LOCUS       BGC0001374             17250 bp    DNA     linear   BCT 31-JUL-2016
DEFINITION  Streptomyces albogriseolus strain MJ286-76F7 thienodolin gene
            cluster, complete sequence.
ACCESSION   BGC0001374
VERSION     BGC0001374
KEYWORDS    .
SOURCE      Streptomyces albogriseolus
  ORGANISM  Streptomyces albogriseolus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces; Streptomyces albogriseolus group.
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-10-17 15:25:47
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 17250
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     source          1..17250
                     /country="Japan"
                     /db_xref="taxon:1887"
                     /isolation_source="soil"
                     /mol_type="genomic DNA"
                     /organism="Streptomyces albogriseolus"
                     /strain="MJ286-76F7"
     subregion       1..17250
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0001374"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..17250
                     /contig_edge="True"
                     /product="unknown"
                     /region_number="1"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            53..1873
                     /gene="thdK"
     CDS             53..1873
                     /codon_start=1
                     /gene="thdK"
                     /gene_functions="regulatory (smcogs) SMCOG1048:sensor
                     histidine kinase (Score: 159.8; E-value: 1.8e-48)"
                     /gene_kind="regulatory"
                     /note="ThdK"
                     /product="putative histidine kinase"
                     /protein_id="ANW12111.1"
                     /transl_table=11
                     /translation="MMRALPPVAYRRSVEVEEAVTPRTARPLLTRLAAASPWGRYRIAG
                     EAVLTVALAGIAGLFDAVGSGFGARTFVVVAGVALLSLTRRALPATALVLSAAAAGALI
                     AAVPLLVYVSWSAGSRIVKPWRVAVAYAAALVAHTALTAHDEIGASSVASPVTAGALGA
                     GVFLALAIVPGLAARYRAQRRALLGALRSNNAQLVREQAMVAREARLLERHRIARDMHD
                     SLGHQLALISVHSGALQVDPELTDRQREGVRILREASVTAMGELREAVGILRDDRDDRE
                     GADGRDGRDGPNPAAGPGDGRPVRRPAASVDGLVESSRAAGAAVELHRSGVHRPLMPAV
                     EQAAYRIAQEGLTNAHKHAPGAPISLALRYEPDSLVVEVANGPVPAGAARGPAVISGGQ
                     GLKGLRERARLVGGMVHTGPTADGGFRIAGMLPYGTGDGEPGPGPDGATSVGPGSDLVG
                     QMRRGAAGDGGAVINRIDPPTEFTTIMTNKKNVAIGCAAVAVVLVGGVVAMGIWGTKEL
                     MKEMKKAEISPSVYESVKVGDAEADVQEKLPDGDSWTTSDLADQGPELPEGATCRHFTS
                     DADESLDSLTVFRFCFRDGKLVAKDTFQAT"
     misc_feature    53..17210
                     /note="thienodolin gene cluster"
     gene            2045..2707
                     /gene="thdL"
     CDS             2045..2707
                     /codon_start=1
                     /gene="thdL"
                     /gene_functions="regulatory (smcogs) SMCOG1016:LuxR family
                     DNA-binding response regulator (Score: 187.1; E-value:
                     4e-57)"
                     /gene_kind="regulatory"
                     /note="ThdL"
                     /product="putative response regulator"
                     /protein_id="ANW12112.1"
                     /transl_table=11
                     /translation="MIRVLVADDEPLIRAGIRMILTSADDIDVVAEAGDGREAVETARG
                     TAVDVALLDIQMPVMDGLAALTELRRAAPDVRVLILTTFGERENVLRALGHGGVGFLLK
                     DSAPDELIHAVRAAAAGNAYLSPAATRHVVDALASPGATTRADEARQRVDRLSARERDV
                     LALLGEGLSNADAGRRLHMSEATVKTYVSRILTKLGCENRVQAALLARDAGMHPDGV"
     gene            3758..5575
                     /gene="thdD"
     CDS             3758..5575
                     /codon_start=1
                     /gene="thdD"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GATase_7"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Asn_synthase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1177:asparagine synthase (glutamine-hydrolyzing)
                     (Score: 629.5; E-value: 9.7e-191)"
                     /gene_kind="biosynthetic-additional"
                     /note="ThdD"
                     /product="amido transferase"
                     /protein_id="ANW12109.1"
                     /sec_met_domain="GATase_7 (E-value: 7.5e-48, bitscore:
                     151.5, seeds: 307, tool: rule-based-clusters)"
                     /sec_met_domain="Asn_synthase (E-value: 7e-91, bitscore:
                     295.3, seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MCGIAGWVDFNRDLTGERSTVLAMTDTMALRGPDDTGIWLSPHAA
                     LGHRRLAVIDVEGGRQPMAADDVAVLTYSGEVYNFRELRVQLEARGHRFRTHSDTEVVL
                     RGYLEWGEDLVDKLNGIYAFALWDVRREELLLIRDRMGVKPLFYYPLPGGGVLFGSEPK
                     AILAHPQADRAVDADGLREIFTITQTPGLSLYKGMHEVRAGQVVKVRRQGLTKRQYWRL
                     TAQEHTDDLDTTVRTVRELLEDIVERQLVSDVPLCSLLSGGLDSSALTALALKHGDTRS
                     FAVDFAGYADHFQPDEMRGSADGPFVRDAVAHLRPDHTDITLDTTELTDPRLRTSVMDA
                     WEYPQFSGDMNTSLYMLFRAIQGHSTVALSGESADEVFGGYAWFHLPKAVDSGTFPWLV
                     FMMQKQRPEDLFDPELRKKLDVLAYERDRYSDALAEVPYLPMVSARERRMREVSYLHLT
