BGC0001369 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001369 (uncultured bacterium)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	HR-T2PKS	1	30,926	High	metatricycloene	PKS

BGC0001369 - Region 1 - HR-T2PKS

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Location: 1 - 30,926 nt. (total: 30,926 nt) Show pHMM detection rules used

Region on contig edge.

HR-T2PKS: (hr-t2pks-ksa and (t2fas or APE_KS2 or ketoacyl-synt))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 30,927
Label		BGC0001369

Tailoring functions

Oxidoreductases: dehydrogenase oxidase oxygenase

ANY57958.1: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

ANY57959.1: FAD linked oxidase domain protein

smcogs: SMCOG1138: FAD linked oxidase domain protein

ANY57964.1: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

ANY57970.1: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

ANY57978.1: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

Transferases: acetyltransferase acylase aminotransferase

ANY57963.1: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

ANY57976.1: Chloramphenicol acetyltransferase

smcogs: SMCOG1156: Chloramphenicol acetyltransferase

ANY57979.1: aminotransferase class V

smcogs: SMCOG1139: aminotransferase class V

Hydrolases: hydrolase

ANY57973.1: asparagine synthase (glutamine-hydrolyzing)

smcogs: SMCOG1177: asparagine synthase (glutamine-hydrolyzing)

Ligases: synthase

ANY57968.1: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

Translocases: transport

ANY57984.1: MMPL domain-containing transport protein

smcogs: SMCOG1035: MMPL domain-containing transport protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001369.3	1.00	PKS	metatricycloene	uncultured bacterium
BGC0002154.2	0.63	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0001160.5	0.62	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001164.3	0.61	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0002276.2	0.58	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0002510.2	0.53	PKS	youssoufene A1, youssoufene B1, youssoufene B2, youssoufene B3, youssoufene B4	Streptomyces sp.
BGC0001201.3	0.52	terpene	eremophilene	Sorangium cellulosum So ce56
BGC0000254.5	0.49	PKS	oxytetracycline	Streptomyces rimosus
BGC0000231.5	0.49	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0001335.5	0.49	other (other)	borregomycin A, borregomycin B, borregomycin C, borregomycin D	uncultured bacterium

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001369.3	1.00	PKS	metatricycloene	uncultured bacterium
BGC0002154.2	0.63	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0001160.5	0.62	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001164.3	0.61	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0002276.2	0.58	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0002510.2	0.53	PKS	youssoufene A1, youssoufene B1, youssoufene B2, youssoufene B3, youssoufene B4	Streptomyces sp.
BGC0001201.3	0.52	terpene	eremophilene	Sorangium cellulosum So ce56
BGC0000254.5	0.49	PKS	oxytetracycline	Streptomyces rimosus
BGC0000231.5	0.49	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0001335.5	0.49	other (other)	borregomycin A, borregomycin B, borregomycin C, borregomycin D	uncultured bacterium

Similar known clusters from MIBiG 4.0

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS substrates

NRPS/PKS substrate predictions

ANY57963.1: mal

PKS_AT (4..296): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 62.5%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 61.3
Methoxymalonyl-CoA: 36.5
Methylmalonyl-CoA: 33.6
inactive: 24.5
Isobutyryl-CoA: 22.1
Propionyl-CoA: 14.6
CHC-CoA: 13.6
fatty_acid: 9.2
Ethylmalonyl-CoA: 7.9
trans-1,2-CPDA: 6.8
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: -1.7

Link to PARAS substrate predictor