LOCUS       BGC0001375             12837 bp    DNA     linear   PLN 01-MAR-2016
DEFINITION  Penicillium simplicissimum DNA, ptmO, ptmJ, ptmK, ptmE, ptmL gene
            cluster, strain: AK-40.
ACCESSION   BGC0001375
VERSION     BGC0001375
KEYWORDS    .
SOURCE      Penicillium simplicissimum
  ORGANISM  Penicillium simplicissimum
            Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
            Eurotiomycetes; Eurotiomycetidae; Eurotiales; Aspergillaceae;
            Penicillium.
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-10-17 15:25:48
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     source          1..12837
                     /db_xref="taxon:69488"
                     /mol_type="genomic DNA"
                     /organism="Penicillium simplicissimum"
                     /strain="AK-40"
     protocluster    1..12837
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[7514:8841]"
                     /cutoff="20000"
                     /detection_rule="(indsynth or dmat or indole_PTase)"
                     /neighbourhood="10000"
                     /product="indole"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      7515..8841
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(indsynth or dmat or indole_PTase)"
                     /neighbourhood="10000"
                     /product="indole"
                     /protocluster_number="1"
     cand_cluster    1..12837
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(indsynth or dmat or indole_PTase)"
                     /kind="single"
                     /product="indole"
                     /protoclusters="1"
                     /tool="antismash"
     subregion       1..12837
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0001375"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..12837
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="indole"
                     /region_number="1"
                     /rules="(indsynth or dmat or indole_PTase)"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            complement(650..2174)
                     /gene="ptmO"
     CDS             complement(join(650..1318,1377..1498,1554..1677,
                     1737..2174))
                     /codon_start=1
                     /gene="ptmO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1138:FAD linked oxidase domain protein (Score: 209.7;
                     E-value: 1.9e-63)"
                     /gene_kind="biosynthetic-additional"
                     /product="putative FAD binding domain protein"
                     /protein_id="BAU61564.1"
                     /transl_table=11
                     /translation="MKHNLPADLVTLWRDSPGYESARSRTFNQRIPPELPYAIVRPKNM
                     EQIQHAVQLAVDLDKQIRIRSGGHSLAGWTLCADSILIDLVDFRHLEYDATTAIASASP
                     SATSAQLNDLLVPHGRFVPVGHCGDVGLGGFFLQGGMGLNCRSYGWACEYLVGVDLITA
                     DGEYKHCSESENADLFWAARGAGPEFPAIVTRFFIRTRPAAAKYEKSTFIWPVACSDAV
                     VSWILKILPELHADIEPLVVSTIVPGLNVAAILVQFLVFLSTNETGAEKLGPSLTAMPD
                     GTLMEFKGVPTSIQQEYVSQEGTMPRDSRYICDSVWFKDGIDFVTVTRRMFREFPRDRS
