LOCUS       BGC0001403             25711 bp    DNA     linear   CON 23-MAR-2015
DEFINITION  Aspergillus fumigatus Af293 chromosome 4, whole genome shotgun
            sequence.
ACCESSION   BGC0001403
VERSION     BGC0001403
KEYWORDS    .
SOURCE      Aspergillus fumigatus Af293
  ORGANISM  Aspergillus fumigatus Af293
            Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
            Eurotiomycetes; Eurotiomycetidae; Eurotiales; Aspergillaceae;
            Aspergillus; Aspergillus subgen. Fumigati.
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-10-17 15:29:17
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 25711
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..25711
                     /aStool="rule-based-clusters"
                     /category="PKS"
                     /contig_edge="True"
                     /core_location="[16736:22267]"
                     /cutoff="20000"
                     /detection_rule="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS
                     or hyb_KS or itr_KS or tra_KS))"
                     /neighbourhood="20000"
                     /product="T1PKS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      16737..22267
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS
                     or hyb_KS or itr_KS or tra_KS))"
                     /neighbourhood="20000"
                     /product="T1PKS"
                     /protocluster_number="1"
     cand_cluster    1..25711
                     /SMILES="CC(=O)C(=O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(PKS_AT and (PKS_KS or ene_KS or
                     mod_KS or hyb_KS or itr_KS or tra_KS))"
                     /kind="single"
                     /product="T1PKS"
                     /protoclusters="1"
                     /tool="antismash"
     subregion       1..25711
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0001403"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..25711
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="T1PKS"
                     /region_number="1"
                     /rules="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or
                     hyb_KS or itr_KS or tra_KS))"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            <4..>1512
                     /locus_tag="AFUA_4G14450"
                     /old_locus_tag="Afu4g14450"
     mRNA            <4..>1512
                     /locus_tag="AFUA_4G14450"
                     /note="transcript AFUA_4G14450A"
                     /old_locus_tag="Afu4g14450"
                     /product="mannitol dehydrogenase, putative"
     CDS             4..1512
                     /EC_number="1.1.1.-"
                     /codon_start=1
                     /locus_tag="AFUA_4G14450"
                     /note="encoded by transcript AFUA_4G14450A; similar to
                     Mannitol 2-dehydrogenase (EC 1.1.1.67) (MDH).
                     (Swiss-Prot:P33216) [Rhodobacter sphaeroides;] similar to
                     GB:CAA96358.1: unnamed protein product; ORF YNR073c
                     (GI:6324401) [Saccharomyces cerevisiae]; GO_component:
                     GO:0008372 - cellular component unknown; GO_function:
                     GO:0046029 - mannitol dehydrogenase activity"
                     /old_locus_tag="Afu4g14450"
                     /product="mannitol dehydrogenase, putative"
                     /protein_id="EAL89350.1"
                     /transl_table=11
                     /translation="MAPLKLNSRNLSQIAAAGGALVKIPTYQRGRAVKEGIVHIGVGGF
                     HRAHLAVYIDQLMQKHGVNDYAICGVGLQPFDSAMRDALASQDHLYTLIERSAKGSFAH
                     VIGSINSYLFAPDNREAVIAKMAHPDTKIVSLTITESGYYYNENTHELQSEHPDIQFDL
                     DPANEKAPRTTFGFLYAGLTRRYQQGLKPFTVMSCDNMQKNGSITRHMLESFARLRNPE
                     VAEWIAEEGAFPNAMVDRITPQTSETDKTALAEKFGIVDSWPVVTEPFTQWVIEDQFSD
                     GRPPFEKVGVQVVKDVHAVEQFEKHKLRLLNGSHSALGYPGQLAGFQYVHEVMANPLFR
                     KFVWQMMQEEVKPLLPEIPGVDIDEYCNTLIERFTNPTIMDQLPRICLNASGKIPQFIM
                     PSIAEAIWETGPFRRLCFVAAAWFHYIKGVDDRGKPFEVVDPMREELQAKARAGGNDPS
                     ELLSIKSLFGDDLRNDERFLREITTAMNDIARDGIMKTLPKYIN"
     gene            complement(<1911..>2870)
                     /locus_tag="AFUA_4G14460"
                     /old_locus_tag="Afu4g14460"
     mRNA            complement(<1911..>2870)
                     /locus_tag="AFUA_4G14460"
                     /note="transcript AFUA_4G14460A"
                     /old_locus_tag="Afu4g14460"
                     /product="conserved hypothetical protein"
     CDS             complement(1911..2870)
                     /codon_start=1
                     /locus_tag="AFUA_4G14460"
                     /note="encoded by transcript AFUA_4G14460A"
                     /old_locus_tag="Afu4g14460"
                     /product="conserved hypothetical protein"
                     /protein_id="EAL89349.1"
                     /transl_table=11
                     /translation="MAVPQSIPPPTAAPIESKDQVFARSKAFWDNYLRGRPQVPPSFFQ
                     RIYRYHREHGGRFGTVHDVGAGIGPYAGELRSQFPHVIVSDIVPKNVQLAEAHLGRDGF
                     RYRAAPVEVADDLPPGSVDLAFATNVMHFADQHAAMQAIATQLRPGGTFACAGFGPARF
                     DDPDIQDVWERISQQGGRILLGMAEHPPDTINVMSRSSKEYNVAPLEPQWFRPGALRIR
                     LNMAQGGITGLLPPERQQEVTDPDFAGPRDVVVYETNEEWRFETDWEGFLQHFRSFPHA
                     GADPAAFTGLLQELKDLLDEGRCLRGCWPATLILATRR"
     gene            complement(<3224..>3759)
                     /locus_tag="AFUA_4G14480"
                     /old_locus_tag="Afu4g14480"
     mRNA            complement(join(<3224..3642,3693..>3759))
                     /locus_tag="AFUA_4G14480"
                     /note="transcript AFUA_4G14480A"
                     /old_locus_tag="Afu4g14480"
                     /product="conserved hypothetical protein"
     CDS             complement(join(3224..3642,3693..3759))
                     /codon_start=1
                     /locus_tag="AFUA_4G14480"
                     /note="encoded by transcript AFUA_4G14480A"
                     /old_locus_tag="Afu4g14480"
                     /product="conserved hypothetical protein"
                     /protein_id="EAL89348.2"
                     /transl_table=11
                     /translation="MPQNASVIITQATAVITGSFLSGLMMGLSVVDIPVVLDTATQASQ
                     LLQHFTRLYDIGHKMMPSLAVTTCLLYGYTASSTRTTGGSGLPHIIAAVTTISMVPFTW
                     LVMAPTNNALFRMHANPAAANLGEVRRLLVRWAQLHAVRSLFPLMGSVLGLRQILRE"
     gene            <4034..>4560
                     /locus_tag="AFUA_4G14470"
                     /old_locus_tag="Afu4g14470"
     mRNA            join(<4034..4198,4246..4442,4494..>4560)
                     /locus_tag="AFUA_4G14470"
                     /note="transcript AFUA_4G14470A"
                     /old_locus_tag="Afu4g14470"
