     /leader_location="[6499:6532](-)"
                     /alternative_weights="5877.5"
                     /alternative_weights="5895.6"
                     /alternative_weights="5913.6"
                     /alternative_weights="5931.6"
                     /alternative_weights="5949.6"
                     /alternative_weights="5967.6"
                     /alternative_weights="5985.7"
     gene            complement(6618..7631)
                     /locus_tag="G339_RS0112005"
     CDS             complement(6618..7631)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="G339_RS0112005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_026341368.1"
                     /transl_table=11
                     /translation="MRSLRTLIGVTAAAALVATGTATAAGAAPAAPAAKTTAATTAATP
                     RLTGGAAVNSASAAAKVAKYWTAARMKAAKPVPEPRSARGTLSAKAAPTGPAGSTPSAR
                     AVASAANKLAGGNAKLAASITESAVVGKVFFHKPSGGDWVCSASALNSASKQLVITAGH
                     CVHEGAGGNWVTNWTFAPRYRSGSRPFGTFAAKQFRTFNSWISSSDQDRDVAMVTTWPL
                     NGNKVVNVVGGNGLNWNWGKTVAVTILGYPQNANGGEIQQWCQGTTYDGGGNKIALGCN
                     FNGGSSGGPWIMNFDNNTGLGQTDGVMSTIDGNGVNRASYFDDAVKAMFDAQGSVT"
     gene            complement(7968..9017)
                     /locus_tag="G339_RS0112010"
     CDS             complement(7968..9017)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1040:alcohol dehydrogenase (Score: 152.4; E-value:
                     2.5e-46)"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020546764.1"
                     /locus_tag="G339_RS0112010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="glucose 1-dehydrogenase"
                     /protein_id="WP_019631328.1"
                     /sec_met_domain="ADH_N (E-value: 2e-14, bitscore: 43.8,
                     seeds: 66, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKAISVVPGDPDSVEVRDVAEPRPGADELLVRGRLLGICGTDADI
                     VSGPGYGWAPPGSDRLVIGHESLGTVLHAPDGSGFAPGDLVAGAVRRPDPEPCVPCAHG
                     EWDFCSNGRYTERGIKELDGYGAQCWTVETDFAVRLDPALGDCGVLLEPTSVVAKAWAQ
                     ADRFTGRTSARPRTALVTGAGPIGLLAALLGVQRGLDVTVLDVNDRGPKAELVTDLGAR
                     FHVGSVADLGLCPDVVIECTGHGPLVAELAAASAPNAVICLAGISSRPGSATVDLDEVN
                     KEIVLRNTLLFGSVSASPGDFRRAADALARADRDWLSRLITRRVPMEEFARNVRKDPDD
                     VKVVVDLEA"
     gene            complement(9105..11105)
                     /locus_tag="G339_RS40375"
     CDS             complement(9105..11105)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 212.6; E-value:
                     1e-64)"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF013245.2"
                     /locus_tag="G339_RS40375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_019631329.1"
                     /transl_table=11
                     /translation="MTLPADAPPAAAAAAVPAIRAAGLRKRYPGVTAVDGVDLCVAPGE
                     SFGFLGPNGAGKSTTIAMLTTLAVPTAGRVEIAGHDTRTDPVAARRSIGLIFQESTLDG
                     ELTAAENLRFHADLYDVPVERVPARVAETLALVGLTDCRDRLVRTLSGGMRRRLEIARA
                     LLHRPRVLFMDEPTIGLDPRTRADVWRYLRLVREREAVTLFLTTHYLDEAEQCDRVAIL
                     HGGRIVAQGSPAELKSVLGADRVELRTGDDAAAARVLRERFGAAVAEGPGGLAFRAPDS
                     ARVLPRLFAELDVPVFEARVTPPSLDDVFLHHTGHRIRDDTEDAPAPPPDTGTGVGAGT
                     DLSAGTASRAGAGADSGPSANTGTGADAGTGVRTGADPRTDPRAGLGADPRAGGCAGRG
                     GVRAELRAMRMVWRREMLHFGRDRAGTAISLLQPLLFLFILGVGLAGLMSGVSSRSYQL
                     FLFSGALVTAAQGPAIGAGSSILWDRQAGFLREMLAGPVHRGTLLLGKCLGGATVATCQ
                     AGVLLAAGWLIGVPHDAVLTVLLLGQLALAALAMTALSILLATFIRRPQTFGTAVTVLA
                     APLVFLSGSMFPLTAMPGWMARVALANPLTYAVDAMRRTMAARLPATPAPLFHPLTWGS
                     WHPSVVLEWALVTGLALLALGWAARRFSRAE"
     gene            complement(11102..12010)
                     /locus_tag="G339_RS0112020"
     CDS             complement(11102..12010)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR03798"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017591582.1"