                     MVYWEPKYPTSRRQLPDMAFSLQADQYLALFAIFEDSQQDEEQGIRIQEFIQEIEPYVL
                     GTFAADGMPAVRKTQYWSAEVIERLYSVCQKWDPAHRLGCTLLDPTRKVKS"
     gene            2770..4607
                     /gene="ptmJ"
     CDS             join(2770..2883,2954..3729,3778..3826,3889..4100,
                     4151..4199,4260..4607)
                     /codon_start=1
                     /gene="ptmJ"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034:cytochrome P450 (Score: 119.9; E-value: 2.3e-36)"
                     /gene_kind="biosynthetic-additional"
                     /product="putative cytochrome P450"
                     /protein_id="BAU61565.1"
                     /sec_met_domain="p450 (E-value: 7.7e-31, bitscore: 95.6,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MMRDSLGPFRTFTLLTVGLLLSLFVIKTVKHRRRYHGLPTPPHNM
                     LLGNLGVVLAEILASPEGFFHLFCVENIRRKYNMPSVFYLDLWPILPSIMVVAEPVVAK
                     HMTQVQPLQRERFSPNLFSPLLTAEFILAMEQKNWKKENPALNAALTSTRVNEATSLLF
                     PSLHSLRSRLHSISQSGKQYPIKDLLISYIIEVGGVIQLGGSFDLLAETSALDPIIKQS
                     LDMMGWNPVKRYICSKEIKQRTDCLNRVLVATVQNTVQTGESGMMSQSPIYLAHVEQLA
                     SGRMDHAESIAYLVNTMKVIILASVVTAGAASYCYLFLHKYPDCLREMREEHDRVFSPD
                     RTQTWELLQKEPHRINSLHFTLAVVKETLRLIGVGGVFKKLKTEEFLETEGNVYPVVCN
                     VAFICHLAMGRRADLFPDPDAFRPHRFLPGANPPIPADSFRPFEKGQLSCPGQTLALKS
                     LVLLLLTTSREFDLVPVFPKGAPRAAEYLGGEGYPEFHIGPHVNKGMPVMVHTRVDA"
     gene            complement(5476..7115)
                     /gene="ptmK"
     CDS             complement(join(5476..6079,6137..6948,6999..7115))
                     /codon_start=1
                     /gene="ptmK"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034:cytochrome P450 (Score: 300.5; E-value: 3.6e-91)"
                     /gene_kind="biosynthetic-additional"
                     /product="putative cytochrome P450"
                     /protein_id="BAU61566.1"
                     /sec_met_domain="p450 (E-value: 4.8e-67, bitscore: 215.0,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIIVTFFWVGIVLSAIWTFYKVVLYPYRVSPLRTLPQSQRGHWLW
                     NHAFSEFLQPIGQLHAELLLQIPNDGMICLRGLFGAPKIFLTSPKSLADVLVHRADDFE
                     KLPGERKILRAVVGDGLVTAEGDVHYQQKRKLLAGFTPPKIRALYPVFWKEATALTQQI
                     RRTLTHDGSGIYTGTTDMVYWAPRVSMDMIGAAGFGQSFHSLRDADSEIIHCYEKAFAI
                     GAGHLLCVFADTLLPRIILQWLPWPRWRQFRQNIDSIRDFCHQWVTDAKATTALGDGIP
                     NNLLANMIHTGEYTFQELIEQVRTFLAAGHENTSSVVMWVMLALASDSQLQSRLRQELQ
                     ANLPEVELDEVDLAILEQLPLLNAVVSEAIRLFPPLPIGNRIAIRDTTVMNHPIPKGTP
                     FLIVPRAINRSSELWGPDADRFNADRWINPDTGRFNNHGGASSNYSFLSFFHGPHNCIG
                     QNFARAELRTVVAAVIRSFDMVLDNPAADVSPVGWFTPRPADGVKVKLRSLV"
     gene            7515..8841
                     /gene="ptmE"
     CDS             join(7515..8665,8715..8841)
                     /codon_start=1
                     /gene="ptmE"
                     /gene_functions="biosynthetic (rule-based-clusters) indole:
