BGC0001384: saprolmycin E biosynthetic gene cluster from Streptomyces sp. TK08046
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Location: 1 - 44,148 nt. (total: 44,148 nt).
This entry is originally from NCBI GenBank LC131463.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
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resistance
TTA codons
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General
Compounds
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Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001384
Short description saprolmycin E biosynthetic gene cluster from Streptomyces sp. TK08046
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Unknown)
Loci
LC131463.1
via
Compounds
  • saprolmycin E
Species Streptomyces sp. TK08046 [taxonomy]
References
Chemical products information
saprolmycin E Evidence:
Copy SMILES
C43H48O16
Chemical database entries
NPAtlas
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • BAV16989.1
  • spr1
 2469 - 3950 (-) putative acyltransferase
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    • BAV16990.1
    • sprR1
    		 4092 - 4439 (-) putative transcriptional regulatory protein
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      • BAV16991.1
      • spr2
      		 4751 - 6217 (-) putative MFS transporter
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        • BAV16992.1
        • spr3
        		 6139 - 7257 (-) putative oxidoreductase
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          • BAV16993.1
          • spr4
          		 7365 - 8945 (-) putative transporter
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            • BAV16994.1
            • spr5
            		 8976 - 9575 (-) putative FMN reductase
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              • BAV16995.1
              • sprR2
              		 9694 - 10431 (+) putative tetR-family regulatory protein
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                • BAV16996.1
                • sprA
                		 10484 - 11413 (+) hypothetical protein
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                  • BAV16997.1
                  • sprB
                  		 11762 - 13249 (+) putative oxygenase
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                    • BAV16998.1
                    • sprC
                    		 13263 - 13589 (+) putative cyclase
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                      • BAV16999.1
                      • sprD
                      		 13586 - 14866 (+) putative ketosynthase
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                        • BAV17000.1
                        • sprE
                        		 14863 - 16107 (+) putative chain length determinant factor
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                          • BAV17001.1
                          • sprF
                          		 16104 - 16478 (+) putative acyl carrier protein
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                            • BAV17002.1
                            • sprG
                            		 16648 - 17433 (+) putative ketoreductase
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                              • BAV17003.1
                              • sprH
                              		 17474 - 18409 (+) putative aromatase
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                                • BAV17004.1
                                • sprI
                                		 18412 - 20400 (+) putative oxygenase-reductase
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                                  • BAV17005.1
                                  • sprJ
                                  		 20420 - 21631 (+) putative transporter
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                                    • BAV17006.1
                                    • sprGT1
                                    		 21689 - 22981 (+) putative O-glycosyltransferase
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                                      • BAV17007.1
                                      • sprGT2
                                      		 23009 - 24223 (+) putative O-glycosyltransferase
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                                        • BAV17008.1
                                        • sprK
                                        		 24220 - 24786 (+) putative NDP-hexose 3,5-epimerase
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                                          • BAV17009.1
                                          • sprGT3
                                          		 24789 - 25919 (+) putative C-glycosyltransferase
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                                            • BAV17010.1
                                            • sprL
                                            		 25945 - 27012 (+) dNDP-glucose synthase
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                                              • BAV17011.1
                                              • sprM
                                              		 27009 - 27992 (+) putative dTDP-glucose 4,6 dehydratase
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                                                • BAV17012.1
                                                • sprN
                                                		 28003 - 29106 (+) NDP-hexose 4-ketoreductase
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                                                  • BAV17013.1
                                                  • sprO
                                                  		 29103 - 30413 (+) putative NDP-hexose dehydratase
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                                                    • BAV17014.1
                                                    • sprP
                                                    		 30469 - 31233 (+) putative NDP-hexose 4-ketoreductase
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                                                      • BAV17015.1
                                                      • sprQ
                                                      		 31282 - 32364 (+) hypothetical protein
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                                                        • BAV17016.1
                                                        • sprR
                                                        		 32459 - 33859 (+) putative NDP-hexose 2,3-dehydratase
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                                                          • BAV17017.1
                                                          • sprS
                                                          		 33856 - 34812 (+) putative NDP-hexose 3-ketoreductase
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                                                            • BAV17018.1
                                                            • sprT
                                                            		 34809 - 35573 (+) putative phosphopantetheine transferase
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                                                              • BAV17019.1
                                                              • sprU
                                                              		 35587 - 37179 (+) putative methylmalonyl-CoA carboxyltransferase
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                                                                • BAV17020.1
                                                                • sprX
                                                                		 37219 - 37902 (+) putative oxidoreductase
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                                                                  • BAV17021.1
                                                                  • sprY
                                                                  		 38025 - 39647 (+) putative FAD/FMN-containing dehydrogenase
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                                                                    • BAV17022.1
                                                                    • sprZ
                                                                    		 39764 - 40201 (+) hypothetical protein
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                                                                      • BAV17023.1
                                                                      • sprR3
                                                                      		 40793 - 41575 (-) putative transcriptional regulator
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                                                                        • BAV17024.1
                                                                        • spr6
                                                                        		 42116 - 44008 (+) putative oxidoreductase
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                                                                          Biosynthesis information
                                                                          Annotation changelog

                                                                          Entry version: 4

                                                                          Date
                                                                          Changes
                                                                          Submitters
                                                                          Reviewers
                                                                          2022-10-07
                                                                          Update chemical activity to schema version 2.11
                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                          Entry version: 3

                                                                          Date
                                                                          Changes
                                                                          Submitters
                                                                          Reviewers
                                                                          2022-09-15
                                                                          Updated bioactivity data
                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                          Entry version: 2

                                                                          Date
                                                                          Changes
                                                                          Submitters
                                                                          Reviewers
                                                                          2019-10-16
                                                                          Migrated from v1.4
                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                          2019-10-16
                                                                          Updated compound(s) information (NPAtlas curation)
                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                          Entry version: 1

                                                                          Date
                                                                          Changes
                                                                          Submitters
                                                                          Reviewers
                                                                          2016-09-03
                                                                          Submitted
                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                          Detailed domain annotation
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