BGC0001393: lugdunin biosynthetic gene cluster from Staphylococcus lugdunensis N920143
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Location: 836,040 - 898,664 nt. (total: 62,625 nt).
This entry is originally from NCBI GenBank FR870271.1.

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
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General
Compounds
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Biosynthesis
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NRPS/PKS domains
General information about the BGC

MIBiG accession | BGC0001393
Short description | lugdunin biosynthetic gene cluster from Staphylococcus lugdunensis N920143
Status | Quality: questionable The quality level of this entry. Status: active The status of this entry. Completeness: unknown Whether the entry covers everything needed for the pathway producing the compound(s)

Biosynthetic class(es)

- NRPS (Type I)

Loci
FR870271.1
850457 - 881240
via
Compounds

- lugdunin

Species Staphylococcus lugdunensis N920143 [taxonomy]
References

- [1] Human commensals producing a novel antibiotic impair pathogen colonization. Zipperer A et al., Nature (2016) PMID:27466123

Chemical products information
lugdunin Evidence:
Copy SMILES
C40H62N8O6S1
Chemical database entries
PubCHEM
ChemSpider
List of genes involved in compound(s) production

Identifiers | Position | Product | Functions | Evidence | Extra
--- | --- | --- | --- | --- | ---
SLUG_08030 CCB53257.1 | 850460 - 850969 (-) | conserved hypothetical protein |  |  | copy AA seq copy Nt seq
SLUG_08040 CCB53258.1 | 851060 - 851299 (+) | conserved hypothetical protein |  |  | copy AA seq copy Nt seq
SLUG_08050 CCB53259.1 | 851286 - 852176 (+) | ABC transporter family protein |  |  | copy AA seq copy Nt seq
SLUG_08060 CCB53260.1 | 852173 - 852937 (+) | conserved hypothetical membrane protein |  |  | copy AA seq copy Nt seq
SLUG_08070 CCB53261.1 | 852950 - 853663 (+) | ABC transporter family protein |  |  | copy AA seq copy Nt seq
SLUG_08080 CCB53262.1 | 853656 - 855197 (+) | hypothetical membrane protein |  |  | copy AA seq copy Nt seq
SLUG_08090 CCB53263.1 | 855424 - 856014 (+) | TetR family transcriptional regulator |  |  | copy AA seq copy Nt seq
SLUG_08100 CCB53264.1 | 856040 - 863164 (+) | non-ribosomal peptide synthetase |  |  | copy AA seq copy Nt seq
SLUG_08110 CCB53265.1 | 863154 - 863528 (+) | hypothetical protein |  |  | copy AA seq copy Nt seq
SLUG_08120 CCB53266.1 | 863681 - 867373 (+) | non-ribosomal peptide synthetase |  |  | copy AA seq copy Nt seq
SLUG_08130 CCB53267.1 | 867391 - 876204 (+) | non-ribosomal peptide synthetase |  |  | copy AA seq copy Nt seq
SLUG_08140 CCB53268.1 | 876201 - 876887 (+) | Thioesterase family protein |  |  | copy AA seq copy Nt seq
SLUG_08150 CCB53269.1 | 876925 - 878664 (+) | AMP-binding enzyme |  |  | copy AA seq copy Nt seq
SLUG_08160 CCB53270.1 | 878672 - 879325 (+) | hypotheical protein |  |  | copy AA seq copy Nt seq
SLUG_08170 CCB53271.1 | 880578 - 881237 (+) | monooxygenase family protein |  |  | copy AA seq copy Nt seq

Biosynthesis information

#### Biosynthetic modules

Name
Unk01
Type
nrps-type1
Genes
SLUG_08100
Substrates
valine (evidence: Structure-based inference)
Integrated Monomers
Domains
adenylation
Name
Unk02
Type
nrps-type1
Genes
SLUG_08100
Substrates
tryptophan (evidence: Structure-based inference)
Integrated Monomers
Domains
adenylation
Name
Unk03
Type
nrps-type1
Genes
SLUG_08120
Substrates
leucine (evidence: Structure-based inference)
Integrated Monomers
Domains
adenylation
Name
Unk04
Type
nrps-type1
Genes
SLUG_08130
Substrates
valine (evidence: Structure-based inference)
Integrated Monomers
Domains
adenylation
Name
Unk05
Type
nrps-type1
Genes
SLUG_08150
Substrates
cysteine (evidence: Structure-based inference)
Integrated Monomers
Domains
adenylation
Annotation changelog

#### Entry version: 4

Date
Changes
Submitters
Reviewers
2022-10-07
Update chemical activity to schema version 2.11

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#### Entry version: 3

Date
Changes
Submitters
Reviewers
2022-09-15
Updated bioactivity data

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2022-09-15
Added NRP substrate specificities

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#### Entry version: 2

Date
Changes
Submitters
Reviewers
2019-10-16
Migrated from v1.4

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2019-10-16
Updated compound(s) information (NPAtlas curation)

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#### Entry version: 1

Date
Changes
Submitters
Reviewers
2016-09-03
Submitted

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