                     /locus_tag="G339_RS0112020"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="Nif11-like leader peptide family natural product
                     precursor"
                     /protein_id="WP_019631330.1"
                     /sec_met_domain="TIGR03798 (E-value: 7.7e-13, bitscore:
                     38.9, seeds: 22, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSVESCAAFLRVVNDDARLRQQLKALTGVAEMIRLGEAHGFRFDG
                     RDLATASASVVPPPAAPPASRAPEPEPEPAAEFLHHEYDLDALAAAHPGFATVLAEFPR
                     LKVRPSDVDLAAFDAEFRPGDLRSTELAPRGEEYRRWAAELAATARPGDRRDFHLVNLD
                     DHVGHADYDDYLDAKTRVVGALEDVFGAEVRFSGSMWYPPSSYRLWHTNETQPGWRMYL
                     IDLDDDFEDAEHTSFFRYQHPETGELVTLRERRRMARFFRIEQRPDRLFWHCIVNPTRR
                     HRWSFGFAVPDSWTAALAGLA"
     gene            complement(12027..15248)
                     /locus_tag="G339_RS0112025"
     CDS             complement(12027..15248)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070:lanthionine synthetase C family protein (Score:
                     610; E-value: 1.4e-184)"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR03897.1"
                     /locus_tag="G339_RS0112025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="type 2 lanthipeptide synthetase LanM family
                     protein"
                     /protein_id="WP_019631331.1"
                     /sec_met_domain="DUF4135 (E-value: 5.2e-61, bitscore:
                     197.1, seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 1.2e-61, bitscore:
                     198.7, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNQLYPADIAARAANLSERARIVAALAPPPDAPHPGAGPLDPFDA
                     WKTRRVADRLAARFREEARRGAAPARHTEAALTETLTAYRRHELGLADPADPFGRAVRD
                     AQRAWLPVYTAALDGFRPESEEAARAGWREPEVYYGRLAKACEPFLLELGRRLTAVLDA
                     APGAGPVVDRRLVEEFQLRLLDRFALALAWAVEADTKVYCRLRGIDPATATTDDYLAFL
                     DKTFADAESYHRFYLDFPVLGRWLAHTTGLLAEHGRDLVVRLRRDAADVGAAFFGQPVA
                     AVRSAGLGRSDDHAGARGVVMVGAELADGTEATFVYKPRCVRGEAGLQRLLVRLRADGV
                     LDFADRAVLPRDGYGYEALIPAGRNRVATREAARPVYAELGGYLAIFYVLGGGDLHFEN
                     VLVADGHAFVCDCETVLGALPKGQPRPAGTLMDSVFKTGLIEWPTPPDAAGEMRLSGYS
                     GGGSFELPMPVPQLGDRRMSFEASVTHRAGLRVDPGSANRVFVGDGLAAPEEYVADVKD
                     GFDRVYRWFQDDPDGTAAQVAELFSGTRVRFVNWSTQIYTQLLLAARHPKCLMDPLEVD
                     LLFNTVRTFPRNWDVEGVLPAWELESMWRLDVPLFTVDADGDRLVHDHRTPVPATLEAG
                     PLEHAAARIRGLTTRNRVQQDQYIAAGLAGGDVTSADFAATCVEQAAALGERLCAALRP
                     QDAPAPWTSYVITAEGRTEVDIEGDLYNGSAGIALFLAYLNDLDPRPEFEHAARRALDH
                     ALASLDGERIGAFPGTGGLIYTLLHLHALWGESALLDRAVALADRIDGLIEQDRHLDVF
                     HGVAGLVPVLLALADATGGRGARQAHRCAARLLATARADGDVLSWPNSDPAASLADLTG
                     LSHGSGGIGWALTLLGTRADRPEYLSAARRAFAYEARHFDADAQDWYDLRTVAGGPTRG
                     GRHYANAWCNGASGIGLTRIASWSLLGGDDEELLRDATVALTTTMRNFPRLGNDSLCHG
                     RTGNAELFLRYALLRDQPAFRLEANVQAQSQWRDLGGARPGREAGFFPGLMLGLAGFGT
                     HFLRLARPDRVPSVLLLDPPRASTN"
     gene            complement(15390..15629)
                     /locus_tag="G339_RS0112030"
     CDS             complement(15390..15629)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017591584.1"
                     /locus_tag="G339_RS0112030"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="cinnamycin family lantibiotic"
                     /protein_id="WP_019631332.1"
                     /transl_table=11
                     /translation="MSPSTILRQAAADAEFRTALLTDPEVFGVAADAVPESVEQQDQES
                     LGFWTEGVAAIDAYACASTCSAGPFTFVCDGTTK"
     gene            complement(15661..16032)
                     /locus_tag="G339_RS0112035"
     CDS             complement(15661..16032)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF039929.1"
                     /locus_tag="G339_RS0112035"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_019631333.1"