                     dmat"
                     /gene_kind="biosynthetic"
                     /product="putative prenyltransferase"
                     /protein_id="BAU61567.1"
                     /sec_met_domain="dmat (E-value: 2.8e-115, bitscore: 374.1,
                     seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGSLSSPTDLTPYQVLSKYKKFPSPDEEFWWDHAASTLADLIKWT
                     KATPAQEYEFLQFFYEHVIPNFSGYRPYDVPGRAWNTGITPSGLPLEYSVNWRNIDANA
                     MVRVGVEPISQFAGTARDPYSHYKIWDTLNQLSQVKALKSFDLELWRHFSSALCTSREE
                     EALLDQTRTLPESFSIAKMQHSMGFDFCDDEVVVKIYLIPNMKARASGTPLAELLTGSI
                     HAIYRDTIDRETLATVINYLDSTSNFNDATWFSFDCIPRSQSRIKLYGSDFRTTWSRAE
                     DLWTVGGRYTDAVTMKGLAYLKELWDLLPIQDFETLPEQAVQNPPMLWAYEIRPGDKIP
                     SPRIYIPGHCLNDKKVADGLSAFFKRVGWSDLGDQYTDRLFSMFPKQDLKDSTALHTWI
                     AFSYTEKSGVYMNCYYLASASFPFKL"
     gene            complement(8942..10840)
                     /gene="ptmL"
     CDS             complement(join(8942..9289,9341..9389,9441..9649,
                     9708..9756,9802..10613,10685..10840))
                     /codon_start=1
                     /gene="ptmL"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034:cytochrome P450 (Score: 160.3; E-value: 1.3e-48)"
                     /gene_kind="biosynthetic-additional"
                     /product="putative cytochrome P450"
                     /protein_id="BAU61568.1"
                     /sec_met_domain="p450 (E-value: 2.3e-42, bitscore: 133.6,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAIPKTMEAPFTHLFLNLTVMTLGQILVIPVALLVVYICIRIGSI
                     RRQFRDLPKPPHHAFLGHFPILLRELRTLPRDIFAPLVVDLVRRKFDLPAVFFLDLYPL
                     FNPIVFISDPGLARKITQEDRSLRYPGVFETLYPAIPTRWFRTVADRAWTKWHPVVGVS
                     FTAAHFVRMVPQMAEDLRAMLDQLNDWSDRDEIFCMERVATDAILAMTGRAYFGMELDC
                     FAPKSQWTSAFRAATTPVVAARNPLRKPFVLPSWKRHARTFHAVIREKVQHTFDKDENH
                     EAGVPSLLASSFAVYRKNGFPEFPRVSQEALSTEYLEELTSTGAAFLIGATSGASVISY
                     AFLLLHQHPNILDDLRREHGQVCGFNRQSILLALQSRPRLLNDLKLTHAVLKETLRLFP
                     MGPVLRKCPSETMEYEGRTYDIRNHIVAISHNSLHRRPDLFPNPDAFNPYRFLPGAAIP
                     IPADAWRPFEKGNGYCVGQELAMIQMKVMLLLTLTEFDFQPKYAREAARGPDIYGGYAY
                     TTGSGIGPTPAGGLPMRVDKRMK"
ORIGIN
        1 gggatagtca agtggaaagg gtcttaacgt aatggctttg gatgcccagg ccagctcgcg
       61 ccggtaaact atacctacct ctttcggcca catcctctga gcatagatta ccggccttag
      121 cgatcaggcc tacgaggtag cagaagggta actaactaac tagttaacta gtagtactgc
      181 ctgtaccgac gcagaagcct agcgtttcga ctccgatgcg caccgtcggg cggatatcac
      241 tgtgatattt gacgcggatt taaaaatgga actccagggg gcttttagaa caaaacaaaa
      301 gcatccaagg ctatatacag tgatagtaga gctcattgcc aatgaacttt cccctccctg
      361 ctttggaacc tacatacacc cacctaatga tgtggcaatc tggtcattac tggggtaccg
      421 caaaaggcca tatgacgcgg cacacggcga gatgagtcta ccgaaaagaa tgttgtgccc
      481 ccgcagcact ggtcaatgtt gggctttgaa ttattgtgtg cccaacgagt acatggatac
      541 tgcaggagta gctgcaagag tagctaccaa atgaatgatc cccccactca ttgctcatcc
