BGC0001381: brasilinolide A biosynthetic gene cluster from Nocardia terpenica
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Location: 1 - 210,303 nt. (total: 210,303 nt).
This entry is originally from NCBI GenBank KP161205.1, but has been modified (see Modifications tab for details).

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
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resistance
TTA codons
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Gene details
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General
Compounds
Genes
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NRPS/PKS domains
KnownClusterBlast
Modifications
General information about the BGC
MIBiG accession BGC0001381
Short description brasilinolide A biosynthetic gene cluster from Nocardia terpenica
Status Minimal annotation: yes
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Polyketide
Loci NCBI GenBank: KP161205.1
Compounds
  • brasilinolide A
  • brasilinolide B
  • brasilinolide C
Species Nocardia terpenica [taxonomy]
References
Chemical products information
brasilinolide A
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C57H98O24
Chemical database entries
NPAtlas
PubCHEM
brasilinolide B
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C59H104O23
Chemical database entries
NPAtlas
PubCHEM
brasilinolide C
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C49H88O20
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AJO72694.1
 1 - 516 (-) hypothetical protein
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  • AJO72695.1
 513 - 1166 (-) hypothetical protein
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  • AJO72696.1
 1498 - 2325 (+) Peptidase
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  • AJO72697.1
 2322 - 2885 (-) Tellurite resistance protein
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  • AJO72698.1
  • nbrT4
 3082 - 3774 (-) Major intrinsic protein/permease
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  • AJO72699.1
  • nbrR6
 3942 - 4553 (+) TetR family transcriptional regulator
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  • AJO72700.1
 4534 - 5418 (-) SAM-dependent methyltransferase
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  • AJO72701.1
 5476 - 6081 (+) HAD-superfamily hydrolase
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  • AJO72702.1
 6404 - 9877 (+) Acyl-CoA ligase/oxidoreductase
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  • AJO72703.1
 10491 - 11714 (+) Kynureninase
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  • AJO72704.1
 11829 - 12791 (-) Glyoxalase/antibiotic resistance protein/dioxygenase
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  • AJO72705.1
 12784 - 14529 (-) Monooxygenase
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  • AJO72706.1
  • nbrR5
 14638 - 15429 (+) IclR family transcriptional regulator
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  • AJO72707.1
  • nbrR4
 15543 - 15905 (-) Lsr2-like protein
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  • AJO72708.1
  • nbrR3
 16234 - 17172 (-) MerR family transcriptional regulator
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  • AJO72709.1
 17299 - 17736 (+) hypothetical protein
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  • AJO72710.1
  • nbrR2
 17751 - 18866 (-) AbrB family membrane protein/regulator
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  • AJO72711.1
 18872 - 19354 (+) hypothetical protein
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  • AJO72712.1
 19363 - 22830 (-) DNA-directed RNA polymerase subunit beta
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  • AJO72713.1
 23101 - 23499 (+) hypothetical protein
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  • AJO72714.1
 23607 - 23957 (-) hypothetical protein
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  • AJO72715.1
  • nbrR1
 24299 - 25051 (+) LuxR family transcriptional regulator
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  • AJO72716.1
  • nbrP
 25110 - 26342 (-) Cytochrome P450 monooxygenase
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  • AJO72717.1
 26559 - 29669 (+) adenylation domain-containing protein
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  • AJO72718.1
  • nbrT3
 29666 - 30511 (+) ABC-2 type transporter
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  • AJO72719.1
  • nbrD
 30516 - 31502 (+) dTDP-4-keto-6-deoxy-hexose 2,3-reductase
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  • AJO72720.1
  • nbrE
 31528 - 32133 (+) dTDP-4-keto-6-deoxy-hexose 3,5-epimerase
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  • AJO72721.1
  • nbrF
 32147 - 33088 (+) dTDP-4-keto-6-deoxy-hexose 4-ketoreductase
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  • AJO72722.1
  • nbrT1
 33248 - 34228 (+) Antibiotic ABC transporter ATPase
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  • AJO72723.1
  • nbrT2
 34225 - 35064 (+) ABC-2 type transporter
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  • AJO72724.1
  • nbrC
 35092 - 36513 (+) dTDP-4-keto-6-deoxy-hexose 2,3-dehydratase
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  • AJO72725.1
  • nbrM
 36517 - 37152 (-) Thymidylate kinase
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  • AJO72726.1
 37342 - 38442 (-) hypothetical protein
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  • AJO72727.1
  • nbrS1
 38714 - 39982 (-) PapA5 Acyltransferase
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  • AJO72728.1
  • nbrQ1
 40001 - 41107 (-) AMP-binding protein
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  • AJO72729.1
  • nbrQ2
 41104 - 42534 (-) MmgE/PrpD family protein
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  • AJO72730.1
  • nbrQ3
 42531 - 43370 (-) putative cyclase
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  • AJO72731.1
  • nbrQ4
 43367 - 44248 (-) putative Citrate lyase beta subunit
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  • AJO72732.1
  • nbrQ5
 44245 - 45447 (-) Acyl-CoA transferase
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  • AJO72733.1
  • nbrS2
 45654 - 47003 (+) Type B carboxylesterase/acyltransferase
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  • AJO72734.1
  • nbrK
 47333 - 60052 (+) Type I modular polyketide synthase
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  • AJO72735.1
  • nbrL
 60104 - 74758 (+) Type I modular polyketide synthase
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  • AJO72736.1
  • nbrG
 74836 - 99387 (+) Type I modular polyketide synthase
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  • AJO72737.1
  • nbrH
 99416 - 119593 (+) Type I modular polyketide synthase
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  • AJO72738.1
  • nbrA
 119605 - 120864 (+) Glycosyltransferase
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  • AJO72739.1
  • nbrR7
 120914 - 121648 (+) TetR/AcrR family transcriptional regulator
