BGC0001402: cyclochlorotine biosynthetic gene cluster from Talaromyces islandicus
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Location: 2,181,848 - 2,216,739 nt. (total: 34,892 nt).
This entry is originally from NCBI GenBank CVMT01000002.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
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Gene details
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General
Compounds
Genes
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001402
Short description cyclochlorotine biosynthetic gene cluster from Talaromyces islandicus
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
Loci NCBI GenBank: CVMT01000002.1
Compounds
  • cyclochlorotine
  • hydroxycyclochlorotine A
  • cyclotine
  • cyclochlorotine B
  • deoxy-Cyclochlorotine
Species Talaromyces islandicus [taxonomy]
References
Chemical products information
cyclochlorotine
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C24H31Cl2N5O7
Chemical database entries
NPAtlas
PubCHEM
hydroxycyclochlorotine A
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C25H33Cl2N5O7
Chemical database entries
NPAtlas
cyclotine
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C24H33N5O7
Chemical database entries
NPAtlas
cyclochlorotine B
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C24H32Cl1N5O7
Chemical database entries
NPAtlas
deoxy-Cyclochlorotine
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C24H31Cl2N5O6
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • PISL3812_02619
  • CRG85572.1
 2182438 - 2199498 (-) nonribosomal peptide synthase, putative
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  • PISL3812_02620
  • CRG85573.1
 2200675 - 2201848 (+) hypothetical protein
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  • PISL3812_02621
  • CRG85574.1
 2202383 - 2206558 (-) hypothetical protein
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  • PISL3812_02622
  • CRG85575.1
 2208067 - 2209417 (+) hypothetical protein
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  • PISL3812_02623
  • CRG85576.1
 2209763 - 2210617 (-) hypothetical protein
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  • PISL3812_02624
  • CRG85577.1
 2211428 - 2216089 (+) hypothetical protein
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NRP-specific information
Subclass N/A
Cyclic? no
NRP-synthases
Gene Modules
PISL3812_02619
Module ?
Specificity: serine
Evidence for specificity:
  • Structure-based inference
Module ?
Specificity: 3S,4R-dichloroproline / 3R-chloroproline / proline
Evidence for specificity:
  • Structure-based inference
Module ?
Specificity: 2-aminobutyric acid
Evidence for specificity:
  • Structure-based inference
Module ?
Specificity: serine / alanine
Evidence for specificity:
  • Structure-based inference
Module ?
Specificity: R-beta-phenylalanine
Evidence for specificity:
  • Structure-based inference
Annotation changelog
MIBiG version Submitter Notes
1.3
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Add additional publication refining location
  • Added NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Changed chemical structures for compounds: hydroxycyclochlorotine A, cyclochlorotine, cyclotine, cyclochlorotine B, deoxy-Cyclochlorotine.
  • Added NPAtlas links to compounds: hydroxycyclochlorotine A, cyclotine, cyclochlorotine B, deoxy-Cyclochlorotine.
  • Renamed compounds: hydroxy-cyclochlorotine to hydroxycyclochlorotine A.
  • Updated NPAtlas ID for compounds: cyclochlorotine.
Detailed domain annotation
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