                     /product="hypothetical protein"
     CDS             join(4034..4198,4246..4442,4494..4560)
                     /codon_start=1
                     /locus_tag="AFUA_4G14470"
                     /note="encoded by transcript AFUA_4G14470A"
                     /old_locus_tag="Afu4g14470"
                     /product="hypothetical protein"
                     /protein_id="EAL89347.1"
                     /transl_table=11
                     /translation="MGESSRKPSRYLCLTICGYRKPGMSEEDYRRYMTEVSAPMTKDLM
                     VKYGVKRWTMVHNTTATRALMAELCDSQMTNVVDFDCFSQVVFESLEDYKRMKQDPWYK
                     EHLFHDHENFADTKKSMMTIGWIEEFVRQGVAVDGMDN"
     gene            <4803..>6930
                     /locus_tag="AFUA_4G14490"
                     /old_locus_tag="Afu4g14490"
     mRNA            join(<4803..4985,5049..5118,5170..5217,5263..5387,
                     5440..5531,5571..5584,5633..>6930)
                     /locus_tag="AFUA_4G14490"
                     /note="transcript AFUA_4G14490A"
                     /old_locus_tag="Afu4g14490"
                     /product="extracellular dihydrogeodin oxidase/laccase,
                     putative"
     CDS             join(4803..4985,5049..5118,5170..5217,5263..5387,
                     5440..5531,5571..5584,5633..6930)
                     /EC_number="1.10.3.2"
                     /codon_start=1
                     /locus_tag="AFUA_4G14490"
                     /note="encoded by transcript AFUA_4G14490A; similar to
                     GB:BAA08486.1: dihydrogeodin oxidase {Aspergillus
                     terreus;}; GO_component: GO:0005886 - plasma membrane;
                     GO_function: GO:0004322 - ferroxidase activity; GO_process:
                     GO:0006827 - high affinity iron ion transport"
                     /old_locus_tag="Afu4g14490"
                     /product="extracellular dihydrogeodin oxidase/laccase,
                     putative"
                     /protein_id="EAL89346.1"
                     /transl_table=11
                     /translation="MITVIKWLVSGCCALAAVTTRAPLPKDCRNTPNSRGCWKDGFDIL
                     TDYTDPKRAPPGKLVEYNLTVSQQVIAPDGYEKLGMVANGQFPGPTIEADWGDTIRISV
                     YNNFTDNNNGSAIHWHGLRQFENNVQDGVPGVTQCPSKPGETQVYEFRATQYGTSWYHS
                     HFSLQCECPLNGLFGPIVIHGPSSMDWDEDLGPWLLHDWYHDDVFSLLWVGETKNRGAI
                     PESTILNGKGKFDCNHHNDTRCTGTGGEYFEVNFRKGVRYKFTIANTGTLLEYMFWIDG
                     HNLTVIAADFVPIEPYVTDVVNVAMGQRYEIIVEANADFTHGSNFWIYAQYCDEVDLLP
                     HKAVGIVRYDEQDRQDPRTPPLSDQHRDFGCEDPDLDNLVPVVQQSVGRRVNRMEMKDY
                     LRMGQEGYPDPMNFDGDLHKWVLGDVPMFVDWKNPSLKKLAVDEHPDFPPETVPILLDF
                     DTGDWVHFVITNNYTFEKVHFPRNLTPVMHPMHLHGHDFAILAQGRGEFDPSIVPKLDN
                     PPRRDVVNVDTGSYVWIAFQVNNPGAWLLHCHIAFHVSSGLSLQFIEQPKKVKPLMEAA
                     GVLGEFHDRCAKWTEYYDSVNIPDNHTIDDSGI"
     gene            <7420..>8757
                     /locus_tag="AFUA_4G14500"
                     /old_locus_tag="Afu4g14500"
     mRNA            <7420..>8757
                     /locus_tag="AFUA_4G14500"
                     /note="transcript AFUA_4G14500A"
                     /old_locus_tag="Afu4g14500"
                     /product="conserved hypothetical protein"
     CDS             7420..8757
                     /codon_start=1
                     /locus_tag="AFUA_4G14500"
                     /note="encoded by transcript AFUA_4G14500A"
                     /old_locus_tag="Afu4g14500"
                     /product="conserved hypothetical protein"
                     /protein_id="EAL89345.1"
                     /transl_table=11
                     /translation="MATASQIRLRPRLGVARATDTNPDGALEAANRLLQKNHNEHHMFW
                     RSVAGHNHVAHSVLNTLALGGGPGDLQRAFDDGAEIQVPIPPMDRDAAASLSTPDQFRA
                     RMGSLEQYPNFLVFFTKEIETRGYPAVVIEYCFSGTSIAESMFANLFEGLYHPLIHLAL
                     GIEFDQPSIVAEGLAQAACHDSMNIEPFLFGTDKLAKTQDAPIDLNTPLLSLFHAVRDN
                     EVLRAAAHRDHGDGVARVRDGILGRAREEISLIAARFRVDVDELDHRAAEMISCAAYLA
                     GSAQRPGKARKIDFFHLHAVTASLGLIVLLQQPWVTPEQKARLIEWKARVDLVWYAASG
                     AVELRRKDIVDYRPRHGLTWDSLYQAVRRVHDDGHLAKFIRALKAGEQISRPFEQGKRA
                     EAFPIKGSMWLRIAQMAYDSSAGRPIEEKWIWGAGFEPNWATVPAV"
     gene            complement(<8918..>9941)
                     /locus_tag="AFUA_4G14510"
                     /old_locus_tag="Afu4g14510"
     mRNA            complement(join(<8918..9303,9359..9415,9472..9510,
                     9575..>9941))
                     /locus_tag="AFUA_4G14510"
                     /note="transcript AFUA_4G14510A"
                     /old_locus_tag="Afu4g14510"
                     /product="hypothetical protein"
     CDS             complement(join(8918..9303,9359..9415,9472..9510,
                     9575..9941))
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089:methyltransferase (Score: 68.1; E-value:
                     1.3e-20)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="AFUA_4G14510"
                     /note="encoded by transcript AFUA_4G14510A"
                     /old_locus_tag="Afu4g14510"
                     /product="hypothetical protein"
                     /protein_id="EAL89344.2"
                     /transl_table=11
                     /translation="MLEKVFHEKSFADQYTYGAKISELYAETLITESGIAKSHQRPLII
                     LDNACGTGSISSTLQRTLDERNKRSLKLTCGDLSEGMVDYTKQRMQAEGWNNAEAKIVN
                     AQDTGLPSDHYTHVYTAFAFNMFPDYKAALRECLRILQPGGTLATSTWKTANWCTIMKP
                     VIATMPGQLSYPTMDEINTMLNKGWDRESDVRAEFEQAGFDHVNITTVEKQCLLPVQEF
                     GEACKILLPYILSKFWTQEQRDQYEADVPSYLMRYLEREYGKDGLAPMKGVAIIASGRK
                     P"
     gene            <10528..>11319
                     /locus_tag="AFUA_4G14520"
                     /old_locus_tag="Afu4g14520"
     mRNA            <10528..>11319
                     /locus_tag="AFUA_4G14520"
                     /note="transcript AFUA_4G14520A"
                     /old_locus_tag="Afu4g14520"
                     /product="toxin biosynthesis protein, putative"
     CDS             10528..11319
                     /codon_start=1
                     /locus_tag="AFUA_4G14520"
                     /note="encoded by transcript AFUA_4G14520A; similar to
                     SP:Q00713: Putative sterigmatocystin biosynthesis protein
                     stcQ [Emericella nidulans]"
                     /old_locus_tag="Afu4g14520"
                     /product="toxin biosynthesis protein, putative"
                     /protein_id="EAL89343.1"
                     /transl_table=11
                     /translation="MPYAVLGATGNCGTALIQNLLQSSTSKVHAYCRDRRKLLYLLPHL
                     ADNKQVDIFDGSIHDLPLITECVRNCHAVFLVISTNDNVPQCRMALDTATAVIQALRIL
                     HGEGASMPKLVLLSSATLDDQLSQNTAPWVRWILLKSASQVYQDLSQAEAFLRQQQDWI
