BGC0001364 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001364 (Actinomadura atramentaria DSM 43919)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	lanthipeptide-class-ii	1	25,248	High	cinnamycin B	ribosomal:RiPP

BGC0001364 - Region 1 - lanthipeptide-class-ii

Download region GenBank file

Download region SVG

Location: 1 - 25,248 nt. (total: 25,248 nt) Show pHMM detection rules used

Region on contig edge.

lanthipeptide-class-ii: cds(LANC_like and DUF4135)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

Lanthipeptides

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 25,249
Label		BGC0001364

Tailoring functions

Oxidoreductases: dehydrogenase

G339_RS0112010: alcohol dehydrogenase

smcogs: SMCOG1040: alcohol dehydrogenase

Lyases: cyclase

G339_RS0112025: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001364.3	0.93	ribosomal	cinnamycin B	Actinomadura atramentaria DSM 43919
BGC0001660.3	0.70	ribosomal	mathermycin	Marinactinospora thermotolerans
BGC0001576.3	0.62	ribosomal	divamide A	Prochloron didemni
BGC0002346.3	0.61	ribosomal	kyamicin	Saccharopolyspora sp.
BGC0001579.4	0.60	ribosomal	duramycin	Streptomyces cinnamoneus
BGC0000503.5	0.54	ribosomal	cinnamycin	Streptomyces cinnamoneus
BGC0000563.4	0.46	ribosomal	venezuelin	Streptomyces venezuelae ATCC 10712
BGC0001226.4	0.46	ribosomal	streptocollin	Streptomyces collinus Tu 365
BGC0001210.5	0.43	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0000517.4	0.41	ribosomal	haloduracin β, haloduracin α	Bacillus halodurans C-125

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001364.3	1.00	ribosomal	cinnamycin B	Actinomadura atramentaria DSM 43919
BGC0001660.3	0.70	ribosomal	mathermycin	Marinactinospora thermotolerans
BGC0001576.3	0.62	ribosomal	divamide A	Prochloron didemni
BGC0002346.3	0.61	ribosomal	kyamicin	Saccharopolyspora sp.
BGC0001579.4	0.60	ribosomal	duramycin	Streptomyces cinnamoneus
BGC0000503.5	0.53	ribosomal	cinnamycin	Streptomyces cinnamoneus
BGC0000563.4	0.46	ribosomal	venezuelin	Streptomyces venezuelae ATCC 10712
BGC0001226.4	0.46	ribosomal	streptocollin	Streptomyces collinus Tu 365
BGC0001210.5	0.43	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0000517.4	0.41	ribosomal	haloduracin β, haloduracin α	Bacillus halodurans C-125

Similar known clusters from MIBiG 4.0

Lanthipeptide predictions

Lanthipeptide(s) for G339_RS0112025

G339_RS0112000

Leader:

MKRTLAVIVAA

Core:

AAAVGCVVAARVALASADRPGGKEPAKSSTSPVQPPNTGYWTPERMQSAKPAPMPDPDD

Core with dehydrations:

AAAVGCysVVAARVALADhaADRPGGKEPAKDhaDhaDhbDhaPVQPPNDhbGYWDhbPERMQDhaAKPAPMPDPDD

antiSMASH-DB 4.0 matches for G339_RS0112000

100.0%

NZ_KB907211.1:

Lanthipeptides: G339_RS0112000_lanthipeptide

AAAVGCVVAARVALASADRPGGKEPAKSSTSPVQPPNTGYWTPERMQSAKPAPMPDPDD

16.9%

NZ_JAMTCR010000003.1:

Lanthipeptides: allorf_0722945_0723160_lanthipeptide

RPGGKEPAKSSTSPVQPPNTGYWTPERMQSAKPA

RP G P + + ++ TG PE + A+ A

RPAGASPRRFESCLLREECTGRGVPEWLIGARCA

15.3%

NC_016582.1and 1 other:

NC_016582.1 Lanthipeptides: SBI_RS34370_lanthipeptide

Lanthipeptides: SBI_RS34370_lanthipeptide

AARVALASADRPGGKEPAKS

A V L+ AD GG +PA +

AELVELSEADVHGGTDPAVT

allorf_18048_18182

Leader:

MSVTGRPAGTNRTSALPTHGECAENGDDAACVAA

Core:

PGSPDTVCRV

Core with dehydrations:

PGDhaPDDhbVCysRV

antiSMASH-DB 4.0 matches for allorf_18048_18182

19.2%

NZ_NBBB01000022.1and 1 other:

NZ_NUOG01000083.1 Lanthipeptides: COE07_RS24905_lanthipeptide

Lanthipeptides: B6F67_RS25205_lanthipeptide

PGSPDTVCRV

PG+ T+CR+

PGTCQTLCRI

12.2%

NZ_BJTV01000019.1:

Lanthipeptides: allorf_110888_111058_lanthipeptide

SPDTVCRV

SPD CRV

SPDVGCRV

allorf_19175_19339

Leader:

MKYAFARLLMESWTVGLSGLRTASGHMKSFQVCMNVSRPRTPAAGRSAGS

Core:

TTCQ

Core with dehydrations:

DhbDhbCysQ

allorf_20422_20655

Leader:

MTSPKSRSKSWVNTIATAAVEVTSGATIPMRKNVLAFIRRSSSAA

Core:

TPSASRSCGTVESTKMPTVLTTACQKSGSWTR

Core with dehydrations:

DhbPDhaADhaRDhaCysGDhbVEDhaDhbKMPDhbVLDhbDhbACysQKDhaGDhaWDhbR

antiSMASH-DB 4.0 matches for allorf_20422_20655

21.9%

NZ_CP024957.1and 1 other:

NZ_CP101140.1 Lanthipeptides: allorf_5323401_5323595_lanthipeptide

Lanthipeptides: allorf_2314001_2314195_lanthipeptide

SASRSCGTVES

S SR+CGT+ S

SGSRACGTIGS

18.2%

NZ_GG730336.1:

Lanthipeptides: SAUG_RS08760_lanthipeptide

GTVESTKMPTVLTTACQK

GTVE PT+ + AC +

GTVEPQATPTISSVACIR

12.5%

NZ_CM002307.1:

Lanthipeptides: allorf_4056428_4056634_lanthipeptide

KMPTVLTTACQKSGSWTR

++P + T Q+ G W+R

RVPQSVRTPHQEVGRWSR

allorf_21210_21431

Leader:

MLFATAGSCSACGEDGNVFLS

Core:

LNAPIWPCGLVRNSASSAASLGCLVCFGTASQEPPHEPPPPGMLAMSHLPLP

Core with dehydrations:

LNAPIWPCysGLVRNDhaADhaDhaAADhaLGCysLVCysFGDhbADhaQEPPHEPPPPGMLAMDhaHLPLP

antiSMASH-DB 4.0 matches for allorf_21210_21431

15.4%

NZ_JAIPUK010000011.1:

Lanthipeptides: allorf_022261_022440_lanthipeptide

WPCGLVRNSASSAASLGCLVCFGTASQE

+ + R S + A++ CL F T Q+

FFTKITRTSIVNYATINCLAPFSTFPQQ

13.5%

NZ_CP011130.1:

Lanthipeptides: LC55x_RS27140_lanthipeptide

FGTASQEPPHE

FG A Q PP E

FGRAKQTPPEE

13.5%

NZ_CP047218.1and 1 other:

NZ_CP053021.1 Lassopeptides: HH800_RS08170_lassopeptide

Lassopeptides: GS397_RS04955_lassopeptide

FGTASQEPPHEPPPPGML

FG + + P + P PG+L

FGGSGADNPDQQPNPGIL

with 1 more sequence matches

11.9%

NZ_BNBI01000017.1:

Lanthipeptides: allorf_039973_040194_lanthipeptide

IWPCGLVRNSASSAASLGC

IWPCG + GC

IWPCGHRTFTGEGVGRKGC

MIBiG 4.0 matches for allorf_21210_21431

17.3%

BGC0002130.3 (QKI29070.1):

Lanthipeptide: cacaoidin

PCGL---VRNSASSAASLGC

PC + V S S+ AS GC

PCTIYASVSASISATASWGC

allorf_21492_21641

Leader:

MSRLSAVCHG

Core:

GVNTWKSEVSLFCSNFSVVSNAVFTAGLLSKTSLLDLSK

Core with dehydrations:

GVNDhbWKDhaEVDhaLFCysDhaNFDhaVVDhaNAVFDhbAGLLDhaKDhbDhaLLDLDhaK

antiSMASH-DB 4.0 matches for allorf_21492_21641

14.0%

NZ_AZVD01000036.1and 1 other:

NZ_KB898432.1 Lanthipeptides: allorf_07386_07619_lanthipeptide

Lanthipeptides: allorf_19664_19897_lanthipeptide

VFTAGLLSKTSLLD

+F+AGLL + L++

LFSAGLLGQEGLIE

allorf_22188_22376

Leader:

MRVTLPSDPPSSPPQAAAVAATSAARAAAAA

Core:

NRGPFRPLTRIASPSRSGGGGCGSAPTKERP

Core with dehydrations:

NRGPFRPLDhbRIADhaPDhaRDhaGGGGCysGDhaAPDhbKERP

antiSMASH-DB 4.0 matches for allorf_22188_22376

30.3%

NZ_CP096658.1:

Lanthipeptides: allorf_3189783_3190004_lanthipeptide

FRPLTRIASPSRSGGGGCGS

FRP R SPSR C S

FRPGVRRLSPSRDARRSCQS

22.6%

NZ_CP034118.1and 1 other:

NZ_CP034118.1 Lanthipeptides: EG886_RS06310_lanthipeptide

Lanthipeptides: EG886_RS06310_lanthipeptide

NRGPFRPLTRIASPS

N G F LT+ PS

NTGQFCTLTKECQPS

21.6%

NZ_CP007597.1:

Lanthipeptides: allorf_2301019_2301156_lanthipeptide

TRIASPSRSGGGGCGSAPTKERP

R+ S +GGG C P + P

MRLLSAVETGGGHCIRPPWRAAP

with 5 more sequence matches

21.2%

NZ_CP042174.1:

Lanthipeptides: FFI11_RS16965_lanthipeptide

GGCGSAPTKER

CGS PTK R

NACGSTPTKGR

20.9%

NZ_DF978419.1:

Lanthipeptides: allorf_0450693_0450881_lanthipeptide

RIASPSRSGGG

RIASP RSG G

RIASPCRSGIG

20.5%

NZ_LR134301.1:

Lanthipeptides: allorf_1753738_1753947_lanthipeptide

LTRIASPSRSGGGGCGSAPTKE

L R+ P+ S G GS PT+

LARVRCPAHSARPGLGSCPTRR

18.8%

NZ_JAENHN010000066.1and 1 other:

NZ_JAENHN010000066.1 Lanthipeptides: JHL18_RS24410_lanthipeptide

Lanthipeptides: JHL18_RS24410_lanthipeptide

LTRIASPSRSGGGGC

+T +A PS++ G C

VTEVACPSKACTGYC

15.3%

NZ_CP041244.1:

Lanthipeptides: allorf_9037809_9038009_lanthipeptide

NRGPFRPLTRIASPSR

N GP RP R A P+R

NAGPLRPF-RAAEPAR

MIBiG 4.0 matches for allorf_22188_22376

16.1%

BGC0002110.3 (QKV49893.1):

Lanthipeptide: birimositide

NRGPFRPLTRIASPS

N G + LT+ P+

NNGGWCTLTKECQPN

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Lanthipeptides

Core peptide predictions

G339_RS0112000 - Class II

Cleavage pHMM score: -3.30

RODEO score: 0

Monoisotopic mass: 5855.9 Da

Molecular weight: 5859.5 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 5877.5 Da N = 1; 5895.6 Da N = 2; 5913.6 Da N = 3; 5931.6 Da N = 4; 5949.6 Da N = 5; 5967.6 Da N = 6; 5985.7 Da N = 7

allorf_18048_18182 - Class II

Cleavage pHMM score: -7.10

RODEO score: 0

Monoisotopic mass: 993.5 Da

Molecular weight: 994.1 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 1012.1 Da N = 1

allorf_19175_19339 - Class II

Cleavage pHMM score: -5.60

RODEO score: 0

Monoisotopic mass: 415.2 Da

Molecular weight: 415.5 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 433.5 Da N = 1

allorf_20422_20655 - Class II

Cleavage pHMM score: -5.20

RODEO score: 0

Monoisotopic mass: 3123.6 Da

Molecular weight: 3125.5 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 3143.5 Da N = 1; 3161.5 Da N = 2; 3179.6 Da N = 3; 3197.6 Da N = 4; 3215.6 Da N = 5; 3233.6 Da N = 6; 3251.6 Da N = 7; 3269.7 Da N = 8; 3287.7 Da N = 9; 3305.7 Da N = 10; 3323.7 Da N = 11

allorf_21210_21431 - Class II

Cleavage pHMM score: -5.00

RODEO score: 0

Monoisotopic mass: 5191.6 Da

Molecular weight: 5195.0 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 5213.0 Da N = 1; 5231.1 Da N = 2; 5249.1 Da N = 3; 5267.1 Da N = 4

allorf_21492_21641 - Class II

Cleavage pHMM score: -6.60

RODEO score: 0

Monoisotopic mass: 3950.2 Da

Molecular weight: 3952.5 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 3970.5 Da N = 1; 3988.5 Da N = 2; 4006.5 Da N = 3; 4024.6 Da N = 4; 4042.6 Da N = 5; 4060.6 Da N = 6; 4078.6 Da N = 7; 4096.6 Da N = 8; 4114.7 Da N = 9; 4132.7 Da N = 10

allorf_22188_22376 - Class II

Cleavage pHMM score: -6.60

RODEO score: 0

Monoisotopic mass: 3057.6 Da

Molecular weight: 3059.4 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 3077.4 Da N = 1; 3095.4 Da N = 2; 3113.5 Da N = 3; 3131.5 Da N = 4; 3149.5 Da N = 5