                     /transl_table=11
                     /translation="MRSGPKPPSDLTKHRNIDTVRQLQHLVLLCSLTPPGTKLHELLTL
                     ALNTDERGLPERVSPVQDLHPQTTKTWLEGIWNPELISADEMELVAWQNNKAHMDVAVD
                     QIQRIERRLGIRLATEKIS"
     gene            16481..16553
                     /locus_tag="G339_RS38740"
     tRNA            16481..16553
                     /anticodon=(pos:334388..334390,aa:Met,seq:cat)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="G339_RS38740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /product="tRNA-Met"
     gene            complement(16577..17587)
                     /locus_tag="G339_RS0112040"
     CDS             complement(16577..17587)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1078:LacI family
                     transcription regulator (Score: 368.1; E-value: 7.3e-112)"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018656771.1"
                     /locus_tag="G339_RS0112040"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="LacI family DNA-binding transcriptional
                     regulator"
                     /protein_id="WP_019631334.1"
                     /transl_table=11
                     /translation="MAGRGTRPTLEEVAARAGVGRGTVSRVVNGSPRVSEQARAAVLKA
                     IEELGYVPNRAARSLVTHRTDTVALVVAESDQRLFGEPYFAGIIRGISTALGDTGLQLL
                     LALARSPGEYARLADYLTAQHVDGVLLTSLHAEDPLPAKLEAGGVPTVLGGRPPGLSPV
                     SYVDVDNRSGARQAVEHLVAHGRRRIATIAGPQDMGVGIDRLGGYRDALADAGLPELIA
                     YGDFSEASGIAAAEELLARDPGLDAVFAADDPMALGALRVLRRLGRTVPGDVAVVGFDD
                     SAAAPLADPPLTTVHQSPEEMGREMARLLVARIRGEDLDEPVVILRPHLVKRESA"
ORIGIN
        1 gctttacagg ccgagttggt cgcgcatcgc gtcggtgtcg agcagggccc agtgctcgat
       61 gatccggccg tcgcggacgc ggaccatgtc caagctgaga acctcgtagc gtcggccgga
      121 tgcggtgtgg gtgccccgca ccgtgtaccg attgacggag gtgtcgccgg agacgacgtt
      181 ctgctcgatc gtcaacgaga cgtcccggaa catactgtcc gcacgccccc gctcccactt
      241 ccgtcgccag gcgtcgcgtc cccggtgatc gacatgagcg ccttcccggt ggtcgacgac
      301 gtcggggtcg atcagctcca gggcgtcctc gaatcggctc tctcgatagc cctcgaagac
      361 gcgccgatgg acctcacccg ggcccgggtg agcggtgcct tctgctccct gcggcatatg
      421 agatcatcgc cgtctactcc gaggaagtgg ccgcgctcgg cgcccggagc cagtccctgc
      481 tggccgaggg cccgctcggc gacgcactct tcgagtggct tcgggatttc atcgcacacg
      541 tggcggccaa gcgggaactg gcgctggcga tcaccgatga ccgcactggc cgccgttccg
      601 cgctgttcga ccgctggcac cattcgatgc gcacggccgc gtccgcgctg ctggtccgag
      661 cgcaaagcgc cggtgccgtc cgcgccgacc tcgacgcatc ggaactgctc gccctggcca
      721 acgggatcgc cctcaccacc accggcgccg cgcaagcaga gcgcctcgtc cttttgatca
      781 ggcaaggcac ggacaccccc gcgaccccgg acgtaagcaa ccgctgaagc ggtcggcacg
      841 ccaccgatct ccctcgcgca cccgcgcccc gggtcgcgcc agcgagccac tcgggcatca
      901 aaaggctgga gagccggagt tgagtcctct atcgtccgga aggtcatgga tggggggacg
      961 ggctcgcggg ttcgttcgtc gtgaacggcg ggtgcggttt gaagtacggg acggcgtcgg
     1021 cggaagcccg catcgacgag gcgagcaatg ttctgatcgc acccgcggat ctgcagaaca
     1081 atgagttgat cagtggcttc tccgggtccg cggtcactcc ggaggccctt gagtccaagg
     1141 cgctcgacct tgctcagaag accgtctacc tgtgcggcga tgtatcggag atcagtgccc
     1201 ggcgactgca tggggcggcc cgggtgttca tcatccggga actgtcggac ggctatcgtg
     1261 cagacgtcga tgggacatgg cctgttgtgg atgttggacg tgttcccgtc cgtgtccacg
     1321 gcgccggggt ttactaccgc cgcttcttcg acctcggtgc cgatcacttc gggagcatcc
     1381 gcgcggagca tgcgttccag tcgctgacgg aatcgaccaa gcccggagcg gcccatcgca
     1441 gtgggatcta tctgacgccc gtcgcgcgtg acggtgacga actgcatttc cgcctgctcc
     1501 ggtgctcaac gaacctttcg gggccgaccg aaggctttcg gccgacggac acgggcatcg
     1561 tcgatgcttt gaaccgcgag gccgcctttg tcttccgcga ccatgccccg ctgaaccatg
     1621 tccttgcgca gatctaccac aacacccctg ccacgaccgg gcgcaagcag gccaaggcca
     1681 agatctcggc ccacgccgac aagaccaagg acatgccggt caacgggatc atggccttct
     1741 gcaccttcta tgaccggctc gacaaactgc agcccctcgc cgatgacgcc ttcgactacg