                     RFVNMLLDRKDRLSMAHGLEVRVPFCDHRLVEYVFNTPWAFKTFDGREKSLLRAAVSDL
                     VPASILERRKSPYPATQDPAYGQALRGTLTDLVADGTAPVLPLLDGEAVRTLLKSPAED
                     TASTVTRISLEMVLDLNSWLESQELRVDV"
     misc_feature    3845..3847
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    4004..4006
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            5695..6156
                     /gene="thdB"
     CDS             5695..6156
                     /codon_start=1
                     /gene="thdB"
                     /note="ThdB"
                     /product="putative DNA binding protein"
                     /protein_id="ANW12110.1"
                     /transl_table=11
                     /translation="MRSSELTIGRSFGLNFDHKEDFFQTLADFCKENDVRQGYIPMFLA
                     AFAETEIAGTCDRVEDPEAPVRLPVYLEKVEAVGSGTFSYDPDRDIVVPHVHVTVGLKQ
                     QSALAYSSHLISATVQYLTEMLIVEVASPHMRRPVKTELYDVPLLTFES"
     gene            6162..7355
                     /gene="thdC"
     CDS             6162..7355
                     /codon_start=1
                     /gene="thdC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007:cytochrome P450 (Score: 429; E-value: 2.7e-130)"
                     /gene_kind="biosynthetic-additional"
                     /note="ThdC"
                     /product="putative cytochrome P450"
                     /protein_id="ANW12113.1"
                     /sec_met_domain="p450 (E-value: 7.8e-28, bitscore: 87.2,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSAEFFPFPEEPLGAVPQSCAWRRESDPLGQVTLPSGDAVRLAVR
                     FEDVEAVLTDPRFSRDLSKPGCPRLQSGADMSDDRDTLINMDPPRHTRVRRLLSRAFTV
                     RNIEKLRPRIREIVQELVDDMAAAAPGPVDLMAGLAEPLPMRVIAGVLGVADSDLAQFR
                     HWSYVAMSITPDMADERVTGREEFFAYLVDLIEQHRREPGTDLLDAMIQATEDGDRLSE
                     AELCDTARSLLLAGHETTMTSIGRGIFTLLRHPEQYAQLVADPSLVPAAVEEVLRHDFP
                     AEVGFLRVATQDVDLPSGQVRRGEGVMPLISSAHRDTKKFADPDRFDIHRVDNAHIAFG
                     KGAHYCIGAYLARVQLQEAYDVIVRTFPDLRLAVPAEEIVWKPDMMTHAIAELPITW"
     gene            7374..8090
                     /gene="thdM"
     CDS             7374..8090
                     /codon_start=1
                     /gene="thdM"
                     /note="ThdM"
                     /product="hypothetical protein"
                     /protein_id="ANW12114.1"
                     /transl_table=11
                     /translation="MSTEEKSSAEKSSVPDGSPVLYRPEDLARITEDLPFIRTIADWCT
                     EFLSKPHPDLGRGGSVCPFIPRALAMNRVSFVVLHTANRTEAEIDGIIASYRQTILDME
                     PRSGQEAIDKAIMVILPDVSGEDAAEVVDETHRRLKAEFVASGLMIGKFHPRSEQGGLH
                     NPGFRPLRSPIPLLAIRHMVDSDLPFLNRVDDPVPDRIKFLESYGQRFEDAEESRWSEK
                     GRAAIGELRVRAESDK"
     gene            8087..8911
                     /gene="thdE"
     CDS             8087..8911
                     /NRPS_PKS="Domain: PKS_KR (8-198). E-value: 8.4e-17. Score:
                     53.5. Matches aSDomain: nrpspksdomains_thdE_PKS_KR.1"
                     /codon_start=1
                     /gene="thdE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001:short-chain dehydrogenase/reductase SDR (Score:
                     192.7; E-value: 1.2e-58)"
                     /gene_kind="biosynthetic-additional"
                     /note="ThdE"
                     /product="putative dehydrogenase/reductase"
                     /protein_id="ANW12115.1"
                     /transl_table=11
                     /translation="MTAATPRTVAIVAGGSRGIGAEISRHLAAAGMDVVIGFAHDTVAA
                     EKLVGEISGAGATGGPGAGAGAGDGPGAGAGAGAGAGQAKAVLADIAEPDGAARLFDEA
                     EQAFGGVDIVVTCAGAHAARRGPLAATDDDDFRRVVDVNFRGTFHMLRAAATRVRTGGR
                     IITFSSSALALGAPGQAVYNASKAAVEVLTRQLAKELAGRDITVNAIAPGPTGTELFLS
                     GRPPEAIEALAGQIPLGRIGRPDDIAAVVDFLLGEQGGWINGQVLHANGGIV"
     aSDomain        8111..8680
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_thdE_PKS_KR.1"
                     /evalue="8.40E-17"
                     /label="thdE_PKS_KR.1"
                     /locus_tag="thdE"
                     /protein_end="198"
                     /protein_start="8"
                     /score="53.5"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="VAIVAGGSRGIGAEISRHLAAAGMDVVIGFAHDTVAAEKLVGEIS
                     GAGATGGPGAGAGAGDGPGAGAGAGAGAGQAKAVLADIAEPDGAARLFDEAEQAFGGVD
                     IVVTCAGAHAARRGPLAATDDDDFRRVVDVNFRGTFHMLRAAATRVRTGGRIITFSSSA
                     LALGAPGQAVYNASKAAVEVLTRQLAK"
     CDS_motif       8117..8179
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_thdE_0001"
                     /evalue="1.30E-05"
                     /label="PKSI-KR_m1"
                     /locus_tag="thdE"
                     /protein_end="31"
                     /protein_start="10"
                     /score="17.8"
                     /tool="antismash"
                     /translation="IVAGGSRGIGAEISRHLAAAG"
     CDS_motif       8579..8638
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_thdE_0002"
                     /evalue="3.90E-05"
                     /label="PKSI-KR_m4"
