LOCUS       BGC0001365             23784 bp    DNA     linear   PLN 15-APR-2013
DEFINITION  Claviceps purpurea 20.1 WGS project CAGA00000000 data, contig
            scaffold00012, whole genome shotgun sequence.
ACCESSION   BGC0001365
VERSION     BGC0001365
KEYWORDS    .
SOURCE      Claviceps purpurea 20.1
  ORGANISM  Claviceps purpurea 20.1
            Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
            Sordariomycetes; Hypocreomycetidae; Hypocreales; Clavicipitaceae;
            Claviceps.
COMMENT     Sequencing was performed by University of Kentucky Advanced Genetic
            Technologies Center
            Guldener U., Oeser B., O'Sullivan D., Tudzynski P. Westfaelische
            Wilhelms-Universitaet Muenster
            Institut fuer Biologie und Biotechnologie der Pflanzen,
            Hindenburgplatz 55, 48143 Muenster, Germany
            birgitt.oeser@uni-muenster.de, tudzyns@uni-muenster.de NIAB,
            Huntingdon Road, Cambridge CB3 0LE, UK
            donal.osullivan@niab.com.
            ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-10-17 15:24:34
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..23784
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="True"
                     /core_location="[16069:22331]"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or
                     A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      16070..22331
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or
                     A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
     cand_cluster    1..23784
                     /SMILES="NC(CCCCN)C(=O)NC([*])C(=O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(Condensation and (AMP-binding or
                     A-OX))"
                     /detection_rules="(indsynth or dmat or indole_PTase)"
                     /kind="neighbouring"
                     /product="NRPS"
                     /product="indole"
                     /protoclusters="1"
                     /protoclusters="2"
                     /tool="antismash"
     subregion       1..23784
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0001365"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..23784
                     /candidate_cluster_numbers="1"
                     /candidate_cluster_numbers="2"
                     /contig_edge="True"
                     /product="NRPS"
                     /product="indole"
                     /region_number="1"
                     /rules="cds(Condensation and (AMP-binding or A-OX))"
                     /rules="(indsynth or dmat or indole_PTase)"
                     /subregion_numbers="1"
                     /tool="antismash"
     exon            4..158
                     /locus_tag="CPUR_02671"
     gene            4..1273
                     /locus_tag="CPUR_02671"
     CDS             join(4..158,239..572,656..1273)
                     /codon_start=1
                     /locus_tag="CPUR_02671"
                     /note="CP_02671.2"
                     /product="related to C6 transcription factor GliZ2"
                     /protein_id="CCE28980.1"
                     /transl_table=11
                     /translation="MNPMLTNNSQPSNYTAGNAKGKIKKLRSACDACHASKVRCSGEPI
                     CARCQRDNVACHYSYRAHQGKPKGSLNRKTIERMKAAGFIEQRQRPAASQPPGHGTSRD
                     SSVCASGTTTDNLLNFIEIQPPGESNESPVAIHATPSPCFAMTGGLLPDFDAANLDAFL
                     EAYQTPEDSCLRAVEEFPGASPADMDCIFIGTPSSMSRDYTEVATCRCVREITQQINNV
                     HAASADRSTTGLDDVLHYTREISACISGLLQCYSCGGQVQVFVLASVVLSLLMELMHPL
                     LDSSTDTSRPRAQIRVGNYDMSGQLGDVLEKVIVRSIITKLRQVVDKFEMKADFLRSET
                     AQAEFLKSEARRLKRGFGRIEEGTATLP"
     exon            239..572
                     /locus_tag="CPUR_02671"
     exon            656..1273
                     /locus_tag="CPUR_02671"
     exon            1776..2496
                     /locus_tag="CPUR_02672"
     gene            1776..2755
                     /locus_tag="CPUR_02672"
     CDS             join(1776..2496,2631..2755)
                     /codon_start=1
                     /locus_tag="CPUR_02672"
                     /note="CP_02672.1"
                     /product="uncharacterized protein"
                     /protein_id="CCE28981.1"
                     /transl_table=11
                     /translation="MESVVDGSSQSRHQSENDRLNIQHALIKSIMGGKLLMAPVNLERP
                     DLRILDSGTAQANWLLDLAALVPTTAQLTGTDIAPEQFPPPSQRPPNMTLQKQSIFDPW
                     NEAMLGSFDVVHQRFVLAACQSDEHGQRAVADLLALTKPGGWIELHEGNMLAIQEGEAH
                     SAMMRFRDIAVAAWVSIGQVPDPGPRLTDWMRDAGVVDMHEEVQTIGLGAAARNQQEAE
                     WSTELCLNMLRTIRRMTAGKGADAPSEQEFDTLEVALREELQEVGNQWYYYLAYGRRRT
                     "
     protocluster    2586..23784
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[12585:14129]"
                     /cutoff="20000"
                     /detection_rule="(indsynth or dmat or indole_PTase)"
                     /neighbourhood="10000"
                     /product="indole"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      12586..14129
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(indsynth or dmat or indole_PTase)"
                     /neighbourhood="10000"
                     /product="indole"
                     /protocluster_number="2"
     cand_cluster    2586..23784
                     /candidate_cluster_number="2"
                     /contig_edge="True"
                     /detection_rules="(indsynth or dmat or indole_PTase)"
                     /kind="single"
                     /product="indole"
                     /protoclusters="2"
                     /tool="antismash"
     exon            2631..2755
                     /locus_tag="CPUR_02672"
     exon            3121..3407
                     /locus_tag="CPUR_02673"
     gene            3121..4691
                     /locus_tag="CPUR_02673"
     CDS             join(3121..3407,3483..3780,3842..3918,3996..4085,
                     4166..4691)
                     /codon_start=1
                     /locus_tag="CPUR_02673"
                     /note="CP_02673.1"
                     /product="related to microsomal dipeptidase precursor"
                     /protein_id="CCE28982.1"
                     /transl_table=11
                     /translation="MATAAQPSLELALELMSKVPLIGNISQSTHKIPIQCTGLTREQDG
                     HNDWMHMIRAYYDFQVDDRFQPTKDLAGHVDLKRLVQGRAGAVFWSVYVECPKGENDFS
                     DAVHHASMRDTFQQIDLLQRIMELYSDRMEMAHKADDVMRIFRSGKCASLMGAEGLHQL
                     GNSSSVLRIFHRLGVRYVTLAHAKNNLYVDSATSEAPIHHGLSPQGRDMVREMNRIGMI
                     VDLSHVSEKAMVDALDVSLAPVIFSHSSAYALVPHVRNVPDHVLDRLKQNRGIIMISFI
                     PWLTNKDPEKATVENVVDHVLHVGNRIGFDHLGLGSDFDGMPSHVQGLEDVSKYPNVVA
                     AMLQRGISTENVEKIMGMNVIRVLREVEDVAASQKGLLPVLEDAVPQLWDDGIRAYVKK
                     LYPHAEHDRTGASETTTVDKAIEKDV"
     exon            3483..3780
                     /locus_tag="CPUR_02673"
     exon            3842..3918
                     /locus_tag="CPUR_02673"
     exon            3996..4085
                     /locus_tag="CPUR_02673"
     exon            4166..4691
                     /locus_tag="CPUR_02673"
     exon            complement(4764..5063)
                     /locus_tag="CPUR_02674"
     gene            complement(4764..5606)
                     /locus_tag="CPUR_02674"
     CDS             complement(join(4764..5063,5131..5266,5374..5606))
                     /codon_start=1
                     /locus_tag="CPUR_02674"
                     /note="CP_02674.1"
                     /product="uncharacterized protein"
                     /protein_id="CCE28983.1"
                     /transl_table=11
                     /translation="MSASVFIERRKIRPLRTEAACIPTHALCFNVLGIPYMDPGNGGIR
                     PLNPDDSDATACVHGVAYLLTSDDLKKVILSEGGGIAYQVARLNAKLLLDDSPIVVDTL
                     IGRHNVDASNERLPSARYIGVLTRGANELNLPLSYQRRLAEQPIYQPKSGWWFQLGVAL
                     FLWPWTRAAIITERLVYKHQGPDGHVPAWFLFIFDCLLWLMWAQHDYIHGPIFGRGDGR
                     "
     exon            complement(5131..5266)
                     /locus_tag="CPUR_02674"
     exon            complement(5374..5606)
                     /locus_tag="CPUR_02674"
     exon            6185..6340
                     /locus_tag="CPUR_02675"
     gene            6185..7868
                     /locus_tag="CPUR_02675"
     CDS             join(6185..6340,6396..7868)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1005:Drug
                     resistance transporter, EmrB/QacA (Score: 350.1; E-value:
                     2.3e-106)"
                     /gene_kind="transport"
                     /locus_tag="CPUR_02675"
                     /note="CP_02675.1"
                     /product="probable DHA14-like major facilitator; ABC
                     transporter"
                     /protein_id="CCE28984.1"
                     /transl_table=11
                     /translation="MATVGTEEKNPIGSASNTAEPNVTEPQKQYASGFKLTIIVISLCL
                     SLFLCGLDQTIITTAVPIITNDFKAIEDVGWYTTAYLLTTSSFQIAYGKLYTTLSVKMI
                     LLMALAIFELGSIICAAAPNSTTLIVGRAIAGLGAAGIFPGSTLVLVHAAPMERRPALL
                     GITTGMFGIASLCGPFIGGAFADGASWRWCFIINVPLGVITAVIVTFFVFTPVDPLYAE
                     WTFKDKLAYAKIPEILVLVAALVCLVLGLQWGGTTYAWSDGRIIALLVVFAVLTTAFLV
