BGC0001381: brasilinolide A biosynthetic gene cluster from Nocardia terpenica
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Location: 1 - 210,303 nt. (total: 210,303 nt).
This entry is originally from NCBI GenBank KP161205.1, but has been modified (see Modifications tab for details).

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General
Compounds
Genes
Biosynthesis
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KnownClusterBlast
NRPS/PKS domains
Modifications
General information about the BGC

MIBiG accession | BGC0001381
Short description | brasilinolide A biosynthetic gene cluster from Nocardia terpenica
Status | Quality: questionable The quality level of this entry. Status: active The status of this entry. Completeness: unknown Whether the entry covers everything needed for the pathway producing the compound(s)

Biosynthetic class(es)

- PKS (Unknown)

Loci
KP161205.1
via
Compounds

- brasilinolide A
- brasilinolide B
- brasilinolide C

Species Nocardia terpenica [taxonomy]
References

- [1] Target-specific identification and characterization of the putative gene cluster for brasilinolide biosynthesis revealing the mechanistic insights and combinatorial synthetic utility of 2-deoxy-l-fucose biosynthetic enzymes. Chiu HT et al., Org Biomol Chem (2016) PMID:26754528

Chemical products information
brasilinolide A Evidence:
Copy SMILES
C57H98O24
Chemical database entries
NPAtlas
PubCHEM
brasilinolide B Evidence:
Copy SMILES
C59H104O23
Chemical database entries
NPAtlas
PubCHEM
brasilinolide C Evidence:
Copy SMILES
C49H88O20
Chemical database entries
NPAtlas
List of genes involved in compound(s) production