                     STIFIKPGGLSVDVQRGHRLSLTEEKSPLSYLDLAAAMIEAADDPDGRYDLRNVGVAYT
                     DGPARFPRGAPMCIFMGLVRHFLPFLHPYLPATGPNQGFLC"
     repeat_region   complement(11609..11642)
                     /note="microsatellite"
                     /rpt_type=tandem
                     /rpt_unit_seq="ta"
     repeat_region   complement(11713..11737)
                     /note="microsatellite"
                     /rpt_type=tandem
                     /rpt_unit_seq="tgtctgtctcgg"
     gene            <11737..>12414
                     /locus_tag="AFUA_4G14530"
                     /old_locus_tag="Afu4g14530"
     mRNA            <11737..>12414
                     /locus_tag="AFUA_4G14530"
                     /note="transcript AFUA_4G14530A"
                     /old_locus_tag="Afu4g14530"
                     /product="glutathione S-transferase Ure2-like, putative"
     CDS             11737..12414
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GST_N_3"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GST_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1193:glutathione S-transferase (Score: 151.1; E-value:
                     4.9e-46)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="AFUA_4G14530"
                     /note="encoded by transcript AFUA_4G14530A; similar to
                     Ure2p prion protein (GI:6324100) [Saccharomyces cerevisiae]
                     PubMed=1990286; GO_component: GO:0005625 - soluble
                     fraction; GO_function: GO:0003714 - transcription
                     corepressor activity; GO_process: GO:0006808 - regulation
                     of nitrogen utilization"
                     /old_locus_tag="Afu4g14530"
                     /product="glutathione S-transferase Ure2-like, putative"
                     /protein_id="EAL89342.1"
                     /sec_met_domain="GST_N_3 (E-value: 1.6e-15, bitscore: 47.3,
                     seeds: 52, tool: rule-based-clusters)"
                     /sec_met_domain="GST_C (E-value: 6.6e-15, bitscore: 45.1,
                     seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPDIQPITVYGKGGPNPPRVAIILAELDLPHKVIEVPLSKVKEPD
                     YVAINPNGRIPAIYDPNTDLTLWESGAIVEYLVSHYDPDHRISFPAGSNLAALATQWLF
                     FQASGQGPYYGQASWFKKFHHEKVPSAIERYVKEINRVTGVLEGHLSRQKVAADGDGPW
                     LVGGKCSFADLAWIPWQVIVTAIIQPEDGYTVEDYPHVKNWLDRMMARPGVQKGMADIF
                     PST"
     gene            complement(<12504..>13694)
                     /locus_tag="AFUA_4G14540"
                     /old_locus_tag="Afu4g14540"
     mRNA            complement(<12504..>13694)
                     /locus_tag="AFUA_4G14540"
                     /note="transcript AFUA_4G14540A"
                     /old_locus_tag="Afu4g14540"
                     /product="C6 transcription factor (AflR), putative"
     CDS             complement(12504..13694)
                     /codon_start=1
                     /locus_tag="AFUA_4G14540"
                     /note="encoded by transcript AFUA_4G14540A; GO_component:
                     GO:0005634 - nucleus; GO_function: GO:0003700 -
                     transcription factor activity; GO_process: GO:0045449 -
                     regulation of transcription"
                     /old_locus_tag="Afu4g14540"
                     /product="C6 transcription factor (AflR), putative"
                     /protein_id="EAL89341.2"
                     /transl_table=11
                     /translation="MRSPASSRRASALHRLCDSCRACGLSKVRCSKEKPTCSRCRRRGT
                     VCEYVVTKRPGRKPDSRSEVEPEPGHLSHPLPSPESSTAISQGNLPDPDAFDPLFALPE
                     PFDSTPELHSGPLSTVDSSLSSALTTWCPDFDDFFSFPVSTEDTLSGDRGAVYDGTIKH
                     PPNLRRHSESPPAVPDDTIYLFGKPVDPAPPDQSLPATTTIGRRASPPSGRESEAGSRR
                     LSCRCLIRALDLLKHFEVIRREAEIESSLPSIDAVVEVNKQTTEAITGMLQCPCSQKDG
                     YLLVLLALIVCKILDRYAAAAIPGTEQGHDPTRRLDEGPMAGQRVLGELHCIQRVMNQL
                     GPRLRMHGAQGASPGQAFHGTPAPLSVGLGDQLEPELHQRLSRLSSEIIRLLREAQ"
     gene            complement(<15066..>16431)
                     /locus_tag="AFUA_4G14550"
                     /old_locus_tag="Afu4g14550"
     mRNA            complement(join(<15066..15629,15682..>16431))
                     /locus_tag="AFUA_4G14550"
                     /note="transcript AFUA_4G14550A"
                     /old_locus_tag="Afu4g14550"
                     /product="toxin biosynthesis regulatory protein AflJ,
                     putative"
     CDS             complement(join(15066..15629,15682..16431))
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1042:O-methyltransferase (Score: 97.2; E-value:
                     1.9e-29)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="AFUA_4G14550"
                     /note="encoded by transcript AFUA_4G14550A; similar to AafJ
                     protein (GI:8980855) [Aspergillus sojae] PMID: 14736460"
                     /old_locus_tag="Afu4g14550"
                     /product="toxin biosynthesis regulatory protein AflJ,
                     putative"
                     /protein_id="EAL89340.1"
                     /transl_table=11
                     /translation="MDSITQLEARANEVAAAARRLAEYCRNARVDGACLPAVVPSEAPR
                     AIREIQRLLLSNVDHLQILLTEPADLVQRLAVQSQLLSCLQWLGEFQVLACLPLTDTVS
                     IADLARLSGVPEAQLARIIRFTITIGFLQEPQRGHVAHSPLSSLFVSRPSLRDAVMFLA
                     DSAAPTALQMASATGRFGDTVASETDTAYNIAFDHRDPFYFACEQRPKLQRRWSAYLQH
                     TGGDARDLTQQVLSRVDWFNLNNACVVEVLGPQSQSVTMMLDQLHPMLHFIVQEARIPN
                     GSTHAALHQDVRSVQIRELGGPQRVRDAAIYILNLGPLPHAILSTSVLTELRAHFSVLA
                     ANSCAMLILTAGLLLPKPGAVDARVETSVRLHDLSLLQLANDRLMEEDELVEMVHGVKD
                     SVGRLAVVNRLHLPCTTTVALGVRYQAFGHGDSSAKSL"
     gene            complement(<16737..>22267)
                     /locus_tag="AFUA_4G14560"
                     /old_locus_tag="Afu4g14560"
     mRNA            complement(join(<16737..17954,18000..20366,20413..21525,
                     21571..21871,21918..>22267))
                     /locus_tag="AFUA_4G14560"
                     /note="transcript AFUA_4G14560A"
                     /old_locus_tag="Afu4g14560"
                     /product="polyketide synthase, putative"
     CDS             complement(join(16737..17954,18000..20366,20413..21525,
                     21571..21871,21918..22267))
                     /NRPS_PKS="Domain: SAT (37-266). E-value: 2.1e-60. Score:
                     196.1. Matches aSDomain: nrpspksdomains_AFUA_4G14560_SAT.1"
                     /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (409-841). E-value:
                     7.9e-143. Score: 468.2. Matches aSDomain:
                     nrpspksdomains_AFUA_4G14560_PKS_KS.1"
                     /NRPS_PKS="Domain: PKS_AT (947-1245). E-value: 1.8e-83.
