BGC0001370: lipopeptide 8D1-1 biosynthetic gene cluster from Streptomyces rochei
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Location: 1 - 79,876 nt. (total: 79,876 nt).
This entry is originally from NCBI GenBank KT362047.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001370
Short description lipopeptide 8D1-1 biosynthetic gene cluster from Streptomyces rochei
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
KT362047.1
via
Compounds
  • lipopeptide 8D1-1
  • lipopeptide 8D1-2
Species Streptomyces rochei [taxonomy]
References
Chemical products information
lipopeptide 8D1-1 Evidence:
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C66H82N14O27
lipopeptide 8D1-2 Evidence:
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C66H84N14O28
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ALV82383.1
 11 - 1630 (+) ABC transporter
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    • ALV82361.1
    		 2626 - 4263 (+) regulator
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      • ALV82382.1
      		 4330 - 4545 (-) putative mbtH protein
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        • ALV82365.1
        		 4676 - 5842 (-) lipase
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          • ALV82351.1
          		 6073 - 6504 (-) putative secreted protein
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            • ALV82369.1
            		 6577 - 7434 (-) prephenate dehydrogenase
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              • ALV82372.1
              		 7515 - 7970 (-) putative secreted protein
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                • ALV82348.1
                		 8152 - 8910 (-) ABC transporter
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                  • ALV82359.1
                  		 8956 - 9909 (-) ABC transporter ATP-binding protein
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                    • ALV82374.1
                    		 9932 - 10051 (-) hypothetical protein
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                      • ALV82363.1
                      		 10046 - 11761 (+) two component sensor kinase
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                        • ALV82366.1
                        		 11780 - 12448 (+) regulator
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                          • ALV82375.1
                          		 12463 - 13788 (-) putative aminotransferase
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                            • ALV82386.1
                            		 13785 - 14984 (-) putative oxidase
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                              • ALV82353.1
                              		 14981 - 16054 (-) 4-hydroxyphenylpyruvic acid dioxygenase
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                                • ALV82390.1
                                		 16163 - 16393 (-) hypothetical protein
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                                  • ALV82356.1
                                  • cda2PSI
                                  		 16367 - 38248 (+) CDA peptide synthetase I
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                                    • ALV82384.1
                                    • cda2PS2
                                    		 38245 - 49158 (+) CDA peptide synthetase II
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                                      • ALV82388.1
                                      • cda2PS3
                                      		 49143 - 56366 (+) CDA peptide synthetase III
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                                        • ALV82377.1
                                        		 56371 - 57189 (+) hydrolase
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                                          • ALV82370.1
                                          		 57201 - 58094 (+) phosphotransferase
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                                            • ALV82355.1
                                            		 58162 - 60012 (-) ABC transporter
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                                              • ALV82360.1
                                              		 60052 - 61053 (-) oxygenase
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                                                • ALV82380.1
                                                		 61236 - 62039 (-) secreted protein
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                                                  • ALV82350.1
                                                  		 62093 - 63310 (-) salicylate hydroxylase
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                                                    • ALV82391.1
                                                    		 63341 - 64327 (-) 3-oxoacyl-[acyl carrier protein] synthase, KASIII
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                                                      • ALV82371.1
                                                      		 64324 - 66051 (-) acyl-CoA oxidase
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                                                        • ALV82387.1
                                                        		 66150 - 67370 (-) 3-oxoacyl-[acyl-carrier-protein] synthase, KASII
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                                                          • ALV82381.1
                                                          		 67367 - 67612 (-) acyl carrier protein
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                                                            • ALV82385.1
                                                            		 67632 - 67949 (-) hypothetical protein
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                                                              • ALV82352.1
                                                              		 68240 - 68770 (-) DNA-binding protein
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                                                                • ALV82362.1
                                                                		 69081 - 69662 (+) membrane protein
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                                                                  • ALV82378.1
                                                                  		 70038 - 70583 (+) hypothetical protein
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                                                                    • ALV82358.1
                                                                    		 70677 - 71183 (-) flavodoxin
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                                                                      • ALV82376.1
                                                                      		 71200 - 71931 (-) hypothetical protein
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                                                                        • ALV82373.1
                                                                        		 71944 - 72084 (-) hypothetical protein
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                                                                          • ALV82354.1
                                                                          		 72387 - 73250 (-) universal stress protein
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                                                                            • ALV82389.1
                                                                            		 73256 - 74278 (-) alcohol dehydrogenase
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                                                                              • ALV82357.1
                                                                              		 74317 - 75243 (-) stress-inducible protein
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                                                                                • ALV82368.1
                                                                                		 75375 - 75875 (-) membrane protein
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                                                                                  • ALV82379.1
                                                                                  		 76256 - 77176 (-) stress-inducible protein
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                                                                                    • ALV82367.1
                                                                                    		 77301 - 78224 (-) carbamate kinase
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                                                                                      • ALV82349.1
                                                                                      		 78228 - 79229 (-) ornithine carbamoyltransferase
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                                                                                        • ALV82364.1
                                                                                        		 79252 - 79794 (-) arginine deiminase
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                                                                                          Biosynthesis information