Identifiers | Position | Product | Functions | Evidence | Extra
--- | --- | --- | --- | --- | ---
AJO72694.1 | <1 - 516 (-) | hypothetical protein |  |  | copy AA seq copy Nt seq
AJO72695.1 | 513 - 1166 (-) | hypothetical protein |  |  | copy AA seq copy Nt seq
AJO72696.1 | 1498 - 2325 (+) | Peptidase |  |  | copy AA seq copy Nt seq
AJO72697.1 | 2322 - 2885 (-) | Tellurite resistance protein |  |  | copy AA seq copy Nt seq
AJO72698.1 nbrT4 | 3082 - 3774 (-) | Major intrinsic protein/permease |  |  | copy AA seq copy Nt seq
AJO72699.1 nbrR6 | 3942 - 4553 (+) | TetR family transcriptional regulator |  |  | copy AA seq copy Nt seq
AJO72700.1 | 4534 - 5418 (-) | SAM-dependent methyltransferase |  |  | copy AA seq copy Nt seq
AJO72701.1 | 5476 - 6081 (+) | HAD-superfamily hydrolase |  |  | copy AA seq copy Nt seq
AJO72702.1 | 6404 - 9877 (+) | Acyl-CoA ligase/oxidoreductase |  |  | copy AA seq copy Nt seq
AJO72703.1 | 10491 - 11714 (+) | Kynureninase |  |  | copy AA seq copy Nt seq
AJO72704.1 | 11829 - 12791 (-) | Glyoxalase/antibiotic resistance protein/dioxygenase |  |  | copy AA seq copy Nt seq
AJO72705.1 | 12784 - 14529 (-) | Monooxygenase |  |  | copy AA seq copy Nt seq
AJO72706.1 nbrR5 | 14638 - 15429 (+) | IclR family transcriptional regulator |  |  | copy AA seq copy Nt seq
AJO72707.1 nbrR4 | 15543 - 15905 (-) | Lsr2-like protein |  |  | copy AA seq copy Nt seq
AJO72708.1 nbrR3 | 16234 - 17172 (-) | MerR family transcriptional regulator |  |  | copy AA seq copy Nt seq
AJO72709.1 | 17299 - 17736 (+) | hypothetical protein |  |  | copy AA seq copy Nt seq
AJO72710.1 nbrR2 | 17751 - 18866 (-) | AbrB family membrane protein/regulator |  |  | copy AA seq copy Nt seq
AJO72711.1 | 18872 - 19354 (+) | hypothetical protein |  |  | copy AA seq copy Nt seq
AJO72712.1 | 19363 - 22830 (-) | DNA-directed RNA polymerase subunit beta |  |  | copy AA seq copy Nt seq
AJO72713.1 | 23101 - 23499 (+) | hypothetical protein |  |  | copy AA seq copy Nt seq
AJO72714.1 | 23607 - 23957 (-) | hypothetical protein |  |  | copy AA seq copy Nt seq
AJO72715.1 nbrR1 | 24299 - 25051 (+) | LuxR family transcriptional regulator |  |  | copy AA seq copy Nt seq
AJO72716.1 nbrP | 25110 - 26342 (-) | Cytochrome P450 monooxygenase |  |  | copy AA seq copy Nt seq
AJO72717.1 | 26559 - 29669 (+) | adenylation domain-containing protein |  |  | copy AA seq copy Nt seq
AJO72718.1 nbrT3 | 29666 - 30511 (+) | ABC-2 type transporter |  |  | copy AA seq copy Nt seq
AJO72719.1 nbrD | 30516 - 31502 (+) | dTDP-4-keto-6-deoxy-hexose 2,3-reductase |  |  | copy AA seq copy Nt seq
AJO72720.1 nbrE | 31528 - 32133 (+) | dTDP-4-keto-6-deoxy-hexose 3,5-epimerase |  |  | copy AA seq copy Nt seq
AJO72721.1 nbrF | 32147 - 33088 (+) | dTDP-4-keto-6-deoxy-hexose 4-ketoreductase |  |  | copy AA seq copy Nt seq
AJO72722.1 nbrT1 | 33248 - 34228 (+) | Antibiotic ABC transporter ATPase |  |  | copy AA seq copy Nt seq
AJO72723.1 nbrT2 | 34225 - 35064 (+) | ABC-2 type transporter |  |  | copy AA seq copy Nt seq
AJO72724.1 nbrC | 35092 - 36513 (+) | dTDP-4-keto-6-deoxy-hexose 2,3-dehydratase |  |  | copy AA seq copy Nt seq
AJO72725.1 nbrM | 36517 - 37152 (-) | Thymidylate kinase |  |  | copy AA seq copy Nt seq
AJO72726.1 | 37342 - 38442 (-) | hypothetical protein |  |  | copy AA seq copy Nt seq
AJO72727.1 nbrS1 | 38714 - 39982 (-) | PapA5 Acyltransferase |  |  | copy AA seq copy Nt seq
AJO72728.1 nbrQ1 | 40001 - 41107 (-) | AMP-binding protein |  |  | copy AA seq copy Nt seq
AJO72729.1 nbrQ2 | 41104 - 42534 (-) | MmgE/PrpD family protein |  |  | copy AA seq copy Nt seq
AJO72730.1 nbrQ3 | 42531 - 43370 (-) | putative cyclase |  |  | copy AA seq copy Nt seq
AJO72731.1 nbrQ4 | 43367 - 44248 (-) | putative Citrate lyase beta subunit |  |  | copy AA seq copy Nt seq