      601 cagcgacata gcaaagtacg tgcttcagtt gcatagtgac acaggatcgc tatgatttca
      661 ccttccgcgt tgggtctagc agagtgcatc cgagtcgatg agcaggatcc catttttggc
      721 acactgagta cagtctctcg atgacctccg ccgaccagta ctgagttttg cgcaccgcag
      781 gcatcccgtc tgcagcgaaa gttcccagaa cataaggctc aatctcttga atgaactctt
      841 ggatacgaat accctgttct tcatcttgtt gggagtcttc gaagatcgcg aacagggcga
      901 ggtattgatc tgcctggaga ctaaaggcca tgtctggtaa ctgtctccta ctcgttggat
      961 atttaggctc ccagtagacc attgatcgat cccgaggaaa ttcacggaac atccgccggg
     1021 tgacggtgac aaagtcaatc ccatctttga accacacact gtcacagatg tagcgagagt
     1081 ctcgaggcat ggtgccctct tgggacacat attcctgttg gatgctggtg ggtacgccct
     1141 tgaactccat gagggtccca tctggcatgg ccgtcagaga gggccccagt ttctctgcgc
     1201 cagtttcatt ggtactcaaa aagaccagaa actgcaccag aatggcagcg acgttgagtc
     1261 cagggacaat ggtactgacc acgagtggtt caatgtcggc gtgtagttcg gggagaatct
     1321 gcgtgcgcgg atccggcctc aatatggctg tgttgactta gagagggggt ccataccttt
     1381 aaaatccacg acaccaccgc gtccgaacag gctacaggcc agataaaggt gctcttctcg
     1441 tattttgcgg ctgctggtcg cgtccggata aaaaaccggg taacaattgc ggggaattct
     1501 atcgaggtgg tttgttagag gcatggagag aagttataag atggtagagg tacctggacc
     1561 agcgcctcga gctgcccaga ataggtccgc attttcactt tcgctacaat gtttgtattc
     1621 gccgtcggcc gtaatcaaat caacgcctac caggtactcg catgcccacc catagctcta
     1681 ctcgttctgt taatgtggat gcaatagatc ctgaggtttg caaatcccta acgtacccga
     1741 caattaagtc ccatcccacc ttggagaaag aatccaccca gtccgacatc tccacagtgg
     1801 ccgacgggca caaagcgccc atgggggacc agcaggtcgt tcagctgggc gctcgtggca
     1861 ctgggagagg cactggcaat ggcagtcgtg gcatcgtact ccagatgcct gaagtcgacc
     1921 aaatcgatga gaatagaatc cgcacacaac gtccagcctg ctaggctatg gcctccggat
     1981 cggatgcgga tttgcttgtc aaggtcaacg gcaagctgca ccgcatgctg gatttgctcc
     2041 atattctttg gtctcacaat cgcatagggt aattccggcg ggattcgctg attgaaagtc
     2101 ctgctgcgtg ccgattcata tcctggactg tcccgccata gagtgacaag atcggctggg
     2161 agattatgct tcatttttat tgtcgagtta agctgatacg caaaatgaaa agggattcaa
     2221 atctttgaac tactgagaag gatggccacc cttcttgtta aaaaccaggg aattttacgt
     2281 attatcccgt tgagccccac agggacacta cgttctaatg gcgacaggta tcaccaccaa
     2341 tatgcaatgg ttgcgcataa tgaggcccag gttgccactc agaggccgca tgcagtgtga
     2401 tattgattcc acttgatccc gaccctatgt tgtatgcgag aaagcaattg tcagtcgaag
     2461 ataaactcct gcatattgag acaagttgat caatgcatat gtacggtgtt atgcatctgt
     2521 ttcacacacc gacatttaat tcatgttcag aaggctaaca aaatatatat aagcgataga
     2581 acaacagtac cgttagggaa taccctgaaa taatttgcca aaggattaag caattaacac
     2641 aaggctgtca cttcccatat tgttattgtc cttcccgcta gcctgtcaaa tccagtttca
     2701 ttttggagac gacccgatcc cgggaagcag aatatgtctt caactctgct ccagtctgca
     2761 cccattgcca tgatgcggga ttccctagga ccattcagaa ccttcactct cctgactgtc
     2821 gggcttctcc tgagtctctt cgtgatcaag acagtgaagc atcgacggcg gtatcatgga
     2881 ttagtaggca ctccccttcc cccacagctc cattgtaata tgtgaggtta atcggttcct
     2941 atcctcgctg tagccaacgc ctccgcataa tatgttgctt gggaatctgg gggtcgtgct
     3001 agccgagatt ctggcatcgc ccgaggggtt tttccatcta ttctgtgttg agaacatccg