                     LQVLLPKSRTIPTSIVKNRNIWFASIFALCSSGAMFIAVTYLPIYFQAIKNASALSSGV
                     NVMPLILGFLVMSIISGVITNTTGYYNPSMFLCTILASVGAGLVSTFDVGTPQPKWIGY
                     QALLGFGIGFGLQQPIVCAQHVLDERDVPFGVAFINMMQMLGGAIFVAVSQNVFLNGLA
                     NGIAEALPGFNTHKIIEGGLTDFKNLFTSDQLPKAIPVYAHVLGQVFLIATGLCVGTLL
                     GSLGVQWRSVKKAKVTEDQADVERK"
     exon            6396..7868
                     /locus_tag="CPUR_02675"
     exon            8582..8654
                     /locus_tag="CPUR_02676"
     gene            8582..9413
                     /locus_tag="CPUR_02676"
     CDS             join(8582..8654,8737..9413)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GST_N_3"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GST_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1193:glutathione S-transferase (Score: 153.9; E-value:
                     6.8e-47)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="CPUR_02676"
                     /note="CP_02676.1"
                     /product="uncharacterized protein"
                     /protein_id="CCE28985.1"
                     /sec_met_domain="GST_N_3 (E-value: 1.2e-10, bitscore: 31.3,
                     seeds: 52, tool: rule-based-clusters)"
                     /sec_met_domain="GST_C (E-value: 1.4e-07, bitscore: 21.3,
                     seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEAQQDFTKHPEVAQDRLVLYVRKAIPAPTANSLKPLMILEALEI
                     PYSIHLISSLSQETWYHEINPYKQLPALEDIDLVETSGGSKRRLNVFDSSAMLIYLCDK
                     HDKDGLFIGRNATERAQVTSWLIAYAAGLGATGEWWLKMRHDENLKPALRVIENAIRRE
                     YDILEKRLGEPGQRWIALADRPTVADFAIQPLANPRVARNAAIDFEAWPRTKAWSEAVD
                     RLAYIDRAKRLNNKLGMTEEEIELHGR"
     exon            8737..9413
                     /locus_tag="CPUR_02676"
     exon            complement(9685..9918)
                     /locus_tag="CPUR_02677"
     gene            complement(9685..11610)
                     /locus_tag="CPUR_02677"
     CDS             complement(join(9685..9918,9993..10100,10157..10221,
                     10289..10508,10576..11173,11245..11423,11497..11610))
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034:cytochrome P450 (Score: 166.9; E-value: 1.2e-50)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="CPUR_02677"
                     /note="CP_02677.1"
                     /product="uncharacterized protein"
                     /protein_id="CCE28986.1"
                     /sec_met_domain="p450 (E-value: 4.7e-53, bitscore: 170.0,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVFKMVMLKDVFPILVFLVALRLLKSQIAQWMIESIVTKLLQALN
                     PVHDSLGKGISGPRWQYLNGQTLDKFLDGREKVQEWQKYGPVYRIWAGTTPEIVITKPE
                     DVRAFHVDSSRHNKARSSNAGWLFHQLLGECMGLISGTRWIKVRSEFEPAFSHSAITMK
                     AAEVSNDAQCYVNKLEKSRSSSFTVQAAEAVARFPFFCTATHLYGELSEEERNELWELG
                     QRNLKMMGHVLSGGLFRFPIARWLYRSAVQDLESFLCDWASFNERIYKKKVGCGAKTPI
                     VSAWKKVIDGDLTREEAIHTLSEILFANLDVATGNLSWLVIYLAANEDIQRQVVEEISQ
                     HRHELDHYCARKDTLLAYCVLETLRLRPFTAFSIPESSPNQKVLHGFTVPGNTSVVVNT
                     LAINYNAAFWGDKAEVFSPNRFHSINRLALRYNLFTFGMGTRKCLGSHFAEMMMKYFAM
                     HLLNRFSLHIPVEKDRSKAQTEDTSMSTWVPISDKEVALQKRTMGLF"
     exon            complement(9993..10100)
                     /locus_tag="CPUR_02677"
     exon            complement(10157..10221)
                     /locus_tag="CPUR_02677"
     exon            complement(10289..10508)
                     /locus_tag="CPUR_02677"
     exon            complement(10576..11173)
                     /locus_tag="CPUR_02677"
     exon            complement(11245..11423)
                     /locus_tag="CPUR_02677"
     exon            complement(11497..11610)
                     /locus_tag="CPUR_02677"
     exon            complement(12586..12709)
                     /locus_tag="CPUR_02678"
     gene            complement(12586..14129)
                     /locus_tag="CPUR_02678"
     CDS             complement(join(12586..12709,12783..13942,14009..14048,
                     14119..14129))
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) indole:
                     dmat"
                     /gene_kind="biosynthetic"
                     /locus_tag="CPUR_02678"
                     /note="CP_02678.1"
                     /product="uncharacterized protein"
                     /protein_id="CCE28987.1"
                     /sec_met_domain="dmat (E-value: 1.1e-107, bitscore: 350.2,
                     seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPFMFETILSRVKWTANTLVARLTTLYEYEYPRTAKEETGIDKEY
                     HIKLWDEDIGAMLVSMMRLAGYSEQSQKTHRIFFKEQVARSLGLYPTTYPHQSAWESFM
                     TDDHTPVEMSWSWSGNTPTPVVRYAAEPISWHAGTASDPLNSEATTECLASTAPLAPSL
                     DLRWYRHFLKHLVADDSDGQHDTTDHLSQEFIAFDLDKDSMTVKYYFLPTLKSLACGKT
                     NLELMEESILSLPEADEAVRSSLKVLTTYIRAYPQDEQPQAEIFAVDCVNPANSRLKIY
                     VRSRKTTFDSMLEMMTLGGQTPDLTRDAIDSLRELWCACFALPNNPSVTSKPLRSKEHR
                     TGGLLYYFELRPGAALPTSKVYLPVRHYGKTDDQIARGLSSYLYKRGQCLEGGLSYYEG
                     VRRICKHRSLKQGLGFQTYITCAVKKGVVSVNAYFNPETCQYSRG"
     exon            complement(12783..13942)
                     /locus_tag="CPUR_02678"
     exon            complement(14009..14048)
                     /locus_tag="CPUR_02678"
     exon            complement(14119..14129)
                     /locus_tag="CPUR_02678"
     exon            14601..14786
                     /locus_tag="CPUR_02679"
     gene            14601..16011
                     /locus_tag="CPUR_02679"
     CDS             join(14601..14786,14855..15463,15529..16011)
                     /NRPS_PKS="Domain: Aminotran_1_2 (37-404). E-value:
                     1.2e-48. Score: 157.9. Matches aSDomain:
                     nrpspksdomains_CPUR_02679_Aminotran_1_2.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1019:aminotransferase (Score: 162.2; E-value:
                     2.9e-49)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="CPUR_02679"
                     /note="CP_02679.1"
                     /product="related to 1-aminocyclopropane-1-carboxylate
                     synthase"
                     /protein_id="CCE28988.1"
                     /sec_met_domain="Aminotran_1_2 (E-value: 2.5e-49, bitscore:
                     157.8, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MMSKRCLKRNQTLIPELLKNHGALLYGDTSVVDLSTAENQLLMEE
                     LLPEFQAAFDANTWSSQELAYSEGVGGCPKVRGLIADLVNSHFQPHAQVDKSHIVLGAG
                     GCFALNALIEAICDPGDGILIAAPYWPGLDLSISVHNDAKAVVVRVPHEDFFRVESIRH
                     YSKALLSAPNLVKAMIICNPHNPLGRNYPRETLQAIVDFCAERQIHLISDEVYALSQHV
                     QPTSENPSAGFVSALSLDASHARGLVHVVYSLSKDFGCNGIRLGAFISQDNKAVVMSGA
                     LSTHCQTSTMATLVAQKIILTDENIQFVNTYGRGLLKSAYTVMEEFLNQHRIEFVSAEC
                     GMYIFAKLCGDRTSVDDEWLFQAILRRNGLVLSAGTDYHCKTPGWFRICYGCDREKLRH
                     GLDRLRDCLQEFGETEFKFPFNDACF"
     aSDomain        join(14712..14786,14855..15463,15529..15945)
                     /aSDomain="Aminotran_1_2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CPUR_02679_Aminotran_1_2.1"
                     /evalue="1.20E-48"
                     /label="CPUR_02679_Aminotran_1_2.1"
                     /locus_tag="CPUR_02679"
                     /protein_end="404"
                     /protein_start="37"
                     /score="157.9"
                     /tool="antismash"
                     /translation="ENQLLMEELLPEFQAAFDANTWSSQELAYSEGVGGCPKVRGLIAD
                     LVNSHFQPHAQVDKSHIVLGAGGCFALNALIEAICDPGDGILIAAPYWPGLDLSISVHN
                     DAKAVVVRVPHEDFFRVESIRHYSKALLSAPNLVKAMIICNPHNPLGRNYPRETLQAIV
                     DFCAERQIHLISDEVYALSQHVQPTSENPSAGFVSALSLDASHARGLVHVVYSLSKDFG
                     CNGIRLGAFISQDNKAVVMSGALSTHCQTSTMATLVAQKIILTDENIQFVNTYGRGLLK
                     SAYTVMEEFLNQHRIEFVSAECGMYIFAKLCGDRTSVDDEWLFQAILRRNGLVLSAGTD
                     YHCKTPGWFRICYGCDREKLRHGLDRL"
     exon            14855..15463
                     /locus_tag="CPUR_02679"
     exon            15529..16011
                     /locus_tag="CPUR_02679"
     exon            complement(16070..21588)
                     /locus_tag="CPUR_02680"
     gene            complement(16070..22331)
                     /locus_tag="CPUR_02680"
     CDS             complement(join(16070..21588,21701..22331))
                     /NRPS_PKS="Domain: AMP-binding (12-395). E-value: 5.5e-81.
                     Score: 264.1. Matches aSDomain:
                     nrpspksdomains_CPUR_02680_AMP-binding.1"
                     /NRPS_PKS="Domain: PP-binding (504-569). E-value: 5.4e-13.
                     Score: 41.2. Matches aSDomain:
                     nrpspksdomains_CPUR_02680_PP-binding.1"
                     /NRPS_PKS="Domain: Condensation_DCL (608-902). E-value:
                     2.5e-36. Score: 117.2. Matches aSDomain:
                     nrpspksdomains_CPUR_02680_Condensation_DCL.1"
                     /NRPS_PKS="Domain: AMP-binding (1070-1452). E-value:
                     9.8e-74. Score: 240.2. Matches aSDomain:
                     nrpspksdomains_CPUR_02680_AMP-binding.2"
                     /NRPS_PKS="Domain: PP-binding (1555-1619). E-value: 3e-10.