                     Score: 272.2. Matches aSDomain:
                     nrpspksdomains_AFUA_4G14560_PKS_AT.1"
                     /NRPS_PKS="Domain: PT (1330-1647). E-value: 3e-117. Score:
                     383.3. Matches aSDomain: nrpspksdomains_AFUA_4G14560_PT.1"
                     /NRPS_PKS="Domain: ACP (1715-1779). E-value: 1.2e-13.
                     Score: 43.0. Matches aSDomain:
                     nrpspksdomains_AFUA_4G14560_ACP.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     itr_KS"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     PKS_AT"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1093:Beta-ketoacyl synthase (Score: 86.4; E-value:
                     2.7e-26)"
                     /gene_kind="biosynthetic"
                     /locus_tag="AFUA_4G14560"
                     /note="encoded by transcript AFUA_4G14560A; similar to
                     polyketide synthase PKS19 (GI:40787399) [Cochliobolus
                     heterostrophus] PUBMED 14676319; GO_function: GO:0016218 -
                     polyketide synthase activity"
                     /old_locus_tag="Afu4g14560"
                     /product="polyketide synthase, putative"
                     /protein_id="EAL89339.1"
                     /sec_met_domain="itr_KS (E-value: 4.8e-159, bitscore:
                     519.5, seeds: 96, tool: rule-based-clusters)"
                     /sec_met_domain="PKS_AT (E-value: 4.5e-84, bitscore: 272.2,
                     seeds: 1682, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 6e-13, bitscore:
                     39.1, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRPVDFTPSSESPTAEKGMKVVYFGNELPQDGIQGICRRLHTYTK
                     DRRYPLLARFIEESTWAVHDEVRQLHAAQKALVSPFESVLHLAEQPELCRGPLCGSIEG
                     VLLCVIQLGTFIGYYEDSPNEYTFDSANTYLTGLGLGLLASTAVSLSPTLADLPLAGAE
                     VVRVAFRLGVLVADVSQNLQPADATGERDSWAYVIPNVAPKEAEEELAVIHTRENTPEA
                     SRIFISAISRTSVTISGPPARLRRLFRMSDFFRDRTFVALPVYGGLCHAKHIYNSQHAR
                     SVVQGPSIAALDTRFIARYPILSTGSGEPFPTATTATELFEHVMTEILTQAIEWENVIQ
                     GVVERAKLLSVSEVQVQVFRNSHPVHDLLSALETSLREGVEVAIKDLGPWITRTRDEER
                     PPPRGTAQSKIAIVGMSCRMPSGATDTEKFWDILEQGLDVHRKIPPDRFDVDSHYDPAG
                     KRVNASHTPYGCFIDEPGLFDAPFFNMSPREAQQTDPMQRLAIVTAYEALERAGYVANR
                     TRSSNKHRMGTFYGQASDDYREVNSAQEISTYFIPGGCRAFGPGRINYFFKLWGPSFSI
                     DTACSSSLATIQAACTALWNGDTDTVVAGGMNVLTNSDAFAGLSHGHFLTKTPNACKTW
                     DCEADGYCRADGVASIVMKRLEDAEADNDNILGVILGAATNHSAEAISITHPHAGAQSC
                     LSRQVLRSAGIDPMDVSYVEMHGTGTQAGDAEEIKSVSDVFAPAVKRRSSQQPVFIGAV
                     KANVGHGEAVAGVTALVKVLLMFQKEAIPPHVGIKNSINPGFPKDLDQRNLRIPYEKKP
                     WPRRPGRKRIAMVNNFSAAGGNSTLAIEEGPLRPKPAGAIDPRSSHLVTVSAKSKISLK
                     GNLERLLSFLDAHPDVALSDLAYTTTARRHHHNHRVAVATSDIADLKAQLCKTLESDSV
                     NTLQPISATGPPPIAFAFTGQGSSYKSWDLQLFQHSPYFRSQILHLDTLAQGQGFPSFV
                     PAIDGSYPRDHAHCPVITQLALVCTEIALAKYWVSLGVTPDVVVGHSLGEYAALHIAGV
                     LSASDAIFLVGQRACLLQERCQPSSHQMMAVRASLEQIEQFAGSLPYEIACVNGPREMV
                     LSGTREEMAAVARLLEAEGFKCIVLEVAFAFHSAQMDPILDEFEALAASGVVFQAPNLP
                     VISPLLSKVVFDEHTIDSVYMRRATRETVHFLSAMKMAHKISTIDDATVWVEIGPHPVC
                     VNFVRSSLPSTSVTVPSFRRGEDNWVTLTSSLGILHCAGVPVDWNEFHQPFERALRLLD
                     LPTYSWNEKTYWIQYQGNWALTKGNTFYDDEAPQTKALAGLASELRTSTVQQIIHEQYD
                     GAAGSVVMQSDLMQPDFLAAAYGHKMNGRGVVTSSIHADIAFTLGEYLYKKLNPNQEPH
                     MNIANLEVVKALVAQENTKSPQLIQVSASTDNIRSRQAHLKWHNVINGSIEEPFASATV
                     YYEEASDWLASWRPATHLVQGRIHALEQLAEDGVANRFTRRMAYGLFASSLVDYADKYR
                     GMQSVVLHELEAFADVVLTTEKGGTWTVPPYFIDSVAHLAGFIMNVSDANDTNANFCVT
                     PGWSSMRFAAPLLPGSKYRSYVKMIPTVEDNNIYLGDVYILQDETIVGMVGGIKFRRYP
                     RILLNRFFSAPDADARKSTPATSAPAPAPPAGSEALQPKAAPASTPAAPASADAPTTNG
                     VKAAAEPDANSTAAKAIALVATEAGLGLSDLKDSASFSSLGIDSLMSLVISEKFRETLG
                     VTVTGSLFLEYPTVGDLKSWLLEYYS"
     aSDomain        complement(16749..16940)
                     /aSDomain="ACP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AFUA_4G14560_ACP.1"
                     /evalue="1.20E-13"
                     /label="AFUA_4G14560_ACP.1"
                     /locus_tag="AFUA_4G14560"
                     /protein_end="1779"
                     /protein_start="1715"
                     /score="43.0"
                     /tool="antismash"
                     /translation="LVATEAGLGLSDLKDSASFSSLGIDSLMSLVISEKFRETLGVTVT
                     GSLFLEYPTVGDLKSWLLE"
     aSModule        complement(16749..20949)
                     /complete
                     /domains="nrpspksdomains_AFUA_4G14560_PKS_KS.1"
                     /domains="nrpspksdomains_AFUA_4G14560_PKS_AT.1"
                     /domains="nrpspksdomains_AFUA_4G14560_PT.1"
                     /domains="nrpspksdomains_AFUA_4G14560_ACP.1"
                     /iterative
                     /locus_tags="AFUA_4G14560"
                     /monomer_pairings="mal -> mal"
                     /tool="antismash"
                     /type="pks"
     aSDomain        complement(join(17145..17954,18000..18140))
                     /aSDomain="PT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AFUA_4G14560_PT.1"
                     /evalue="3.00E-117"
                     /label="AFUA_4G14560_PT.1"
                     /locus_tag="AFUA_4G14560"
                     /protein_end="1647"
                     /protein_start="1330"
                     /score="383.3"
                     /tool="antismash"
                     /translation="TSTVQQIIHEQYDGAAGSVVMQSDLMQPDFLAAAYGHKMNGRGVV
                     TSSIHADIAFTLGEYLYKKLNPNQEPHMNIANLEVVKALVAQENTKSPQLIQVSASTDN
                     IRSRQAHLKWHNVINGSIEEPFASATVYYEEASDWLASWRPATHLVQGRIHALEQLAED
                     GVANRFTRRMAYGLFASSLVDYADKYRGMQSVVLHELEAFADVVLTTEKGGTWTVPPYF
                     IDSVAHLAGFIMNVSDANDTNANFCVTPGWSSMRFAAPLLPGSKYRSYVKMIPTVEDNN
                     IYLGDVYILQDETIVGMVGGIKFRRYPRILLNRFFS"
     aSDomain        complement(18396..19289)
                     /aSDomain="PKS_AT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AFUA_4G14560_PKS_AT.1"
                     /evalue="1.80E-83"
                     /label="AFUA_4G14560_PKS_AT.1"
                     /locus_tag="AFUA_4G14560"
                     /protein_end="1245"
                     /protein_start="947"
                     /score="272.2"
                     /specificity="substrate consensus: mal"
                     /specificity="PKS signature: Malonyl-CoA"
                     /specificity="Minowa: mal"
                     /tool="antismash"
                     /translation="FTGQGSSYKSWDLQLFQHSPYFRSQILHLDTLAQGQGFPSFVPAI