     3061 acgtaagtac aacatgccct cggtcttcta tcttgacctt tggccgatcc taccctcgat
     3121 catggtcgtc gccgaaccgg tcgtcgccaa gcacatgacg caagtacagc ccctgcaacg
     3181 cgagcgattt tcgccaaatc tgttcagtcc gctattgact gccgaattta tcctggccat
     3241 ggaacagaag aattggaaga aggagaaccc ggccctgaat gcggccctca catcgacacg
     3301 cgtgaacgaa gccacgtcct tgctgttccc cagcctacat tcgttacgct cccgcctaca
     3361 ctcaatatcc caaagtggga agcagtatcc tatcaaagac ctgttgattt cgtatatcat
     3421 tgaggttggc ggcgtcatcc agctaggcgg gtccttcgat ctcctggccg agacaagcgc
     3481 cttggatccc attattaagc agtcattgga tatgatggga tggaatcccg tcaagcgata
     3541 tatctgctcg aaggaaataa aacagcgcac agactgtctc aatagggttc ttgttgcaac
     3601 tgtccaaaac acagtgcaaa caggggaatc tggcatgatg agccaatcac cgatctattt
     3661 ggcccatgtg gaacaattgg caagcggtcg aatggatcat gcagaatcga tcgcctatct
     3721 ggttaacacg tatgtagctg tcttcctagg agaatcgcgc taactgagtc cacgcagaat
     3781 gaaggtgatc attttggctt cagttgtcac agcaggggcg gcctcggtat gtattctgga
     3841 tgctatacta caatataccg cagtcacagc taacctaggt caatctagta ctgttacctg
     3901 ttcctgcata agtatcccga ctgcttgcgg gagatgcggg aagaacatga tcgtgtgttt
     3961 tcccccgaca gaacccagac atgggagctg ttgcagaagg agccacaccg gatcaattca
     4021 ttacatttta ccctggccgt cgtcaaggaa accctgcgcc tgattggtgt tggtggggtg
     4081 tttaagaaac tgaaaactga gtaggttgcc ctgagataag gggatagaac caatattaaa
     4141 aaccttctag ggagttcctc gaaaccgaag gcaacgtata tccggtggtg tgcaacgtgg
     4201 taggtgcttc caattccctc attccatgca acgtatagtc ctatactgat gatttccagg
     4261 ctttcatctg tcacttggcc atgggtcgtc gtgcagacct gttccctgat cccgatgcct
     4321 ttaggcctca tcgcttcctc cctggggcca acccccccat tcctgctgac tcatttcgtc
     4381 cttttgagaa aggccaactg agttgcccgg ggcaaactct agctttaaaa tcgctggttt
     4441 tgctgctctt aaccactagc cgcgagtttg acttggttcc tgtgtttccc aaaggtgccc
     4501 cccgagcggc agaatacctg ggtggcgaag ggtatcctga gttccacatt gggcctcatg
     4561 tgaataaagg aatgcccgtg atggttcaca ccagggttga cgcatgatag gtggtctctc
     4621 aatagataat attctttttc atggccatcc agaaatagta tcctttctat ttattccatt
     4681 gctaagatgg gactagagag tgtaaatagc atctataaat ggaccaattt gcttgatgct
     4741 gcagtcgccg gtcagaacat attaggtcac ttctattggt gacctcacgc ggtcaagagg
     4801 gacgagaaaa gtatagtttg gctataaccg gtcacctgtt gctgcggttg tagaccgtag
     4861 cgtcagctaa ggcccgtctg cgatcctttg taggaaggca atgtgtctgt attgcagtag
     4921 attatatatg tagagggaag gcgggaggga caaaatcgag acttgactgg gtgagagatg
     4981 acgagctacc cgcagaggca agcaactgac aactgactct cgagttgtag gagggaagag
     5041 aagcccttcg taatgtcggt gactcggtgt agacatcaca tgagacaggt atctgggaat
     5101 tgctgtcgga atacgtaatc cgatgcacca accttgggat cagtgatctc aacaactctg
     5161 gtttcttaat agtatcctat ccaccttgaa ttcaggtcaa caattgtgag gcaaccgcaa
     5221 ataaactacc ccctcgatat ttaaaggcat attctttgga atttcttgaa ttgcatgtat
     5281 tgaaattaag ctaaataaaa tatgtcgggt taaataaaaa cttgcgaaat gtagtccatg
     5341 gttttggtac catataccat attgtcttga cttctaatat atcatacccg taagctccaa
     5401 catacgcatt tgaacggctg gtggactatt gacagatgtc attctggccc tagagtgcaa
     5461 agtctcgaac atcaatcaca ccagggagcg tagcttcact ttgaccccgt ctgctggccg
