BGC0001377: uncialamycin biosynthetic gene cluster from Streptomyces uncialis
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Location: 1 - 45,001 nt. (total: 45,001 nt).
This entry is originally from NCBI GenBank KT762610.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001377
Short description uncialamycin biosynthetic gene cluster from Streptomyces uncialis
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Unknown)
Loci
KT762610.1
via
Compounds
  • uncialamycin
Species Streptomyces uncialis [taxonomy]
References
Chemical products information
uncialamycin Evidence:
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C26H17N1O6
Chemical database entries
NPAtlas
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AMK92551.1
 820 - 1356 (-) alpha-L-arabinofuranosidase
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    • AMK92552.1
    		 1518 - 4265 (-) hypothetical protein
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      • AMK92553.1
      		 4826 - 5890 (+) 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase
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        • AMK92554.1
        • ucmF
        		 6048 - 6701 (-) hypothetical protein
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          • AMK92555.1
          • ucmD
          		 6745 - 8064 (-) PBS lyase HEAT-like repeat protein
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            • AMK92556.1
            • ucmC
            		 8138 - 9406 (-) ketone reductase
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              • AMK92557.1
              • ucmR3
              		 9440 - 10750 (-) hypothetical protein
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                • AMK92558.1
                • ucmT2
                		 11041 - 12675 (-) MFS transporter
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                  • AMK92559.1
                  • ucmE10
                  		 12717 - 13151 (-) type II thioesterase
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                    • AMK92560.1
                    • ucmE
                    		 13144 - 18996 (-) enediyne polyketide synthase
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                      • AMK92561.1
                      • ucmE5
                      		 18993 - 19994 (-) hypothetical protein
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                        • AMK92562.1
                        • ucmE4
                        		 19991 - 21940 (-) hypothetical protein
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                          • AMK92563.1
                          • ucmE3
                          		 21955 - 22938 (-) hypothetical protein
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                            • AMK92564.1
                            • ucmS3
                            		 23486 - 23860 (+) glyoxalase/bleomycin resistance protein/dioxygenase
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                              • AMK92565.1
                              • ucmR4
                              		 24216 - 24752 (+) Arac family transcriptional regulator
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                                • AMK92566.1
                                • ucmS2
                                		 24795 - 25202 (+) glyoxalase/bleomycin resistance protein/dioxygenase
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                                  • AMK92567.1
                                  • ucmT1
                                  		 25230 - 26894 (+) tetracenomycin c resistance and export protein
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                                    • AMK92568.1
                                    • ucmS1
                                    		 26972 - 27352 (+) glyoxalase/bleomycin resistance protein/dioxygenase
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                                      • AMK92569.1
                                      • ucmR2
                                      		 27437 - 28765 (-) hypothetical protein
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                                        • AMK92570.1
                                        • ucmP
                                        		 28808 - 29950 (-) FAD-dependent oxidoreductase
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                                          • AMK92571.1
                                          • ucmO
                                          		 29947 - 30468 (-) putative hydroxylase
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                                            • AMK92572.1
                                            • ucmN
                                            		 30521 - 30997 (-) putative hydroxylase
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                                              • AMK92573.1
                                              • ucmM
                                              		 31212 - 32234 (+) rieske (2Fe-2S) iron-sulfur domain protein
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                                                • AMK92574.1
                                                • ucmK2
                                                		 32300 - 33739 (-) hydrolase
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                                                  • AMK92575.1
                                                  • ucmK1
                                                  		 33736 - 35244 (-) hydrolase
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                                                    • AMK92576.1
                                                    • ucmJ
                                                    		 35294 - 36364 (-) SAM-dependent methyltransferase
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                                                      • AMK92577.1
                                                      • ucmR1
                                                      		 36590 - 37297 (+) hypothetical protein
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                                                        • AMK92578.1
                                                        • ucmI
                                                        		 37382 - 38173 (+) oxidoreductase
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                                                          • AMK92579.1
                                                          • ucmG
                                                          		 38402 - 40612 (-) hypothetical protein
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                                                            • AMK92580.1
                                                            • ucmB
                                                            		 40958 - 41848 (+) enediyne self-sacrifice resistance protein
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                                                              • AMK92581.1
                                                              • ucmR7
                                                              		 41906 - 42751 (+) Arac family transcriptional regulator
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                                                                • AMK92582.1
                                                                		 43509 - 44027 (+) pyridoxamine 5'-phosphate oxidase
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                                                                  Biosynthesis information
                                                                  Annotation changelog

                                                                  Entry version: 4

                                                                  Date
                                                                  Changes
                                                                  Submitters
                                                                  Reviewers
                                                                  2022-10-07
                                                                  Update chemical activity to schema version 2.11
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                  Entry version: 3

                                                                  Date
                                                                  Changes
                                                                  Submitters
                                                                  Reviewers
                                                                  2022-09-15
                                                                  Merged publication from duplicate entry BGC0001815
                                                                  • (ID: SJG3CBEHSM6A3I74YXLH6GLA)
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                  2022-09-15
                                                                  Updated bioactivity data
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                  Entry version: 2

                                                                  Date
                                                                  Changes
                                                                  Submitters
                                                                  Reviewers
                                                                  2019-10-16
                                                                  Migrated from v1.4
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                  2019-10-16
                                                                  Updated compound(s) information (NPAtlas curation)
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                  Entry version: 1

                                                                  Date
                                                                  Changes
                                                                  Submitters
                                                                  Reviewers
                                                                  2016-09-03
                                                                  Submitted
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                  Detailed domain annotation
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