                     /locus_tag="thdE"
                     /protein_end="184"
                     /protein_start="164"
                     /score="16.2"
                     /tool="antismash"
                     /translation="ITFSSSALALGAPGQAVYNA"
     gene            8908..9624
                     /gene="thdY"
     CDS             8908..9624
                     /codon_start=1
                     /gene="thdY"
                     /note="ThdY"
                     /product="hypothetical protein"
                     /protein_id="ANW12116.1"
                     /transl_table=11
                     /translation="MTSPSFPERSTTMLESTVPLGESDPGGILENIDVVVIDTETFAPF
                     VEDAIEQYSLGLASVKAAGSRLHRPNSFGLLGGTFEGDAMIVKQVAFATNVRAVESVPL
                     EEFKENIVPQFGKQYDDGERGFWCDSRELLKIVREFENAGLEMLGSVHMHPDWHRIGPA
                     HERGTENLSENPSRMDEYLFRNAGWPLNIICYLESRGGGITHTYAAWRPPALDDPSGRA
                     RKVTVRHFAHGHVGSE"
     gene            9752..11158
                     /gene="thdO"
     CDS             9752..11158
                     /codon_start=1
                     /gene="thdO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1138:FAD linked oxidase domain protein (Score: 399.4;
                     E-value: 5.3e-121)"
                     /gene_kind="biosynthetic-additional"
                     /note="ThdO"
                     /product="putative FAD-dependent oxidase"
                     /protein_id="ANW12117.1"
                     /transl_table=11
                     /translation="MDRYPRNAGTVVSPADPDYERARRIWNNRFDCRPRAIMYPRDEAE
                     AAAALGYARDNEVPFRIRSGGHNSEGFCTVDDGIIIDLSKLGSIAVNNDRTRAVISPGV
                     MLGEVYANLWSVGGTIPAGVCPDIRIGGHVLGGGIGMLVRSRGLLIDNLVGLTVVDARG
                     ERLQVDADHHPDLFWACKGGGGGNYGIATSYTFEMRPISDVTIFKLQWDWQGGMAVLDA
                     WQHWLLSADSRVNARFNVFSSTVGTVMTVGLFEGSADELKSILQPLVEKFPPRDSFVRT
                     MPYMECVGTFSEQVPSIRAKFVPALSAGPLDADALKTLERWHKDAPTGVKTGLYGLGGE
                     VLGSVSPDSSAFAHRDASICVEYLGHWQGAEHDREHLGWLSGVREEMDAFMTGGAYVNS
                     PDRDLENWLHAYYGESLPRLMDVKRRYDPDNVFAFEQSIPGSLTLPEARAAGLTDTVVE
                     DLRARGLLSA"
     gene            11305..12900
                     /gene="thdH"
     CDS             11305..12900
                     /codon_start=1
                     /gene="thdH"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Trp_halogenase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1119:halogenase (Score: 79.3; E-value: 5.5e-24)"
                     /gene_kind="biosynthetic-additional"
                     /note="ThdH"
                     /product="tryptophan 6-halogenase"
                     /protein_id="ANW12118.1"
                     /sec_met_domain="Trp_halogenase (E-value: 1.2e-169,
                     bitscore: 554.8, seeds: 23, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDNRIKTVVILGGGTAGWMTAAYLGKALQNTVKIVVLEAPTIPRI
                     GVGEATVPNLQRAFFDYLGIPEEEWMRECNASYKMAVKFINWRTPGEGSPDPRTLDDGH
                     TDTFHHPFGLLPSADQIPLSHYWAAKRLQGETDENFDEACFADTAIMNAKKAPRFLDMR
                     RATNYAWHFDASKVAAFLRNFAVTKQAVEHVEDEMTEVLTDERGFITALRTKSGRILQG
                     DLFVDCSGFRGLLINKAMEEPFIDMSDHLLCNSAVATAVPHDDEKNGVEPYTSSIAMEA
                     GWTWKIPMLGRFGSGHVYSDHFATQDEATLAFSKLWGLDPDNTEFNHVRFRVGRNRRAW
                     VRNCVSVGLASCFVEPLESSGIYFIYAAIHMLAKHFPDKTFDKVLVDRFNREIEEMFDD
                     TRDFLQAHYYFSPRVDTPFWRANKELKLADSIKDKVETYRAGLPVNLPVTDEGTYYGNF
                     EAEFRNFWTNGSYYCIFAGLGLMPRNPLPALAYKPQSIAEAELLFADVKRKGDTLVESL
                     PSTYDLLRQLHGAS"
     gene            12897..13478
                     /gene="thdF"
     CDS             12897..13478
                     /codon_start=1
                     /gene="thdF"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1160:flavin reductase domain protein FMN-binding
                     (Score: 118.3; E-value: 4.1e-36)"
                     /gene_kind="biosynthetic-additional"
                     /note="ThdF"
                     /product="flavin reductase"
                     /protein_id="ANW12119.1"
                     /transl_table=11
                     /translation="MTGAAGGVTTEQQHYRDLMSAFPTGIAVVTSLDAQGVPRGMTCSS
                     VTSATLSPPTLLVCLRNGSATLDAVSATRGFAVNLLHDGGRHAAEVFSGPDPNRFSRVQ
                     WKQCRSGLPWLSKDAFAVAECRVSGTQEVGDHTVVFGEVARIAQTDGTPLLYGLRSFAA
                     WPLPSESARQGSEAAPRGSEPAYGARSSRG"
     gene            13601..14752
                     /gene="thdN"
     CDS             13601..14752
                     /NRPS_PKS="Domain: Aminotran_1_2 (55-373). E-value:
                     1.6e-46. Score: 150.9. Matches aSDomain:
                     nrpspksdomains_thdN_Aminotran_1_2.1"
                     /codon_start=1
                     /gene="thdN"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1019:aminotransferase (Score: 140.4; E-value:
                     1.3e-42)"
                     /gene_kind="biosynthetic-additional"
                     /note="ThdN"
                     /product="aminotransferase"
