Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0001377.1:
Cluster 1Polyketide145001

BGC0001377, uncialamycin biosynthetic gene cluster from Streptomyces uncialis. Locus 1. Partial MIBiG entry.

Chemical compounds

Compound: uncialamycin
PubChem ID: 16744765
SMILES string: Copy to clipboard
Molecular formula: C26H17NO6
Average molecular mass: 439.423 Da

Class-specific details

Biosynthetic class(es):
Polyketide synthase subclass:
Modular Type I

Gene cluster description

uncialamycin (BGC0001377). Gene Cluster 1. Biosynthetic class = Polyketide. GenBank KT762610. Click on genes for more information.


biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

Literature references

1. Ge HM et al. (2014) Enediyne polyketide synthases stereoselectively reduce the beta-ketoacyl intermediates to beta-D-hydroxyacyl intermediates in enediyne core biosynthesis. Org Lett 16(15):3958-61. doi: 10.1021/ol501767v. Epub 2014 Jul 14.