BGC0001367 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001367 (Haliangium ochraceum DSM 14365)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS,NRPS	1	39,720	haliamide	NRPS:Type I+PKS	100%

BGC0001367 - Region 1 - NRPS,T1PKS

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Location: 1 - 39,720 nt. (total: 39,720 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))
NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 39,721
Label		BGC0001367

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001367	1.77	NRP, Polyketide	haliamide	Haliangium ochraceum DSM 14365
BGC0000041	0.65	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0001276	0.57	Polyketide	6-methylsalicyclic acid	Aspergillus terreus
BGC0002631	0.55	RiPP	myxarylin	Pyxidicoccus fallax
BGC0000353	0.51	NRP	tacrolimus	Streptomyces sp. MA6548
BGC0000160	0.49	Polyketide	terreic acid	Aspergillus terreus NIH2624
BGC0001235	0.45	NRP, Polyketide	antalid	Polyangium spumosum
BGC0002259	0.44	Polyketide, NRP	beauveriolide I, beauveriolide III	Cordyceps militaris CM01
BGC0002171	0.43	NRP, Polyketide	pyrophen, campyrone B	Aspergillus niger ATCC 1015
BGC0002275	0.43	NRP, Polyketide	pyrophen, campyrone B	Aspergillus niger CBS 101883

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001367	1.00	NRP, Polyketide	haliamide	Haliangium ochraceum DSM 14365
BGC0000677	0.66	Terpene	cyclooctatin	Streptomyces melanosporofaciens
BGC0000041	0.66	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0002721	0.66	Saccharide	α-hydroxynitrile glucoside, β-hydroxynitrile glucoside, γ-hydroxynitrile glucoside	Hordeum vulgare subsp. vulgare
BGC0002631	0.65	RiPP	myxarylin	Pyxidicoccus fallax
BGC0001223	0.63	Other	hydroxysporine	uncultured bacterium
BGC0000686	0.63	Terpene	helvolic acid	Aspergillus fumigatus Af293
BGC0001605	0.63	Terpene	gibberellin	Sinorhizobium fredii NGR234
BGC0001276	0.62	Polyketide	6-methylsalicyclic acid	Aspergillus terreus
BGC0002221	0.61	Terpene	ent-kauren-16alpha-ol	Serpula lacrymans var. lacrymans S7.9

Similar known gene clusters from MIBiG 4.0

Module view

Legend

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 39720:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X - Me-ccmal) + (ohmal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

Hoch_0798

AMP-binding (458..837): X

nrpys: Gly, Ala

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DIAQ-TLVWK
Nearest Stachelhaus code(s):: Ala DILQITLVYK (74% 8Å match); Gly DILQLGLVWK (62% 8Å match)
Stachelhaus code match:: 70% (weak)

PKS_AT (2793..3081): mmal

ATSignature: Ethylmalonyl-CoA, Methylmalonyl-CoA, Methoxymalonyl-CoA

Top 3 matches:: Ethylmalonyl-CoA: 87.5%; Methylmalonyl-CoA: 87.5%; Methoxymalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 147.6
Ethylmalonyl-CoA: 143.2
Methoxymalonyl-CoA: 128.7
2-Methylbutyryl-CoA: 74.5
trans-1,2-CPDA: 73.4
Malonyl-CoA: 71.1
Propionyl-CoA: 64.8
CHC-CoA: 60.9
Isobutyryl-CoA: 51.2
Benzoyl-CoA: 44.6
Acetyl-CoA: 42.1
3-Methylbutyryl-CoA: 24.5
fatty_acid: 17.5
inactive: 13.2

Hoch_0799

PKS_AT (550..840): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 79.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 210.3
inactive: 115.9
Methoxymalonyl-CoA: 83.8
Methylmalonyl-CoA: 79.5
Propionyl-CoA: 61.1
Isobutyryl-CoA: 60.2
Benzoyl-CoA: 44.4
Acetyl-CoA: 40.2
Ethylmalonyl-CoA: 38.6
trans-1,2-CPDA: 38.5
2-Methylbutyryl-CoA: 33.4
CHC-CoA: 32.2
fatty_acid: 29.6
3-Methylbutyryl-CoA: 26.6