Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0001391.1:
Cluster 1RiPP110393

BGC0001391, thusin biosynthetic gene cluster from Bacillus thuringiensis. Locus 1. Partial MIBiG entry.

Chemical compounds

Compound: thusin

Class-specific details

Biosynthetic class(es):
RiPP
RiPP subclass:
Other

Gene cluster description

thusin (BGC0001391). Gene Cluster 1. Biosynthetic class = RiPP. GenBank KT454399. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Detailed annotation

thsA1 leader / core peptide, putative Class II
MLDVIKNRKKIEEKLELPEILLEEVEEHSAMGG - INDhbWNDhbDhbADhbDhaDhbDhaIIIDhaEDhbFGNKGKVCDhbYDhbVECVNNCRG
thsA2 leader / core peptide, putative Class II
MLKEEKLEKITGLIPESELEEHLSG - EDhaDhaGAGDhbPAIDhbDhbAIDhaAIIAADhbAQDhaPCPDhbDhaACDhaKDhaCNK
thsA2_ leader / core peptide, putative Class II
MKEQKLEKITGLIPESELEEHLSGESSGAGTPAITTAISAIIGA - DhbAQDhaPCPDhbDhaACDhaKDhaCNK

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Literature references

1. Xin B et al. (2016 TI) Thusin, a Novel Two-Component Lantibiotic with Potent Antimicrobial Activity against Several Gram-Positive Pathogens. Front Microbiol 7:1115. doi: 10.3389/fmicb.2016.01115. eCollection