     5521 tggagtgaac cagcccacgg gggagacatc ggccgcggga ttgtcaagga ccatatcaaa
     5581 cgaccgaatg accgcagcga cgaccgtccg gagttcggcc cgcgcaaaat tttgtccaat
     5641 gcagttatgg ggtccgtgga aaaacgagag aaaggaatag ttgctgctcg caccaccatg
     5701 gttattgaaa cgacccgtgt cgggattgat ccatcggtcc gcattgaatc gatcggcatc
     5761 gggaccccag agttcggagg accggttgat ggctcttggc acgatcaaaa acggcgtccc
     5821 tttgggaatc ggatggttca tgacggtggt gtcccgaatg gcgatgcggt tgccaatcgg
     5881 taacgggggg aacagccgaa tagcctcact cacgacagca ttcagaagag gcagctgttc
     5941 gaggatcgcc aggtcgacct cgtctaactc aacttccggg aggttcgcct gcaactcctg
     6001 acggaggcga gattgtagct gagaatcgga ggcgagggcc agcatgaccc acatcaccac
     6061 cgaggaggtg ttttcatggc tgtggcactc aatcagtata taatatggta aaataggaat
     6121 cgagggaaat gcatacccgg ccgctagaaa ggtccggacc tgttcaatta actcctgaaa
     6181 tgtatattcg ccggtatgga tcatatttgc cagcagattg tttggtatcc catccccgag
     6241 ggcagtcgtc gcctttgcat cggtcaccca ttgatgacag aagtctcgga tggagtcgat
     6301 attctggcgg aattgccgcc atcggggcca tggtagccat tgtaggatga tccgtggaag
     6361 cagggtgtcg gcgaagacac acagcagatg tcctgctccg atcgcgaagg ctttctcata
     6421 gcaatggatg atctcgctgt ccgcgtcgcg cagggaatga aaagactggc caaagccggc
     6481 tgctccgatc atatccatgc tgacccgtgg tgcccagtag accatgtctg tggtccctgt
     6541 atagatccca gacccatcat gggtcagggt tcgtctgatc tgctgggtca gcgcggtcgc
     6601 ctctttccaa aagaccggat agagggcacg gatcttcggc ggcgtgaagc cagccagcag
     6661 ctttcgtttc tgctggtaat gcacatcacc ttcggccgta accaggccat cgcccaccac
     6721 agcgcggagg atcttccgct cgcctgggag cttctcgaaa tcgtctgccc ggtggacaag
     6781 aacatcggcc aggctcttgg gggacgtgag gaagatctta ggcgcgccaa acaggccgcg
     6841 tagacagatc ataccgtcat tgggtatttg caacaaaagc tctgcgtgca attggccaat
     6901 gggttggagg aactcggaaa aggcatgatt ccatagccag tggccgcgct gcactctatc
     6961 agccactcac cctgggagat ctgggtggga gtgcctacct gggactgagg tagagtcctc
     7021 aacggcgaca cgcgataggg gtacaggacg accttgtaga aagtccatat ggcgctcagg
     7081 acaattccta cccagaagaa ggtgacaatg atcatggtgg aaagacagac actggatggg
     7141 aggccaatgg aggatctggc cagccctgaa aagaaaaagc tcagttatca ggcacagcgg
     7201 gccattgacg gtggatcata ttattttttc acaataaagg acgtgcccta atgcaattgt
     7261 cccacgctat ctctcaccga ttcttccttc cccctttctt gcgactttct cgctgtgcat
     7321 ttctattaca ttgcatgtga gagagccaac atgcatatgc agtcacaatg caggtctgct
     7381 gcatgatgtg ttgtcccctc aaggaactcg agacaggtat ggatgaaaat cgtcaatgat
     7441 aaagaatggg aggcccccga cagctgtgta gtccacttct gttaaaatta catctggacc
     7501 tcctcacccg catcatgggc tctctttcgt ccccaaccga cctcaccccc tatcaggtgc
     7561 tttccaaata taagaaattc cctagtcccg atgaggagtt ctggtgggat catgccgcgt
     7621 ccacgttggc cgatcttatc aagtggacca aggccacccc tgcccaagaa tatgagttcc
     7681 tgcagttttt ctatgagcat gtaatcccca acttctccgg gtatcgaccc tatgatgtgc
     7741 ccggccgggc atggaacacg gggattaccc ccagtggact gcccctggaa tacagcgtca
     7801 attggcgaaa cattgacgca aatgcaatgg tccgcgttgg tgttgagcca atcagccagt
     7861 tcgcgggcac tgctcgtgat ccatacagtc actacaaaat ctgggacacg ttgaaccagc