                     /protein_id="ANW12120.1"
                     /sec_met_domain="Aminotran_1_2 (E-value: 3.9e-47, bitscore:
                     151.0, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTARQVTQPSFRTSELDRFSAYRATEGTEATEATQGTEATQGTEA
                     TEATEPGRAEDILDLSNNELMLPPLPAVVDSLRRSSLQVNLYPDPTARVLKTTLARHFG
                     AETEETVVGPGSGGVLQQLLLVLAGRGDEVLHAWPGFDAYPLLIAVSGAKGVPVPLTTT
                     GEHDLAGLLERVNPRTRAVILCSPHNPTGRRIPTGDLLGFLDSLPSHVVAILDQAYMEF
                     DEEEDPHDLGLIREYPNVVLLRTFSKAYGLAGLRVGYAFASSEIAVRARKTVIPFSVTR
                     SGERAAVISLAQESDLAERLATVRRMRADLRSDLGAQGLVPLPSSANFVWLPLGPDSDR
                     FAAAALRAGVRVRSYSGDGVRISVGTEEAHRRVLIAAKDFLSV"
     aSDomain        13766..14719
                     /aSDomain="Aminotran_1_2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_thdN_Aminotran_1_2.1"
                     /evalue="1.60E-46"
                     /label="thdN_Aminotran_1_2.1"
                     /locus_tag="thdN"
                     /protein_end="373"
                     /protein_start="55"
                     /score="150.9"
                     /tool="antismash"
                     /translation="DILDLSNNELMLPPLPAVVDSLRRSSLQVNLYPDPTARVLKTTLA
                     RHFGAETEETVVGPGSGGVLQQLLLVLAGRGDEVLHAWPGFDAYPLLIAVSGAKGVPVP
                     LTTTGEHDLAGLLERVNPRTRAVILCSPHNPTGRRIPTGDLLGFLDSLPSHVVAILDQA
                     YMEFDEEEDPHDLGLIREYPNVVLLRTFSKAYGLAGLRVGYAFASSEIAVRARKTVIPF
                     SVTRSGERAAVISLAQESDLAERLATVRRMRADLRSDLGAQGLVPLPSSANFVWLPLGP
                     DSDRFAAAALRAGVRVRSYSGDGVRISVGTEEAHRRV"
     gene            14958..16220
                     /gene="thdA"
     CDS             14958..16220
                     /codon_start=1
                     /gene="thdA"
                     /gene_functions="transport (smcogs)
                     SMCOG1117:sodium/hydrogen exchanger (Score: 345.9; E-value:
                     4.8e-105)"
                     /gene_kind="transport"
                     /note="ThdA"
                     /product="putative Na+/H+ antiporter"
                     /protein_id="ANW12121.1"
                     /transl_table=11
                     /translation="MTGNAVSDFFLALTLAITAAKLLGAALQRIGQPAVVGEILAGILV
                     SPMVLSATVSEKIFPESVQPVFSGLANVGLATFMFLVGYEMDGALLRGRKRIPLSIAVG
                     SVVLPLAGGVALAIPLASTYAPGSHTGFVLFVGVAMSVTAFPVLARILSDRELNRTATG
                     AIVLVAAAIGDIVAWICLAGVIAFTGATGEWRFVLLPLYVLALAFLVRPALKKAVHYAE
                     HHDKQATVLFPVLIAGLLVSSAATEWLGIHFIFGAFAFGAIMPRAMSESLRVLVVNQMQ
                     QTGYLLLPLYFVVAGMKVDLAGFGGGVLLTLVLVIAVAVVTKTLGVYAAGRLAGADHGQ
                     ALTASVLMNTRGLTEIVIVSVGLEMALIDQKFYSIMVVMAVVTTVLTGPLLKRIGAHRL
                     VGANPPEGASAAAREKQNAPG"
     gene            complement(16254..17210)
                     /gene="thdR"
     CDS             complement(16254..17210)
                     /codon_start=1
                     /gene="thdR"
                     /gene_functions="regulatory (smcogs) SMCOG1014:LysR family
                     transcriptional regulator (Score: 131; E-value: 8.5e-40)"
                     /gene_kind="regulatory"
                     /note="ThdR"
                     /product="putative LysR family transcriptional regulator"
                     /protein_id="ANW12122.1"
                     /transl_table=11
                     /translation="MTPTQLRAYAAVVRLGSVKGAAADLSVSEAAVSMHVAQLRKELGD
                     KLFARTGAGLAFTPGGLRLASRATELLGLQDRTILEVSQAGSGRRLLRVATSSLFAEHA
                     APGLIELFAGRADDLDVELSVHSPQRFATLLRNRTVDVAIGPRPAAVDDGMKCTPFLNY
                     QMVGVVGPDHPLAARRPGPGELRRQTWLLGPSAADRAGLVPSVLQQLQVDEENQRIFQS
                     HAAALEEAKHGKGVALALSFSVTRALSGGELKQLLSPALPAKGSWNALALPGRDAPPAA
                     AELMRFVTTPRALQAMLRGEGVTAGRFRPAIHVTLWS"
ORIGIN
        1 tccgccctgg caagagttgt caactttcgt cgttcgcccg tacgacgggg ggatgatgcg
       61 ggcgctcccg cccgttgcct atcgtcggtc cgtggaagtg gaagaagcag tcacccctcg
      121 caccgcccgg ccgctcctga cccggcttgc cgccgcgtcg ccctggggcc gttaccggat
      181 cgccggggag gccgtgctca ccgttgccct cgccgggatc gcggggctgt tcgacgccgt
      241 gggctccggg ttcggtgccc ggaccttcgt cgtcgtcgcg ggcgtcgccc tgctgtcgct
      301 gacccggcgc gccctgccgg cgacggcgct ggtcctctcc gccgcggcgg cgggggcgct
      361 gatcgcggcg gttccgctgc tggtctacgt gagctggtcg gcgggcagcc gcatcgtgaa
      421 accctggcgg gtggccgtcg cgtacgccgc cgcactcgtg gcccatacgg cgctcaccgc
      481 ccacgacgag atcggcgcca gctccgtcgc gtcgccggtc accgcgggcg cgctgggcgc
      541 gggggtgttt ctggcactgg cgatcgtgcc ggggctggcc gcccgctacc gcgcccagcg
      601 ccgtgcgctg ctcggtgcgc tgcggagcaa caacgcccag ctcgtacggg agcaggcgat
      661 ggtggcacgg gaggcgcgcc tgttggagcg ccaccgtata gccagggaca tgcacgacag
      721 cctcggccac caactcgccc tgatatccgt gcactcgggc gccctgcagg tcgatccgga
      781 gctgaccgac cgccagcggg aaggggtacg gatcctgcgg gaggcctccg tgaccgcgat
      841 gggggagctg cgcgaggccg tcgggatcct ccgcgacgac cgcgacgacc gggagggggc
      901 ggacggacgg gacggacggg acggtcccaa cccggccgcc ggaccgggtg acgggcgtcc
      961 ggtccggcgg ccggccgcct ccgtcgacgg tctggtcgag tcctcccggg ccgcgggcgc
