BGC0001397: lidamycin biosynthetic gene cluster from Streptomyces globisporus C-1027
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Location: 20,150 - 92,825 nt. (total: 72,676 nt).
This entry is originally from NCBI GenBank CP013739.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
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resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001397
Short description lidamycin biosynthetic gene cluster from Streptomyces globisporus C-1027
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Unknown)
Loci
CP013739.1
20150 - 92825
via
Compounds
  • lidamycin
Species Streptomyces globisporus C-1027 [taxonomy]
References
Chemical products information
lidamycin Evidence:
Copy SMILES
C43H42Cl1N3O13
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • WQO_33745
  • ALU98527.1
 20150 - 21469 (+) hypothetical protein
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    • WQO_33750
    • ALU98419.1
    		 21575 - 23902 (-) daunorubicin resistance protein DrrC
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      • WQO_33755
      • ALU98420.1
      		 23983 - 25365 (-) sodium:proton exchanger
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        • WQO_33760
        • ALU98528.1
        		 25352 - 26830 (-) tryptophan halogenase
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          • WQO_33765
          • ALU98421.1
          		 27013 - 28080 (+) glucose-1-phosphate thymidylyltransferase
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            • WQO_33770
            • ALU98422.1
            		 28213 - 28599 (-) hypothetical protein
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              • WQO_33775
              • ALU98423.1
              		 28691 - 29923 (-) dTDP-4-dehydro-6-deoxyglucose aminotransferase
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                • WQO_33780
                • ALU98424.1
                		 29920 - 30654 (-) SAM-dependent methyltransferase
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                  • WQO_33785
                  • ALU98425.1
                  		 30654 - 31925 (-) SAM-dependent methyltransferase
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                    • WQO_33790
                    • ALU98426.1
                    		 32032 - 33189 (-) epoxide hydrolase
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                      • WQO_33795
                      • ALU98529.1
                      		 33263 - 33820 (-) anthranilate synthase subunit II
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                        • WQO_33800
                        • ALU98427.1
                        		 33922 - 35403 (-) aminodeoxychorismate synthase component I
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                          • WQO_33805
                          • ALU98530.1
                          		 35420 - 36832 (-) CoF synthetase
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                            • WQO_33810
                            • ALU98428.1
                            		 36871 - 37542 (-) NADPH-dependent FMN reductase
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                              • WQO_33815
                              • ALU98429.1
                              		 37562 - 38797 (-) hypothetical protein
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                                • WQO_33820
                                • ALU98430.1
                                		 38983 - 39561 (-) dTDP-4-dehydrorhamnose 3,5-epimerase
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                                  • WQO_33825
                                  • ALU98431.1
                                  		 39812 - 41167 (+) FAD-binding monooxygenase
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                                    • WQO_33830
                                    • ALU98432.1
                                    		 41211 - 42590 (+) hypothetical protein
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                                      • WQO_33835
                                      • ALU98433.1
                                      		 42587 - 43585 (+) dTDP-glucose 4,6-dehydratase
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                                        • WQO_33840
                                        • ALU98434.1
                                        		 43629 - 45194 (+) MFS transporter
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                                          • WQO_33845
                                          • ALU98435.1
                                          		 45277 - 46587 (+) phenylacetate--CoA ligase
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                                            • WQO_33850
                                            • ALU98436.1
                                            		 46556 - 46765 (+) hypothetical protein
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                                              • WQO_33855
                                              • ALU98531.1
                                              		 46866 - 48389 (+) Pyoverdin chromophore biosynthetic protein pvcC
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                                                • WQO_33860
                                                • ALU98437.1
                                                		 48463 - 49299 (-) hydrolase
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                                                  • WQO_33865
                                                  • ALU98438.1
                                                  		 49521 - 49943 (-) DUF4440 domain-containing protein
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                                                    • WQO_33870
                                                    • ALU98439.1
                                                    		 50224 - 51495 (+) cinnamoyl-CoA reductase
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                                                      • WQO_33875
                                                      • ALU98440.1
                                                      		 51564 - 52943 (+) hypothetical protein
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                                                        • WQO_33880
                                                        • ALU98441.1
                                                        		 52988 - 53269 (+) phosphopantetheine-binding protein
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                                                          • WQO_33885
                                                          • ALU98442.1
                                                          		 53372 - 54985 (-) tyrosine 2,3-aminomutase
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                                                            • WQO_33890
                                                            • ALU98443.1
                                                            		 55057 - 57672 (-) hypothetical protein
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                                                              • WQO_33895
                                                              • ALU98444.1
                                                              		 57908 - 60016 (+) hypothetical protein
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                                                                • WQO_33900
                                                                • ALU98445.1
                                                                		 60170 - 61171 (+) methyltransferase
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                                                                  • WQO_33905
                                                                  • ALU98532.1
                                                                  		 61243 - 62484 (+) cytochrome
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                                                                    • WQO_33910
                                                                    • ALU98446.1
                                                                    		 62537 - 63718 (-) acyl-CoA dehydrogenase
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                                                                      • WQO_33915
                                                                      • ALU98447.1
                                                                      		 64022 - 64357 (+) hypothetical protein
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                                                                        • WQO_33920
                                                                        • ALU98448.1
                                                                        		 64354 - 65394 (+) alkylhydroperoxidase
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                                                                          • WQO_33925
                                                                          • ALU98449.1
                                                                          		 65425 - 66345 (-) short-chain dehydrogenase
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                                                                            • WQO_33930
                                                                            • ALU98450.1
                                                                            		 66370 - 66921 (-) alkylhydroperoxidase
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                                                                              • WQO_33935
                                                                              • ALU98451.1
                                                                              		 67250 - 67888 (-) hypothetical protein
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                                                                                • WQO_33940
                                                                                • ALU98533.1
                                                                                		 68148 - 69383 (+) DNA-binding protein
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                                                                                  • WQO_33945
                                                                                  • ALU98452.1
                                                                                  		 69910 - 70884 (+) hypothetical protein
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                                                                                    • WQO_33950
                                                                                    • ALU98453.1
                                                                                    		 70931 - 71734 (-) wyosine base formation domain-containing protein
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                                                                                      • WQO_33955
                                                                                      • ALU98454.1
                                                                                      		 71837 - 72307 (-) 4-hydroxybenzoyl-CoA thioesterase
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                                                                                        • WQO_33960
                                                                                        • ALU98455.1
                                                                                        		 72444 - 74099 (-) glucose-methanol-choline oxidoreductase
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                                                                                          • WQO_33965
                                                                                          • ALU98456.1
                                                                                          		 74096 - 74686 (-) regulator
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                                                                                            • WQO_33970
                                                                                            • ALU98457.1
                                                                                            		 74971 - 76023 (+) transcriptional regulator
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                                                                                              • WQO_33975
                                                                                              • ALU98458.1
                                                                                              		 76049 - 76903 (+) hypothetical protein
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                                                                                                • WQO_33980
                                                                                                • ALU98459.1
                                                                                                		 76791 - 78140 (-) cytochrome P450
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                                                                                                  • WQO_33985
                                                                                                  • ALU98460.1
                                                                                                  		 78137 - 78685 (-) flavin reductase
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                                                                                                    • WQO_33990
                                                                                                    • ALU98461.1
                                                                                                    		 78811 - 84630 (-) erythronolide synthase
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                                                                                                      • WQO_33995
                                                                                                      • ALU98462.1
                                                                                                      		 84627 - 85757 (-) enediyne biosynthesis protein
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                                                                                                        • WQO_34000
                                                                                                        • ALU98463.1
                                                                                                        		 85754 - 87622 (-) RNA-binding protein
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                                                                                                          • WQO_34005
                                                                                                          • ALU98534.1
                                                                                                          		 87679 - 88584 (-) enediyne biosynthesis protein
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                                                                                                            • WQO_34010
                                                                                                            • ALU98464.1
                                                                                                            		 88761 - 89789 (-) enediyne biosynthesis protein
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                                                                                                              • WQO_34015
                                                                                                              • ALU98465.1
                                                                                                              		 89926 - 90369 (-) HxlR family transcriptional regulator
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                                                                                                                • WQO_34020
                                                                                                                • ALU98466.1
                                                                                                                		 90516 - 91079 (+) hypothetical protein
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                                                                                                                  • WQO_34025
                                                                                                                  • ALU98467.1
                                                                                                                  		 91084 - 91545 (+) hypothetical protein
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                                                                                                                    • WQO_34030
                                                                                                                    • ALU98468.1
                                                                                                                    		 91635 - 92822 (-) hypothetical protein
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                                                                                                                      Biosynthesis information