                     DGSYPRDHAHCPVITQLALVCTEIALAKYWVSLGVTPDVVVGHSLGEYAALHIAGVLSA
                     SDAIFLVGQRACLLQERCQPSSHQMMAVRASLEQIEQFAGSLPYEIACVNGPREMVLSG
                     TREEMAAVARLLEAEGFKCIVLEVAFAFHSAQMDPILDEFEALAASGVVFQAPNLPVIS
                     PLLSKVVFDEHTIDSVYMRRATRETVHFLSAMKMAHKISTIDDATVWVEIGPHPVCVNF
                     VRSSLPSTSVTVPSFRR"
     CDS_motif       complement(18801..18839)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AFUA_4G14560_0005"
                     /evalue="2.50E-02"
                     /label="PKSI-AT-M_m5"
                     /locus_tag="AFUA_4G14560"
                     /protein_end="1110"
                     /protein_start="1097"
                     /score="8.1"
                     /tool="antismash"
                     /translation="ACVNGPREMVLSG"
     CDS_motif       complement(18933..19055)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AFUA_4G14560_0004"
                     /evalue="9.40E-17"
                     /label="PKSI-AT-M_m3"
                     /locus_tag="AFUA_4G14560"
                     /protein_end="1066"
                     /protein_start="1025"
                     /score="53.1"
                     /tool="antismash"
                     /translation="GVTPDVVVGHSLGEYAALHIAGVLSASDAIFLVGQRACLLQ"
     aSDomain        complement(join(19608..20366,20413..20949))
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AFUA_4G14560_PKS_KS.1"
                     /domain_subtypes="Iterative-KS"
                     /evalue="7.90E-143"
                     /label="AFUA_4G14560_PKS_KS.1"
                     /locus_tag="AFUA_4G14560"
                     /protein_end="841"
                     /protein_start="409"
                     /score="468.2"
                     /tool="antismash"
                     /translation="IAIVGMSCRMPSGATDTEKFWDILEQGLDVHRKIPPDRFDVDSHY
                     DPAGKRVNASHTPYGCFIDEPGLFDAPFFNMSPREAQQTDPMQRLAIVTAYEALERAGY
                     VANRTRSSNKHRMGTFYGQASDDYREVNSAQEISTYFIPGGCRAFGPGRINYFFKLWGP
                     SFSIDTACSSSLATIQAACTALWNGDTDTVVAGGMNVLTNSDAFAGLSHGHFLTKTPNA
                     CKTWDCEADGYCRADGVASIVMKRLEDAEADNDNILGVILGAATNHSAEAISITHPHAG
                     AQSCLSRQVLRSAGIDPMDVSYVEMHGTGTQAGDAEEIKSVSDVFAPAVKRRSSQQPVF
                     IGAVKANVGHGEAVAGVTALVKVLLMFQKEAIPPHVGIKNSINPGFPKDLDQRNLRIPY
                     EKKPWPRRPGRKRIAMVNNFSAAGGNSTLAIEE"
     CDS_motif       complement(19950..19997)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AFUA_4G14560_0003"
                     /evalue="9.90E-04"
                     /label="PKSI-KS_m5"
                     /locus_tag="AFUA_4G14560"
                     /protein_end="727"
                     /protein_start="711"
                     /score="11.6"
                     /tool="antismash"
                     /translation="YVEMHGTGTQAGDAEE"
     CDS_motif       complement(20316..20354)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AFUA_4G14560_0002"
                     /evalue="6.50E-01"
                     /label="PKSI-AT-M_m5"
                     /locus_tag="AFUA_4G14560"
                     /protein_end="605"
                     /protein_start="592"
                     /score="3.8"
                     /tool="antismash"
                     /translation="ALWNGDTDTVVAG"
     CDS_motif       complement(20422..20466)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AFUA_4G14560_0001"
                     /evalue="1.00E-05"
                     /label="PKSI-KS_m3"
                     /locus_tag="AFUA_4G14560"
                     /protein_end="585"
                     /protein_start="570"
                     /score="17.7"
                     /tool="antismash"
                     /translation="GPSFSIDTACSSSLA"
     aSDomain        complement(join(21379..21525,21571..21871,21918..22156))
                     /aSDomain="SAT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AFUA_4G14560_SAT.1"
                     /evalue="2.10E-60"
                     /label="AFUA_4G14560_SAT.1"
                     /locus_tag="AFUA_4G14560"
                     /protein_end="266"
                     /protein_start="37"
                     /score="196.1"
                     /tool="antismash"
                     /translation="RRLHTYTKDRRYPLLARFIEESTWAVHDEVRQLHAAQKALVSPFE
                     SVLHLAEQPELCRGPLCGSIEGVLLCVIQLGTFIGYYEDSPNEYTFDSANTYLTGLGLG
                     LLASTAVSLSPTLADLPLAGAEVVRVAFRLGVLVADVSQNLQPADATGERDSWAYVIPN
                     VAPKEAEEELAVIHTRENTPEASRIFISAISRTSVTISGPPARLRRLFRMSDFFRDRTF
                     VALPVYG"
     gene            <22406..>23671
                     /locus_tag="AFUA_4G14570"
                     /old_locus_tag="Afu4g14570"
     mRNA            <22406..>23671
                     /locus_tag="AFUA_4G14570"
                     /note="transcript AFUA_4G14570A"
                     /old_locus_tag="Afu4g14570"
                     /product="metallo-beta-lactamase domain protein, putative"
     CDS             22406..23671
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1170:metallo-beta-lactamase family protein (Score:
                     159.5; E-value: 1.2e-48)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="AFUA_4G14570"
                     /note="encoded by transcript AFUA_4G14570A; GO_function:
                     GO:0003824 - catalytic activity; GO_process: GO:0008152 -
                     metabolic process"
                     /old_locus_tag="Afu4g14570"
                     /product="metallo-beta-lactamase domain protein, putative"
                     /protein_id="EAL89338.1"
                     /transl_table=11
                     /translation="MLALHQTQRDVPCSEVHDALGLQGARSIYFGRPTGRSILSDPIRP
                     RPMPTVTVIIYSDIRFLLEFPSVFLCAYVLPVQRTVIMANEKRGGYRQINQALNICAWE
                     GYLNEQHARLPTLEDVEQISPRVLRVLGQNEGKVRRADGYYTCSSRLIEGPQFTLQGTN
                     TYIVGTGRHRLLIDTGQGIPEWASLISSTLAGSSIELSHVLLTHWHGDHTGGVPDLLRM
                     YPDLSDSIYKHTPGKGQKPISDGQTFRVEGATVRAVHTPGHSHDHMCFILEEENAMFTG
                     DNVLGHGSSAVEVLSTWMSSLRMMQSLRCAVGYPAHGAVIRDLPSKLDLELTQKARRED
                     RVVETLKQMKTETQRNGARGKGSVTVQQLVTAMHGHDLDEQVRTMALEPFVDEVLRKLA
                     QDDRVAFEVRGGQKKWFAIEYT"
     gene            <24072..>25708
                     /locus_tag="AFUA_4G14580"
                     /old_locus_tag="Afu4g14580"
     mRNA            join(<24072..24459,24540..24983,25038..25305,25360..>25708)
                     /locus_tag="AFUA_4G14580"
                     /note="transcript AFUA_4G14580A"
                     /old_locus_tag="Afu4g14580"
                     /product="O-methyltransferase, putative"
     CDS             join(24072..24459,24540..24983,25038..25305,25360..25708)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1042:O-methyltransferase (Score: 292.4; E-value:
                     7.8e-89)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="AFUA_4G14580"
                     /note="encoded by transcript AFUA_4G14580A; similar to
                     GB:BAA32788.1: Ich1 [Coprinopsis cinerea] PUBMED 9671586;
                     GO_function: GO:0008171 - O-methyltransferase activity"
                     /old_locus_tag="Afu4g14580"
                     /product="O-methyltransferase, putative"
                     /protein_id="EAL89337.1"
                     /transl_table=11
                     /translation="MERQPKSLCDATQLLETANIISDTVQTIIAEWSAEAKAPQGSGKQ
                     NAPMLPSRELFDAQRTILAAVGKLTELVSDPSARILEVATQFQESRSLYIAAERRIPDL
                     LAAGDEGGVHIDQISQKAKIEPRKLARILRYLCSIGIFKQTGPDTFANNRISAALVSNE
                     PLRAYVQLVNSEGFTASDRLPHTLLHPDTGPSYDVAKTAWQNAVCTKKTRWEWLEERVA
                     PEQLLESGGHYPGIPSLVMGLPPREDDGLVARPELEIMGLSMVGGGRVFGTAHVYDFPW
                     ASLGDALVVDVGGGVGGFPLQLSKVYPQLRFIVQDRGPVVKQGLEKVWPRENPEALHQG
                     RVQFVEHSFFDTNPTEGADIYFLRYVLHDWSDDYCVRILAAIRSSMAAHSRLLICDQVM
                     NTTIGDPDLDSAPSPLPANYGYHTRFSHSRDITMMSCINGIERTPAEFKGLLQAAGLKL
                     KKIWDCRSQVSLIEAVLPEMNGFR"
ORIGIN
        1 acaatggcac ctctcaagct caatagcagg aacctgtcgc aaatcgcagc ggcaggtggc
       61 gcgctggtga agatccctac ctaccagcgc ggtcgcgccg tcaaggaggg aatcgtccac
      121 attggtgtcg gcggtttcca ccgggcgcac ctggctgtct acatcgacca gttgatgcag
      181 aagcatgggg taaacgacta cgccatttgc ggagtgggct tgcagccctt cgactcggcc
      241 atgcgcgacg cgttggcctc gcaggaccac ctctacaccc tcattgagcg ttcggccaag
      301 ggcagctttg cccacgtcat cggcagcatc aactcctacc tctttgcccc cgataaccgc
      361 gaggcggtca tcgccaagat ggctcacccg gacacgaaga ttgtgtccct caccatcacc
      421 gagagcggtt actactacaa tgagaacacc cacgagctgc agagtgagca cccggacatc
      481 cagttcgacc tggacccggc caacgagaag gccccgcgca cgaccttcgg tttcctctac
      541 gcgggcctga cccgccgcta ccagcagggc ctcaagccct tcaccgtcat gtcctgcgac
      601 aacatgcaga agaacggatc catcacccgc cacatgctcg agtcgtttgc ccgcctgcgc
      661 aacccggagg tcgcggagtg gattgccgag gaaggcgcct tcccgaacgc catggtcgat
      721 cgcatcaccc ctcagacgtc ggagaccgac aaaacggcac tggcagagaa gtttggcatt
      781 gtggactcgt ggcccgtcgt cacggagccc ttcacgcagt gggtcatcga ggatcagttc
      841 tccgacggcc gtccgccctt cgagaaggtt ggggtccagg tggtcaagga tgtgcacgct
      901 gtcgagcagt tcgagaagca caagctgcgc ttgctcaacg gcagccactc ggccctgggc
      961 taccccggtc agctggcggg cttccagtac gtgcacgagg tcatggcgaa cccgctgttc
     1021 cgcaagttcg tgtggcagat gatgcaggag gaggtcaagc cgctcctgcc ggagatcccg
     1081 ggcgtcgaca tcgacgagta ttgcaacacc ctcatcgagc gctttaccaa ccccaccatt
     1141 atggaccagc tgccccgtat ctgtctcaac gcgtccggca agattcctca gttcatcatg
     1201 ccctcgattg ccgaggcgat ctgggagacg ggtccgttcc gccgcctgtg cttcgtcgcc
     1261 gccgcctggt tccactacat caagggggtc gacgaccgtg gcaagccgtt cgaggtggtc
     1321 gaccccatgc gcgaggagct ccaggccaag gctcgcgccg gaggcaacga cccgtccgag
     1381 ctgctcagca tcaagagcct gttcggggat gacctgcgca acgacgagcg gttcctcagg
     1441 gagatcacca ccgctatgaa tgacattgcc cgggacggca tcatgaagac gctccccaag
     1501 tacattaact aatcgcccgg cgagacttgt tggatggtac acccctgcgt ttgcgagcga
     1561 gatttttaaa ttttgcatat ttcatgagtg atttggacaa aagcacccca tagagaatag
     1621 agatgataga ctacgtcccc taattctcgc tttttgcgca tccgtcattc agacctgcgg
     1681 gagaactggg ccgaatatgc ttgtgatgga tttggatgga ttgggacgga tttggatttg
     1741 gctctgggca tttatacacg gttgcagtac ataggagttt acacataata ttgatcacaa
     1801 tcatcctaca cacggcctct atcttacaga tggtgatcaa acttgggtgt tggtccttga
     1861 cactgtataa ttgactgcaa tacactgcag gagggtacct aggtagattc ctaacgccgc
     1921 gtcgcgagga tcaaagtcgc cggccaacag ccacgcaaac atcgcccctc gtccaagagg
     1981 tccttgagct cctgcaacaa tcccgtaaag gccgcgggat cagcccctgc gtgaggaaac
     2041 gagcggaaat gctgcaggaa accctcccag tcggtttcaa agcgccattc ctcattcgtc
     2101 tcgtacacga ccacatccct cggtcccgcg aagtcaggat ccgtcacttc ctgctgtcgc
     2161 tccggcggca gaaggcccgt gatgccgccc tgggccatgt tcagccggat gcgcaatgcc
     2221 cctggtcgaa accactgcgg ctccagcgga gccacgttgt actccttcga actgcgactc
     2281 atgacgttaa tggtgtccgg cggatgctcc gccatgccca ggaggatccg gccgccctgc
     2341 tggctgatcc gctcccagac atcttggata tcagggtcat caaagcgcgc ggggccaaac
     2401 cccgcgcacg caaaggtgcc tcccggccgg agctgcgtcg caatcgcctg catggccgcg
     2461 tgctggtccg caaagtgcat cacgttggtt gcaaaggcca gatccacgct cccgggcggc
     2521 aggtcgtcgg cgacttcgac tggcgcggcg cgatagcgga agccgtctcg tccgaggtgc
     2581 gcctcggcca gctggacgtt tttcggcacg atgtcggaga caatgacgtg ggggaactgg
     2641 gaccgtagct cccctgcgta gggcccgatt cctgcgccca catcgtggac tgtcccaaac
     2701 cgcccgccgt gctctcgatg gtagcgatag atgcgttgga agaagctcgg tggcacctga
     2761 gggcggcctc ggagatagtt gtcccagaac gccttgctgc gggcgaaaac ctggtctttg
     2821 gactcgatag gggctgccgt tggaggggga atgctctggg ggacagccat gctgacgttt
     2881 gatctactgt gttgttggct gctgtcaata gtattatatc tactctgtta gtacggtgga
     2941 caagaataca tacaacaccg cagtatgtaa tctgcatagt ctcatcacct tacctaagcc
     3001 cagcggtgcc ctcactgacc gtcagaatcg ggctcgggga tcttgggtta tgaggaaatg
     3061 gtccgagagt ctatgaagtc acctccactg aatactaccg gacactgtca cttggtcctg
     3121 tactcctctc caccgatcat tctgtcaatt atcttgatta tccggcctcg tgtcccataa
     3181 cagctatgct ctcagaccct cgcttaatcc tcttgtctaa tgcctactcc ctgagaatct
     3241 gcctcaaacc caggactgac cccatcagcg ggaatagcga gcgcaccgca tgcagctgtg
     3301 cccatcggac aagtagtcgc cgcacctcac cgaggttcgc tgcagcggga ttggcatgca
     3361 ttcgaaagag agcattgttg gtcggggcca tgaccagcca cgtaaaaggc accatcgaga
     3421 tcgttgtcac cgccgcaatg atatggggga gtcccgaccc gcccgtagtg cgcgtgctgc
     3481 tcgcagtata gccgtagagc agacaggttg tgacagccag actgggcatc atcttatgtc
     3541 caatatcata aaggcgtgtg aaatgttgca atagttgcga ggcttgagta gcagtgtcga
     3601 gcaccacagg gatgtcaacg accgaaagtc ccatcatgag gcctgcgtcg gcgttaagtc
     3661 tctctacgtg gattcgacat aggatgacat acccgagaga aaggagcctg taatgactgc
     3721 agtcgcctgc gtaataatca cggaagcatt ctgcggcata ttgatagaag tgcagttcga
     3781 aggtgctaga gaatagagac aaatgccaat agctgtagcg aaacgatcgc agttatagag
     3841 gagcccaggt gcaaagacga gaattgcccc gatagtcagt tcggttacat caaagagctc
     3901 ggtctggtgg atctggtcag aacaaatcat cccgctggcc gatttaagga tctctgcgtc
     3961 gtggaaaccg ccagcatgca gattactatc cagacccctt tcatatctcg actcctctaa
     4021 tctgcatgaa aagatgggcg aatcctccag gaagccgagc agatatctct gcctcaccat
     4081 ctgcggctac cgcaagccgg gcatgagtga agaagactac cgccgctata tgaccgaggt
     4141 ttccgccccg atgaccaagg acctgatggt aaaatatggc gtcaagcgat ggacgatggt
     4201 ggatttgcac tactcccatt gtatactcgg ttactaacag aacaggtgca taacacgacc
     4261 gccacccgcg cgctcatggc cgagttgtgc gactcgcaaa tgaccaacgt cgtggacttt
     4321 gactgtttca gtcaggtcgt cttcgagagc ctggaggact acaagcgcat gaagcaggat
     4381 ccttggtaca aggagcattt gttccacgat catgagaatt tcgcggatac caagaaaagc