     1801 gtgtgaaagg cgtcagcggc ctgaccaagc tccggttccg tctcaaggac ccgaccgcag
     1861 aacgcgacgc ggtcgcgcta ccgccgcagt tcacgctgac cctttatccc ggctccgtgt
     1921 tcttcatgcc gctgtccacc aaccgcttgt atacgcacga gatccgatcc tcgatgttgg
     1981 atgccgaact gctcccgacc cgtttggggt acgtggtgcg ctgttcgagt gccgaggccg
     2041 ttcacaagca cggcgacacg ttcctcaaag tggacggcga cctggtgaag ctggggccgc
     2101 ccacgccgga gggcatggac aggctgcgca ggctgtacgc cgaggagaac aagaccacgt
     2161 cgttcattga ttacggcgac gagttgcttt tcagcatgaa cgagggggac tacgttgccc
     2221 cgaggccctg agatctcgga cgagatcctt gcgtgcgtcc tgccgaccga cgaaaacctc
     2281 ttcgcagagc tgtttacatc cactcgatgg gaggacgtgg gaaaaggccg gcagggtgcc
     2341 gtgctcgcca gggtcgatga cgcgggcggc gtgccgctcg tgcgcaccgc cacgcgttac
     2401 gtcagaccgg cgcagcgttt ccgcgcggta cacgaacggc tggcgaacca gatccaagaa
     2461 catgcagcgt ttccgaccgc cttcaacaac gccctggtcg agtgctacac gaacgcttac
     2521 aggaagatgg gcggccactc cgaccaggcc ctcgatctgg ccgacgggtc gttcatcgcc
     2581 gtcttctcct gctaccggca ccctgacgcg gacccgccgc gaaagctgat cttcgagccg
     2641 aaagaacccg gcggcgagaa gttcgatatt cccctcgccc acaacagcgt cgtcgctttc
     2701 tcgattgact cgaaccggcg gctcaagcac aagatcgtgc tggacgcacc cgtccagacg
     2761 ccggacaacc aatggttggg cgtgaccttc cgggcgtcga aaacgctggt tcagttccac
     2821 gacggaaacg cttaccttcc gcagggtgcg cgcctcacgt tggccgacga cgagcaaaag
     2881 ggcgagttct accaactccg gcgccgcgag aacaacgaaa cagatttcgt ctaccccccg
     2941 ctggcctaca ccatcagcga aagcgacctg atcccgcccg tctgatacgc gttctgacgg
     3001 cgagaacgcc cggccgccgg ccgcgcgagt ccggcccggc ccgacgcgga cacgtccctc
     3061 acgagcccgt ctgccgccga cggggtccgc gcggccacgg gtggtgcggc tcgtgcgagc
     3121 gacgcctgtt ccttaaaatt ccctatcaac ccctgagtca ggtagcttag ggagtgatgg
     3181 acaacaaact gtactcagtt gaggacgtcg cggagttgct tgggcttcac gtgcgcacgg
     3241 tgcggggtta catccggtcc gggcggctca gggccgtccg gatcgggaag cagtaccgga
     3301 tcgcgcgcgc ggatctggac gagctgatcg ggaagcccga gcccgcgagc accgccgcgt
     3361 cggccgaggt gtcgagcatc gtgcagctcg acggcgtcga ccggcgcacc gcggaccggc
     3421 tgagcacgct cgtcctcgcc gccgtcaacg gcggctccga tcctggccgc ccgctgcgcg
     3481 tccaggtcgt ccacgacgag gagaggcagc gcatgaagat cgtgatcttg ggcggcgtcg
     3541 ccgagacggc cgacgtcctc caactgatcg acgccatgtt cggcgaggag gcccgcgatg
     3601 gctgacgcgg tgcagacgcg cgccggggtc gccgtgctgg tgtgcgaccc ggacggcccg
     3661 ccgatcgcca cgatggacga cgcgctcgac ctcatcggcg cgacctacct gggcgccgag
     3721 gccgtcgccg tccccgccgc ccgcctggac gagcggttct tctcgctcgg cacccgtttc
     3781 gcgggcgaga tcatgcagaa gttcgccaac taccggctga ccctcgccgt cgtcggcgac
     3841 atctccgagc atctggcggc gagttcggcg ctgcgcgcgc tcgtccgcga gtcggacagg
     3901 tccggccacg tctggttcgt cccggacctg gacgcgctcg acgcgcgcct ggcggggcgg
     3961 cggccctgac cgacgagtcc gaggccgagc ggcggcaagt cccgcaaggg cctcgtcgac
     4021 gacggcggga ccctcgggtc gacacgacgt tcaccgccag ccccgccttg accatcaccg
     4081 ccccctgaga gatgggaacg ccgcccgcgc cggagtgtcg gcggggtggt gcaggatcgg
     4141 ccgcgtcggg agcgtcgaga ggacggagca cgcggtggcg atcacgaacg agcaggtgtc
     4201 cgagcaccgg ttccttgagg agatgttcgg cgacacctat ttcccggacc acctcgtgga
     4261 acgcgggaag cagatcctgc tgcggttctg cgagcgcatc gaggccgagc gcccggcgga
     4321 cctgcccgcc ctctacgcgc tgtcggcggc ggcgaccgcc gagttcaacg aactccagga
     4381 ggacttctgg gcggcgggca gcgagatcga gaccgccgcg cgggactgca tcgcggtcga
     4441 cttcgggttc gtcgcgaccg cctacggctt cccgaacgcg gatttggagg aactcgtcgc
     4501 cgaccgcgac tggtgaccgg ggcgatcccc cggtcagccg gtgaagtcgg ccgcgtggtc
     4561 ggccgcccac cgcgcgaacg tccgcgcggg gcggcccgtc acggtgcgga cggtgtcggt
     4621 cgtcggctgc gcgcggccga cgagcgccgc gaggcgcgcg atgcgggcct ccagcaggtc
     4681 cggcgggagc cggtccgcca gcgacgcctg gtagtcgtcc aggctctgcg ccgcgacctc
     4741 gaccgggcgg ccgatcgcct cgccgatcag ctcggcgtgc cgccgcgccg tctgcgactc
     4801 cggcccggtc acgctgtgga tcgcgcccgc ctggcccggc agggtgaggg ccgccagcgc
     4861 gaccgccgcg acgtccgcct cgtggaccag cgccgactgc gactcgggga acgggtccag
     4921 caccggcccg cccgccctcg tcatcggcgc ccacatcagc cggttcgtcg cgaagccgcc