AJO72732.1 nbrQ5 | 44245 - 45447 (-) | Acyl-CoA transferase |  |  | copy AA seq copy Nt seq
AJO72733.1 nbrS2 | 45654 - 47003 (+) | Type B carboxylesterase/acyltransferase |  |  | copy AA seq copy Nt seq
AJO72734.1 nbrK | 47333 - 60052 (+) | Type I modular polyketide synthase |  |  | copy AA seq copy Nt seq
AJO72735.1 nbrL | 60104 - 74758 (+) | Type I modular polyketide synthase |  |  | copy AA seq copy Nt seq
AJO72736.1 nbrG | 74836 - 99387 (+) | Type I modular polyketide synthase |  |  | copy AA seq copy Nt seq
AJO72737.1 nbrH | 99416 - 119593 (+) | Type I modular polyketide synthase |  |  | copy AA seq copy Nt seq
AJO72738.1 nbrA | 119605 - 120864 (+) | Glycosyltransferase |  |  | copy AA seq copy Nt seq
AJO72739.1 nbrR7 | 120914 - 121648 (+) | TetR/AcrR family transcriptional regulator |  |  | copy AA seq copy Nt seq
AJO72740.1 nbrB | 122135 - 123346 (+) | MGT family glycosyltransferase |  |  | copy AA seq copy Nt seq
AJO72741.1 nbrV | 123429 - 124703 (+) | Cytochrome P450 monooxygenase |  |  | copy AA seq copy Nt seq
AJO72742.1 nbrI | 124717 - 135606 (+) | Type I modular polyketide synthase |  |  | copy AA seq copy Nt seq
AJO72743.1 nbrJ | 135628 - 144387 (+) | Type I modular polyketide synthase |  |  | copy AA seq copy Nt seq
AJO72744.1 nbrO | 144496 - 145248 (+) | Type II thioesterase |  |  | copy AA seq copy Nt seq
AJO72745.1 nbrS3 | 145963 - 146778 (+) | alpha/beta-Hydrolase or acyltransferase |  |  | copy AA seq copy Nt seq
AJO72746.1 nbrN | 146982 - 147848 (-) | Glucose-1-phosphate thymidylyltransferase |  |  | copy AA seq copy Nt seq
AJO72747.1 nbrT5 | 147888 - 148652 (-) | putative membrane protein |  |  | copy AA seq copy Nt seq
AJO72748.1 nbrR8 | 150022 - 151659 (+) | LuxR family transcriptional regulator |  |  | copy AA seq copy Nt seq
AJO72749.1 | 151839 - 153368 (+) | Polyprenyl phospho-mannosyltransferase |  |  | copy AA seq copy Nt seq
AJO72750.1 nbrR9 | 154077 - 154697 (-) | TetR family transcriptional regulator |  |  | copy AA seq copy Nt seq
AJO72751.1 | 154819 - 157857 (+) | alpha-Mannosidase |  |  | copy AA seq copy Nt seq
AJO72752.1 nbrU | 158110 - 159432 (+) | Crotonyl-CoA carboxylase/reductase |  |  | copy AA seq copy Nt seq
AJO72753.1 | 159461 - 160114 (+) | HAD-superfamily hydrolase |  |  | copy AA seq copy Nt seq
AJO72754.1 | 160578 - 161561 (-) | beta-Ribofuranosylaminobenzene 5'-phosphate synthase |  |  | copy AA seq copy Nt seq
AJO72755.1 | 161609 - 162610 (-) | Phosphoribosylaminoimidazole-succinocarboxamide synthase |  |  | copy AA seq copy Nt seq
AJO72756.1 | 162812 - 164419 (-) | Fumarate reductase/succinate dehydrogenase |  |  | copy AA seq copy Nt seq
AJO72757.1 | 164452 - 165021 (-) | NADPH-dependent FMN reductase |  |  | copy AA seq copy Nt seq
AJO72758.1 | 165060 - 166241 (-) | amidohydrolase |  |  | copy AA seq copy Nt seq
AJO72759.1 nbrT6 | 166241 - 167449 (-) | MFS transporter |  |  | copy AA seq copy Nt seq
AJO72760.1 | 167484 - 168914 (-) | Adenylosuccinate lyase |  |  | copy AA seq copy Nt seq
AJO72761.1 | 168926 - 170152 (-) | Arene(phthalate) dioxygenase |  |  | copy AA seq copy Nt seq
AJO72762.1 | 170169 - 172199 (-) | Methionine-tRNA ligase |  |  | copy AA seq copy Nt seq
AJO72763.1 | 172196 - 173524 (-) | L-Lysine 6-monooxygenase |  |  | copy AA seq copy Nt seq
AJO72764.1 | 173521 - 174723 (-) | Saccharopine dehydrogenase |  |  | copy AA seq copy Nt seq
AJO72765.1 | 174734 - 175984 (-) | Phosphoribosylglycinamide synthetase |  |  | copy AA seq copy Nt seq
AJO72766.1 | 176152 - 177261 (+) | (Glycated) amino acid oxidase |  |  | copy AA seq copy Nt seq
AJO72767.1 | 177675 - 178697 (+) | Monooxygenase |  |  | copy AA seq copy Nt seq
AJO72768.1 | 178703 - 180025 (+) | Monooxygenase |  |  | copy AA seq copy Nt seq