                     Score: 32.4. Matches aSDomain:
                     nrpspksdomains_CPUR_02680_PP-binding.2"
                     /NRPS_PKS="Domain: Condensation_LCL (1650-1926). E-value:
                     5.3e-37. Score: 119.3. Matches aSDomain:
                     nrpspksdomains_CPUR_02680_Condensation_LCL.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     AMP-binding"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     Condensation"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002:AMP-dependent synthetase and ligase (Score:
                     242.6; E-value: 1.1e-73)"
                     /gene_kind="biosynthetic"
                     /locus_tag="CPUR_02680"
                     /note="CP_02680.1"
                     /product="non-ribosomal peptide synthetase"
                     /protein_id="CCE28989.1"
                     /sec_met_domain="PP-binding (E-value: 1.1e-13, bitscore:
                     41.2, seeds: 164, tool: rule-based-clusters)"
                     /sec_met_domain="Condensation (E-value: 9.1e-36, bitscore:
                     112.9, seeds: 42, tool: rule-based-clusters)"
                     /sec_met_domain="AMP-binding (E-value: 1.8e-80, bitscore:
                     260.0, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MATVPVSVHDLIRHHAEAHPEALAISKNEDQITYGELYAASTRIA
                     QLLADQGVEKGDVVPLLGSRCLEMIACTLAIFMIGATLVPMEAGSWSEARIQTVLDALE
                     YKTLLVTADGDVRRRKTIDYHEIQRAMTGGNGWDCGNAKVPINGPESVRDVAYIIFTSG
                     TTGNPKGVKVTHQSLLNYVWPAHANAPFNLGVGPSDTSLLLFSVAFDAFYGVLLSTLCN
                     GGHVLLSEPSTFIDDAKKCTLLPATPTLLGTISDVSPYSNVRGIFLGGETPTPDVVRKW
                     WTPSRSMWNAYGPTETTVSVTMAELRPDVPIVLGEPIRNSKIIILDSNLEEATQGEICV
                     LGSTVLALGYYKNQAQTDDKFVLWNNERIYRTGDMAKWTENGLKFLGRKDQLIKNRGFL
                     INLEADVIPAILSQNNVETATVLMHRQRLIAFVTPLTVNGDLVRQEMARRFDQFLVPDE
                     IQSRDQLPQTINGKVDNRALYDELVQRDTVGVASNAPIATADTKLSALMNTMSEALTIP
                     AQMIRPELSFTDVGGNSLLAIKMLSALRQKGLSLSMSSLFLLPTISEISNHIIEFDASV
                     SHDDDDQQAADLAGCGKSLSLPGATRSAREITMTDVQRGMIRSTLHDAPTGYMLITISL
                     HQNARDIHPSRLSNAVSQVLGRHDIFCSSFDLVRGTISVNDRYQHDWETRALDGSPMSQ
                     AIADESELLNQRARMSDTSNEFFRPVNAFRLLLGENSESVLLWLVHHALVDGWSVGKLL
                     NDFRAQLLTEHSQAAQQSQFSQYTAALTPHLEKVHEPAELFWRESMAGLLDGTELKVGR
                     LEDGASNGSRIEHECLSLGLSLEQTEIAARALGFSPAVIFHAAWALLLSSYASEDAVVF
                     GSVFSARSFHVPRIEEIVGPLINLCPFPVQVHALGSKMDLLSSVQSLLLQISEYQWSAS
                     KILQDIASGSHARIFSTALFLEYDLPLYASSDQHELAAWTYDRKDWPEFGLTLQVQCVG
                     EHLGFRAVIKDPKYESPLASRLLGHFRNLCLFLLSPKISTLAEANDSMLEPTEMLCLTR
                     TSTSLFTPYSGPPTLKQAFEIGVAAWPMSVALESLSGKLLYQELDDITNALACSIRGLI
                     RPRDVVALLSDGSQNWLLGVISIIKAGATYLPLDTKLPAQRMEAMMETSGACLCVYPNA
                     SSLAAFSDLSKPRYLVYEHAAVKTMNGSSSDRLEDIVGPDDYAYIMFTSGSTGTPKGIR
                     VTHRATTSHLSFEPARLHARPGRRHAQVFSPGFDVNIAEIFGTLCYGATLVLKDPADPF
                     AHLSRVDAAMITPSFLSVLSPTELQNLDSIYLIGEAVSQSLADRWSPGRVLYNFYGPCE
                     CTIAVAYTRLEIGRPVTLGKTIPRVGCYILDRLLRPVPMGVIGEICLYGVQTMEGYIGQ
                     NADEVTKRAFVQDPFRRPGERMYRTGDLAFWTENMEMRYVGRADHQVKVRGYRIELEEI
                     ENVIRRSDENVSQSVAIVHQDTIYAFATPQGARIDQIQQCLRQHLPSYAVPQLIIALEA
                     FPTTPNQKLDRKALINLLAPVCSRENETTDHTELVVSQVWREVIGLDEEIALSIDDDFL
                     AIGGNSLRQIAAAQKICSKLGCRVPLSLFITSRSIRSLAASVKKHLAQQSLASTTSVSL
                     AEFSNQCQFLSSKLSYLEKEFLRMHKQASNPSSFNVVHRVRLQGDVDSLLLERALRTVV
                     SKHDILRASYVEVDGVPQRVIQTNTIQIDRIECSDDVAKLHDYISTKFELSGVLIRIAL
                     VERCGATDVVLVQHHIITDQVSVQIFLTNLSMEYRALACRDESGQTICTSDHSTNDYHV
                     WALWRDSQLEQPPENTHCEFWRSQFGEKTESIRLVQHQKHPAGEFHSVPRRLKRNSSSG
                     SIEVYLAAAALALQKVSRLNTIRLGVPFLDRLEPGTENMMGVFLDALPVCVQIEPHTDL
                     PSLLSTIRTTLTSALAHAIPSFMIKDIVGLDSIFEVMIVYNRFEDRVTRNMSIPGVSIS
                     VEAMRAQGAKFPLLIEFNEHVDHVTLEIEYSEDVLTPSSLSRFEQEICNLLDPQIVV"
     aSDomain        complement(16442..17269)
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CPUR_02680_Condensation_LCL.1"
                     /domain_subtypes="Condensation_LCL"
                     /evalue="5.30E-37"
                     /label="CPUR_02680_Condensation_LCL.1"
                     /locus_tag="CPUR_02680"
                     /protein_end="1926"
                     /protein_start="1650"
                     /score="119.3"
                     /tool="antismash"
                     /translation="KLSYLEKEFLRMHKQASNPSSFNVVHRVRLQGDVDSLLLERALRT
                     VVSKHDILRASYVEVDGVPQRVIQTNTIQIDRIECSDDVAKLHDYISTKFELSGVLIRI
                     ALVERCGATDVVLVQHHIITDQVSVQIFLTNLSMEYRALACRDESGQTICTSDHSTNDY
                     HVWALWRDSQLEQPPENTHCEFWRSQFGEKTESIRLVQHQKHPAGEFHSVPRRLKRNSS
                     SGSIEVYLAAAALALQKVSRLNTIRLGVPFLDRLEPGTENMMGVFLDALPVCVQ"
     CDS_motif       complement(16451..16534)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CPUR_02680_0016"
                     /evalue="1.60E-03"
                     /label="C5_LCL_267-296"
                     /locus_tag="CPUR_02680"
                     /protein_end="1923"
                     /protein_start="1895"
                     /score="11.0"
                     /tool="antismash"
                     /translation="IRLGVPFLDRLEPGTENMMGVFLDALPV"
     CDS_motif       complement(16862..16912)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CPUR_02680_0015"
                     /evalue="2.00E-03"
                     /label="C3_LCL_132-143"
                     /locus_tag="CPUR_02680"
                     /protein_end="1786"
                     /protein_start="1769"
                     /score="11.0"
                     /tool="antismash"
                     /translation="HHIITDQVSVQIFLTNL"
     CDS_motif       complement(17096..17209)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CPUR_02680_0014"
                     /evalue="1.40E-09"
                     /label="C2_LCL_024-062"
                     /locus_tag="CPUR_02680"
                     /protein_end="1708"
                     /protein_start="1670"
                     /score="30.4"
                     /tool="antismash"
                     /translation="SFNVVHRVRLQGDVDSLLLERALRTVVSKHDILRASYV"
     aSDomain        complement(17363..17554)
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CPUR_02680_PP-binding.2"
                     /evalue="3.00E-10"
                     /label="CPUR_02680_PP-binding.2"
                     /locus_tag="CPUR_02680"
                     /protein_end="1619"
                     /protein_start="1555"
                     /score="32.4"
                     /tool="antismash"
                     /translation="VSQVWREVIGLDEEIALSIDDDFLAIGGNSLRQIAAAQKICSKLG
                     CRVPLSLFITSRSIRSLAA"
     aSModule        complement(17363..20395)
                     /complete
                     /domains="nrpspksdomains_CPUR_02680_Condensation_DCL.1"
                     /domains="nrpspksdomains_CPUR_02680_AMP-binding.2"
                     /domains="nrpspksdomains_CPUR_02680_PP-binding.2"
                     /locus_tags="CPUR_02680"
                     /monomer_pairings="X -> X"
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       complement(17834..17899)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CPUR_02680_0013"
                     /evalue="1.60E-11"
                     /label="NRPS-A_a8"
                     /locus_tag="CPUR_02680"
                     /protein_end="1462"
                     /protein_start="1440"
                     /score="36.1"
                     /tool="antismash"
                     /translation="YVGRADHQVKVRGYRIELEEIE"
     aSDomain        complement(17864..19009)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CPUR_02680_AMP-binding.2"
                     /evalue="9.80E-74"
                     /label="CPUR_02680_AMP-binding.2"
                     /locus_tag="CPUR_02680"