                                                                                          Biosynthetic modules

                                                                                          Name
                                                                                          Unk01
                                                                                          Type
                                                                                          nrps-type1
                                                                                          Genes
                                                                                          cda2PSI
                                                                                          Substrates
                                                                                          serine (evidence: Structure-based inference [1])
                                                                                          Integrated Monomers
                                                                                          Domains
                                                                                          adenylation
                                                                                          Name
                                                                                          Unk02
                                                                                          Type
                                                                                          nrps-type1
                                                                                          Genes
                                                                                          cda2PSI
                                                                                          Substrates
                                                                                          threonine (evidence: Structure-based inference [1])
                                                                                          Integrated Monomers
                                                                                          Domains
                                                                                          adenylation
                                                                                          Name
                                                                                          Unk03
                                                                                          Type
                                                                                          nrps-type1
                                                                                          Genes
                                                                                          cda2PSI
                                                                                          Substrates
                                                                                          tryptophan (evidence: Structure-based inference [1])
                                                                                          Integrated Monomers
                                                                                          Domains
                                                                                          adenylation
                                                                                          Name
                                                                                          Unk04
                                                                                          Type
                                                                                          nrps-type1
                                                                                          Genes
                                                                                          cda2PSI
                                                                                          Substrates
                                                                                          aspartic acid (evidence: Structure-based inference [1])
                                                                                          Integrated Monomers
                                                                                          Domains
                                                                                          adenylation
                                                                                          Name
                                                                                          Unk05
                                                                                          Type
                                                                                          nrps-type1
                                                                                          Genes
                                                                                          cda2PSI
                                                                                          Substrates
                                                                                          aspartic acid (evidence: Structure-based inference [1])
                                                                                          Integrated Monomers
                                                                                          Domains
                                                                                          adenylation
                                                                                          Name
                                                                                          Unk06
                                                                                          Type
                                                                                          nrps-type1
                                                                                          Genes
                                                                                          cda2PSI
                                                                                          Substrates
                                                                                          4-hydroxyphenylglycine (evidence: Structure-based inference [1])
                                                                                          Integrated Monomers
                                                                                          Domains
                                                                                          adenylation
                                                                                          Name
                                                                                          Unk07
                                                                                          Type
                                                                                          nrps-type1
                                                                                          Genes
                                                                                          cda2PS2
                                                                                          Substrates
                                                                                          aspartic acid (evidence: Structure-based inference [1])
                                                                                          Integrated Monomers
                                                                                          Domains
                                                                                          adenylation
                                                                                          Name
                                                                                          Unk08
                                                                                          Type
                                                                                          nrps-type1
                                                                                          Genes
                                                                                          cda2PS2
                                                                                          Substrates
                                                                                          glycine (evidence: Structure-based inference [1])
                                                                                          Integrated Monomers
                                                                                          Domains
                                                                                          adenylation
                                                                                          Name
                                                                                          Unk09
                                                                                          Type
                                                                                          nrps-type1
                                                                                          Genes
                                                                                          cda2PS2
                                                                                          Substrates
                                                                                          asparagine, 3-hydroxyasparagine (evidence: Structure-based inference, Knock-out studies)
                                                                                          Integrated Monomers
                                                                                          Domains
                                                                                          adenylation
                                                                                          Name
                                                                                          Unk10
                                                                                          Type
                                                                                          nrps-type1
                                                                                          Genes
                                                                                          cda2PS3
                                                                                          Substrates
                                                                                          glutamic acid (evidence: Structure-based inference [1])
                                                                                          Integrated Monomers
                                                                                          Domains
                                                                                          adenylation
                                                                                          Name
                                                                                          Unk11
                                                                                          Type
                                                                                          nrps-type1
                                                                                          Genes
                                                                                          cda2PS3
                                                                                          Substrates
                                                                                          tryptophan (evidence: Structure-based inference [1])
                                                                                          Integrated Monomers
                                                                                          Domains
                                                                                          adenylation
                                                                                          Annotation changelog

                                                                                          Entry version: 3

                                                                                          Date
                                                                                          Changes
                                                                                          Submitters
                                                                                          Reviewers
                                                                                          2022-09-15
                                                                                          Added NRP substrate specificities
                                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                          Entry version: 2

                                                                                          Date
                                                                                          Changes
                                                                                          Submitters
                                                                                          Reviewers
                                                                                          2019-10-16
                                                                                          Migrated from v1.4
                                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                          Entry version: 1

                                                                                          Date
                                                                                          Changes
                                                                                          Submitters
                                                                                          Reviewers
                                                                                          2016-09-03
                                                                                          Submitted
                                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                          Detailed domain annotation
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