BGC0001396 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001396 (Streptomyces sp. A1(2016))

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T1PKS	1	81,762	High	aldgamycin J/aldgamycin K/aldgamycin P/aldgamycin E	PKS

BGC0001396 - Region 1 - T1PKS

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Location: 1 - 81,762 nt. (total: 81,762 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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resistance

TTA codons

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 81,763
Label		BGC0001396

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase oxygenase

almBI: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

almCI: aldo/keto reductase family oxidoreductase

smcogs: SMCOG1039: aldo/keto reductase family oxidoreductase

almDIII: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

almK: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

almPI: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

almPII: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

almPIII: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

Transferases: aminotransferase glycosyltransferase transferase

almAI: glucose-1-phosphate adenylyl/thymidylyltransferase

smcogs: SMCOG1064: glucose-1-phosphate adenylyl/thymidylyltransferase

almBII: DegT/DnrJ/EryC1/StrS aminotransferase

smcogs: SMCOG1056: DegT/DnrJ/EryC1/StrS aminotransferase

almTI: glycosyltransferase, MGT family

smcogs: SMCOG1062: glycosyltransferase, MGT family

almTII: glycosyltransferase

smcogs: SMCOG1102: glycosyltransferase

Hydrolases: esterase

almM: thioesterase

smcogs: SMCOG1004: thioesterase

Lyases: dehydratase

almAII: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

almEII: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

Ligases: synthase

almDII: 1-deoxy-D-xylulose-5-phosphate synthase

smcogs: SMCOG1110: 1-deoxy-D-xylulose-5-phosphate synthase

almHI: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

almHII: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

almHIII: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

almHIV: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

almHV: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001396.5	0.97	PKS	aldgamycin J, aldgamycin K, aldgamycin P, aldgamycin E	Streptomyces sp. A1(2016)
BGC0000047.5	0.88	PKS	10,11-dihydro-8-deoxy-12,13-deepoxy-12,13-dihydrochalcomycin	Streptomyces sp. KCTC 0041BP
BGC0000035.5	0.78	PKS	chalcomycin A	Streptomyces bikiniensis
BGC0001273.3	0.76	PKS	asperlactone	Aspergillus ochraceus
BGC0001276.3	0.76	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001244.3	0.76	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001275.3	0.76	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0000041.3	0.69	PKS	oronofacic acid	Pseudomonas syringae
BGC0001257.3	0.66	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0002154.2	0.66	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001396.5	1.00	PKS	aldgamycin J, aldgamycin K, aldgamycin P, aldgamycin E	Streptomyces sp. A1(2016)
BGC0000047.5	0.91	PKS	10,11-dihydro-8-deoxy-12,13-deepoxy-12,13-dihydrochalcomycin	Streptomyces sp. KCTC 0041BP
BGC0001273.3	0.76	PKS	asperlactone	Aspergillus ochraceus
BGC0001276.3	0.76	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001244.3	0.76	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001275.3	0.76	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0000035.5	0.72	PKS	chalcomycin A	Streptomyces bikiniensis
BGC0000041.3	0.69	PKS	oronofacic acid	Pseudomonas syringae
BGC0001257.3	0.66	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0002154.2	0.66	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15

Similar known clusters from MIBiG 4.0

Module view

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Detailed domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 68720:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (pk - Me-ccmal - Me-ohmal - pk) + (ccmal) + (Me-ccmal - Me-redmal) + (Me-ohmal) + (mal)
Non-colinear ordering:: almHI + almHII + almHIII + almHIV + almHV

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

almHV: mal

PKS_AT (578..888): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 75.0%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 212.4
inactive: 103.9
Methoxymalonyl-CoA: 67.3
Methylmalonyl-CoA: 55.2
Propionyl-CoA: 35.4
Isobutyryl-CoA: 25.1
Benzoyl-CoA: 19.7
Acetyl-CoA: 17.5
Ethylmalonyl-CoA: 16.7
2-Methylbutyryl-CoA: 10.7
fatty_acid: 9.4
CHC-CoA: 6.0
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0

almHIV: mmal

PKS_AT (565..859): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 208.8
Ethylmalonyl-CoA: 200.4
Methoxymalonyl-CoA: 172.9
2-Methylbutyryl-CoA: 127.8
CHC-CoA: 114.3
trans-1,2-CPDA: 111.0
Propionyl-CoA: 110.6
Malonyl-CoA: 108.9
Isobutyryl-CoA: 76.6
fatty_acid: 58.6
Benzoyl-CoA: 57.1
Acetyl-CoA: 46.7
3-Methylbutyryl-CoA: 35.9
inactive: 29.0