     1021 ggccgtggag ctgcaccggt ccggcgtcca ccggccgctg atgcccgccg tcgagcaggc
     1081 ggcgtaccgc atagcccagg aaggcctgac caacgcccac aagcacgcgc cgggcgcccc
     1141 gatcagcctg gccctgcgct acgagccgga cagcctggtg gtggaggtcg ccaacgggcc
     1201 cgtaccggcc ggggcggcgc gggggccggc cgtgatcagc ggcggccagg gactgaaggg
     1261 cctgcgggaa cgggcccggc tcgtcggcgg gatggtgcac accggtccca ccgcggacgg
     1321 cggattccgt atcgccggca tgctgccgta cggaaccggg gacggggagc cggggcccgg
     1381 cccggacggc gcgacttccg tcggtcccgg gagcgacctt gtggggcaga tgaggagggg
     1441 cgcggcgggc gacggtggag ccgtcatcaa ccgcatcgat ccgccaacgg agttcaccac
     1501 catcatgacc aacaagaaga acgtggccat cggttgtgcc gctgtcgccg tcgtcctcgt
     1561 cgggggtgtc gtcgccatgg ggatatgggg gacgaaggag ttgatgaagg agatgaagaa
     1621 ggccgagata tcgccgagcg tgtacgagtc ggtgaaggtg ggcgatgccg aggcggacgt
     1681 acaggagaaa ctgcccgacg gggactcgtg gacgacctcg gacctggcgg accagggtcc
     1741 tgagctaccc gagggcgcga cctgccgcca cttcacctcc gacgcggacg agagcctcga
     1801 cagcctgacc gtcttccggt tctgcttccg tgacgggaag ctggtcgcga aggacacctt
     1861 ccaagcgacg tgacccggcg cgcggtgccg accggccttc gcgtgacgta cggcggtgcc
     1921 gaccgacctc cgcgtgaggt acggagggtg gcaccgtacc tcggtgcggg gtacccgatc
     1981 gggtcagggc atgatggcgg ggccacgcca tccgctccat gaccgacacc gcgcaggagg
     2041 ctgtgtgatc cgggtcctcg tcgccgacga cgagccgctc atccgggccg gcatcaggat
     2101 gatcctcacc tcggccgacg acatcgacgt cgtcgccgag gcgggcgacg gccgtgaggc
     2161 ggtggagacc gcccggggca ccgccgtgga cgtggccctg ctggacatcc agatgccggt
     2221 gatggacgga ctggcggccc tcaccgagct gcgccgcgcc gcgccggacg tgcgggtgct
     2281 gatcctcacc accttcggcg agcgggagaa cgtgctgcgc gcgctcggcc acggcggcgt
     2341 cggcttcctg ctcaaggact ccgcgcccga cgagctgatc cacgcggtgc gggcggcggc
     2401 ggccgggaac gcctatctct cgcccgcggc cacccggcac gtggtggacg ccctcgcctc
     2461 cccgggggcc accacccgcg ccgacgaggc cagacagcgc gtcgaccggc tgtcggcccg
     2521 ggagcgcgac gtgctcgcgc tgctcggcga gggcctctcc aacgcggacg cgggcaggcg
     2581 gctgcacatg agcgaagcca ccgtgaagac ctacgtcagc cgcatcctga ccaagctcgg
     2641 gtgcgagaac cgggtacagg cggcgctgct cgcccgcgac gccggaatgc acccggacgg
     2701 ggtgtgacct ccaggcgctg ataccgcgcc ggtgccgtcc ggtcgaggtg gctgcttcct
     2761 gccctccgcc ggacggaatt cctggcacgt tcccggctgt tgtatccagc aagacatcct
     2821 ggggcacacc ggctgtcctc aagggcaaac aaactggtca aaggtgcagt tcgcgcgaaa
     2881 gacgccgaat cgccaccgag tgtttccgga gctctttccc cgtcgcgcgg aaagcctctc
     2941 ggagtattaa cggcgtatga aatgagctct attcagccat ccgggacgag cccggatcgc
     3001 cgcgggggcc gaccgatact cacaccgtgc ccggcttcgg tgcgaagccg tgtgccgggg
     3061 atccggagcg gtgcggtccg gtagcggaaa cgtttctgcg aatggttgcc gacgcggccg
     3121 gcgctccgtg tccaatggac cgtcggtggc ccggacaagg cttcggaatg gcctgactgt
     3181 ggccgaacgg gcagtggctc atggccggtt cgtcatgcgg tgaggctgga atgcgcaggc
     3241 gctaagaagc cggtctggac cgcgagaagg ggccatggca ggatctggcc ccgacgcagt
     3301 gcttgaccgt attcgtgtga ttgaccgtta ccaagcacct cggccggtgt ctgctctcgc
     3361 cggccccttg cacagagcga atctccgcat ccaccccacg gatgcgcgac cacatacctc
     3421 tgaaagacat cggatctgca ggccccctgt catcgagccc cccttccgcc gaatccaacc
     3481 cgccgccctt tccggcgcgt catcgggtaa ttgtttcaat ctgaccctta ctgctgacct
     3541 ctgctgaccc cggcacagac cactccgtag agaccactcc gtagagacca ctccgtagag
     3601 accctgaatc cgtagtcccg cgttgtcccg cgttccgatc ctaccgacgt gcgcccatct
     3661 ctcacagacg gccttggcat gccgattcgc cgggaccggg gcctggcgta ccggtggggt
     3721 cggggtcgaa gcgatcgaac cgagaatggg aagccatatg tgcggtatcg caggctgggt
     3781 agatttcaac cgcgacctga ccggagagcg gtccacagtg ctggccatga cggacaccat
     3841 ggcgttacga gggccggacg acaccggaat ctggctttct ccccatgcgg cgctcggcca
     3901 ccgccggctc gcggtgatcg atgtcgaagg cggccgccag ccgatggccg cggacgacgt
     3961 ggccgtcctc acctacagtg gcgaagtcta caacttccgt gaattaaggg ttcagttgga
     4021 ggcgagagga caccgcttcc gcacccacag cgacaccgag gtcgtcctgc gcggctacct
     4081 ggagtggggc gaggacctcg tcgacaagct caacgggatc tacgccttcg cgctgtggga
     4141 cgtccggcgc gaggaactcc tgctcatccg cgacaggatg ggtgtcaagc cgctcttcta
     4201 ctacccgctc cccggcggcg gtgtgctctt cggatccgaa ccgaaggcca tcctcgccca
     4261 tccgcaggcc gaccgggccg tggacgccga cggactgcgg gagatcttca ccatcacgca
     4321 gacgcccggg ctctccctct acaagggcat gcacgaagtg cgcgcgggac aagtggtgaa
     4381 ggtacggcgc cagggcctga ccaagcggca gtactggcgg ctcacggccc aggaacacac
     4441 cgacgacctg gacacgacgg tccgtacggt gcgcgagctc ctggaggaca tcgtcgagcg
     4501 gcagctcgtc tcggacgtcc cgctgtgcag cctgctgtcg ggcgggctcg attcgagcgc
     4561 gctcaccgcc ctggccctga aacacgggga cacccggtcg ttcgccgtcg acttcgccgg
     4621 ctacgccgac cacttccagc ccgacgagat gcgcggcagc gccgacgggc ccttcgtacg
     4681 cgacgcggtg gcacacctgc gccccgatca caccgacatc acactcgaca ccaccgagct
     4741 caccgatcca cggctgcgca ccagtgtgat ggacgcctgg gaataccccc agttcagcgg
     4801 cgacatgaac acctcgctgt acatgctgtt ccgcgcgatc cagggacact cgaccgtcgc
     4861 gctgtcaggg gagtccgcgg acgaggtctt cggcgggtac gcctggttcc acctgccgaa
     4921 ggcggtggat tccggcacgt tcccctggct cgtcttcatg atgcagaagc agcggcccga
     4981 ggacctcttc gaccccgagc tgcgcaagaa gctcgacgtc ctcgcgtacg agcgggaccg
     5041 gtacagcgac gcgctggccg aggtgccgta cctgccgatg gtcagcgccc gcgaacgccg