     4981 gggccgcacg aacgaccact ccaggcccga gtccagcacc gcccgctccg cctcgccgtg
     5041 cgcgcgcgtg atcgcgtcgg cggcgtgcgg ggacgcgccg agggcggaca gcagcaccac
     5101 gtgccgcacc cccgccgccc cggccgccgc gaggaacccg ccgagccccg accgctcggc
     5161 gtacacgaag accttctcga cgcccgccag cgccggcccg aggtcgcccg gacgcgtcgg
     5221 gtccgccgcg acgacctcca ccccggcggg ggcgtccacc tcggcgggga cgcggccccc
     5281 cgcccggacc cggtggcccg cgtcgtgaag ctgccgtacg agggagcgcg cgaccgtgcc
     5341 gcgcgccccg gtgatcagga tcgtcatgcg ccgagcctcg cgggccgccg cgccgcccgg
     5401 gtaggcaccg ccgagaccgg tacggccggt accacccgcg gcgcgcgtca tgatggaacc
     5461 gtggacggat cggaactggg cggtttcctg cggagccgcc gcgcgcgcgt ccggccggcc
     5521 gacgcgggct tcgcggacgg cggacgccgc cggacgcccg gtctgcgccg cgccgaggtc
     5581 gcgctgctcg ccgggatctc ggtggactac tacgtccggc tcgaacaggg ccggggcccc
     5641 cgcccgtcgg cgcaggtgct caccgcgctc ggccgcgccc tccggctcac cgccgacgag
     5701 cgcgactacc tgctgcggct cggcgcgccg ccgccgcccg agcgcgccgc cgccggaccg
     5761 acgtccccgc gaccgtgcgg cggctcctcg accggctcga cgacgtcccc gccctcgcca
     5821 tcgacgcccg ctacgacctg gtcgcctgga acgcgatgct cgtcgcgctg atcggcgacc
     5881 cggcggagct gccgcccgcg cggcgcaacc ggctgcggct gctgttcgac ggcccgtcgc
     5941 ccgccgccgc gcggctgccc gacctcgccg cgcaggtcgt cgcggacgtc cgcgcgagcg
     6001 gccggtaccc cgccgacccc ggcctgcgcg acctggtgga cgggctgcgc gcccgcagcc
     6061 ccgggttcgc cgagctgtgg gagcggcggg aggtcgaggc gcggcgcagc atcaccaagc
     6121 ggaccgtcca cccggtcgtg ggggagctgg agctggactg cgagatcctg gccgtgcccg
     6181 gcggggagca ccgcgtcctg atctacacgg ccgagccggg gaccgcgtcc gccgaggcgc
     6241 tgcgccgcct cgctcgccaa gtcccggtca ggtcggagcc gccaggcgag ggccgtgggc
     6301 cgggacttgg aaacaccggc tagtcgtccg ggtcgggcat cggggcgggt ttcgcggact
     6361 gcatccgctc cggcgtccag tagccggtgt tcggcggctg gacggggctg gtgctcgact
     6421 tcgcgggttc cttgccgccc ggacggtcgg cggacgccag cgcgacgcgg gccgccacga
     6481 cgcagccgac cgccgcggcc gcggcgacga tgacggcgag ggttcgtttc atgtccggtc
     6541 cccttccggc ggacgggcgg gagcccgccg gtccagccta ggcggccggg accggcgggc
     6601 ggcgggtcac cgcacggtca ggtgacgctg ccctgcgcgt cgaacatcgc cttgaccgcg
     6661 tcgtcgaagt acgacgcccg gttcacgccg ttcccgtcga tcgtgctcat gacgccgtcg
     6721 gtctggccga ggcccgtgtt gttgtcgaag ttcatgatcc acgggccgcc gctggacccg
     6781 ccgttgaagt tgcagccgag ggcgatcttg ttgccgccgc cgtcgtacgt cgtgccctgg
     6841 caccactgct ggatctcacc gccgttggca ttctgcgggt aaccgagaat ggtcaccgcg
     6901 acggtcttgc cccagttcca gttgaggccg ttcccgccca ccacgttcac gaccttgttg
     6961 ccattcagcg gccaggtcgt caccattgcg acgtcgcggt cctggtcgct gctgctgatc
     7021 cacgaattga acgtccggaa ctgcttggcc gcgaacgtgc cgaacggccg ggaaccgctg
     7081 cggtaacgcg gggcgaacgt ccagttcgtc acccagttcc cgcccgcgcc ctcgtggacg
     7141 cagtggcccg cggtgatgac gagctgcttg gacgcgctgt tgagcgcgct cgccgagcac
     7201 acccagtcgc cgccgctcgg cttgtggaag aacacctttc cgaccaccgc cgactcggtg
     7261 atggacgccg cgagcttggc gttcccgccg gcgagcttgt tcgccgccga cgcgacggcc
     7321 ctggcggacg gcgtggaccc cgcgggcccg gtcggcgcgg ccttggccga cagcgtcccg
     7381 cgcgcggagc gcggctcggg caccggcttg gcggccttca tccgcgcggc cgtccagtac
     7441 ttggcgacct tcgcggcggc ggacgcgctg ttcacggccg cgccgccggt gagcctgggg
     7501 gtggcggcgg tggtcgccgc cgtcgtcttc gcggccgggg cggcgggcgc ggcgccggcc
     7561 gccgtcgccg ttcccgtggc gaccaacgcg gccgccgccg tcacgccgat gagtgttcgt
     7621 agggaccgca tgcggacctc gcttctcgaa acgctccgtt gacgggctca atgagacgcg
     7681 agcgggttgc tgaccgcaat gcctgttatg tggccttata aggtcaccgt aaggttcagg
     7741 tggcattagc cgaggttgca cgtgtttcac ggtgcgcggc cgggcgctgt gcggagaatt
     7801 tcccggcggt gcgctgtgcg tttccggggt ggcgtgctac ggggccgctc gataaactcc
     7861 ggtgtttact ggagcgaaaa aaccgccgcg tccgccattc gtcccgtctc cgcgtcgtgg
     7921 aacgcggcac ccgactccgt tttcgtcgcg cggaacggcg gcgggcgtca cgcctccaga
     7981 tccacgacga ccttcacgtc gtcggggtcc ttccgaacgt tgcgcgcgaa ctcctccatc
     8041 gggacgcgcc gcgtgatgag ccgcgacagc cagtcgcggt cggcgcgggc gagcgcgtcg
     8101 gcggcccgcc ggaagtcgcc cggcgacgcg ctcaccgatc cgaacagcag cgtgttccgc