                     /protein_end="1452"
                     /protein_start="1070"
                     /score="240.2"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="VAAWPMSVALESLSGKLLYQELDDITNALACSIRGLIRPRDVVAL
                     LSDGSQNWLLGVISIIKAGATYLPLDTKLPAQRMEAMMETSGACLCVYPNASSLAAFSD
                     LSKPRYLVYEHAAVKTMNGSSSDRLEDIVGPDDYAYIMFTSGSTGTPKGIRVTHRATTS
                     HLSFEPARLHARPGRRHAQVFSPGFDVNIAEIFGTLCYGATLVLKDPADPFAHLSRVDA
                     AMITPSFLSVLSPTELQNLDSIYLIGEAVSQSLADRWSPGRVLYNFYGPCECTIAVAYT
                     RLEIGRPVTLGKTIPRVGCYILDRLLRPVPMGVIGEICLYGVQTMEGYIGQNADEVTKR
                     AFVQDPFRRPGERMYRTGDLAFWTENMEMRYVGRADHQVKVR"
     CDS_motif       complement(18014..18079)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CPUR_02680_0012"
                     /evalue="5.90E-05"
                     /label="NRPS-A_a6"
                     /locus_tag="CPUR_02680"
                     /protein_end="1402"
                     /protein_start="1380"
                     /score="15.5"
                     /tool="antismash"
                     /translation="PMGVIGEICLYGVQTMEGYIGQ"
     CDS_motif       complement(18179..18205)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CPUR_02680_0011"
                     /evalue="1.40E-01"
                     /label="NRPS-A_a5"
                     /locus_tag="CPUR_02680"
                     /protein_end="1347"
                     /protein_start="1338"
                     /score="5.5"
                     /tool="antismash"
                     /translation="YGPCECTIA"
     CDS_motif       complement(18536..18595)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CPUR_02680_0010"
                     /evalue="4.90E-09"
                     /label="NRPS-A_a3"
                     /locus_tag="CPUR_02680"
                     /protein_end="1228"
                     /protein_start="1208"
                     /score="28.3"
                     /tool="antismash"
                     /translation="AYIMFTSGSTGTPKGIRVTH"
     CDS_motif       complement(18797..18835)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CPUR_02680_0009"
                     /evalue="2.80E-03"
                     /label="NRPS-A_a2"
                     /locus_tag="CPUR_02680"
                     /protein_end="1141"
                     /protein_start="1128"
                     /score="11.3"
                     /tool="antismash"
                     /translation="SIIKAGATYLPLD"
     aSDomain        complement(19514..20395)
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CPUR_02680_Condensation_DCL.1"
                     /domain_subtypes="Condensation_DCL"
                     /evalue="2.50E-36"
                     /label="CPUR_02680_Condensation_DCL.1"
                     /locus_tag="CPUR_02680"
                     /protein_end="902"
                     /protein_start="608"
                     /score="117.2"
                     /tool="antismash"
                     /translation="MTDVQRGMIRSTLHDAPTGYMLITISLHQNARDIHPSRLSNAVSQ
                     VLGRHDIFCSSFDLVRGTISVNDRYQHDWETRALDGSPMSQAIADESELLNQRARMSDT
                     SNEFFRPVNAFRLLLGENSESVLLWLVHHALVDGWSVGKLLNDFRAQLLTEHSQAAQQS
                     QFSQYTAALTPHLEKVHEPAELFWRESMAGLLDGTELKVGRLEDGASNGSRIEHECLSL
                     GLSLEQTEIAARALGFSPAVIFHAAWALLLSSYASEDAVVFGSVFSARSFHVPRIEEIV
                     GPLINLCPFPVQV"
     CDS_motif       complement(19529..19615)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CPUR_02680_0008"
                     /evalue="1.10E-07"
                     /label="C5_DCL_263-294"
                     /locus_tag="CPUR_02680"
                     /protein_end="897"
                     /protein_start="868"
                     /score="24.4"
                     /tool="antismash"
                     /translation="VVFGSVFSARSFHVPRIEEIVGPLINLCP"
     CDS_motif       complement(19952..20005)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CPUR_02680_0007"
                     /evalue="1.10E-05"
                     /label="C3_DCL_135-156"
                     /locus_tag="CPUR_02680"
                     /protein_end="756"
                     /protein_start="738"
                     /score="18.1"
                     /tool="antismash"
                     /translation="VHHALVDGWSVGKLLNDF"
     CDS_motif       complement(20225..20296)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CPUR_02680_0006"
                     /evalue="7.30E-03"
                     /label="C2_DCL_024-062"
                     /locus_tag="CPUR_02680"
                     /protein_end="665"
                     /protein_start="641"
                     /score="8.6"
                     /tool="antismash"
                     /translation="IHPSRLSNAVSQVLGRHDIFCSSF"
     aSDomain        complement(20513..20707)
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CPUR_02680_PP-binding.1"
                     /evalue="5.40E-13"
                     /label="CPUR_02680_PP-binding.1"
                     /locus_tag="CPUR_02680"
                     /protein_end="569"
                     /protein_start="504"
                     /score="41.2"
                     /tool="antismash"
                     /translation="ALMNTMSEALTIPAQMIRPELSFTDVGGNSLLAIKMLSALRQKGL
                     SLSMSSLFLLPTISEISNHI"
     aSModule        complement(20513..22295)
                     /complete
                     /domains="nrpspksdomains_CPUR_02680_AMP-binding.1"
                     /domains="nrpspksdomains_CPUR_02680_PP-binding.1"
                     /locus_tags="CPUR_02680"
                     /monomer_pairings="Lys -> Lys"
                     /starter_module
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       complement(21014..21067)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CPUR_02680_0005"
                     /evalue="6.80E-04"
                     /label="NRPS-A_a8"
                     /locus_tag="CPUR_02680"
                     /protein_end="402"
                     /protein_start="384"
                     /score="12.5"
                     /tool="antismash"
                     /translation="FLGRKDQLIKNRGFLINL"
     aSDomain        complement(join(21035..21588,21701..22295))
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CPUR_02680_AMP-binding.1"
                     /evalue="5.50E-81"
                     /label="CPUR_02680_AMP-binding.1"
                     /locus_tag="CPUR_02680"
                     /protein_end="395"
                     /protein_start="12"
                     /score="264.1"
                     /specificity="substrate consensus: Lys"
                     /tool="antismash"
                     /translation="RHHAEAHPEALAISKNEDQITYGELYAASTRIAQLLADQGVEKGD
                     VVPLLGSRCLEMIACTLAIFMIGATLVPMEAGSWSEARIQTVLDALEYKTLLVTADGDV
                     RRRKTIDYHEIQRAMTGGNGWDCGNAKVPINGPESVRDVAYIIFTSGTTGNPKGVKVTH
                     QSLLNYVWPAHANAPFNLGVGPSDTSLLLFSVAFDAFYGVLLSTLCNGGHVLLSEPSTF
                     IDDAKKCTLLPATPTLLGTISDVSPYSNVRGIFLGGETPTPDVVRKWWTPSRSMWNAYG
                     PTETTVSVTMAELRPDVPIVLGEPIRNSKIIILDSNLEEATQGEICVLGSTVLALGYYK
                     NQAQTDDKFVLWNNERIYRTGDMAKWTENGLKFLGRKDQLIKN"
     CDS_motif       complement(21137..21214)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CPUR_02680_0004"
                     /evalue="9.10E-03"
                     /label="NRPS-A_a6"
                     /locus_tag="CPUR_02680"
                     /protein_end="361"
                     /protein_start="335"
                     /score="8.5"
                     /tool="antismash"
                     /translation="GEICVLGSTVLALGYYKNQAQTDDKF"
     CDS_motif       complement(21320..21346)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CPUR_02680_0003"
                     /evalue="2.00E-02"
                     /label="NRPS-A_a5"
                     /locus_tag="CPUR_02680"
                     /protein_end="300"
                     /protein_start="291"
                     /score="7.9"
                     /tool="antismash"
                     /translation="YGPTETTVS"