     5101 gatgagggag gtctcctacc tccacctcac ccgcttcgtg aacatgctgc tcgaccgcaa
     5161 ggaccggctg agcatggcgc acggcctgga ggtccgggtg ccgttctgcg accaccggct
     5221 ggtggagtac gtcttcaaca cgccctgggc cttcaagacc ttcgacggac gcgagaagag
     5281 cctgctgcgt gccgcggtct ccgacctcgt accggcgtcg atcctggagc ggcgcaagag
     5341 cccgtacccc gccacccagg accccgcgta cgggcaggcg ctgcgcggca cactcaccga
     5401 cctggtcgcg gacgggaccg cccccgtact gccgctgctg gacggtgagg ccgtacggac
     5461 cctgctcaag tcgccggccg aggacaccgc gtccacggtg acacgcatca gcctggagat
     5521 ggtgctcgac ctgaactcct ggctggagtc ccaggagctg cgcgtcgacg tctgacgccg
     5581 cgcgcgccgg actctccttc ccctctcttc tcctcgcttc cctcttcgcc tttcctcctt
     5641 cctcctttcc tccgcatttt ccctgcccac acgtacgacg ggagtggttt cagcatgcgc
     5701 agcagcgagc tcacgatcgg aaggtccttc ggactcaatt tcgaccacaa ggaggacttc
     5761 ttccagacgc tggccgactt ctgcaaggaa aacgatgtcc ggcagggtta catcccgatg
     5821 ttcctcgcgg ctttcgccga gaccgagatc gcgggaacgt gcgaccgggt cgaggacccg
     5881 gaagcccccg tccgcctccc cgtatacctg gagaaggtcg aggccgtcgg cagcggcacc
     5941 ttctcctacg accccgaccg ggacatcgtc gtgccgcacg tgcatgtcac ggtcggactg
     6001 aagcagcagt cggccctcgc ctattccagt catctgatat cggccacggt ccagtacctg
     6061 accgagatgc tgatcgtcga ggtcgcctcc ccgcacatgc gtcgtccggt gaagaccgag
     6121 ctgtacgacg tgcccctgct caccttcgaa agctgagagc catgtccgct gaattctttc
     6181 cctttcccga agagccgctc ggcgcggttc cgcagagctg cgcctggcgg cgtgagtccg
     6241 atcccctcgg gcaggtcacc ctgcccagcg gtgacgccgt acggctcgcg gtgcgcttcg
     6301 aggacgtcga ggccgtcctg accgacccgc ggttcagccg cgacctgagc aagcccggat
     6361 gcccccggct gcagtccggt gcggacatgt ccgacgaccg cgacacgctc atcaacatgg
     6421 acccgccgcg gcacacccgg gtccgccgcc tcctcagccg cgcgttcacc gtgcggaaca
     6481 tcgagaagct gcggccgcgc atccgggaga tcgtccagga actcgtcgac gacatggcgg
     6541 ccgccgcccc gggccccgtc gacctgatgg ccggcctcgc cgaaccgctg cccatgcggg
     6601 tgatcgcggg ggtgctcggg gtcgccgaca gcgatctcgc ccagttccgc cactggtcgt
     6661 acgtggccat gagcatcacg cccgacatgg cggacgagcg cgtcacgggg cgcgaggagt
     6721 tcttcgcgta cctggtcgac ctcatcgagc agcaccgcag ggagccgggg accgatctcc
     6781 tcgacgccat gatccaggcg acggaggacg gcgaccggct gagcgaggcg gagctgtgcg
     6841 acaccgcgcg ctcgctgctg ctcgccgggc acgagaccac catgacgtcg atcgggcgcg
     6901 ggatcttcac gctgctgcgc caccccgagc agtacgcgca gctcgtggcg gatccgtcgc
     6961 tggtgcccgc ggcggtcgag gaggtgctcc ggcacgactt ccccgccgag gtgggcttcc
     7021 tccgtgtcgc gacgcaggac gtcgacctgc cgtccggtca ggtccgccga ggtgaggggg
     7081 tcatgccgct catctcctcg gcgcaccgcg acacgaagaa gttcgcggac cccgaccggt
     7141 tcgacatcca ccgggtggac aacgcgcaca tcgctttcgg gaagggcgcg cattactgca
     7201 tcggcgcgta tctcgcgcgg gtgcagctcc aggaggcgta cgacgtgatc gtgcgcacct
     7261 tcccggatct gcggctggcg gtgcccgccg aggagatcgt ctggaagccg gacatgatga
     7321 cgcatgccat cgcggaactc ccgattacct ggtgaaccgg aggtgaggtc gatatgagta
     7381 ccgaagagaa gagttctgcg gagaagagtt ccgtgccgga cgggagcccc gtgctctacc
     7441 gcccggagga cctggcccgc atcacggagg atctgccgtt catccggacc atcgccgact
     7501 ggtgtacgga gttcctttcg aagccgcatc ccgatctcgg gcggggcggt tcggtctgtc
     7561 ccttcattcc gcgtgccctg gccatgaacc gggtctcgtt cgtcgtcctg cacacggcga
     7621 accgcaccga ggccgagatc gacgggatca tcgcctcgta ccggcagacc atcctcgaca
     7681 tggaaccccg gtcggggcag gaggccatcg acaaggcgat catggtgatc ctccccgatg
     7741 tgagcgggga ggacgcggcc gaggtggtgg acgaaacaca ccgcaggctg aaggcggagt
     7801 tcgtcgcctc cggtctcatg atcgggaagt tccacccgcg cagcgagcag ggcgggctcc
     7861 acaacccggg gttccggccg ctgcgcagtc cgattccgct gctggccatc cggcacatgg
     7921 tcgactccga cctgccgttc ctgaaccggg tcgacgatcc cgtgcccgac cgcatcaagt
     7981 tcctggagtc gtacgggcag cggttcgagg acgcggagga gtcccgctgg tcggagaagg
     8041 gccgggcggc catcggtgag ctgcgcgtcc gtgcggagtc ggacaagtga cggccgccac
     8101 gccacgtacg gtggcgatcg tggccggcgg cagccgcggc atcggggcgg agatctcccg
     8161 gcacctcgcg gccgccggca tggatgtggt catcggcttc gcccatgaca ccgtggccgc
     8221 cgagaagctg gtgggggaga tctccggagc cggagccacg ggcggtcccg gagccggagc
     8281 aggagccggg gatggtcccg gagccggagc cggagccgga gccggagccg gacaggcgaa
     8341 ggccgtgctc gccgacatcg cggaaccgga cggtgccgcg cgcctcttcg acgaggcgga
     8401 acaggccttc ggcggcgtag acatcgttgt cacctgcgcg ggtgcccacg ccgcgcggcg
     8461 cggccccctc gcggccaccg acgacgacga cttccgccgg gtcgtggacg tcaacttccg
     8521 cggcacgttc cacatgctgc gggcggcggc gacccgggtc cgtacgggcg gacggatcat
     8581 caccttctcc agctccgctc tggccctggg ggcgcccggc caggcggtct acaacgcctc
     8641 caaggccgcc gtcgaggtgc tgacgcggca gctggccaag gaactggccg gccgggacat
     8701 cacggtcaac gcgatcgccc cgggacccac cggcaccgaa ctgttcctca gcggccggcc
     8761 gccggaggcg atcgaggcgc tggccgggca gatcccgctg ggcaggatcg gccggccgga
     8821 cgacatcgcg gcggtggtgg acttcctgct cggcgagcag ggcggctgga tcaacgggca
     8881 ggtgctgcac gccaacggcg gaatcgtgtg acgtccccgt cattcccgga gaggagcacc
     8941 acaatgctgg agagcacggt cccgctgggc gagagcgacc ccggtggaat cctggagaac
     9001 atcgacgtgg tggtcatcga caccgagacc ttcgcgccct tcgtcgagga cgcgatagag
     9061 cagtacagcc tcggtctggc gtcggtgaag gcggccggtt cgcggctgca ccggcccaac