almHIII: mmal - mmal

PKS_AT (505..800): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 209.4
Ethylmalonyl-CoA: 200.0
Methoxymalonyl-CoA: 171.2
2-Methylbutyryl-CoA: 127.6
Malonyl-CoA: 115.1
CHC-CoA: 114.7
Propionyl-CoA: 111.8
trans-1,2-CPDA: 111.2
Isobutyryl-CoA: 78.5
Benzoyl-CoA: 61.1
fatty_acid: 53.5
Acetyl-CoA: 49.4
3-Methylbutyryl-CoA: 34.8
inactive: 32.1

PKS_AT (1996..2290): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 206.9
Ethylmalonyl-CoA: 199.0
Methoxymalonyl-CoA: 171.3
2-Methylbutyryl-CoA: 128.6
CHC-CoA: 112.2
Malonyl-CoA: 112.0
trans-1,2-CPDA: 110.1
Propionyl-CoA: 108.6
Isobutyryl-CoA: 79.2
Benzoyl-CoA: 51.5
fatty_acid: 51.1
Acetyl-CoA: 50.7
3-Methylbutyryl-CoA: 38.1
inactive: 29.1

almHII: mal

PKS_AT (565..860): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 87.5%; 2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 213.5
inactive: 110.1
Methoxymalonyl-CoA: 71.5
Methylmalonyl-CoA: 68.1
Propionyl-CoA: 49.1
Isobutyryl-CoA: 34.2
Ethylmalonyl-CoA: 27.2
Acetyl-CoA: 26.9
CHC-CoA: 25.8
fatty_acid: 25.0
2-Methylbutyryl-CoA: 21.9
trans-1,2-CPDA: 20.0
Benzoyl-CoA: 13.5
3-Methylbutyryl-CoA: 11.7

almHI: pk - mmal - mmal - pk

PKS_AT (523..819): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; Methylmalonyl-CoA: 83.3%; Methoxymalonyl-CoA: 83.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 181.5
Ethylmalonyl-CoA: 162.3
Methoxymalonyl-CoA: 151.8
CHC-CoA: 109.7
trans-1,2-CPDA: 98.7
2-Methylbutyryl-CoA: 98.4
Malonyl-CoA: 94.1
Propionyl-CoA: 84.4
Isobutyryl-CoA: 72.9
Benzoyl-CoA: 46.9
fatty_acid: 43.2
inactive: 28.6
3-Methylbutyryl-CoA: 27.5
Acetyl-CoA: 24.6

PKS_AT (1536..1831): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 209.4
Ethylmalonyl-CoA: 200.0
Methoxymalonyl-CoA: 171.2
2-Methylbutyryl-CoA: 127.6
Malonyl-CoA: 115.1
CHC-CoA: 114.7
Propionyl-CoA: 111.8
trans-1,2-CPDA: 111.2
Isobutyryl-CoA: 78.5
Benzoyl-CoA: 61.1
fatty_acid: 53.5
Acetyl-CoA: 49.4
3-Methylbutyryl-CoA: 34.8
inactive: 32.1

PKS_AT (3027..3321): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 207.9
Ethylmalonyl-CoA: 199.6
Methoxymalonyl-CoA: 172.7
2-Methylbutyryl-CoA: 124.9
CHC-CoA: 112.3
trans-1,2-CPDA: 111.7
Propionyl-CoA: 108.6
Malonyl-CoA: 108.3
Isobutyryl-CoA: 74.6
Benzoyl-CoA: 58.2
fatty_acid: 56.3
Acetyl-CoA: 47.1
3-Methylbutyryl-CoA: 34.9
inactive: 32.0

PKS_AT (4524..4820): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; Methylmalonyl-CoA: 83.3%; Methoxymalonyl-CoA: 83.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 184.6
Ethylmalonyl-CoA: 168.3
Methoxymalonyl-CoA: 152.8
CHC-CoA: 113.2
2-Methylbutyryl-CoA: 100.3
Malonyl-CoA: 97.7
trans-1,2-CPDA: 97.4
Propionyl-CoA: 88.0
Isobutyryl-CoA: 76.1
Benzoyl-CoA: 50.4
fatty_acid: 42.0
inactive: 29.0
Acetyl-CoA: 28.3
3-Methylbutyryl-CoA: 26.0

Link to PARAS substrate predictor