BGC0001376 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001376 (Streptosporangium sp. FXJ7.131)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T2PKS	1	35,845	High	WS79089A/hexaricin B/hexaricin C	PKS

BGC0001376 - Region 1 - T2PKS

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Location: 1 - 35,845 nt. (total: 35,845 nt) Show pHMM detection rules used

Region on contig edge.

T2PKS: (t2ks and t2clf)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 35,846
Label		BGC0001376

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase oxygenase

AMK51261.1: monooxygenase FAD-binding

smcogs: SMCOG1246: monooxygenase FAD-binding

AMK51268.1: oxidoreductase

smcogs: SMCOG1083: oxidoreductase

AMK51269.1: oxidoreductase

smcogs: SMCOG1083: oxidoreductase

AMK51275.1: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

AMK51276.1: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

AMK51284.1: 3-hydroxyisobutyrate dehydrogenase

smcogs: SMCOG1100: 3-hydroxyisobutyrate dehydrogenase

AMK51285.1: dehydrogenase

smcogs: SMCOG1222: dehydrogenase

AMK51286.1: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

AMK51287.1: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

AMK51289.1: oxidoreductase

smcogs: SMCOG1083: oxidoreductase

Transferases: halogenase methyltransferase

AMK51264.1: O-methyltransferase

smcogs: SMCOG1042: O-methyltransferase

AMK51266.1: O-methyltransferase

smcogs: SMCOG1042: O-methyltransferase

AMK51270.1: flavin-dependent cycline orsellinic halogenase

halogenases: flavin-dependent cycline orsellinic halogenase
MITE: MITE0000024Halogenation (identity: 74.10%)
smcogs: SMCOG1119: halogenase

Hydrolases: hydrolase

AMK51263.1: asparagine synthase (glutamine-hydrolyzing)

smcogs: SMCOG1177: asparagine synthase (glutamine-hydrolyzing)

Lyases: cyclase

AMK51278.1: cyclase/dehydrase

smcogs: SMCOG1128: cyclase/dehydrase

AMK51283.1: Polyketide synthesis cyclase

smcogs: SMCOG1225: Polyketide synthesis cyclase

Ligases: synthase

AMK51280.1: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

AMK51281.1: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001376.5	1.00	PKS	WS79089A, hexaricin B, hexaricin C	Streptosporangium sp. FXJ7.131
BGC0002732.3	0.90	PKS	WS 79089B, benaphthamycin, WS 79089D, WS 79089A, WS 79089C	Streptosporangium roseum DSM 43021
BGC0002608.2	0.77	NRPS, PKS	ochratoxin A	Aspergillus steynii
BGC0002341.2	0.77	other (other)	3,5-dibromo-p-anisic acid	Planctomycetales bacterium 10988
BGC0000231.5	0.71	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0000234.5	0.61	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0001160.5	0.60	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001164.3	0.59	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0002276.2	0.58	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0000272.3	0.56	PKS	spore pigment	Streptomyces collinus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001376.5	1.00	PKS	WS79089A, hexaricin B, hexaricin C	Streptosporangium sp. FXJ7.131
BGC0002732.3	0.90	PKS	WS 79089B, benaphthamycin, WS 79089D, WS 79089A, WS 79089C	Streptosporangium roseum DSM 43021
BGC0002608.2	0.77	NRPS, PKS	ochratoxin A	Aspergillus steynii
BGC0002341.2	0.77	other (other)	3,5-dibromo-p-anisic acid	Planctomycetales bacterium 10988
BGC0000231.5	0.71	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0000234.5	0.61	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0001160.5	0.60	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001164.3	0.59	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0002276.2	0.58	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0000272.3	0.56	PKS	spore pigment	Streptomyces collinus

Similar known clusters from MIBiG 4.0

Detailed domain annotation

Selected features only

Show module domains

Type II PKS

Type II PKS gene cluster prediction details

Cluster section:: 0 to 35845
Starter unit(s):: malonamyl-CoA (Score: 627.0; E-value: 0)
Malonyl elongations:: 11|12 (Score: 707.9; E-value: 6.8e-216)
Product class(es):: pentangular polyphenol
Product molecular weight(s):: malonamyl-CoA_11: 588 Da
malonamyl-CoA_12: 630 Da

AMK51263.1: AMID (Score: 853.2; E-value: 2.2e-259); AMID ELQ83270.1_Oxytetracycline_malonamyl-CoA (Score: 627.0; E-value: 0.0)
AMK51264.1: MET C13O|C17O (Score: 423.2; E-value: 1.3e-129)
AMK51266.1: MET C13O|C17O (Score: 467.5; E-value: 4.8e-143)
AMK51267.1: OXY (Score: 37.6; E-value: 3.2e-12)
AMK51270.1: HAL (Score: 638.1; E-value: 1.8e-194)
AMK51275.1: OXY (Score: 312.4; E-value: 1.4e-95)
AMK51276.1: KR C19 (Score: 392.7; E-value: 1.6e-120)
AMK51278.1: CYC C9-C14 (Score: 264.5; E-value: 5.3e-82)
AMK51279.1: ACP (Score: 106.3; E-value: 1.4e-33)
AMK51280.1: CLF 11|12 (Score: 707.9; E-value: 6.8e-216)
AMK51281.1: KS (Score: 767.9; E-value: 5.3e-234)
AMK51282.1: CYC C5-C18 (Score: 205.5; E-value: 5.3e-64)
AMK51283.1: CYC C4-C21/C2-C23|C2-C19 (Score: 181.2; E-value: 9.1e-57)
AMK51286.1: KR (Score: 212.3; E-value: 2.2e-65)
AMK51287.1: KR C11 (Score: 358.8; E-value: 3.2e-110)