     7921 tgtcgcaggt caaggcactc aagtcctttg accttgagct atggcggcac ttctccagcg
     7981 ctctgtgcac aagtcgcgaa gaggaggcct tgctcgacca gacgcgcacg ctgcccgagt
     8041 ccttctccat tgcgaagatg caacactcaa tgggattcga cttttgtgat gacgaggtgg
     8101 tcgtcaagat ctacctgatc cccaatatga aggcgcgcgc ctcagggacc cccctggcgg
     8161 agctgctgac ggggtccatc cacgccatct atcgcgacac gattgatcgc gagacgctgg
     8221 ccaccgtgat caactatttg gatagcacca gcaacttcaa cgatgccacc tggttctcat
     8281 tcgactgcat cccgcgcagc cagtcgcgca tcaagctcta cggctcggat ttccgcacca
     8341 cctggagccg agccgaggac ctgtggaccg tcggcggccg ctacacggac gcagtcacga
     8401 tgaagggtct tgcctatctt aaggagctct gggatctgct gcccattcaa gacttcgaga
     8461 cgctgcccga gcaggctgtg cagaatcccc ccatgctatg ggcttacgaa attcgccctg
     8521 gtgacaagat cccatcgccc cggatctaca tccctggtca ctgtctcaac gacaagaagg
     8581 tggctgatgg attgtcagct ttctttaaac gggtaggatg gtcggacctg ggcgaccagt
     8641 atacagatcg gttgttctca atgttgtagg tgcttctctc ccccggtgac tagactgtgc
     8701 taaatgattc gcagccccaa gcaggacctc aaggactcga ctgcgttgca tacatggatt
     8761 gccttttctt acaccgaaaa gagcggcgtg tatatgaact gctactatct tgccagtgcc
     8821 tcgtttccct ttaaactgta gttacgggtt ttagcctaga cgagatgaat gcgaggatgt
     8881 caaatggaaa gtcaagtaga gtataagagc ccggcagcac gctatatatg aaagctttct
     8941 ctcacttcat tcgtttatcc acacgcattg gtagtcctcc agctggtgtc ggtccgatac
     9001 ccgagccggt cgtgtacgcg tatccgccgt agatatctgg gcccctagca gcttctcgcg
     9061 cgtactttgg ctgaaaatcg aactctgtta aagtcaacag caacatgact ttcatttgga
     9121 tcatagccag ctcctgtccc acgcagtatc cgttcccctt ttcgaatggg cgccaggcgt
     9181 cggcggggat gggaatggcg gcaccgggca gaaaccgata tggattgaaa gcatcggggt
     9241 tggggaagag gtcagggcgg cgatggaggg agttgtgcga gatagcgacc tactccggtc
     9301 aagatcgaac agagagagca tgagaggtag tgagacttac gatatgattc cgaatatcat
     9361 atgtcctgcc ctcatattcc atcgtctcgc taggaatcct tattagcatc gtagagctca
     9421 acggacctga aactaattac ctaggacact tgcgcagaac agggcccata ggaaagagcc
     9481 tgagcgtctc cttcaacact gcgtgggtta gctttaagtc gttcaacagg cgagggcgac
     9541 tctgtaatgc aaggaggatg gactgtcggt tgaatccgca cacctgcccg tgctccctac
     9601 gcaggtcgtc cagtatgttt ggatgctggt ggaggagcag aaaggcatac taccgtgtcc
     9661 gaaacgatca gcgttcttct tcagatgatc agaccaagac atcttacact gatcacggat
     9721 gcaccactcg tggctccgat caagaaggct gcaccactac gttcgttagc ccacatcgcc
     9781 gattcaaggg agaggcctta cgtagaggtc agttcttcta gatactccgt ggaaagagct
     9841 tcttgggaga ctcgaggaaa ctcggggaac ccgttcttcc gatagacagc aaaggaggat
     9901 gctaataacg agggaacccc ggcttcatgg ttttcatcct tgtcgaacgt atgctggact
     9961 ttctcccgaa ttaccgcatg gaaagttcgg gcatgtctct tccacgacgg caacacaaat
    10021 ggcttccgca aagggttcct cgctgctact accggtgtgg tagcagctcg gaaggccgac
    10081 gtccattggc ttttcggggc gaaacagtcc agctccatac caaaatacgc ccgtccagtc
    10141 atggcgagga tggcatcagt ggccacgcgc tccatgcaaa atatctcgtc ccggtcggac
    10201 cagtcgttca gttgatccaa catagctcgc aggtcctcgg ccatctgtgg caccatccgg
    10261 acgaagtgcg cagccgtaaa ggagacgccg accacgggat gccatttggt ccatgctcga
    10321 tccgctacgg tgcgaaacca tcgagttgga atggccggat acagcgtctc aaagacaccc