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  • AJO72740.1
  • nbrB
 122135 - 123346 (+) MGT family glycosyltransferase
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  • AJO72741.1
  • nbrV
 123429 - 124703 (+) Cytochrome P450 monooxygenase
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  • AJO72742.1
  • nbrI
 124717 - 135606 (+) Type I modular polyketide synthase
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  • AJO72743.1
  • nbrJ
 135628 - 144387 (+) Type I modular polyketide synthase
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  • AJO72744.1
  • nbrO
 144496 - 145248 (+) Type II thioesterase
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  • AJO72745.1
  • nbrS3
 145963 - 146778 (+) alpha/beta-Hydrolase or acyltransferase
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  • AJO72746.1
  • nbrN
 146982 - 147848 (-) Glucose-1-phosphate thymidylyltransferase
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  • AJO72747.1
  • nbrT5
 147888 - 148652 (-) putative membrane protein
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  • AJO72748.1
  • nbrR8
 150022 - 151659 (+) LuxR family transcriptional regulator
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  • AJO72749.1
 151839 - 153368 (+) Polyprenyl phospho-mannosyltransferase
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  • AJO72750.1
  • nbrR9
 154077 - 154697 (-) TetR family transcriptional regulator
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  • AJO72751.1
 154819 - 157857 (+) alpha-Mannosidase
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  • AJO72752.1
  • nbrU
 158110 - 159432 (+) Crotonyl-CoA carboxylase/reductase
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  • AJO72753.1
 159461 - 160114 (+) HAD-superfamily hydrolase
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  • AJO72754.1
 160578 - 161561 (-) beta-Ribofuranosylaminobenzene 5'-phosphate synthase
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  • AJO72755.1
 161609 - 162610 (-) Phosphoribosylaminoimidazole-succinocarboxamide synthase
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  • AJO72756.1
 162812 - 164419 (-) Fumarate reductase/succinate dehydrogenase
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  • AJO72757.1
 164452 - 165021 (-) NADPH-dependent FMN reductase
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  • AJO72758.1
 165060 - 166241 (-) amidohydrolase
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  • AJO72759.1
  • nbrT6
 166241 - 167449 (-) MFS transporter
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  • AJO72760.1
 167484 - 168914 (-) Adenylosuccinate lyase
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  • AJO72761.1
 168926 - 170152 (-) Arene(phthalate) dioxygenase
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  • AJO72762.1
 170169 - 172199 (-) Methionine-tRNA ligase
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  • AJO72763.1
 172196 - 173524 (-) L-Lysine 6-monooxygenase
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  • AJO72764.1
 173521 - 174723 (-) Saccharopine dehydrogenase
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  • AJO72765.1
 174734 - 175984 (-) Phosphoribosylglycinamide synthetase
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  • AJO72766.1
 176152 - 177261 (+) (Glycated) amino acid oxidase
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  • AJO72767.1
 177675 - 178697 (+) Monooxygenase
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  • AJO72768.1
 178703 - 180025 (+) Monooxygenase
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  • AJO72769.1
  • nbrR10
 180039 - 180935 (+) Transcriptional regulator
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  • AJO72770.1
 181132 - 181593 (+) hypothetical protein
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  • AJO72771.1
 181620 - 182345 (-) hypothetical protein
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  • AJO72772.1
 182812 - 183363 (-) ArsR family transcriptional regulator
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  • AJO72773.1
 183454 - 184719 (+) hypothetical protein
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  • AJO72774.1
 185177 - 185617 (-) MarR family transcriptional regulator
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  • AJO72775.1
 186303 - 186608 (+) hypothetical protein
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  • AJO72776.1
 186605 - 188671 (+) hypothetical protein
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  • AJO72777.1
 188668 - 189021 (+) hypothetical protein
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  • AJO72778.1
 189241 - 189792 (+) hypothetical protein
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  • AJO72779.1
 189797 - 190243 (+) YbaB/EbfC DNA-binding protein
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  • AJO72780.1
 190325 - 190648 (+) putative surface-exposed protein
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  • AJO72781.1
 190664 - 191674 (+) hypothetical protein
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  • AJO72782.1
 192408 - 193742 (-) hypothetical protein
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  • AJO72783.1
 194523 - 195779 (-) hypothetical protein
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  • AJO72784.1
 195964 - 196494 (+) hypothetical protein
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  • AJO72785.1
 198311 - 199093 (+) hypothetical protein
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  • AJO72786.1
 199483 - 200106 (+) hypothetical protein
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  • AJO72787.1
 200185 - 200553 (+) hypothetical protein
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  • AJO72788.1
 201103 - 201591 (+) hypothetical protein
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  • AJO72789.1
 202274 - 202546 (-) hypothetical protein
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  • AJO72790.1
 202685 - 203083 (-) hypothetical protein
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  • AJO72791.1
 204148 - 205044 (+) Lipase
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  • AJO72792.1
  • Putative_phenazine_biosynthesis_protein
 206736 - 207920 (+) Adenylase
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  • AJO72793.1
  • Putative_phenazine_biosynthesis_protein_rename1
 207920 - 209344 (+) Arylcarboxylate reductase
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  • AJO72794.1
 209327 - 210082 (-) putative antiporter/lipoprotein
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Annotation changelog
MIBiG version Submitter Notes
1.3
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Updated bioactivity data
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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Modifications to original record
  • renamed CDS with name Putative_phenazine_biosynthesis_protein at [207919:209344](+) to Putative_phenazine_biosynthesis_protein_rename1 to avoid duplicates