     exon            complement(21701..22331)
                     /locus_tag="CPUR_02680"
     CDS_motif       complement(21807..21866)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CPUR_02680_0002"
                     /evalue="7.00E-09"
                     /label="NRPS-A_a3"
                     /locus_tag="CPUR_02680"
                     /protein_end="175"
                     /protein_start="155"
                     /score="27.8"
                     /tool="antismash"
                     /translation="AYIIFTSGTTGNPKGVKVTH"
     CDS_motif       complement(22074..22112)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CPUR_02680_0001"
                     /evalue="5.50E+00"
                     /label="NRPS-A_a2"
                     /locus_tag="CPUR_02680"
                     /protein_end="86"
                     /protein_start="73"
                     /score="1.4"
                     /tool="antismash"
                     /translation="LAIFMIGATLVPM"
     exon            complement(22750..23311)
                     /locus_tag="CPUR_02681"
     gene            complement(22750..23781)
                     /locus_tag="CPUR_02681"
     CDS             complement(join(22750..23311,23378..23781))
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1176:alkyl hydroperoxide reductase subunit (Score:
                     229.3; E-value: 1.4e-69)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="CPUR_02681"
                     /note="CP_02681.1"
                     /product="uncharacterized protein"
                     /protein_id="CCE28990.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 5.9e-21, bitscore:
                     64.4, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTSNIVDALIIGGGPAGLSAALAFARQNQSAIVFDSGRYRNAAT
                     DYMHLIPGLDHKAPAEFRATARSQITDRYDKIRILEGVDIVAAKKTDADSFELSDEAGQ
                     TWNGRKLILATGVEDVMLDIPGYAELWGKSIVHCLYCKGYEQRGGSAGVLAVGPLGNVN
                     MALHIARQETALSKRVTLYSNGNESLAGELVSAFGSATAMRTDARKIKEFVAGADGKGV
                     AIRFEDGSEVVEDYLAHQAPVKAREGLADLLGLEKGPNGEVKVSSPFQQASVRGVFAAG
                     DNGAMLKNVPNAVFSGHVAGQMASTQLLADLNGQKSIFPI"
     exon            complement(23378..23781)
                     /locus_tag="CPUR_02681"
ORIGIN
        1 gagatgaatc cgatgttgac caacaactcc cagccatcca actacacggc tgggaatgcg
       61 aagggaaaga taaagaaact tcgttccgcg tgtgatgcct gtcatgcttc aaaggtccgc
      121 tgcagcgggg agccaatatg tgcgcggtgt caaagagagt acgttcccca agattatggc
      181 ccgggggctg tctgaaagtt ttgggggaac ttgcaggtaa cacgagaaac gcccgtagta
      241 atgttgcctg ccattatagc tacagggccc atcaaggcaa gccgaagggc agtctcaaca
      301 ggaaaaccat cgagcgcatg aaggccgcag gctttattga gcaacgccaa cgaccagcag
      361 catcgcaacc tccagggcat ggaacgagca gagacagctc tgtctgtgct tctggaacaa
      421 caacagacaa tcttctcaat ttcatcgaga ttcagcctcc cggcgagagc aatgagtctc
      481 ccgttgcgat tcatgccaca ccaagtccgt gctttgccat gacggggggc ttgctcccgg
      541 atttcgacgc agccaatctt gacgcctttc tagttgagta caactcattt acaattcatc
      601 atttgcgctg cttgtctaaa catgcaatcg ccgctaacct ttctgttcat ctaaggaagc
      661 ctaccaaaca cccgaggata gctgcctaag agcagttgaa gaattccctg gtgcgagtcc
      721 cgccgatatg gactgcatct ttatcggtac cccttcttcc atgtccagag actatacaga
      781 ggtagcaacg tgcagatgcg tccgagaaat cacccagcag atcaacaatg tgcacgcagc
      841 atcagcagat cgatccacga ccggactcga cgacgtgctg cactacacgc gagagatatc
      901 agcctgcata tcggggcttc tccaatgtta ctcgtgtggt ggtcaagtcc aagtctttgt
      961 gcttgcatcc gtcgtgcttt cgctgcttat ggaactcatg cacccgttgt tggactcgtc
     1021 aactgatacg tcccgaccca gagcacagat cagggttggt aattacgaca tgtcgggaca
     1081 gctgggggat gtattggaga aagtcattgt gcggtccatc atcacgaagc tccgccaggt
     1141 ggtagataaa tttgagatga aagccgactt tttgcgcagt gagactgcac aagctgaatt
     1201 tttaaagtcg gaggcacgga ggctgaaaag ggggtttgga agaatcgaag agggtactgc
     1261 gacccttccg tagcgctccg aggagttttc tgcgaagcgt cgtcaaaaga aatcccgtct
     1321 ggttcgtggg tgagccgcgg aggacgtaga agagttctct gatgttagtg tctagactct
     1381 agatgtcata cacgtttggt agtaaagata gtagaatcac attcatggat ggaatctcgt
     1441 ttcctgtgaa agttccacca gccaatcgtt ttggttcctg tgcttgccaa cactacatga
     1501 cagaggaagt atcggaacgg gccagaaatt tgcctctccg aagcatgtcc gaccgcgtac
     1561 aggcctccat ctcggtgttc aatttgaccg ggccgtaaat ctgcattttt agacacacag
     1621 gaaacccctt actggcacag tccaacttaa aagctgggta agtacgccgg gaaacgggct
     1681 gctagacgaa tgagcctcaa ttcacattcg ccttagagtc ccatcagcgc agccatatac
     1741 agtaaatcga agaagcatct cgttcgtcat tcgccatgga gtccgtcgta gacggaagct
     1801 cgcagtcccg acaccaaagc gaaaatgacc gtctcaacat ccagcacgcc ctcatcaagt
     1861 ccatcatggg aggcaaactc ctcatggcac ccgtcaacct tgagcgcccc gacttgcgca
     1921 tcttagactc gggaaccgcc caggcaaact ggttgcttga cctggctgcc ctagtcccca
     1981 cgacggcgca gctgacgggc acagatattg cgcccgagca gttccccccg ccaagccaac
     2041 gaccaccgaa catgacgctg cagaagcagt ccatctttga cccttggaac gaggccatgt
     2101 tgggcagctt cgacgttgtg caccaacgct tcgtgcttgc ggcgtgtcag tctgacgagc
     2161 atggccagcg ggccgtggct gatctcttgg cgctcacgaa gcccggaggc tggatcgagc
     2221 tacatgaggg aaatatgctg gccattcagg aaggggaagc ccatagcgcc atgatgagat
     2281 ttcgggacat cgccgtggcg gcgtgggtca gcatcggaca ggtgcccgac ccgggccctc
     2341 ggcttacgga ctggatgcgg gatgcaggtg tcgtggacat gcatgaggag gtccagacga
     2401 ttgggctggg agctgcggcg aggaatcaac aggaagcaga gtggtcgact gagctttgcc
     2461 tgaacatgct gcggacgatt aggcgaatga cggccggtga gttgctgttt tgtcttattt
     2521 tctcgcgctt cgcagacgcc actagcagct cagctgggac gaatagggct ctgccaagcc
     2581 ttgtggtgag gggatgtaag tgtgcgcata ttgctgacca tcggatgcag gtaagggcgc
     2641 cgacgccccg agtgagcagg agtttgatac cttggaggtg gccttgcgcg aagaattgca
     2701 ggaggtgggc aatcagtggt actattatct ggcgtatggc aggcggcgca cctgagacag
     2761 taatgcatga acttcaatcc cgacctttcc agagcagtga gaagtcggag gagcgaccgg
     2821 aggaacggga agggggtgga acgattaatg cagaccgttg acgccgtggc cactggccac
     2881 gatggaagca gggctggtgc aacagtcatt gtggttcgcc gacgagacgt cgtacattga
     2941 atgcattgtg aggtcccgaa tatgtggtcg ggttgaggct tccgctaggc tgtcggtcag
     3001 agataaagaa acgttcaaga cttagttaga atgctctgac aagtgtaggc agaagaattt
     3061 tgacaacact ttgtgtctcg atgcattgta cgcccatagt gtctgcctga atacctgaaa
     3121 atggccaccg cagcccaacc tagtctcgag ctggctctgg agttgatgtc aaaggtgcct
     3181 ctgataggta acatctccca aagtacacac aagataccta tacagtgcac gggtctgacc
     3241 agagaacaag acggccacaa tgactggatg cacatgatcc gcgcctacta cgacttccaa
     3301 gtcgacgacc gtttccagcc taccaaagat ctagcaggac atgtcgactt gaagagactg
     3361 gtgcaaggca gagccggagc cgtcttctgg agcgtctatg tcgaatggta tatcgtgtca
     3421 tgccacatat cacccgtata aaacagatgc aacaaaagtg tctaacagtt gagggagcac
     3481 agccctaagg gggaaaatga tttctcggac gcagttcacc acgcgagcat gcgtgacacg
     3541 ttccagcaaa tcgatctgct gcagcgcatc atggaattgt actccgacag gatggagatg
     3601 gcgcacaaag cagacgacgt aatgcgcatc ttcaggagcg gaaaatgcgc gagcctcatg
     3661 ggcgctgagg gtctgcacca acttggtaac agtagcagcg tgcttcgcat tttccaccgc
     3721 ttgggcgtcc ggtatgtgac gttggcgcat gcgaagaaca atctctatgt ggacagcgcg
     3781 gtaagttgtc tattcgacct gggcggtgat tcaagacggg cagctcactc tttgcgatta
     3841 gacgtccgaa gccccaatcc atcatgggct atcgcctcaa gggagagaca tggtccgaga
     3901 gatgaaccgc ataggaatgt aggtctcgtg ctgcgagggg gagtagtagt acagtactac
     3961 ccgcgatgaa aggagtttgg ctaatttgtg cacaggattg tcgatctgtc tcatgttagt
     4021 gaaaaggcta tggtggatgc actggatgtt tcgctggcgc cagtcatctt ttcacactcc
     4081 tctgcgtaag tgagaataca gacagatccg agaacatgcg aaagagaaga taaaaaatct
     4141 gagcgagtct aatcaatcct cgtagctacg ctctggtacc gcacgtgcga aatgtcccag
     4201 accatgtcct ggatcggctc aagcagaacc gtggtatcat catgatcagc ttcatcccct
     4261 ggctcaccaa caaagatccc gagaaggcca cagtcgaaaa tgtagtcgat cacgttctgc
     4321 atgtcggcaa caggatcggg tttgaccatc tcggcctggg atccgacttt gacgggatgc
     4381 catctcacgt ccaaggtttg gaagacgtct ccaagtaccc caatgtggtg gcagcaatgc
     4441 ttcagcgcgg tatttcgacc gaaaacgtgg aaaagatcat gggcatgaat gtcattaggg
     4501 tattgagaga agtcgaagac gttgctgcct ctcagaaagg gctgctgccg gtactggagg
     4561 acgctgtgcc tcagttgtgg gacgacggca tcagagcgta tgtaaagaag ttgtatcccc