     9121 agcttcggac tgctgggcgg tacgttcgag ggcgacgcga tgatcgtgaa gcaggtcgcc
     9181 ttcgccacca acgtccgggc cgtcgagtcc gtccccctgg aggagttcaa ggagaacatc
     9241 gtcccccagt tcggcaagca gtacgacgac ggggagcgcg ggttctggtg cgactcgcgt
     9301 gaactcctca agatcgtccg ggagttcgag aacgccggtc tggagatgct cggatcggtc
     9361 cacatgcacc cggactggca ccgcatcggg cccgcgcacg aacggggcac ggagaacctg
     9421 agcgagaacc ccagccggat ggacgagtac ctcttccgta acgcgggctg gccgctcaac
     9481 atcatctgct acctggagag ccggggcggc ggcatcaccc atacgtacgc cgcgtggcgt
     9541 ccgcccgccc tcgacgatcc gtcggggcgg gccaggaagg tcaccgtcag gcacttcgca
     9601 cacggccacg tcggctccga gtgacgtgcc aggcgccatg acgtgccagg cgccatgacg
     9661 tgacgcatgc cgtggcacga cgcatgccgt gacgtgccag gtgctgtgac gcaccggaac
     9721 tcccaggctg tccgaaggtg gaggacgacg aatggacagg tatccccgga acgccggcac
     9781 ggtggtctcg ccggccgacc cggactacga acgggcacga cgcatctgga acaaccgctt
     9841 cgactgccgg ccccgcgcca tcatgtaccc gcgcgacgaa gcggaggcgg cggccgcgct
     9901 gggatacgcg cgggacaacg aggtcccgtt ccgtatccgc tccggcggtc acaacagcga
     9961 gggtttctgc acggtcgacg acggcatcat catcgacctg tcgaagctcg gctcgatcgc
    10021 cgtgaacaac gaccggaccc gggccgtcat cagccccggt gtcatgctcg gtgaggtgta
    10081 cgcgaacctc tggtccgtgg gcggcaccat ccccgccggg gtctgcccgg acatcaggat
    10141 cggcgggcac gtgctcggcg gcggcatcgg gatgctcgtc cgctcgcggg gcctgctcat
    10201 cgacaatctg gtgggcctca ccgtggtcga cgcgcggggg gagaggctcc aggtcgacgc
    10261 ggaccaccac ccggatctct tctgggcctg caagggaggc ggcggcggca actacgggat
    10321 cgccacctcg tacaccttcg agatgcggcc catctccgac gtgacgatct tcaagctgca
    10381 gtgggactgg cagggcggca tggcggtgct cgacgcctgg cagcactggc tcctctcggc
    10441 ggactcgcgg gtcaacgccc ggttcaacgt cttctccagt acggtcggta cggtcatgac
    10501 ggtcggcctg ttcgagggtt cggccgacga gctgaagtcg atcctccagc cgctggtcga
    10561 gaagttcccg ccgcgtgact ccttcgtacg caccatgccc tacatggagt gcgtggggac
    10621 gttcagcgag caagtgccct ccatacgggc caagttcgtg cccgcgctgt cggcgggacc
    10681 gctcgacgcc gacgcactga agaccctgga gcgctggcac aaggacgcac cgaccggggt
    10741 caagacgggg ctctacgggc tcggcggcga ggtgctcggc agtgtgtcgc cggacagctc
    10801 ggcgttcgcc caccgcgacg cgtccatctg cgtcgagtac ctcggccact ggcagggggc
    10861 ggaacacgac cgggaacacc tcggctggct gtccggcgtc cgcgaggaga tggacgcctt
    10921 catgacgggc ggagcctacg tcaacagtcc ggaccgcgat ctggagaact ggctgcacgc
    10981 ctactacggg gagagcctcc cgcggctgat ggacgtgaag aggcggtacg accccgacaa
    11041 cgtcttcgcc ttcgagcaga gcatcccggg atccctcacc ctcccggagg cccgcgccgc
    11101 gggcctgacc gacacggtcg tcgaagacct gcgcgcccgc ggacttctct ccgcctgacg
    11161 ccggcacccg cgggcgccca ccgaggcgcc cgcgggcccc cgagaactcg cccttccgaa
    11221 gaaccggcct ccctcaagag gcagaagcgg cgtgcccgga ccaccgaaaa gcccactttg
    11281 ctcgaatctc tgaaggagaa caacgtggac aatcgaatca agacagtcgt gatcctgggc
    11341 ggcggcaccg ccggctggat gactgcggcg tatctcggca aggcgctgca gaacacggtg
    11401 aagatcgtgg tcctggaggc gcccaccatc ccgcggatcg gtgtgggcga agccaccgtc
    11461 cccaacctgc agcgcgcgtt cttcgactac ctcggcatcc ccgaggagga gtggatgcgc
    11521 gagtgcaacg ccagttacaa gatggcggtg aagttcatca actggcgcac accgggggag
    11581 ggcagcccgg atccccggac gctcgacgac ggtcacaccg acaccttcca ccaccccttc
    11641 ggactgctgc cgtccgccga ccagataccg ctctcccact actgggcggc caagcggctc
    11701 cagggcgaga ccgacgagaa cttcgacgag gcgtgtttcg ccgacaccgc gatcatgaac
    11761 gccaagaagg cgccccgctt cctcgacatg cggcgggcga ccaactacgc ctggcacttc
    11821 gacgccagca aggtcgccgc gttcctgcgc aacttcgccg tcaccaagca ggcggtcgag
    11881 cacgtcgagg acgagatgac cgaggtcctc accgacgaac ggggcttcat caccgccctg
    11941 cgcaccaagt cgggacggat cctgcagggt gacctcttcg tcgactgctc cggcttccgc
    12001 gggctgctga tcaacaaggc catggaggag ccgttcatcg acatgagcga ccacctcctg
    12061 tgcaacagcg cggtcgccac ggccgtaccg cacgacgacg agaagaacgg tgtcgagccg
    12121 tacacctcct cgatcgccat ggaggccggc tggacctgga agattcccat gctgggccgg
    12181 ttcggcagcg gtcacgtcta ctccgaccac ttcgccaccc aggacgaggc caccctggcc
    12241 ttctcgaagc tgtggggcct cgacccggac aacaccgagt tcaaccacgt ccgcttccgg
    12301 gtcggccgca accgcagggc ctgggtgcgc aactgcgtca gcgtcggcct cgcgtcgtgc
    12361 ttcgtggagc cgctggagtc cagcggcatc tacttcatct acgcggccat ccacatgctg
    12421 gccaagcact tccccgacaa gaccttcgac aaggtgctcg tcgaccggtt caaccgggag
    12481 atcgaggaga tgttcgacga cacccgggac ttcctccagg cgcactacta cttctcgccg
    12541 cgcgtcgaca cgccgttctg gcgggcgaac aaggaactga agctggccga ctccatcaag
    12601 gacaaggtcg agacgtaccg ggccgggctg ccggtcaacc tgccggtcac cgacgagggg
    12661 acctactacg gcaacttcga ggccgagttc cggaacttct ggaccaacgg cagctactac
    12721 tgcatcttcg ccggcctcgg cctgatgccg cgcaacccgc tgcccgcgct cgcctacaag
    12781 ccgcagtcga tcgcggaggc cgagctgctg ttcgccgacg tcaagcgcaa gggggacacc
    12841 ctggtcgagt cgctgccgtc gacctatgac ctgctgcgtc agttgcacgg tgcgtcgtga
    12901 cgggtgcggc gggcggcgtg acgaccgagc agcagcacta ccgcgatctg atgagcgcct
    12961 tccccaccgg gatcgcggtg gtgaccagcc tcgacgccca gggtgtgcca cgcggcatga
    13021 cctgctcgtc ggtcaccagc gccaccctgt ccccgccgac gctgctggtc tgcctgcgca
    13081 acggcagcgc caccctggac gcggtctcgg ccacccgcgg gttcgccgtc aacctgctgc
    13141 acgacggcgg acggcacgcg gcggaggtgt tctcgggccc cgacccgaac cgcttctcgc