     8161 aggacgatct ccttgttgac ctcgtcgagg tccaccgtgg ccgaacccgg ccgcgacgag
     8221 atccccgcca ggcagatcac cgcgttcggc gccgacgccg ccgccagctc cgcgaccagc
     8281 gggccgtggc ccgtgcattc gatcaccacg tccgggcaga ggccgaggtc cgcgacgctc
     8341 ccgacgtgga accgcgcgcc gaggtcggtg accagctcgg ccttcgggcc ccggtcgttg
     8401 acgtccagga cggtgacgtc cagcccccgc tgcacgccga gcagcgcggc cagcagcccg
     8461 atcgggcccg cgcccgtgac cagcgccgtc cggggccgcg ccgacgtgcg gccggtgaac
     8521 cggtcggcct gcgcccacgc cttcgcgacc accgaggtcg gctccagcag gacgccgcag
     8581 tcgcccagcg ccgggtccag cctgaccgcg aagtcggtct cgaccgtcca gcactgcgcg
     8641 ccgtacccgt ccagctcctt gatgccgcgc tcggtgtacc ggccgttgct gcagaagtcc
     8701 cactcgccgt gcgcgcacgg cacgcacggc tcggggtcgg gccgccgcac cgcgcccgcg
     8761 accaggtcgc ccggcgcgaa cccgctgccg tccggcgcgt gcaggacggt gcccagcgac
     8821 tcgtgcccga tgacgagccg gtccgagccc ggcggggccc agccgtagcc cggaccggag
     8881 acgatgtcgg cgtccgttcc gcagatgccg agcaggcggc cccggaccag cagctcgtcc
     8941 gcgccgggcc gcggctccgc gacgtcccgc acctccaccg agtccggatc gcccggaaca
     9001 acgctgatcg ccttcacgtg ccctcccgca ggccgacggc cggaaccggc cgaatccccc
     9061 cgatcaggtc actaccctcg gtgatcagcg acacacaccg ggcgtcactc ggcgcgggag
     9121 aagcggcgcg ccgcccaccc cagcgcgagc agcgccagac ccgtcaccag cgcccactcc
     9181 aggacgacgg acggatgcca cgaaccccac gtcagcgggt ggaacagcgg cgccggcgtc
     9241 gccggcagcc gcgccgccat cgtccggcgc atcgcgtcca ccgcgtacgt cagcgggttc
     9301 gccagcgcga cgcgcgccat ccagcccggc atcgccgtga gcgggaacat cgagcccgac
     9361 aggaacacca gcggtgcggc caggacggtc accgccgtcc cgaacgtctg cggacggcgg
     9421 atgaacgtcg ccagcaggat cgacagcgcc gtcatcgcca gcgccgcgag cgcgagctgg
     9481 ccgagcagca gcaccgtcag caccgcgtcg tgcgggacgc cgatcagcca cccggccgcc
     9541 agcaggaccc ccgcctggca cgtcgcgacc gtcgcgccgc ccaggcactt gccgagcagc
     9601 agcgtgcccc ggtggacggg accggccagc atctcccgca ggaacccggc ctgccggtcc
     9661 cacaggatcg acgagcccgc gccgatcgcc gggccctgcg ccgccgtcac cagcgccccc
     9721 gagaacagga agagctggta cgagcggctg ctgacgcccg acatcagccc cgcgaggccg
     9781 acgccgagga tgaacaggaa cagcagcggc tggagcagcg agatcgccgt cccggcgcgg
     9841 tcgcgcccga agtgcagcat ctcccgccgc cacaccatcc gcatcgcccg caactccgcc
     9901 cgaaccccgc cccgccccgc gcaaccaccc gcacgcgggt ccgcgcccag gcccgcacgc
     9961 gggtccgtgc gcgggtccgc gcccgtgcgc acgcccgtgc cagcgtccgc gcccgtgccc
    10021 gtgttcgcgc ttgggcccga gtcggcgccc gcgcccgcgc gtgaggcggt gcccgcgctc
    10081 aggtcagtgc ccgcgccgac gcccgtgccc gtgtccggtg gcggggcggg tgcgtcctcg
    10141 gtgtcgtcgc ggatgcggtg gcccgtgtgg tgcaggaaca cgtcgtccag cgacggcggc
    10201 gtcacccgcg cctcgaacac cggcacgtcc agctccgcga acaggcgcgg cagcacccgc
    10261 gcgctgtcgg gcgcgcggaa cgccagcccg cccggcccct cggcgacggc cgcgccgaac
    10321 cgctcgcgca gcacccgcgc cgccgccgcg tcgtcgccgg tgcgcagctc cacccggtcc
    10381 gcgccgagca ccgacttcag ctccgccggg ctgccctgcg cgacgatgcg gccgccgtgc
    10441 aggatcgcga cgcggtcgca ctgctcggcc tcgtccagat agtgcgtggt gaggaacagc
    10501 gtgacggcct cgcgctcgcg gaccagccgc aggtaccgcc agacgtccgc gcgggtgcgc
    10561 gggtccagcc cgatcgtcgg ctcgtccatg aacagcacgc gcggccggtg cagcagcgcc
    10621 cgcgcgatct ccagccgccg ccgcatcccg cccgacagcg tccggacgag ccggtcccgg
    10681 cagtccgtca gcccgacgag cgccagcgtc tcggcgaccc gcgcgggaac ccgctcgacg
    10741 ggcacgtcgt acaggtcggc gtggaaccgc aggttctcgg cggcggtcag ctccccgtcg
    10801 agcgtcgact cctggaagat cagcccgatg ctgcggcgcg ccgcgaccgg gtcggtccgg
    10861 gtgtcgtggc ccgcgatctc cacccgaccc gccgtgggca cggccagcgt cgtcagcatc
    10921 gcgatcgtcg tggacttgcc cgccccgttc ggcccgagga acccgaagct ctcgcccggc
    10981 gcgacgcaca ggtccacccc gtccaccgcc gtgacgcccg gataccgctt gcgcagcccc
    11041 gccgcccgga tcgccgggac cgccgccgcg gcggccgccg gaggagcgtc cgcgggcagc
    11101 gtcacgcgag ccccgccagc gcggccgtcc aggagtcggg caccgcgaag ccgaaactcc
    11161 accggtgccg ccgcgtcggg ttgacgatgc agtgccagaa caaccggtcc ggccgctgct
    11221 cgatccggaa gaaccgggcc atccgccgcc gctcccgcag cgtgaccagc tcgcccgtct