     4621 atgccgagca cgacagaacc ggagcgagcg agacgacgac tgtggacaaa gccattgaaa
     4681 aagatgtttg agactgctgc tatatagtta agaccatttc tgctgaatga gaccgttgct
     4741 gtgtccgtct ttcccccccc cattcaccgt ccatcgcctc gtccaaagat gggcccgtga
     4801 atgtaatcgt gttgcgccca catcagccac agtagacagt cgaagatgaa caagaaccag
     4861 gccggcacat gcccatcggg tccctggtgt ttgtagacga gccgttccgt gatgatggct
     4921 gctcgcgtcc acggccacag aaacagcgcc acgcccagct ggaaccacca tccgcttttc
     4981 ggttgataaa ttggctgctc ggccaaccgt cgctgatacg acagaggcag gttcagctcg
     5041 tttgcgcccc gtgtcaggac gccctgaatc gtgttattag catcatcgcg tgctgaatga
     5101 tctgatgagc gtgtgggaga gatcgcgtac aatgtatcgt gcggacggga gtcgctcgtt
     5161 cgacgcgtcg acattgtgcc tgccgatgag ggtatccacc acaataggtg agtcgtccag
     5221 taggagcttg gcattcagcc gcgcaacctg gtaagcgatt cctccactgc caatcacagc
     5281 acgcgaatcg ttagccacaa aggaggaaga tgaatacggt gcacgaatcc acgatcatgg
     5341 aatcagcaac tggagcttct cttctggacg cacccttcgc tgagaatcac cttcttgagg
     5401 tcatccgatg tcaataggta ggccacgcca tgtacgcagg ccgtcgcgtc tgaatcgtcc
     5461 ggattaaggg gtcgaattcc cccattgcca gggtccatgt aggggatccc caagacattg
     5521 aagcacagtg cgtgcgtcgg aatgcacgcg gcctcggttc gcaacggacg gatcttgcgc
     5581 ctctcaatga agactgaggc ggacatattg gcgccgaacc caaaatacca tgctgccgtt
     5641 gctcgttcgt ttttgatcga ttccatggct cagatgtgaa gatgttgaaa tcggagggac
     5701 gtgtcggcga ggagaagtga cgagagctca gagatcagaa acgagagatg ggcgaaccaa
     5761 agcgaatggc ttcatcccca gttgtttatc ttatgtcccc ctgctttctt catatctaag
     5821 tacttggcag ttcatggctg tctcgggctt ttttcttcat cctaggtctc ggtacaagtg
     5881 gtgtgcctcg ctgcattaca aatgccgtga tgtctgtgtc gccgtttagt gtccgagaag
     5941 tttccgaagt cacgtccaac tatcaatttt tcgggtcccc ctaattctct cttcttgttt
     6001 tcaaaaacat caatccttca cttggttacg caaaaaaaag aactcttcag atccccttct
     6061 ttgtcaagcg ggcctaccgc gagctcactc ggagttgttc cttgagaagg aggctaggaa
     6121 aaacgacaag ggaaaaaggg gaggaaatat cgtaacacag agaggggaga aaagagaatc
     6181 aaccatggcc accgtgggaa ctgaggaaaa gaacccaatt ggctcagcta gcaacacagc
     6241 tgagcctaat gtcacagagc ctcagaaaca gtacgcatct ggcttcaagc ttactatcat
     6301 cgtcatttct ctatgtctgt cgctcttcct atgtggactg gtaagatttg aacgcttcat
     6361 ctacgtcaag gcatagcagc tgatcgtcat accaggacca aaccattatt acgacagccg
     6421 ttcccatcat cacgaatgac ttcaaggcca tcgaagacgt cggctggtac acgaccgcgt
     6481 acctgctcac gacgtcctcc ttccaaatcg cctacggcaa gctatacacc accctgtccg
     6541 tcaagatgat attgctgatg gctctcgcca tattcgagct cggttccatc atctgtgccg
     6601 cggcaccaaa ttccacaacc ctcatcgtgg gcagagctat tgcaggtctc ggtgcggccg
     6661 gcattttccc cggcagtaca ctcgtgcttg ttcacgctgc gccaatggag cgacggccgg
     6721 cgctcctcgg catcacgacc ggcatgtttg gcattgccag cctgtgtggt ccctttattg
     6781 gtggcgcgtt cgccgacggc gcgagctggc ggtggtgttt tatcatcaat gttcctctgg
     6841 gtgtcataac agcggttatt gtgacgtttt tcgtcttcac gcctgtggat cctttatacg
     6901 ccgaatggac gttcaaggac aagctcgcct acgccaagat cccggagatt cttgttcttg
     6961 tcgcggcact cgtttgcctt gtgctggggc tccaatgggg tggcaccacc tacgcttgga
     7021 gtgatggccg gatcattgct ctgctggtgg tttttgcagt tctgactacc gcgttcttgg
     7081 ttctgcaggt cttgctgcct aaatcacgca cgattcccac gagcatcgtc aagaacagaa
     7141 acatctggtt tgcgtctatt tttgccttgt gcagctccgg cgcaatgttt atcgccgtga
     7201 cctatctacc catttacttc caggccatca agaatgcgtc ggcactctct tctggtgtca
     7261 atgtgatgcc attgatcctg ggctttctcg tcatgtccat tatctcgggt gtcatcacaa
     7321 acactacggg ctactataac ccatccatgt ttctctgcac tatactcgcc tccgttgggg
     7381 ctggtctcgt ctccacgttt gacgtcggca cccctcaacc caagtggatt ggataccaag
     7441 ccctcctcgg cttcggcatt ggcttcggtc tccagcaacc cattgtgtgc gcgcagcacg
     7501 ttctggacga gagagacgta ccttttggcg tcgcattcat caacatgatg cagatgctgg
     7561 gcggtgccat attcgtcgct gtttcgcaaa acgtctttct gaatgggctg gcgaatggca
     7621 tcgcagaggc cttgccggga ttcaacactc acaagatcat cgagggaggc ttgacggact
     7681 tcaagaatct cttcacttcg gatcagctgc caaaggcgat acctgtctat gcccacgtcc
     7741 ttggacaagt gtttttgatt gctactggac tgtgcgtggg cactctactc gggtcgcttg
     7801 gtgtacagtg gcgctctgtg aagaaggcaa aggtgaccga ggatcaggca gatgttgagc
     7861 ggaaatagcc cgtgaatgtg tgtgtatgag ctccgttatt tacaagctta tgagtaaaat
     7921 gttccctaaa agagcatatt ttgcataggt ctttctgatt tcatgtcgct gtagtaaaga
     7981 aacaagcaac gagccgtggg ttctaggaca atagggtatg acaacgggaa cgagccatag
     8041 ctggcagtta atgataatag aatgatgata aaagatacaa agccaaaagc aaactcttac
     8101 catgaacagg atttctcgcc taccgatcaa tgggaagatc tacataccta cctagttaca
     8161 tctcaccaat cggatggcgg ttctcacatc gcacattggt aggcccaata gcgtcccgcc
     8221 gtcatgccct gcattcttga atcgccgaat cggtccccga cggacaatac ttcagcggaa
     8281 cagagatagg ctgaggattc aaccggctga tatggcgttt cattcccttg acgtaccggg
     8341 ttttatgttc tcattgtgat cgtgctcaga tagtcgccgg ctggagagtc ggcaccatac
     8401 cgagaagaga acagcgcgtt gtcacaaaca agtgccgtgg tcagtaagca gtcgagtacg
     8461 ttgaactcat tatctttcgt ccatttttct ccctcgtctt catgctcaca aacgcaaaaa
     8521 agtatcttcg gtgaccattt acgtgctaga tctcaaggca atcagataat tgaaagttcc
     8581 aatggaggcg caacaagact tcaccaagca tcctgaagtg gctcaggaca ggctcgtcct
     8641 ttatgtcaga aaaggtaaat aatgaattcc cgcggatcgt tcagggccac acgcaggcgc
     8701 ctctagggaa atcgagacac tgacacgcaa cgcaagcgat cccggcccct acggccaaca
     8761 gtctcaagcc gctcatgata ctcgaagcgc tggaaatacc ctactccatc caccttatct
     8821 cgtctctgtc ccaggaaacc tggtaccacg agatcaatcc gtacaagcag ctcccggccc
     8881 tcgaagacat tgacctggtg gagaccagcg gcggaagcaa gcgacgcctg aacgtctttg
     8941 acagcagcgc catgctcatc tacctctgcg acaagcacga caaggacggc ctcttcattg
     9001 ggagaaacgc gactgagcgc gctcaggtta cgagctggct gattgcctac gcggccggtc
     9061 tcggagcaac cggagagtgg tggctcaaga tgcgccacga cgaaaacctc aagcccgcgt
     9121 tgagggtcat cgagaatgcg attcggagag aatacgatat tctggagaaa cgactcgggg
     9181 agccgggtca gcgatggatc gcgctggcag accggccgac tgtggccgat tttgcgattc
     9241 agccgctggc gaacccgcgc gtggcgagaa atgcagcgat cgattttgag gcgtggccga
     9301 ggactaaggc gtggagtgag gctgtggata ggcttgcgta tattgaccgg gcgaagaggc
     9361 taaacaataa gttgggaatg acagaggaag agattgagct gcatggaaga tgaacgacag
     9421 tgggtgtgac tcgtgaggcg ggattgaact gcttgcgaag ttgcgaggat ttgtagttca
     9481 gaggtacata cctcagcctg taatgttacc ttggtacagt ggagtcgtaa aaatagctca
     9541 cattctcacc tactctttgg cgcgtgaatg tgaggttatt ttgccaagtg gttgtactag
     9601 ttacagctcc aggccaaatt gctcgaacaa aggcattcgg caagatcttt cttttttgcc
     9661 atgcttactc aactcctcca gcaatcaaaa caagcccatt gtccgctttt gcagggcaac
     9721 ctccttgtcc gaaattggta cccatgtgct cattgacgta tcctccgttt gcgccttgga
     9781 tctatccttc tctactggaa tatgcagaga gaaccgattg agcagatgca tggcaaaata
     9841 cttcatcatc atctccgcaa agtgcgagcc aagacacttt cttgtgccca tgccaaaggt
     9901 gaacagatta taccgcagct gtccacacca cgcagttctg catcagcaca tatattcgca
     9961 ttacacaaca ggaagaggaa cttgggacgt acagcaagcc gattgatcga gtggaagcgg
    10021 ttcggcgaaa atacttccgc cttgtcgccc caaaaggcag cattgtagtt gatggccaac
    10081 gtattgacaa ctacggacgt ctatgacacg attagcttca cgattctatg ctccagactc
    10141 atgtccgctt atttacattt ccaggcaccg tgaagccatg caacaccttc tgatttggtg
    10201 agctttccgg tatggagaac gctgcgagga cacgtcagtt tttatgcgtt cgcgattgat
    10261 gtaaacctgg gattctcagg gttcttacct gtaaatggcc gtagccgaag tgtctccagg
    10321 acgcagtatg ctaacaaggt gtcttttcgc gcgcagtagt ggtcaagttc gtgtctatgc
    10381 tgcgaaattt cttccacgac ttgtcgctgg atgtcttcat ttgctgctaa ataaatgacg
    10441 agccaggata gattgccggt ggcgacgtcg aggtttgcaa agaggatttc gctcaacgtg
    10501 tggatagcct ggtgatgagt gtcagctatg ccgataagta catgtaagta tatttgtgat
    10561 tggggattta ctaacttctt ctcgtgtcaa gtcgccgtca atgaccttct tccaagccga
    10621 aacgattgga gtcttcgcgc cgcaaccgac ttttttctta taaatacgct cattgaaact
    10681 ggcccagtca caaagaaagc tttcgagatc ctggaccgcg cttctataaa gccatcgcgc
    10741 gatggggaat cgaaacaatc cgccagaaag cacgtgtccc atcattttca gattacgctg
    10801 gcccagctcc cacagttcat tccgctcctc ctcgctgagc tcgccgtaca gatgcgtggc
    10861 cgtacagaaa aaaggaaaac gcgccacagc ctctgccgct tggacagtga acgaagagct
    10921 ccttgacttc tccaatttgt tcacatagca ttgggcatcg ttgctcactt ccgcggcttt