     4441 atgtaagtca ctcgttcatg tgtagaggga agactcacgc tggttgccct caggatgacg
     4501 attgggtgga tcgaggagtt tgttcggcag ggagtcgctg tggatgggat ggataactaa
     4561 ccgctcttgt tctgttctgt tcataaatag ggtagaatgg tagatccatg ttcaaccgct
     4621 ctgttgtctt gtcaaaccct ccgagccttt ggtccgagtg tcctgctggc atttctttct
     4681 accgatgtaa ctagaatagg tcgggctcga ttaataagag tcctgttcat aagtgcccta
     4741 atgatcatgc actggctaat agactgtcag gcgtaattat cttcagatct tgcagtcaca
     4801 caatgatcac tgtcatcaag tggctcgtct ctggctgctg tgctctcgca gccgtgacaa
     4861 ccagagcccc tttgccaaaa gattgccgga atactccaaa cagtcgaggc tgctggaaag
     4921 acgggtttga tattctgaca gactacaccg atcccaaacg cgccccgcct ggaaagctgg
     4981 tcgaggtcag tggtcttccg tgttgtgctc gtcctggttg aatggatcag ataccaacgt
     5041 gataatagta caatcttacc gtcagtcaac aagtcatcgc tcccgatgga tacgagaaac
     5101 taggaatggt ggccaatggt tcgtatggtc gcatacgtgg gaggacgtgg gaataatgag
     5161 actctacagg gcagtttccc ggtcctacga tcgaagcaga ttggggggac acaatccgta
     5221 cgactctact tgcatacaca tgtaaactac tgacaggtac aggcattagc gtatacaaca
     5281 atttcaccga caacaacaac ggtagcgcta tccactggca tgggcttcgt cagttcgaga
     5341 acaatgtcca ggacggagtc cccggagtca cacagtgtcc gagcaaggta acaattagcc
     5401 cagcggagta tcggagaagc gactgacctg tcattatagc ctggagaaac gcaggtatac
     5461 gagtttcggg cgacgcaata tggaacgtcc tggtatcatt cgcatttcag cttgcagtgt
     5521 gagtgtcctc tgttcagttc aaagtatggc tagtaatgga tctcagacag caatggactc
     5581 tttggtacgt aatcatccta cgacaatgtg gctatactga agacgtcgcc aggaccgatc
     5641 gtcattcatg gcccgtcaag catggactgg gatgaggacc tggggccctg gctcctgcac
     5701 gactggtacc acgacgatgt gttttccttg ctttgggtag gcgagacgaa aaatcgagga
     5761 gctattcccg agtccaccat cctcaatggc aaggggaagt tcgactgtaa tcaccacaac
     5821 gacacgcgct gcaccggaac gggtggagag tattttgagg tcaacttccg aaagggcgtc
     5881 aggtacaagt tcaccatcgc caatacgggg accctgctag aatatatgtt ctggattgat
     5941 gggcataacc tgaccgtcat tgcggccgac ttcgtcccca tcgaacccta tgtcaccgac
     6001 gtggtcaatg tggcgatggg ccagcggtat gaaatcatcg tcgaggcaaa cgccgacttc
     6061 acgcacggtt ctaacttctg gatttacgcc caatactgtg acgaggtcga tctgctgccc
     6121 cacaaggcag tgggaattgt gcgctacgac gaacaggacc gtcaggaccc ccggacgcca
     6181 cctctcagcg accagcatcg agactttggc tgcgaggacc ccgatctaga caacctcgtt
     6241 cctgtcgtcc agcagtcggt cggcaggcga gtgaaccgca tggagatgaa ggactacctg
     6301 agaatgggcc aagagggcta ccccgacccg atgaacttcg acggtgacct ccacaaatgg
     6361 gtcctggggg atgtcccgat gtttgtggat tggaagaatc ccagcctcaa gaaattggcc
     6421 gtagatgagc atccggactt tccaccggag accgttccca tcctgctgga cttcgataca
     6481 ggcgactggg ttcacttcgt cattaccaac aactatacct tcgaaaaggt gcatttcccg
     6541 cgcaatctga ccccggtcat gcatccgatg cacttgcacg ggcatgactt tgccattctc
     6601 gctcagggca gaggcgagtt tgacccgagc atagtcccga agctggataa tcctccccgc
     6661 cgcgacgtgg tgaacgtcga tactggcagc tatgtctgga ttgccttcca ggtcaacaac
     6721 ccgggggcat ggctgctgca ttgccacatc gccttccatg tcagtagtgg gctctccttg
     6781 cagttcatcg agcagcccaa gaaggtcaag ccgctcatgg aggcggccgg tgtgttgggg
     6841 gagtttcacg atcgatgcgc gaaatggaca gaatattacg acagcgtgaa catccctgat
     6901 aaccatacca tcgacgactc gggcatctag gaaagtccag ggcctatcta gagggattga
     6961 gtgagctgga agctcaccat aactttaccg caacgtccta atgagcttgg gtgaagatat
     7021 gtttagctta ctgattatat ctaggtgact gagtgagttg gacttggaag agagtagtca
     7081 gctgtatagt tccatgccat aagaattcag acaggttcta gtctgtggcc caatctatcc
     7141 atttgccagt ctggaatatt gctgcgtatg catgccctca gttgcaatgt agttaagaac
     7201 tcaaagatgc ctgttcactc tgtcgatttt atactcgatt ctatactctg tcgtggtatt
     7261 gtggctacaa gtgcctctgt gccatcctcc atggtgattc tcgggacaat tcaaggtgac
     7321 gtcgggcaga tcggggcccg catgaactcc aacaaagacc ccttaaatgg ttctcttact
     7381 actgaacttt ccctagaccg ctgcagtaac gttttctaaa tggcaacagc ttcacaaatc
     7441 cggcttcgtc ctcgcttggg cgtcgcccgc gccaccgaca ccaatccgga cggtgcgctg
     7501 gaggccgcga atcgactgct ccaaaagaac cacaatgaac atcacatgtt ttggcggagt
     7561 gttgccggcc acaatcacgt cgcccactcg gtgctaaaca ctctggccct tggtggcggg
     7621 cccggagatc tccagcgcgc attcgacgat ggggccgaga ttcaggtgcc tattccgcca
     7681 atggatcgtg acgcagcggc cagcttgagc accccggatc agtttcgggc gcggatgggc
     7741 tccttggaac agtatccgaa cttcctggtc ttcttcacca aagagataga aaccagaggg
     7801 tatccagctg tcgtgatcga gtactgtttc agcggtacat ccatcgcgga gagcatgttc
     7861 gcgaacctct tcgaaggtct atatcatccg ctgatccacc tggcgctggg aatcgaattc
     7921 gatcagccca gtatcgtggc agaaggcctc gctcaggctg cctgccatga ctccatgaac
     7981 attgaaccat tcttatttgg caccgacaag ctggccaaga cccaggatgc cccaatcgac
     8041 ttgaatacac cgttgctaag tctgtttcat gctgtgcgag ataacgaggt cctccgggcc
     8101 gcagcccaca gggaccacgg tgacggtgtg gcccgagtgc gagatggcat cttgggcagg
     8161 gcccgagagg agatcagctt aattgccgcg agatttcgag tcgatgttga tgaattggat
     8221 caccgagcgg ccgagatgat cagctgtgcg gcctacctag ctgggtcggc gcagcggccg
     8281 ggcaaggcgc gcaagattga cttcttccac ctgcacgccg ttactgcctc gctgggactg
     8341 attgtgttgc tccagcagcc ctgggtcaca cccgagcaga aagcgcgtct gatcgagtgg
     8401 aaggcccgcg tcgatctggt gtggtatgcg gccagtggtg ctgtggagct tcgtcgcaag
     8461 gacatcgtgg attacaggcc tcgtcacggg ttgacctggg acagccttta ccaggcagtc
     8521 cggcgtgtgc atgacgatgg acacttggcc aagtttatcc gggctttgaa ggccggagag
     8581 cagatctcaa ggccgtttga gcaggggaaa agggccgagg cattcccgat caagggctct
     8641 atgtggctcc gaatcgcaca aatggcatat gattcgagtg ctggtcgtcc aatcgaagaa
     8701 aaatggatct ggggagcggg atttgagccg aactgggcca cagtgccagc agtgtgaaac
     8761 tgattgacgt cgggtagggt ttgacaagta cggttttcaa tagaatcaat cattcggtac
     8821 aattgtgact tcctaataag catattgaag aacactccta catacattcc cagtataact
     8881 tgctgtccac ctggttgcac agtttctgaa ccaacattca aggcttacgc ccgcttgcaa
     8941 tgatcgcaac gcctttcatc ggagccagcc catccttgcc atattctctc tccagatacc
     9001 gcatgagata gcttggcacg tcggcctcat actggtcccg ctgctcctgg gtccagaact
     9061 tgctgaggat gtagggcagg agaatcttgc acgcctcgcc aaactcttgc accgggagta
     9121 agcattgttt ctccacggtg gtgatgttga catgatcgaa ccctgcctgc tcaaattcgg
     9181 cgcgtacgtc ggactcgcgg tcccagcctt tattgagcat cgtattgatt tcatccattg
     9241 tgggatatga cagctgtccc ggcatagttg caatgacagg cttcatgata gtgcaccagt
     9301 tggctatgaa aaagatcagt atgtgtgcat gtacctaggg cctgtaggag ggaagtacca
     9361 gtcttccagg ttgaggtcgc taatgtcccg cctggttgaa gtattctgag gcattctggt
     9421 gcaaatggtc gttagagtct tccgcgtgat gcacatagaa agggcaatca cctctcaatg
     9481 ctgctttgta gtcagggaac atgttgaaag ctatcggaag cagtggagtc agaatgcgaa
     9541 gtactggatg gactctcctt gcttctgtgc tcaccaaatg ctgtatacac atgggtgtaa
     9601 tgatcactgg gcagaccagt atcctgcgca ttcacgatct ttgcttccgc attgttccac
     9661 ccttcggcct gcatccgctg cttggtgtag tccaccatac cctccgatag atcaccacag
     9721 gtcaacttca agctcctttt atttctctcg tccagggtac gctgaagggt actggagatg
     9781 gaacccgtcc cacaggcatt gtccaagata atcaacggtc tctgatggga tttggcgatg