    11281 ccgggtgctg gtagcggaag aacgacgtgt gctcggcgtc ctcgaagtcg tcgtcgaggt
    11341 cgatcaggta catccgccag cccggctgcg tctcgttggt gtgccacaac cggtacgacg
    11401 acggcgggta ccacatgctg ccggagaagc ggacctccgc gccgaacacg tcctccagcg
    11461 cgccgacgac ccgcgtcttg gcgtcgaggt agtcgtcgta gtcggcgtgg ccgacgtggt
    11521 cgtccaggtt gaccaggtgg aagtcgcgcc ggtcgccggg ccgcgccgtc gccgccagct
    11581 ccgccgccca ccgccggtac tcctcgccgc gcggcgcgag ctcggtggag cgcaggtcgc
    11641 cggggcggaa ctccgcgtcg aacgccgcga ggtccacgtc ggacgggcgg accttcagcc
    11701 gggggaactc cgcgagcacc gtcgcgaacc ccggatgcgc cgccgccagc gcgtccaggt
    11761 cgtactcgtg gtgcaggaac tccgccgccg gctcgggctc gggctcgggc gcgcgcgacg
    11821 cgggcggcgc ggcgggcggc gggaccaccg acgccgacgc cgtcgccagg tcccggccgt
    11881 cgaaccggaa cccgtgcgcc tcgccgagcc ggatcatctc cgcgaccccg gtcagcgcct
    11941 tcaactgctg ccgcaggcgc gcgtcgtcgt tgacgacccg caggaacgcc gcgcaggact
    12001 cgaccgacat ctgtactccg tctccttcag ttggtggacg cccgcggcgg gtccagcagc
    12061 agcaccgagg gcacccggtc cggccgcgcc agccgcagga agtgcgtgcc gaacccggcg
    12121 agcccgagca tcaggccggg gaagaagccc gcctcccggc ccggccgcgc gccgcccagg
    12181 tcgcgccact gggactgcgc ctgcacgttg gcctccagcc ggaacgcggg ctggtcgcgc
    12241 agcagcgcgt agcgcaggaa cagctcggcg ttgcccgtcc ggccgtggca cagcgagtcg
    12301 ttgccgagcc gggggaagtt gcgcatcgtc gtggtcagcg cgacggtcgc gtcgcgcagc
    12361 agctcctcgt cgtcgccgcc gagcagcgac cagctcgcga tccgcgtcag cccgatcccg
    12421 gacgcgccgt tgcaccacgc gttggcgtag tggcggccgc cgcgcgtcgg gccgcccgcg
    12481 acggtccgca ggtcgtacca gtcctgcgcg tcggcgtcga agtgccgggc ctcgtaggcg
    12541 aacgcgcgcc gcgccgccga caggtactcg ggccggtcgg cgcgcgtccc gagcagggtc
    12601 agcgcccagc cgatcccgcc gctgccgtgc gacaggccgg tcaggtccgc gagggaggcc
    12661 gccgggtcgc tgttcggcca ggacaggacg tcgccgtcgg cgcgcgcggt cgcgagcagg
    12721 cgcgcggcgc accggtgggc ctgccgggcg ccccggccgc cggtcgcgtc ggccagcgcc
    12781 agcagcaccg ggacgagtcc ggcgacgccg tggaagacgt ccagatgccg gtcttgctcg
    12841 atgagcccgt cgatccggtc ggccagggcg accgcgcggt ccagcagcgc ggactcgccc
    12901 cacagcgcgt gcaggtgcag cagcgtgtag atcagcccgc ccgtgccggg aaacgcgccg
    12961 atgcgttcgc cgtccaggga cgccagcgcg tggtcgagcg cccgtcgcgc cgcgtgctcg
    13021 aactccgggc gcgggtcgag gtcgttcagg tacgccagga acagcgcgat gcccgccgac
    13081 ccgttgtaga ggtcgccctc gatgtccacc tcggtgcggc cctcggcggt gatgacgtac
    13141 gacgtccacg gcgcgggcgc gtcctgcggg cgcagcgccg cgcacagccg ctcgccgagc
    13201 gccgccgcct gctccacgca cgtcgccgcg aagtccgcgc tggtgacgtc gccgcccgcc
    13261 aggcccgccg cgatgtactg gtcctgctgg acgcggttgc gcgtggtcag cccccggatg
    13321 cgcgccgccg cgtgctccag cgggcccgcc tccagcgtcg ccgggacggg cgtgcggtgg
    13381 tcgtggacga gccggtcgcc gtccgcgtcg accgtgaaca gcggcacgtc cagccgccac
    13441 atcgactcca gttcccacgc cggaaggacg ccctcgacgt cccagttgcg ggggaacgtc
    13501 cggacggtgt tgaacagcag gtccacctcc agcgggtcca tcaggcactt ggggtgccgc
    13561 gcggccagca ggagctgcgt gtagatctgc gtgctccagt tgacgaaccg gacgcgcgtg
    13621 ccggagaaca gctccgcgac ctgcgccgcc gtgccgtccg gatcgtcctg gaaccagcgg
    13681 tacacccggt cgaagccgtc cttgacgtcc gcgacgtact cctccggcgc ggccagcccg
    13741 tccccgacga acacccggtt cgccgagccc gggtcgacgc gcagccccgc ccggtgcgtg
    13801 accgacgcct cgaacgacat ccgccggtcc ccgagctgcg gcaccggcat cggcagctcg
    13861 aacgagccgc cgccggagta gccgctgagc cgcatctccc cggccgcgtc cggcggggtc
    13921 ggccactcga tcaggccggt cttgaacacc gagtccatca gcgtcccggc cgggcgcggc
    13981 tgccccttgg gcagcgcgcc gaggacggtc tcgcagtcgc agacgaacgc gtgcccgtcc
    14041 gcgaccagga cgttctcgaa gtgcaggtcc ccgccgccga gcacgtagaa gatcgccagg
    14101 tagccgccca gctccgcgta caccggccgg gccgcctccc gcgtcgcgac ccggttgcgg
    14161 cccgccggga tcagcgcctc gtagccgtac ccgtcgcggg ggaggacggc ccggtcggcg
    14221 aagtccagca cgccgtcggc gcgcagccgg accagcagcc gctgcagccc ggcctcgccg
    14281 cgcacgcagc gcggcttgta gacgaacgtc gcctcggtcc cgtcggccag ctccgcgccg
    14341 accatcacca cgccgcgcgc gcccgcgtgg tcgtcggagc ggccgagccc cgccgagcgc
    14401 accgccgcga cgggctgccc gaagaacgcc gcgccgacgt cggcggcgtc gcggcgcagc
