BGC0001372 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001372 (Penicillium thymicola)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	indole,NRPS	1	53,605	penigequinolone A	terpene	100%

BGC0001372 - Region 1 - NRPS,indole

Download region GenBank file

Download region SVG

Location: 1 - 53,605 nt. (total: 53,605 nt) Show pHMM detection rules used

Region on contig edge.

indole: (indsynth or dmat or indole_PTase)
NRPS: cds(Condensation and (AMP-binding or A-OX))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 53,606
Label		BGC0001372

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001372	0.94	Terpene	penigequinolone A	Penicillium thymicola
BGC0000342	0.29	NRP	enniatin	Fusarium equiseti
BGC0000313	0.28	NRP	beauvericin	Beauveria bassiana
BGC0000391	0.28	NRP	methylpendolmycin, pendolmycin	Marinactinospora thermotolerans
BGC0000293	0.27	NRP	acetylaszonalenin	Aspergillus fischeri NRRL 181
BGC0002272	0.26	NRP	asterrelenin, epi-aszonalenin A	Aspergillus terreus NIH2624
BGC0000405	0.25	NRP	δ-(L-α-aminoadipyl)-L-cysteine-D-valine, isopenicillin N, benzylpenicillin, phenoxymethylpenicillin	Penicillium chrysogenum
BGC0000384	0.24	NRP	lyngbyatoxin	Lyngbya majuscula
BGC0000348	0.24	NRP	ergovaline	Epichloe festucae var. lolii
BGC0000307	0.24	NRP	AbT1	Aureobasidium pullulans

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001372	1.00	Terpene	penigequinolone A	Penicillium thymicola
BGC0000811	0.65	Alkaloid	fumigaclavine C	Aspergillus fumigatus Af293
BGC0000342	0.62	NRP	enniatin	Fusarium equiseti
BGC0000313	0.61	NRP	beauvericin	Beauveria bassiana
BGC0001706	0.60	Terpene	nodulisporic acid F	Hypoxylon pulicicidum
BGC0001777	0.60	Terpene	shearinine D	Escovopsis weberi
BGC0001547	0.59	Terpene	citreohybridonol	Aspergillus stellatus
BGC0001775	0.59	Terpene	sespendole	Cordana terrestris
BGC0001082	0.58	Terpene	paxilline, paspaline, 13-dehydroxypaxilline, paspaline B	Penicillium paxilli
BGC0001260	0.57	Terpene	terpendole E	Tolypocladium album

Similar known gene clusters from MIBiG 4.0

Module view

Legend

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 5708 - 53605:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X - NMe-X)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 3, location 24920 - 53605:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X - NMe-X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

ANY57892.1

AMP-binding (234..625): X

nrpys: Phe, Trp

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Unpolar aromatic ring (Phe, Trp)
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: GMIIVAAICK
Nearest Stachelhaus code(s):: 4clBza or 2clBza GVIILAAGIK (59% 8Å match); S-bohPhe or Phe DALIVAAVCK (38% 8Å match); bOH-Tyr DTSKVAAICK (35% 8Å match)
Stachelhaus code match:: 60% (weak)

AMP-binding (1327..1731): X

nrpys: Leu, Ile

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DAFFYGVVVK
Nearest Stachelhaus code(s):: Leu or Ile DAFFLGNVVK (59% 8Å match)
Stachelhaus code match:: 80% (moderate)