    13201 gcgtgcagtg gaagcagtgc cggtcgggtc tgccgtggct gtccaaggac gcgttcgcgg
    13261 tggcggagtg ccgggtcagc ggcacccagg aggtgggcga ccacaccgtg gtcttcggtg
    13321 aggtcgccag aatcgcccag accgacggca ccccgctgct gtacggcctg cgctccttcg
    13381 ccgcctggcc gctgccgtcg gagtctgcgc gccagggctc ggaggccgcg ccacggggct
    13441 cggagcctgc ctacggggct cggagcagcc gcggctgaac ccggcgtgaa ccgcccgaca
    13501 ccggtgtgaa ccggggccgt gagcccccgt gggttccccg cggcacgtct cacggccccg
    13561 gtccgggacc gaaaccgcta ctcacagaaa cagggcactg atgacggcac gccaagtcac
    13621 gcagccatcc ttcaggacgt ccgagctgga caggttctcc gcctaccgcg ccacggaagg
    13681 gacggaggcg acggaggcga cgcagggaac ggaggcgacg cagggaacgg aggcgacgga
    13741 ggcgacggaa cccggcaggg ccgaggacat cctggacctt tccaacaacg aactcatgct
    13801 gccacccctg ccggcggtgg tggactcgct gcgccggagc agcctccagg tcaatctgta
    13861 ccccgacccc accgcccgcg tactcaagac cacactggcc cggcacttcg gcgccgagac
    13921 cgaggagacg gtggtcggcc ccggcagcgg cggcgtcctc cagcaactgc tcctggtcct
    13981 ggccggccgc ggcgacgaag tcctccacgc ctggccgggc ttcgacgcct accccctgct
    14041 gatcgccgtc tccggcgcca agggggtacc ggtaccgctc accaccaccg gtgagcacga
    14101 cctggcgggg ctgctggagc gggtgaaccc ccgtacaagg gcggtcatcc tgtgctcccc
    14161 gcacaacccc accggccgcc ggatccccac gggtgatctg ctggggttcc tggacagcct
    14221 cccgtcccac gtggtcgcca ttctcgacca ggcgtacatg gagttcgacg aggaggagga
    14281 tccgcacgac ctcggcctga tccgggagta cccgaacgtc gtcctgctgc ggacgttctc
    14341 caaggcgtac ggcctggcgg ggctgcgggt cggctacgcc ttcgcctcgt cggagatcgc
    14401 cgtgcgcgcc cgtaagacgg tcatcccctt ctccgtcaca cgctccggcg agcgggcggc
    14461 cgtgatctcg ctggcccagg agagcgacct ggccgagcgg ctggctacgg tacggcgcat
    14521 gcgcgcggac ctccggtcgg atctcggcgc acaggggctg gtgccgctgc cgtcgtcggc
    14581 caacttcgtc tggcttcccc tcggaccgga ctcggaccgc ttcgccgccg cggcgctgcg
    14641 ggccggggtg cgggtcaggt cgtactccgg cgacggtgtc cggatctccg tggggacgga
    14701 ggaggcccac cggcgcgtgc tgatcgccgc gaaggacttc ctgtcggtgt gacgcgtcac
    14761 gggtgaggcg tcacgggtga ggcgaccacc ggcgccggac acactgcccg cccgtcacgc
    14821 gaccccacgc accacccctg tgcagcacgt gtgttgaaca caccgcggtg ggcctgcggt
    14881 cacagcaggc ccaccggtcc acccaccgtg cccggccggc cgcgacacgc ccggccaccc
    14941 accagaggcc gatactgatg actggtaacg ccgtatcaga cttcttcctg gcgctgacac
    15001 tcgccatcac cgcagccaaa ctgctgggag ccgcactcca acggatcgga cagcccgccg
    15061 tcgtgggaga gattcttgcc ggcatcctcg tcagccccat ggtgctgtcg gcgaccgtga
    15121 gcgagaagat cttcccggag agtgtgcagc ccgtcttctc cggcctggcc aacgtcggcc
    15181 tcgcgacctt catgttcctc gtcggttacg agatggacgg ggcgctgctg cgcggccgca
    15241 agcgcatccc cctgagcatc gccgtgggct cggtcgtgct cccgctcgcg ggcggagtcg
    15301 ccctggcgat accgctcgcc tccacttacg cgcccgggag tcacaccggc ttcgtgctct
    15361 tcgtcggtgt ggccatgtcc gtgacggcct tccccgtgct ggcgcgcatc ctgtccgacc
    15421 gcgagctgaa ccgtacggcg acgggcgcca tcgtgctcgt cgcggcggcc atcggtgaca
    15481 tcgtcgcctg gatctgcctg gccggtgtca tcgcgttcac cggcgcgacc ggcgagtggc
    15541 gcttcgtgct gctgccgctc tacgtactgg cgttggcctt cctggtccgg ccggcgctca
    15601 agaaggccgt tcactacgcc gaacaccacg acaagcaggc cacggtcctc ttccccgtgc
    15661 tgatcgccgg cctgctggtg tccagcgccg ccaccgagtg gctcggcatc cacttcatct
    15721 tcggcgcgtt cgccttcggt gcgatcatgc cccgtgcgat gtccgagtcg ctgcgcgtcc
    15781 tcgtcgtgaa ccagatgcag cagaccggct atctgctgct gccgctctac ttcgtcgtcg
    15841 ccggcatgaa ggtcgacctc gccggattcg gcggtggggt cctcctcacc ctcgtgctgg
    15901 tcatcgccgt cgccgtcgtc accaagacgc tcggggtcta cgccgccgga cgcctggccg
    15961 gcgcggacca cggccaggcg ctgacggcgt ccgtcctgat gaacacgcgc gggctcaccg
    16021 agatcgtcat cgtctccgtc ggcctggaaa tggccctgat cgaccagaag ttctactcga
    16081 tcatggtggt gatggccgtg gtgaccaccg tcctcaccgg cccgctgctg aagcggatcg
    16141 gcgcacaccg cctggtcggc gccaacccac cggaaggcgc ctccgccgcg gcgagggaga
    16201 agcagaacgc acccggctga gcgcgcggcc cgccggcgca ccggggagcc ccgtcagctc
    16261 cacagcgtca catggatcgc cgggcggaac ctccccgccg tcacaccctc cccgcgcagc
    16321 atcgcctgga gggcgcgcgg cgtggtgacg aaacgcatca actcggcggc cgcgggcggc
    16381 gcgtcacgcc ccgggagggc gagggcgttc caggatccct tggcgggcag cgcggggctc
    16441 aggagctgtt tgagttcccc gccggagagc gcccgggtga cggagaagga gagcgccagc
    16501 gccacgccct tgccgtgctt ggcctcctcc agggccgccg cgtggctctg gaagatccgc
    16561 tggttctcct cgtccacctg gagctgctgg agtacggagg ggacgaggcc cgcgcggtcc
    16621 gcggccgacg ggccgagcag ccaggtctgg cggcgcagtt cgcccggtcc cgggcgccgg
    16681 gcggcgagcg ggtggtccgg gccgacgacg cccaccatct ggtagttgag gaacggcgtg
    16741 cacttcatgc cgtcgtccac ggccgccgga cgcgggccga tcgccacgtc cacggtgcgg
    16801 ttgcgcagca gggtggcgaa ccgctgcggg ctgtgcacgc tcaactcgac gtccaggtcg
    16861 tcggcccggc ccgcgaacag ctcgatgagg ccgggcgccg cgtgctccgc gaagaggctc
    16921 gacgtggcga cgcgcagcag cctgcggccc gaaccggcct ggctgacctc caggatggtc
    16981 cggtcctgga gccccagcag ctccgtggca cggctggcca gccgtagccc gccgggggtg
    17041 aacgcgaggc ccgcgcccgt cctggcgaac agcttgtcgc ccaactcctt gcggagctgg
    17101 gcgacatgca tggagaccgc ggcctcggac accgagagat ctgccgcggc ccccttgacc
    17161 gaacccaggc ggacgaccgc ggcgtacgcc cgaagctgag tcggcgtcat atctgatcgt
    17221 gtctcccacc cggccgcccg agccgatgcg
//