                                                                                                                      Biosynthetic modules

                                                                                                                      Name
                                                                                                                      Unk01
                                                                                                                      Type
                                                                                                                      nrps-type1
                                                                                                                      Genes
                                                                                                                      WQO_33890
                                                                                                                      Substrates
                                                                                                                      S-beta-tyrosine, R-beta-tyrosine (evidence: ATP-PPi exchange assay [1])
                                                                                                                      Integrated Monomers
                                                                                                                      Domains
                                                                                                                      adenylation
                                                                                                                      Annotation changelog

                                                                                                                      Entry version: 4

                                                                                                                      Date
                                                                                                                      Changes
                                                                                                                      Submitters
                                                                                                                      Reviewers
                                                                                                                      2022-10-07
                                                                                                                      Update chemical activity to schema version 2.11
                                                                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                                                      Entry version: 3

                                                                                                                      Date
                                                                                                                      Changes
                                                                                                                      Submitters
                                                                                                                      Reviewers
                                                                                                                      2022-09-15
                                                                                                                      Updated bioactivity data
                                                                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                                      2022-09-15
                                                                                                                      Added NRP substrate specificities
                                                                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                                                      Entry version: 2

                                                                                                                      Date
                                                                                                                      Changes
                                                                                                                      Submitters
                                                                                                                      Reviewers
                                                                                                                      2019-10-16
                                                                                                                      Migrated from v1.4
                                                                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                                      2019-10-16
                                                                                                                      Updated compound(s) information (NPAtlas curation)
                                                                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                                                      Entry version: 1

                                                                                                                      Date
                                                                                                                      Changes
                                                                                                                      Submitters
                                                                                                                      Reviewers
                                                                                                                      2016-09-03
                                                                                                                      Submitted
                                                                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                                      Detailed domain annotation
                                                                                                                      Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
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