    10981 catggtgatg gcagagtggc taaaggcagg ttcaaactcg gagcgaacct tgatccatcg
    11041 tgttccgctg atgaggccca tgcattctcc taataactgg tggaacagcc atcccgcgtt
    11101 gcttgatcgc gctttgttgt gacgactaga atcgacgtgg aaagctcgca catcctcggg
    11161 ctttgtaatg actctgagat tgggtcagaa aacatgtgca aacttgagca aagatgtgac
    11221 acaaacgcta tcctcggcac atacatttca ggagtcgtcc ctgcccatat gcgatacaca
    11281 gggccatact tttgccactc ttggaccttt tcccggccgt ccaagaactt atccaacgtt
    11341 tgaccattca ggtactgcca tcttggacca gagatccctt tccccagact gtcatgcacg
    11401 ggattcagag cttgtagaag tttctgagac gccgttgccg ttagtttcgc cttgcaaaaa
    11461 cgcggtacac actgtaccag tacggagatg tcttaccgtg acgatcgatt caatcatcca
    11521 ctgggcaatc tgtgacttca acagtcgcag agctaccaga aatacgagta taggaaacac
    11581 gtccttcagc ataaccatct tgaataccat ggtggcagat gcgacaatgt atgatgagac
    11641 tgctaccctc gaagttgctg ccatcatgat tcatggcata gacttttgca acaaacatct
    11701 tgtcgcgcct cgttatatcc tgacggttcc atttctggaa tcaccactgg ggccccggtc
    11761 ttggctgtca ggccaccacc tacatcggcg actcacatac gagggcattg tcagtaataa
    11821 gcaccgaggc tgagagcttc agccactcgg acaacgattc tcaagcgcac tctgtatctg
    11881 acgccgtttc cattgcgtgc gtgtttccga agtgccttta accgtaggcc accagtcaga
    11941 gcaaattagt agagcgatca tctgatcatt tcggaaattc gaatcatggt gggacttgtc
    12001 tggttcaaag actgatcagc ctcagaacta agggccgttg cttcgtgtaa tacgtggtag
    12061 ggcaatgctt tgcacagtat cggcagaacc catcactcca ttagtcggcg taagtctatc
    12121 caatagcctt tcctagcttt gcggttgggt cgtgagagaa gtaagtcatt ttagcccttg
    12181 tgcgaccgac ctaccgtggg tattacgtcg gaagaggcac gatggagatg cgttcagaca
    12241 tggcgaaggt acacttagct caatggattt ggcggtatgc atagttcatc aaagcagcca
    12301 gaaagcgatg atgacgagac ctaagccaag catcgctact atctcgttga ctgggacggg
    12361 gaatgctcct cagtatacgt agagaccatc gacttctttt aggctcttgc atctatgtat
    12421 aagaaaagca tggacaaatg aaactctatc tatagcaacg agactaattc taggtcggaa
    12481 gaagtataac tcagacaaaa catacaaaac tacaacgaaa ctctttctac acatgaggtt
    12541 cgaactgtat gaaagaccca agcccaccaa tccgtcatca agtaatcaac cccttgaata
    12601 ctgacatgtt tccggattga aatatgcatt gacagacaca acccccttct tgaccgcaca
    12661 ggtaatatac gtctggaagc caagaccctg cttcaaactt cgatgcttgc tgtctcgtcg
    12721 gtcaacttgt ctgcctagta tagattgagt tcgaaattgc ccaggatcgg gggctgactt
    12781 accaaattct cctgacaccc tcgtagtacg acaaaccccc ttctagacat tggccccgtt
    12841 tgtacagata gctggacaat ccgcgcgcga tctgatcgtc cgtcttcccg tagtgtctta
    12901 ccggcagata gaccttcgat gttggcagcg cggccccagg tcttagttca aagtaataca
    12961 gaaggccacc cgtgcggtgc tccttgctcc ggaggggctt cgacgttaca ctgggattat
    13021 tcgggagcgc gaagcaagca caccagagct ccctcagaga atcgatggcg tctcgagtaa
    13081 gatcaggcgt ctggcctccc agagtcatca tttccagcat gctgtcgaag gttgtctttc
    13141 gagatcggac gtagattttc aggcgtgagt tggccggatt gacacagtca accgcgaata
    13201 tctcagcctg gggctgctcg tcttgcggat aagccctgat gtacgtggta agtaccttga
    13261 gcgaactgcg cactgcctca tcggcttcgg gtaaactcag aatactctct tccatcaact
    13321 cgaggttcgt ctttccacaa gcaagggact tgagagtcgg taagaagtag tacttgacag
    13381 tcatactatc tttgtccaga tcaaatgcga tgaattcttg tgaaaggtga tcagtcgtat
    13441 cgtgttgccc gtctgaatcg tccgcaacaa gatgtttcag aaagtgccta taccatcgca
    13501 gatcgaggct gggagccaac ggcgccgtgc tagccagaca ttctgtcgtc gcttcactat
    13561 ttagcggatc tgatgcggta cctgcatgcc agctaatggg ctctgcggcg tatcgaacaa
    13621 ccggagtagg tgtgttgccg gaccagctcc aactcatctc tacgggagta tggtcgtctg
    13681 tcatgaagct ttcccaagct gactggtgcg gatacgttgt cgggtagagc cctagcgagc
    13741 gtgcaacctg ttccttgaag aaaatacgat gagtcttctg ggactgttct gagtatccgg
    13801 ccagcctcat catggagacg agcatcgctc cgatatcctc atcccacaat tttatgtggt
    13861 actctttatc tattccagtc tcttccttgg ctgtgcgtgg atactcatat tcataaagtg
    13921 ttgtcaatct tgcgacgagg gtctgaacta ggatgttagc atttatcaag aaactggctt
    13981 tggcttttga aggcggctgt tttcttacat tcgcggtcca tttgacccgg gaaagtatgg
    14041 tctcaaacct gccttcagtt agtctgatgt tcttctgagg tggttacatc aagttggtat
    14101 ctctacgcgg ttacatacat aaagggcata attgtcgtgt aacgcgttgc aaaggagtgc
    14161 ttcagaagtt caagtctcaa acaacgagag ccatttagtt accgctgaac gaagtcgtag
    14221 ggagactttt attctttatt gacgagggga tccggttgat atctgactaa gagcctcgtt
    14281 cattctccgt aagacttctt gttattcgca ttgcttttcc gctttgggaa gtagttcacg
    14341 cgcaaataat ggcaaagtaa gacggtcaca cacatccagc ggcctccaat aagcctagta
    14401 tcagctccac agtgtccatt tggcattgac aagagcttcc ctagatgatt cgccgagttg
    14461 aggtccagct cggcgagtat gtcaacgaag ccgcgcgcct tatatctgtt aagcctggtg
    14521 aggggcaagt ggcggcctca ccttgctttt tcctacccca ttcttatttc tacgcaattc
    14581 ttcatacttc ttttgtcaaa atgatgtcaa agcgctgctt gaagcgtaac cagacgctga
    14641 tccccgagct cttaaagaat catggtgcgc tcctctatgg agacacctcc gtcgttgact
    14701 tgagcacagc ggaaaaccaa ctcttgatgg aagagctgct cccagaattt caggccgcgt
    14761 ttgatgcaaa tacttggtct agtcaggtaa gctgatcaag aagaagccac aaacaaaaag
    14821 cctgtaaggc agtactgctc acgctttcgt ccaggagcta gcttacagcg aaggagttgg
    14881 tggctgtccc aaggtccgtg gtctgattgc ggacctcgtg aattcccatt tccaacccca
    14941 cgctcaagtg gataagtccc atattgtatt gggtgccggt ggatgctttg ccttgaatgc
    15001 actgatcgag gcgatatgtg atccgggaga cggcatctta attgcggcac catattggcc
    15061 tggcctcgac cttagcatat cggttcataa cgatgccaaa gctgtcgttg ttcgggtgcc
    15121 gcatgaggac ttcttccgtg tagagagcat ccgccattat tcgaaggccc tcctttctgc
    15181 accaaatctc gtcaaggcta tgataatttg caatcctcac aatccactgg gtcggaacta
    15241 cccacgagaa actctccaag ctattgtcga cttctgcgcc gaaagacaaa tccatctgat
    15301 atccgatgag gtctacgcac tttctcagca cgtacagcct acatcggaga accctagcgc
    15361 tggttttgtt tctgcactat cactggacgc atcccatgcg aggggcctcg ttcatgtagt
    15421 gtacagcttg agcaaagact tcggctgtaa tggcattcgc ttggtgagtc gatcgacgca
    15481 acaagttgtc gtgccacttt ctaacttttt ttctttccca ttcatcaggg agcctttatc
    15541 agccaagaca acaaagctgt ggtgatgagc ggtgccttga gtactcactg ccagacatca
    15601 accatggcta ccctcgtagc tcagaaaatc atactcacgg atgaaaatat tcaattcgtg
    15661 aatacctacg gtagaggatt gctcaagtca gcatatacgg tgatggagga atttctgaac
    15721 caacaccgta ttgaattcgt ttccgcagag tgcggcatgt atatatttgc caaactctgc
    15781 ggcgacagga catccgtgga cgacgaatgg ctgtttcaag caattctgcg tcggaatggg
    15841 ctggttcttt ccgccggtac tgactaccat tgcaaaacac ccgggtggtt ccgaatttgc
    15901 tatggctgcg acagggagaa gctcagacat ggtcttgatc gcctgcggga ttgtctccag
    15961 gaattcggag agactgaatt caaatttcct ttcaatgatg catgtttcta aagaagtatg
    16021 gaatggaaac aacaaaatag agagagagaa acgaaaacta catggctcgt caaaccacaa
    16081 tttgtggatc caaaagattg cagatctctt gctcaaaccg cgacagacta ctgggtgtca
    16141 aaacatcctc agagtactca atttcaagtg tgacgtgatc gacatgttcg ttgaactcaa
    16201 tcagcagtgg aaatttggcc ccctgcgctc tcatcgcttc gacgctgatg gatactcctg
    16261 gaatactcat attccgcgta acccggtcct caaatcgatt gtacacaatc atgacttcaa
    16321 atatggagtc caaacccaca atgtctttga tcataaaaga tggaatcgca tgcgctagag
    16381 cagaggtcaa ggtagtgcgt attgtcgaca gtagactcgg caagtccgtg tgaggctcta
    16441 tctgaacaca cacaggcaga gcgtcgagaa aaacgcccat catgttttcc gttccgggct
    16501 ccagtctgtc caaaaaaggt actccaagcc gaatcgtatt caatcttgaa actttttgca
    16561 gagcaagtgc cgccgctgct aagtacacct cgattgatcc cgaggaactg ttgcgcttca
    16621 aacgccgagg gactgagtga aactctccgg cgggatgttt ctgatgctga acgagacgaa
    16681 ttgactcggt tttttcaccg aactgtgatc tccaaaattc acagtgggtg ttttcaggcg
    16741 gctgttctag ctggctgtct cgccataatg cccagacgtg atagtcattc gtggaatggt
    16801 cagatgtgca aatggtctgg ccagactcat cacggcatgc caaggcacga tactccatgc
    16861 tcagattggt gaggaaaatc tgcaccgata cctggtcggt gataatgtga tgctggacga
    16921 gaacaacgtc cgttgcgccg cacctttcaa ctagtgctat ccgtattagc acaccagaaa
    16981 gttcaaactt cgtacttata taatcatgaa gcttggctac atcatctgaa cattcgattc
    17041 tgtcgatctg gatggtgttg gtttgtatga ctctttgtgg caccccgtcc acctctacat
    17101 atgacgctcg tagaatatca tgctttgaca caaccgttcg caaggcgcgc tcgagaagaa
    17161 ggctatccac atcaccctgc agtcgaactc tatgcacaac gttgaaagag gaaggatttg
    17221 aagcttgttt atgcattctc aaaaactcct tttcaaggta cgacaatttg gagctgagaa
    17281 attgacattg attcgagaac tctgccaagg agaccgaagt tgtgcttgcg agtgattgct
    17341 gagccaggtg cttcttcaca gaagccgcga gagaccgtat gcttctgctg gtgatgaata
