BGC0001377: uncialamycin biosynthetic gene cluster from Streptomyces uncialis
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Location: 1 - 45,001 nt. (total: 45,001 nt).
This entry is originally from NCBI GenBank KT762610.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
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NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001377
Short description uncialamycin biosynthetic gene cluster from Streptomyces uncialis
Status Minimal annotation: yes
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Polyketide
Loci NCBI GenBank: KT762610.1
Compounds
  • uncialamycin
Species Streptomyces uncialis [taxonomy]
References
Chemical products information
uncialamycin
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C26H17N1O6
Chemical database entries
NPAtlas
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AMK92551.1
 820 - 1356 (-) alpha-L-arabinofuranosidase
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  • AMK92552.1
 1518 - 4265 (-) hypothetical protein
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  • AMK92553.1
 4826 - 5890 (+) 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase
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  • AMK92554.1
  • ucmF
 6048 - 6701 (-) hypothetical protein
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  • AMK92555.1
  • ucmD
 6745 - 8064 (-) PBS lyase HEAT-like repeat protein
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  • AMK92556.1
  • ucmC
 8138 - 9406 (-) ketone reductase
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  • AMK92557.1
  • ucmR3
 9440 - 10750 (-) hypothetical protein
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  • AMK92558.1
  • ucmT2
 11041 - 12675 (-) MFS transporter
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  • AMK92559.1
  • ucmE10
 12717 - 13151 (-) type II thioesterase
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  • AMK92560.1
  • ucmE
 13144 - 18996 (-) enediyne polyketide synthase
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  • AMK92561.1
  • ucmE5
 18993 - 19994 (-) hypothetical protein
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  • AMK92562.1
  • ucmE4
 19991 - 21940 (-) hypothetical protein
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  • AMK92563.1
  • ucmE3
 21955 - 22938 (-) hypothetical protein
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  • AMK92564.1
  • ucmS3
 23486 - 23860 (+) glyoxalase/bleomycin resistance protein/dioxygenase
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  • AMK92565.1
  • ucmR4
 24216 - 24752 (+) Arac family transcriptional regulator
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  • AMK92566.1
  • ucmS2
 24795 - 25202 (+) glyoxalase/bleomycin resistance protein/dioxygenase
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  • AMK92567.1
  • ucmT1
 25230 - 26894 (+) tetracenomycin c resistance and export protein
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  • AMK92568.1
  • ucmS1
 26972 - 27352 (+) glyoxalase/bleomycin resistance protein/dioxygenase
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  • AMK92569.1
  • ucmR2
 27437 - 28765 (-) hypothetical protein
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  • AMK92570.1
  • ucmP
 28808 - 29950 (-) FAD-dependent oxidoreductase
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  • AMK92571.1
  • ucmO
 29947 - 30468 (-) putative hydroxylase
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  • AMK92572.1
  • ucmN
 30521 - 30997 (-) putative hydroxylase
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  • AMK92573.1
  • ucmM
 31212 - 32234 (+) rieske (2Fe-2S) iron-sulfur domain protein
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  • AMK92574.1
  • ucmK2
 32300 - 33739 (-) hydrolase
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  • AMK92575.1
  • ucmK1
 33736 - 35244 (-) hydrolase
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  • AMK92576.1
  • ucmJ
 35294 - 36364 (-) SAM-dependent methyltransferase
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  • AMK92577.1
  • ucmR1
 36590 - 37297 (+) hypothetical protein
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  • AMK92578.1
  • ucmI
 37382 - 38173 (+) oxidoreductase
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  • AMK92579.1
  • ucmG
 38402 - 40612 (-) hypothetical protein
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  • AMK92580.1
  • ucmB
 40958 - 41848 (+) enediyne self-sacrifice resistance protein
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  • AMK92581.1
  • ucmR7
 41906 - 42751 (+) Arac family transcriptional regulator
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  • AMK92582.1
 43509 - 44027 (+) pyridoxamine 5'-phosphate oxidase
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Annotation changelog
MIBiG version Submitter Notes
1.3
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: SJG3CBEHSM6A3I74YXLH6GLA, no GDPR consent given).
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Merged publication from duplicate entry BGC0001815
  • Updated bioactivity data
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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