BGC0001368: JBIR-126 biosynthetic gene cluster from Streptomyces sp. NRRL F-4474
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Location: 141,430 - 183,860 nt. (total: 42,431 nt).
This entry is originally from NCBI GenBank NZ_JOIB01000012.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001368
Short description JBIR-126 biosynthetic gene cluster from Streptomyces sp. NRRL F-4474
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
NZ_JOIB01000012.1
141430 - 183860
via
Compounds
  • JBIR-126
Species Streptomyces sp. NRRL F-4474 [taxonomy]
References
Chemical products information
JBIR-126 Evidence:
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C24H30Cl1N5O7
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • IF33_RS0114760
  • WP_078857608.1
 141432 - 142709 (-) cation:proton antiporter
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    • IF33_RS0114765
    • WP_225884601.1
    		 142696 - 143316 (-) flavin reductase family protein
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      • IF33_RS0114770
      • WP_030845397.1
      		 143401 - 145002 (-) tryptophan 7-halogenase
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        • IF33_RS0114775
        • WP_051700101.1
        		 145178 - 146176 (+) BTAD domain-containing putative transcriptional regulator
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          • IF33_RS0114780
          • WP_030845402.1
          		 146304 - 147815 (+) aldehyde dehydrogenase family protein
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            • IF33_RS0114785
            • WP_078857609.1
            		 147812 - 149644 (+) non-ribosomal peptide synthetase
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              • IF33_RS0114790
              • WP_051700103.1
              		 149648 - 150394 (+) alpha/beta fold hydrolase
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                • IF33_RS0114795
                • WP_076043097.1
                		 150411 - 150614 (+) MbtH family NRPS accessory protein
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                  • IF33_RS0114800
                  • WP_030845407.1
                  		 150616 - 151830 (+) cytochrome P450
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                    • IF33_RS0114805
                    • WP_051700105.1
                    		 151846 - 155784 (+) non-ribosomal peptide synthetase
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                      • IF33_RS36805
                      • WP_051700107.1
                      		 155784 - 156428 (+) 4'-phosphopantetheinyl transferase superfamily protein
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                        • IF33_RS0114815
                        • WP_030845410.1
                        		 156441 - 157472 (+) winged helix DNA-binding domain-containing protein
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                          • IF33_RS0114820
                          • WP_051700109.1
                          		 157592 - 158869 (+) MFS transporter
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                            • IF33_RS0114825
                            • WP_051700111.1
                            		 159041 - 163132 (+) non-ribosomal peptide synthetase
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                              • IF33_RS0114830
                              • WP_051700112.1
                              		 163125 - 166481 (+) non-ribosomal peptide synthetase
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                                • IF33_RS0114835
                                • WP_030845415.1
                                		 166481 - 167887 (+) condensation domain-containing protein
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                                  • IF33_RS0114840
                                  • WP_051700115.1
                                  		 167967 - 169157 (+) acyl-CoA dehydrogenase family protein
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                                    • IF33_RS0114845
                                    • WP_030845419.1
                                    		 169154 - 170299 (+) acyl-CoA dehydrogenase family protein
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                                      • IF33_RS0114850
                                      • WP_030845421.1
                                      		 170368 - 170949 (-) GNAT family N-acetyltransferase
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                                        • IF33_RS0114855
                                        • WP_078857612.1
                                        		 170976 - 172046 (-) GntG family PLP-dependent aldolase
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                                          • IF33_RS0114860
                                          • WP_051700119.1
                                          		 172043 - 172732 (-) DUF2461 domain-containing protein
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                                            • IF33_RS0114865
                                            • WP_078857614.1
                                            		 172729 - 174129 (-) serine hydroxymethyltransferase
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                                              • IF33_RS0114870
                                              • WP_051700122.1
                                              		 174184 - 177474 (-) non-ribosomal peptide synthetase
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                                                • IF33_RS0114875
                                                • WP_078857623.1
                                                		 177565 - 179439 (-) BTAD domain-containing putative transcriptional regulator
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                                                  • IF33_RS0114880
                                                  • WP_030845436.1
                                                  		 179641 - 179847 (+) hypothetical protein
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                                                    • IF33_RS42580
                                                    • WP_078857615.1
                                                    		 179976 - 183020 (-) BTAD domain-containing putative transcriptional regulator
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                                                      • IF33_RS0114890
                                                      • WP_030845442.1
                                                      		 183161 - 183631 (-) MarR family transcriptional regulator
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                                                        Biosynthesis information

                                                        Biosynthetic modules

                                                        Name
                                                        Unk01
                                                        Type
                                                        nrps-type1
                                                        Genes
                                                        IF33_RS0114805
                                                        Substrates
                                                        6-chlorotryptophan (evidence: Structure-based inference, Homology)
                                                        Integrated Monomers
                                                        Domains
                                                        adenylation
                                                        Name
                                                        Unk02
                                                        Type
                                                        nrps-type1
                                                        Genes
                                                        IF33_RS0114870
                                                        Substrates
                                                        6-chloro-4-hydroxy-1-methyl-indole-3-carboxylic acid (evidence: Structure-based inference, Homology)
                                                        Integrated Monomers
                                                        Domains
                                                        adenylation
                                                        Name
                                                        Unk03
                                                        Type
                                                        nrps-type1
                                                        Genes
                                                        IF33_RS0114785
                                                        Substrates
                                                        2-methylserine (evidence: Structure-based inference, Feeding study, Homology)
                                                        Integrated Monomers
                                                        Domains
                                                        adenylation
                                                        Name
                                                        Unk04
                                                        Type
                                                        nrps-type1
                                                        Genes
                                                        IF33_RS0114825
                                                        Substrates
                                                        lysine (evidence: Structure-based inference, Homology)
                                                        Integrated Monomers
                                                        Domains
                                                        adenylation
                                                        Name
                                                        Unk05
                                                        Type
                                                        nrps-type1
                                                        Genes
                                                        IF33_RS0114830
                                                        Substrates
                                                        2-methylserine (evidence: Structure-based inference, Feeding study)
                                                        Integrated Monomers
                                                        Domains
                                                        adenylation
                                                        Annotation changelog

                                                        Entry version: 4

                                                        Date
                                                        Changes
                                                        Submitters
                                                        Reviewers
                                                        2022-10-07
                                                        Update chemical activity to schema version 2.11
                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                        Entry version: 3

                                                        Date
                                                        Changes
                                                        Submitters
                                                        Reviewers
                                                        2022-09-15
                                                        Updated bioactivity data
                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                        2022-09-15
                                                        Added NRP substrate specificities
                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                        Entry version: 2

                                                        Date
                                                        Changes
                                                        Submitters
                                                        Reviewers
                                                        2019-10-16
                                                        Migrated from v1.4
                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                        2019-10-16
                                                        Updated compound(s) information (NPAtlas curation)
                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                        Entry version: 1

                                                        Date
                                                        Changes
                                                        Submitters
                                                        Reviewers
                                                        2016-09-03
                                                        Submitted
                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                        Detailed domain annotation
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