BGC0001386 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001386 (Streptomyces sp. RI-77)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T2PKS	1	25,601	High	JBIR-76/JBIR-77	PKS

BGC0001386 - Region 1 - T2PKS

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Location: 1 - 25,601 nt. (total: 25,601 nt) Show pHMM detection rules used

Region on contig edge.

T2PKS: (t2ks and t2clf)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 25,602
Label		BGC0001386

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase

BAU98027.1: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

ifnH: acyl-CoA dehydrogenase type 2

smcogs: SMCOG1191: acyl-CoA dehydrogenase type 2

ifnP: flavin reductase domain protein FMN-binding

smcogs: SMCOG1160: flavin reductase domain protein FMN-binding

ifnR: acyl-CoA dehydrogenase type 2

smcogs: SMCOG1191: acyl-CoA dehydrogenase type 2

ifnU: crotonyl-CoA reductase / alcohol dehydrogenase

smcogs: SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase

Transferases: PPTase methyltransferase

ifnC: 4'-phosphopantetheinyl transferase

smcogs: SMCOG1012: 4'-phosphopantetheinyl transferase

ifnS: O-methyltransferase

smcogs: SMCOG1042: O-methyltransferase

Hydrolases: hydrolase

ifnF: alpha/beta hydrolase domain-containing protein

smcogs: SMCOG1066: alpha/beta hydrolase domain-containing protein

Lyases: cyclase

ifnJ: cyclase/dehydrase

smcogs: SMCOG1128: cyclase/dehydrase

Ligases: synthase

ifnN: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

ifnO: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001386.5	1.00	PKS	JBIR-76, JBIR-77	Streptomyces sp. RI-77
BGC0001625.5	0.80	PKS	Isofuranonaphthoquinone A, Isofuranonaphthoquinone B, Isofuranonaphthoquinone C, Isofuranonaphthoquinone D, Isofuranonaphthoquinone E, Isofuranonaphthoquinone F	Streptomyces sp. CB01883
BGC0000272.3	0.61	PKS	spore pigment	Streptomyces collinus
BGC0000231.5	0.58	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0000271.5	0.56	PKS	spore pigment	Streptomyces avermitilis
BGC0001197.5	0.54	PKS	frankiamicin	Frankia sp. EAN1pec
BGC0000234.5	0.53	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0001512.5	0.53	PKS	BE-24566B	Streptomyces sp.
BGC0001513.3	0.52	PKS	anthrabenzoxocinone	Actinobacteria bacterium
BGC0001366.5	0.52	PKS	BE-24566B, zunyimycin A	Streptomyces sp. FJS31-2

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001386.5	1.00	PKS	JBIR-76, JBIR-77	Streptomyces sp. RI-77
BGC0001625.5	0.80	PKS	Isofuranonaphthoquinone A, Isofuranonaphthoquinone B, Isofuranonaphthoquinone C, Isofuranonaphthoquinone D, Isofuranonaphthoquinone E, Isofuranonaphthoquinone F	Streptomyces sp. CB01883
BGC0000272.3	0.61	PKS	spore pigment	Streptomyces collinus
BGC0000231.5	0.58	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0000271.5	0.56	PKS	spore pigment	Streptomyces avermitilis
BGC0001197.5	0.54	PKS	frankiamicin	Frankia sp. EAN1pec
BGC0000234.5	0.53	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0001512.5	0.53	PKS	BE-24566B	Streptomyces sp.
BGC0001513.3	0.52	PKS	anthrabenzoxocinone	Actinobacteria bacterium
BGC0001366.5	0.52	PKS	BE-24566B, zunyimycin A	Streptomyces sp. FJS31-2

Similar known clusters from MIBiG 4.0

Detailed domain annotation

Selected features only

Show module domains

Type II PKS

Type II PKS gene cluster prediction details

Cluster section:: 0 to 25601
Starter unit(s):: acetyl-CoA (Score: 0.0; E-value: 0)
Malonyl elongations:: 7 (Score: 724.9; E-value: 5.1e-221)
Product molecular weight(s):: acetyl-CoA_7: 322 Da

BAU98027.1: KR (Score: 139.0; E-value: 5.2e-43)
ifnA: ACP (Score: 111.1; E-value: 4.5e-35)
ifnJ: CYC C7-C12 (Score: 117.4; E-value: 1.3e-36)
ifnK: CYC C5-C14/C3-C16 (Score: 333.5; E-value: 2e-102)
ifnN: KS (Score: 760.8; E-value: 7.6e-232)
ifnO: CLF 7 (Score: 724.9; E-value: 5.1e-221)
ifnQ: OXY (Score: 23.6; E-value: 5.7e-08)
ifnS: MET (Score: 270.8; E-value: 3.7e-83)