    17401 agctcagagg gactctacat cccaattttg agcaaatttt ctgagcagca gcaatctgtc
    17461 tcaacgagtt tccgccaata gctaagaagt cgtcatctat tgatagcgcg atttcttcgt
    17521 ccaggccgat cacttcgcgc caaacttggg aaacgacgag ttccgtatga tcggttgtct
    17581 cgttttcacg agagcacaca ggtgctagga ggttaatgag cgccttacga tcgagcttct
    17641 gattcggcgt agtgggaaaa gcttcaagtg caattatcag ctgaggcact gcatagcttg
    17701 gcaagtgctg acgcaaacac tgctgtattt ggtcgatgcg tgcaccctgt ggcgttgcaa
    17761 atgcgtagat agtgtcctgg tggacaatgg ccaccgactg gctgacattc tcatcggatc
    17821 gtcgtatcac attctcaatt tcttccaact caatgcgata tcctcgaact tttacttggt
    17881 ggtcggctcg accgacgtac cgcatctcca tattctcggt ccagaatgct aggtctccag
    17941 ttcgatacat gcgctctcct ggtcttctga atggatcttg cacgaacgct ctcttcgtca
    18001 cctcatcggc gttctgtcca atatagcctt ccatggtttg cacgccgtaa aggcagatct
    18061 caccaatgac tcccatagga accggccgga gtaggcgatc gaggatatag catccaacgc
    18121 gcgggatagt tttaccaaga gtcacgggcc tcccaatctc gagtctagta tacgcgaccg
    18181 caatggtgca ttcgcacggg ccataaaagt tatagagaac tctgccaggg gaccagcgat
    18241 cggcgaggct ctgcgaaaca gcctctccaa tcagatatat gctatcaaga ttctggagtt
    18301 ccgttggcga caagactgag agaaacgatg gggtgatcat ggcggcgtca actcggctga
    18361 gatgagcgaa cggatccgcc gggtctttga gaaccaaggt cgccccgtaa cataacgtgc
    18421 cgaagatttc tgcaatattg acatcaaacc ccggagaaaa tacctgcgca tgtcttctac
    18481 cgggacgggc atgtagcctt gcgggctcaa acgagagatg cgacgtggtt gcgcgatgcg
    18541 ttaccctgat gccctttgga gtgcctgttg atcctgacgt gaacatgatg tatgcataat
    18601 catcaggtcc tacgatgtct tccagcctgt ctgacgaact cccgttcatt gttttgacag
    18661 ctgcatgctc gtagacaagg tacctcggct tcgaaagatc cgaaaaggca gctagactag
    18721 atgcgttggg gtatacacac aaacatgcac cagatgtttc catcatggct tccatcctct
    18781 gggcgggtag tttggtatca agaggtagat aggttgcgcc ggccttgatg attgatataa
    18841 cgccgaggag ccagttttgg ctcccgtcgc tgagaagagc cacaacatct cttggccgga
    18901 tcaagcctcg tattgaacac gccaatgcgt tcgtaatatc gtccagctcc tgatataaga
    18961 gcttccccga tagcgactcc agcgcaacag acatcggcca agccgcaacg ccaatttcga
    19021 atgcctgctt cagagtcggt gggccagagt acggggtgaa caacgaagta gaagtccgcg
    19081 tcaaacacaa catctcggta ggttcgagca tactgtcatt tgcctcggcc agtgtgctta
    19141 tctttgggct caagaggaac aaacagagat ttcggaagtg gcccagtaat ctcgatgcca
    19201 aaggcgactc atacttgggg tccttgatca cagctcggaa acccaaatgc tcgcccacac
    19261 attgaacttg caatgtgagt ccaaactctg gccagtcctt cctgtcatat gtccatgcgg
    19321 caagttcgtg ttgatcagag ctcgcataca acggcaagtc gtactctagg aagagtgcag
    19381 tcgagaagat gcgtgcgtga ctaccggatg caatgtcctg caaaattttg gaagccgacc
    19441 attgatactc agatatttgc aggagcaggg attgcacact gctcagtaga tccatcttgc
    19501 tccccaacgc gtgcacttga actggaaaag ggcacaagtt gatcagagga ccaactatct
    19561 cctcaatgcg tggtacgtga aagctcctag ccgagaaaac gctcccaaac accacagcgt
    19621 cctcggaggc gtagctactg agcaacaacg cccaagctgc gtggaaaatg acggcaggac
    19681 tgaagccaag agctcgagca gcaatctctg tttgctccag agaaagtccg agactcaagc
    19741 attcatgttc aatccgactt ccgttgctag caccatcttc taagcgtccg accttcaact
    19801 ctgtgccatc aagtaaccca gccatggact ctctccagaa caactcggca ggttcgtgca
    19861 ctttctccaa gtgaggagtc aaagcggcag tgtattgcga aaattgactc tgttgggccg
    19921 cttgagaatg ctcggtcaac agctgtgctc ggaaatcgtt gagaagtttt cccacagacc
    19981 atccatccac aagcgcgtga tgcacgagcc agagaagtac tgattcgcta ttctcgccga
    20041 gcaagagcct aaacgcattg actggtctga aaaattcatt cgaagtatcg ctcattcttg
    20101 ctcgttggtt caagagttca gattcatctg ctatagcctg actcattggc gaaccgtcga
    20161 gagcccgagt ttcccagtca tgttgatacc tgtcgttgac tgagattgtg cctctcacaa
    20221 ggtcgaaaga ggagcaaaat atatcatgac gcccaagcac ctggctcacc gcattgctga
    20281 gtctcgaggg atgaatatcg cgggcgtttt gatggagaga tatagttatg agcatgtagc
    20341 ccgtgggagc atcgtggaga gttgatcgta tcatccccct ctgaacgtct gtcatggtaa
    20401 tctctctggc agagcgagtc gctccaggaa gagacagcga cttcccacat ccagcgaggt
    20461 ctgcggcctg ctggtcatcg tcatcgtgcg agacggaagc atcaaactcg atgatatgat
    20521 tcgagatttc ggagatagtt ggtagcaaaa agagagacga catggaaagt gacagtcctt
    20581 tttgcctgag agcagacaac atcttgattg ccaacaagga gtttccgccc acgtcagtga
    20641 acgaaagctc tggcctgatc atctgagctg gtattgtcag ggcttcagac attgtgttca
    20701 tcaacgcgct gagctttgtg tcggcggtcg cgatcggcgc atttgatgcc acgcctacag
    20761 tgtctctttg aaccaattcg tcatagagtg ccctgttgtc aactttgcca ttaatggtct
    20821 gggggagctg atctctactt tggatctcat caggaacgag gaattgatcg aatcgccgag
    20881 ccatttcctg acgtacaagg tctccattca ccgtcaaagg tgtgacgaag gcgattaacc
    20941 tttgtcggtg catgaggacc gtggctgtct caacattgtt ttgcgacaaa atggccggga
    21001 tcacgtcagc ctccaagttg atgaggaacc cgcggttctt gatcaactga tccttgcgac
    21061 cgagaaattt gagtccattc tccgtccatt ttgccatgtc tcccgtgcgg tatattcttt
    21121 cgttgttcca taagacaaac ttatcatccg tttgcgcctg gtttttatag tagccaagag
    21181 ctagaacagt cgaaccgaga acgcaaatct caccctgtgt ggcttcttca agattggaat
    21241 ccagaatgat tatcttgctg ttccgaatgg gctctcccag gacgatagga acgtcaggcc
    21301 tgagctcggc catggtgact gagactgtcg tctctgtagg gccataggca ttccacatgc
    21361 tccgcgacgg tgtccaccat ttcctgacca cgtctggtgt tggggtctcg cccccgagaa
    21421 agataccgcg cacgttggaa tatggcgaaa catcgctgat ggtgccgagt agcgtcggag
    21481 tggctggaag gagggtgcat ttcttcgcgt cgtcgatgaa ggtgctaggc tccgacagca
    21541 agacgtgtcc gccattgcac agggtgctga gcagcacgcc gtaaaatgct tcacaagaat
    21601 gctctggtca gtcaaactaa gcgcgtctag aagttgtctt ggacgacagg tgcaccgtgc
    21661 aggtgtgaag tttgtggagt ttgaaggatt caagatttac catcgaaagc gaccgagaac
    21721 aagagcaagc tggtgtctga cggcccgaca cccaaattga acggggcgtt ggcgtgtgcg
    21781 ggccacacgt aattcaaaag actttgatga gtgaccttga ctcccttggg atttcccgtg
    21841 gtgcctgaag tgaaaataat gtatgcaaca tctcgaacac tctcggggcc atttatcgga
    21901 actttggcat ttccacagtc ccagccatta cctcccgtca ttgcacgctg aatctcatgg
    21961 taatcaatcg tctttcgcct gcgcacgtct ccgtctgccg tgaccagcag cgttttgtac
    22021 tccagggcat ccaaaactgt ctggatcctt gcctcactcc atgaaccggc ttccatcggg
    22081 accaatgttg ccccgatcat gaaaatcgcc agcgtacatg cgatcatctc caggcatcgc
    22141 gagccgagca agggaaccac atctcccttt tcgacgcctt gatcggcgag gagctgtgcg
    22201 atgcgggttg aggcggcata caattcgcca tatgttattt ggtcttcgtt tttcgagatg
    22261 gccaaagcct cggggtgagc ttcggcatga tgtcttatga ggtcgtgcac cgaaacggga
    22321 actgtcgcca tgatcccaag actgatatga agcgtcaatt gggagtcaga atgtcggaaa
    22381 tcgagaaatc gaggaagacg aagaatagag gaagagaagg aaagaaaatg aaatagagat
    22441 tggtccgatt gtgggcaaga ggctcaacag agcaagcaaa ctgtttcgca caacggatgg
    22501 cttcaacgcc gtgcagtcag cagtcatgct tcggcgaaat attttcggac cgacggcatt
    22561 catcggttca aattgtcttg ccagagcgga agcacaaaag caagctacaa agtctcataa
    22621 ttattgttga gcgtgcatga cggcttagtg aattattgcc cggcgttctg gctaaatatc
    22681 tatccaatga aacatcatca cggatgccga atacattttc tcgtcaacat cactacgcag
    22741 tcttctgcac tatataggaa aaatcgactt ctggccgttc aagtccgcca ggagctgagt
    22801 agaagccatc tgtcccgcaa catggccact gaacaccgca tttggcacat tcttcaacat
    22861 ggcgccgttg tctcccgcag caaacacgcc acgcacgctg gcttgctgga acggtgaaga
    22921 cactttaacc tcaccattag gtcccttttc caacccgaga agatcagcca aaccttccct
    22981 ggccttgacg ggcgcctggt gggcaagata gtcctccaca acctcggagc cgtcttcgaa
    23041 tcggatagcg acccccttcc catcggcacc ggccacaaac tctttgatct tgcgagcatc
    23101 cgtcctcatg gcggtcgcag agccaaaggc agaaactaac tcgcctgcca aagactcgtt
    23161 gccgttagag tagagcgtaa cgcgtttgct gagagctgtc tcttggcgag ctatgtgaag
    23221 cgccatgtta acattgccca gcggaccaac cgcgagcacg cctgcgctac cccctcgctg
    23281 ctcatagccc ttgcaataca ggcaatgcac actgtgaaca aggttagaga cggttgtctt
    23341 tttcgacttg tggctcatca ttattgggcg cactcacatg gatttgcccc aaagctcagc
    23401 atagccgggg atgtccagca tcacatcctc cacgccagtg gcgagaatca actttctgcc
    23461 attccatgtc tgcccagcct catctgaaag ttcaaagctg tccgcatccg tctttttggc
    23521 ggcgacgatg tcgacacctt cgagaatgcg aatcttgtca tagcggtctg tgatctgtga
    23581 tctggcggtg gcacgaaact ccgccggagc tttatggtct aagccgggaa tcaggtgcat
    23641 gtagtcggtc gccgcattgc ggtatctccc gctgtcaaat acaattgcag attggttttg
    23701 gcgcgcaaac gccagggcag cgctcaagcc agctgggcct ccgccgatga tcagagcatc
    23761 gacaatgttg ctggtagaca tgtt
//