    10381 ggatatcgca gggaccgatc ttcctgcgta atctttcgcg cgaggccggg gtcgctgata
    10441 aacacgatag ggttgaagag aggatacaag tcaagaaaga aaaccgccgg taggtcaaat
    10501 ttgcgacgaa ccagatcaac cactaacggg gcaaagatat ctctgggtaa ggtccggagc
    10561 tcacgcaaga ggatgggaaa gtggcccaga aacgcatggt ggggtggttt aggctgtcaa
    10621 caacaaaggt attcttgtca gtctttggac ccgggaggtg ggggggcaca aatggaaacc
    10681 ataccaggtc gcgaaactgc ctccggatag aaccgattcg aatgcagata tagaccacta
    10741 gaagagccac tgggatgacc aggatctggc ctagagtcat gacagtcagg ttaaggaaaa
    10801 ggtgggtgaa tggggcttcc atggtctttg ggatagccat cgatttattt gtcgaaattt
    10861 tcactgcatt gttcgcggcg ctcgcttcca agtactgtag cctccctcaa tcctctctat
    10921 cagtcgtctg tttcctgccg aatagtgctt gcatcccttg cttcttggag accgatacat
    10981 cgaagacttc cagcccagcc caacccagcc caacatgagc ctcggcgcag tggtctctga
    11041 tactaatatt tgtcgacata tgtatgtgca ataccccgca ctaagcgcat gcatgcttat
    11101 gcgcgctaac gctatcggat gcaagatgct gcatgcccga ttgaccgcta cgatgatgaa
    11161 tatcaactat cacatcagat ggaaaagcaa cgagtttcct aacactctcg tatgccctat
    11221 gattatttcg gattcttatt tactcttttc ctgttgcatt ctactgtttc ataaagatat
    11281 aaatactgcc cactttccat agttaaattg aagaagttta acactctttt gattctgata
    11341 tcagattact cttccacatc gtggatccct tcgatcgcac gacctactca tgatctatta
    11401 caagatcata cgctactcca atcttaccgg gcattacact acggtgcaca gaaggactta
    11461 agactactat ctcaagttcg acaatattta tatccattag ccacatagat caataacgga
    11521 gaatgtgcga caccccaaac tgtaacgtaa tccacggccg agcgggtcac acggtcgagc
    11581 gggtcaccta accctattac aaaacttcaa attcgattat atcaaccaac acctattaat
    11641 tcaactaaat aatacgattt ttacatgaag taatcctgta gctaatttgg ccacatctac
    11701 tacaggtagg cggagccctc ctggccggtc gaaccggctg attaggcaga tcgaccgctt
    11761 catgcgatac tacctcatca gcttctactg gctgaattag ctactgagct agctataggc
    11821 cctcttcgat tattaggccc ccttcgtgtg taatccgcct agtcgatcga gtgcgctttt
    11881 aacgtttctt tttattcgct gcgcgtagat tgtcgttctc cttcgctagt agcgtagtgt
    11941 tatatagtgc tatatagtag cccttgataa tctaattaag catgattttt gacggtgtag
    12001 gcgggctata cgatcgctat tttagaagct ctttaagcat agaagcttac ttttctagct
    12061 aaatcgctgt tttaggcgtt tttagtgtga attagctaga tctactgctt agtcgactta
    12121 atagtagtag aggcgttcga agtgatatat taagcttaga aagcacctaa ctagcattaa
    12181 ctagcataat actagtagct acgaagctac ttcaaataat attcggctga aaagcttcta
    12241 tctattacgg accttaaaga ggcgcggggg ccgtagctat ttaagtagca accgtgtgtt
    12301 atcccgcagt ccgcgacaac gtagggaaac atagaccaat cagcgtaaga taggtaaaag
    12361 tctcctaacc aaaaggtcca ccaagacttc tgaatgctca gaagtcttaa ttcgcggttt
    12421 atatactata tgatccatcc aggatcacac gtgaactaat cattctgcgg acgctaagga
    12481 ttagtattat cacgtgcgtt ttagtatact taggtatgcc ctagggggcc taaggcgaag
    12541 gtattcggga taggagtcag aaacggccta cgactaatcg ttataaataa tacccgctta
    12601 ctctatagga cggttagtgt gacgcaggaa atagctacct ttctaccggc actaagatta
    12661 cgccctaaat ataggtatat agtaaactac acgtgactat atcctattag taataggata
    12721 gacttaatag cgataagtcc tagtatatta gtaataagtc ctaacttatt agtgatagga
    12781 aggactagat atataaggac actcttttac tattatatat ttagttcttc gcgatta
//