AJO72769.1 nbrR10 | 180039 - 180935 (+) | Transcriptional regulator |  |  | copy AA seq copy Nt seq
AJO72770.1 | 181132 - 181593 (+) | hypothetical protein |  |  | copy AA seq copy Nt seq
AJO72771.1 | 181620 - 182345 (-) | hypothetical protein |  |  | copy AA seq copy Nt seq
AJO72772.1 | 182812 - 183363 (-) | ArsR family transcriptional regulator |  |  | copy AA seq copy Nt seq
AJO72773.1 | 183454 - 184719 (+) | hypothetical protein |  |  | copy AA seq copy Nt seq
AJO72774.1 | 185177 - 185617 (-) | MarR family transcriptional regulator |  |  | copy AA seq copy Nt seq
AJO72775.1 | 186303 - 186608 (+) | hypothetical protein |  |  | copy AA seq copy Nt seq
AJO72776.1 | 186605 - 188671 (+) | hypothetical protein |  |  | copy AA seq copy Nt seq
AJO72777.1 | 188668 - 189021 (+) | hypothetical protein |  |  | copy AA seq copy Nt seq
AJO72778.1 | 189241 - 189792 (+) | hypothetical protein |  |  | copy AA seq copy Nt seq
AJO72779.1 | 189797 - 190243 (+) | YbaB/EbfC DNA-binding protein |  |  | copy AA seq copy Nt seq
AJO72780.1 | 190325 - 190648 (+) | putative surface-exposed protein |  |  | copy AA seq copy Nt seq
AJO72781.1 | 190664 - 191674 (+) | hypothetical protein |  |  | copy AA seq copy Nt seq
AJO72782.1 | 192408 - 193742 (-) | hypothetical protein |  |  | copy AA seq copy Nt seq
AJO72783.1 | 194523 - 195779 (-) | hypothetical protein |  |  | copy AA seq copy Nt seq
AJO72784.1 | 195964 - 196494 (+) | hypothetical protein |  |  | copy AA seq copy Nt seq
AJO72785.1 | 198311 - 199093 (+) | hypothetical protein |  |  | copy AA seq copy Nt seq
AJO72786.1 | 199483 - 200106 (+) | hypothetical protein |  |  | copy AA seq copy Nt seq
AJO72787.1 | 200185 - 200553 (+) | hypothetical protein |  |  | copy AA seq copy Nt seq
AJO72788.1 | 201103 - 201591 (+) | hypothetical protein |  |  | copy AA seq copy Nt seq
AJO72789.1 | 202274 - 202546 (-) | hypothetical protein |  |  | copy AA seq copy Nt seq
AJO72790.1 | 202685 - 203083 (-) | hypothetical protein |  |  | copy AA seq copy Nt seq
AJO72791.1 | 204148 - 205044 (+) | Lipase |  |  | copy AA seq copy Nt seq
AJO72792.1 Putative_phenazine_biosynthesis_protein | 206736 - 207920 (+) | Adenylase |  |  | copy AA seq copy Nt seq
AJO72793.1 Putative_phenazine_biosynthesis_protein_rename1 | 207920 - 209344 (+) | Arylcarboxylate reductase |  |  | copy AA seq copy Nt seq
AJO72794.1 | 209327 - 210082 (-) | putative antiporter/lipoprotein |  |  | copy AA seq copy Nt seq

Biosynthesis information

No biosynthesis information available for this record.

Annotation changelog

#### Entry version: 4

Date
Changes
Submitters
Reviewers
2022-10-07
Update chemical activity to schema version 2.11

- (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

- (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

#### Entry version: 3

Date
Changes
Submitters
Reviewers
2022-09-15
Updated bioactivity data

- (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

- (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

#### Entry version: 2

Date
Changes
Submitters
Reviewers
2019-10-16
Migrated from v1.4

- (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

- (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

2019-10-16
Updated compound(s) information (NPAtlas curation)

- (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

- (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

#### Entry version: 1

Date
Changes
Submitters
Reviewers
2016-09-03
Submitted

- (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

- (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

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Modifications to original record

- renamed CDS with name Putative_phenazine_biosynthesis_protein at [207919:209344](+) to Putative_phenazine_biosynthesis_protein_rename1 to avoid duplicates