    14461 cggacgacca ggtcgcggcc gtgctcggcg agcagcccgg tggtgtgcgc cagccagcgg
    14521 ccgaggacgg ggaagtccag gtagaagcgg tggtaggact cggcgtcggc gaacgtcttg
    14581 tccaggaagg ccaggtagtc gtcggtcgtc gcggtcgccg ggtcgatgcc gcgcagccgg
    14641 cagtacacct tcgtgtcggc ctcgaccgcc cacgccagcg ccagcgcgaa ccggtcgagc
    14701 aggcggagct ggaactcctc gacgaggcgg cggtcgacga ccggccccgc gccgggcgcg
    14761 gcgtccagga cggccgtcag acggcggccg agttcgagca ggaacggctc gcacgccttg
    14821 gcgagccgcc catagtacac ctccggctcc cgccagcccg cgcgcgccgc ctcctccgac
    14881 tcgggccgga acccgtccag cgcggcggtg tagacgggca gccacgcgcg ctgcgcgtcg
    14941 cgcacggcgc ggccgaacgg gtcggccggg tcggccaggc ccagttcgtg ccgccggtag
    15001 gcggtcagcg tctcggtcag cgcggcctcg gtgtgccggg cgggggcggc gccgcgccgc
    15061 gcctcctcgc ggaaccgcgc ggcgaggcgg tcggcgaccc gccgggtctt ccaggcgtcg
    15121 aacgggtcga gcggcccggc gccggggtgc ggggcgtccg ggggcggggc gagcgcggcg
    15181 acgatccgcg cccgctcgga caggttcgcg gcgcgggccg cgatgtccgc ggggtagagc
    15241 tggttcacgc gcgggctcct cggcggcggg tcggggcggg cgggggccgg cgggccggcg
    15301 cggggccggc ccaccgggtg ggcgcgtccc cccgtgcccc ggggcacggg ggaacgccgg
    15361 agccttggct cctcctcagg agaggacggt cacttggtgg tgccgtcgca gacgaacgtg
    15421 aacgggccgg cgctgcaggt gctcgcgcag gcgtaggcgt cgatggcggc gacgccctcc
    15481 gtccagaagc cgagggactc ctggtcctgc tgctcgaccg actcgggcac cgcgtccgcg
    15541 gcgacgccga agacctccgg gtcggtcagc agcgcggtcc ggaactcggc gtccgcggcg
    15601 gcctggcgca ggatcgtgct cggggacatg tttcctcctt gtgtgttacc tgatgaccgg
    15661 ctaggagatc ttctccgtgg ccagccgtat tcccagccgc cgttcgatcc gctggatctg
    15721 gtcgacggcg acgtccatgt gggccttgtt gttctgccac gcgaccagtt ccatctcgtc
    15781 ggccgagatg agctccggat tccagatccc ctcgagccac gtcttggtgg tctgggggtg
    15841 gaggtcctgg acgggactga cgcgttcggg aaggccgcgc tcatcggtgt tcagcgcgag
    15901 cgtgagcagt tcgtggagtt tcgtgccggg cggcgtgagc gagcagagca gaaccaggtg
    15961 ctggagctgg cgcaccgtgt cgatgttgcg gtgcttcgtc aggtcgctcg gcggtttggg
    16021 gccggacctc atgcgaaatt gtcccctttc gggaggaggc tcgtgcgttt tgacgggacc
    16081 gctcggaatc tgcggtttcg ccctgccgga ccgcgcgggg gcgccgcgac tcggcctctg
    16141 tcggtatatc cgccgaagca ggccgcaatc ccaaggatcg gtcaagttga caccaagaac
    16201 agcgcgtcag attcaaaaag gatcttcgcg ttgggggttg cttcgcctgg tttccgtccg
    16261 tgaactgcta cgtcctcggc aataacggac aaacttatgc ctggtgtatg tccggcgatt
    16321 ccggatgatc agaacgcgac gtgtcggcaa tggcgtacat gtcgagaatc gcgggcgtcc
    16381 accgcttcgt cgggccgacc ggggcggggt cgcccgtaaa tgagtggaga catgccgaca
    16441 ggtcgggcat agtcggaacc gcaggcggcg gcgcgttctc gacgggaagg aacgctggtg
    16501 cgttcggcgg tctcataaac cgttgcaggc gggttcgatt cccgctcccg tcacccggcg
    16561 gcggaacggc ggaaggctac gccgactccc gcttcaccag atgcggccgc agtatcacga
    16621 ccggttcgtc caggtcctcg ccgcgaatgc gcgccacgag cagccgcgcc atctcccgtc
    16681 ccatctcctc gggggactgg tggacggtcg tcagcggcgg gtccgcgagg ggcgctgcgg
    16741 ccgagtcgtc gaagcccacg acggccacgt cgccggggac ggtccgcccg agccgccgca
    16801 ggacgcgcag cgcgccgagc gccatcgggt cgtcggcggc gaaaacggcg tcgaggcccg
    16861 ggtcgcgcgc gaggagttcc tccgcggccg cgatgccgct ggcctcgctg aagtccccgt
    16921 aggcgatcag ctcgggcagc cccgcgtccg cgagcgcgtc gcggtagccg ccgagccggt
    16981 cgatgccgac gcccatgtcc tgcggcccgg cgatcgtggc gatccggcgg cggccgtgcg
    17041 cgacgaggtg ctcgacggcc tgccgcgccc cgctgcggtt gtccacgtcc acgtagctga
    17101 ccggcgacag gccgggcggc cgcccgccga ggacggtcgg cacgccgccc gcctccagct
    17161 tggcgggcag cgggtcctcc gcgtgcagcg acgtcagcag gacgccgtcg acgtgctgcg
    17221 cggtcaggta gtccgcgagc cgcgcgtact cgccgggcga gcgggcgagc gcgagcagca
    17281 gttgcagccc ggtgtccccg agcgcggtgc tgatgccccg gatgatcccg gcgaagtagg
    17341 gctcgccgaa cagccgctgg tcggattcgg cgacgacgag cgcgaccgtg tcggtccggt
    17401 gcgtcaccag cgaccgcgcc gcccggttcg gcacgtagcc cagttcctcg atcgccttga
    17461 gcaccgccgc gcgggcctgc tcgctgaccc gcggcgagcc gttgacgacc cgcgacaccg
    17521 tcccgcggcc gacgccggcc cgcgccgcga cctcctccag cgtcgggcgc gtgcccctgc
    17581 ccgccatccg
//