     9841 ccagactcag ttattagtgt ctccgcatag agctcactga ttttggcgcc atatgtgtac
     9901 tgatcggcga agctcttttc gtggaatacc ttctcaagca tggtgtcggt gagtctgact
     9961 acttctgcag tttgcaagac agtttggaga tcaccgaaat tcgtgtatgc tgggcagcaa
    10021 ggacggtagt aattctcctt catacgtcaa aggttttacg gacatgtccg tcattcttct
    10081 cctaggctac aaggataccc cgaatcgcta ctctgcgaga aaattgagtc cgccgatccc
    10141 aggtcgggcg aattgctcgg gcgatattca tgcactgaat gcggcacagg cagagccccg
    10201 agaccgagcc ccgacagacc cggctgctcc ggagttggca agagggagac tagcctcctt
    10261 gaatttggaa tgccactaga tcgagcctaa gaacatcttg cagggacgtg tgccattaag
    10321 cggcgggcgc atagtcctcg ctggatccaa gctatgcaaa acctcaagcc gtacccattg
    10381 cgacgtagca agtctcacat catagacaac agcagatggt ttcctagagg tggctggctt
    10441 aaatttacta cttacggcct acctacttgt ggcaggatat caattgaacc caagatccta
    10501 gttcatatct ttctccattc atcagacatg ccctatgcgg ttctgggggc gacaggaaac
    10561 tgcggcactg ccttgatcca gaacctcctc cagtccagca ccagcaaggt ccacgcgtac
    10621 tgccgcgaca ggcgcaagct gctgtacttg ctgccccatc tcgccgacaa caagcaagtc
    10681 gacatctttg acggcagcat ccacgacctg ccactcatta cggagtgcgt ccgcaactgc
    10741 catgccgtct tcctggtgat ctcgaccaac gacaacgtgc cccagtgtcg catggccttg
    10801 gatacagcca ctgcagtcat ccaggccctg cggatcctcc acggcgaagg ggcctccatg
    10861 cccaaactgg tccttctctc ctcagcgacc ctggacgacc agctctccca gaatactgct
    10921 ccctgggtca gatggatcct cctcaaatct gcctcgcaag tctaccagga tctgagccaa
    10981 gccgaggcgt ttctgcgcca gcagcaagac tggatctcaa ccatcttcat caagcccggc
    11041 gggctctcgg tggacgtgca gcggggccac aggctgagtt tgaccgaaga gaagagtccg
    11101 ctgtcctatc tggacctggc agccgccatg atcgaagcgg cggatgaccc ggatggacgc
    11161 tatgacctgc gaaacgtggg cgtcgcatac acagatgggc cagccaggtt tccccgggga
    11221 gcgccgatgt gcatcttcat gggactggtg cgacacttct tgccttttct tcatccctac
    11281 ctcccggcca ccggaccgaa ccagggattt ctgtgctgac cgtgtgccgc aagggacttg
    11341 ggagaatcat tggtgaggtt gactagagta gacaaatcca atgtatgtag catgccaaca
    11401 acatctcccg gtcgtcgtaa actatctatg tactcgctct cgggtggtaa accagtctga
    11461 gcatgtctcc catgccggaa cgcgttgggc accccttgct tactcccctt gcttggtcag
    11521 cgtcgtcgat ggtgacgcca aagacgcccc aaatgatatt attaatggtt aactaatccg
    11581 caggagggtt acatccgcac tgtcgaacta tatatctatc tatctatata tatatatata
    11641 tactactgtc accccaccca gttcttggtg tcatcctgta cgtgacacat ttctcatctt
    11701 tgtccccacc agaccgagac agacaccgag acagacatgc cggacatcca acccatcaca
    11761 gtctacggca agggtggccc caatcccccg cgcgtggcca tcatcctcgc cgaactggat
    11821 cttccgcaca aggtcatcga ggtgcctctc tccaaggtca aggagcccga ctatgtcgcc
    11881 atcaatccca acgggcgcat ccccgccatc tacgatccca acaccgacct cacgctgtgg
    11941 gaatccggcg ccatcgtcga gtacctcgtg agccactacg atcccgacca ccggatcagc
    12001 ttcccggcgg gctccaacct cgccgccctc gcgacgcagt ggctgttttt ccaggccagc
    12061 ggccagggcc cgtactacgg ccaggcgtcc tggttcaaga aattccacca tgaaaaggtc
    12121 cccagcgcga tcgagcgcta cgtcaaagag atcaatcgcg tgaccggcgt gctggaaggc
    12181 catctgtccc gccaaaaggt ggccgcagac ggggacggtc cgtggctcgt cggcggcaag
    12241 tgctcctttg ccgatctggc ctggattccc tggcaggtca tcgtcacggc gattattcag
    12301 ccggaggatg gatacaccgt ggaggactat ccgcatgtga agaactggtt ggaccgtatg
    12361 atggcacggc cgggagttca gaaggggatg gcggacatct tcccctcgac ctgatatgtc
    12421 atgttatagc ctaatgttta ggaactagct acaggattat atgggcgtcg attttgcagg
    12481 atgtaataga agattgttct gttctattgg gcttcgcgta aaagtctgat aatctccgac
    12541 gacagtcgac tcaaccgctg atgcaattcc ggctccaact gatcccccag accaaccgac
    12601 aggggcgcgg gcgtgccgtg aaatgcctgc cccggcgagg caccctgggc tccatgcatt
    12661 cggaggcgcg gtccaagctg attcatcacc cgctggatac agtgcagctc gccgagcacc
    12721 cgctgccccg ccatcgggcc ctcgtcgagc cggcgggtgg gatcgtggcc ctgctcggtc
    12781 ccgggtatcg cggcagcggc gtaccggtcc aagatcttgc agacaatcaa ggccagcagg
    12841 acgaggaggt agccgtcttt ttgcgagcat ggacattgta acattcccgt aatagcctcc
    12901 gtggtctgct tgttcacttc cacgacggcg tcgatcgagg gtaacgagga ttcgatctcc
    12961 gcctcccttc gaatgacctc aaaatgcttg aggaggtcaa gggcgcggat taggcaccgg
    13021 caggacaaac gacgggaacc ggcctccgat tctctacccg aagggggaga agctctcctg
    13081 ccaattgtcg ttgtcgcagg cagcgactgg tctggagggg cgggatccac cggcttgcca
    13141 aacagataga tcgtgtcgtc tggaacagcc ggagggctct cgctgtggcg acgcaggttt
    13201 ggcgggtgtt tgatcgtccc gtcatagacc gcaccacggt ctccagacaa ggtgtcctcg
    13261 gtggagactg gaaaggagaa aaagtcgtca aagtcggggc accaggtggt cagtgcagag
    13321 gacaagctcg agtcaaccgt ggacaagggg cccgaatgca gttcgggcgt gctgtcgaac
    13381 ggctccggca aggcgaagag gggatcgaag gcgtccggat ccggaagatt gccttgcgag
    13441 atcgcggtcg aggactccgg cgagggcaag gggtgcgaca agtggccggg ctctggctcc
    13501 acctcggatc gactgtctgg tttgcggccg ggacgtttgg tcacaacata ctcacagacc
    13561 gtgccccgtc ggcggcatcg ggagcaggtc ggtttctctt tggagcatct gaccttggac
    13621 agcccgcagg cacgacagct gtcacacagt ctgtggagag cacttgcccg acgggaagac
    13681 gctggggacc gcatccaatt ccgttcgaga acaagatggc tggccgcatc agagaggatc
    13741 tagacgacag agtagttgat cattgcaggc aagttcgtat ggtggagtac catattcgac
    13801 tgtgataacc cctgcgattg tgcgttggat atactcctga ggactgacga ttggagagct
    13861 gaggctgacg caatctaccg tgtctggtgc gatgttacac aggatgaggc cagattgacg
    13921 ccagtcactg gtagaaggaa ttgcttcctt catttacgag tcatgcaaac tcaataatct
    13981 agtggtgaat caccacaatt gctacatctc agaacctacg ggaaccagga cgggccgggc
    14041 ctaacgcgtc tagaatgtcg gcttcagtgg cttaacatat ccagactaag ggcattgacg
    14101 ggactcggcg gatatctgag cgtacgtcct gcaagggatg acacatatca agggactggc
    14161 tacccagtct ccggattgct aatggctgtc gagggtatcc cttgtggacc gcacacattt
    14221 ttctcgtcca gcgaagcatt tctgaaccac ggcaccactt cttgacccaa ggcgcaatta
    14281 ccctggccaa ttgccatgaa ccacacctgt ttgtcatgat aatggaaaca gccctagagt
    14341 cttttcacca attatcatga ttccggattc attttcctgt tgaacagtgc tggtcatacg
    14401 tccggtccag ccgtctaaat gcagagacaa cgttacatgc gggtacaaag acataaagat
    14461 aactcgagct tttcactaga gctgcattgg gggaggatag ggtggatcaa actagacacc
    14521 acagtcaagg agtctcgaag acgtccacta ccaaggtcga gtggacctac gctagttcag
    14581 cctatccaga cctgagttca ctatcttagg tttgaaggac tgtggtgacc gttgagtatc
    14641 aagcttagtt ggtagccgta ctgcttccac atcaggtcaa tgttgacaac tcagtcagca
    14701 tgtggcaaac gtagtccaag gtgcttctca tgcaagggag tctcaccgag tctatgagcc
    14761 tgataccgag caggcaggac cggatcttcc tcgctgccag ccctacacag ttccatcact
    14821 tgggcggtta catccacctc agacaatgta agcaagacat taaggcaatc agccattccc
    14881 gtgggcgacg gacttgggca ggctcacact gtttccggcc aacgaagccg cacacaggtc
    14941 tacaggttcc tgcgggtagg aatgtctgtg aaacaccacc catggacact gaccgctaca
    15001 agggggatct tcaacagaag agcgtagtga tctccgtata gggttataca ttcttctctt
    15061 gatagctata gactcttagc cgaactatcg ccatgaccga aagcttgata cctcacaccc
    15121 aaagccacgg tggtggtaca gggcaggtgg agtcgattca ccacagccag tcgcccgaca
    15181 ctgtctttga ccccatggac catctctacc agctcgtcct cctccattaa tcggtcattg
    15241 gccaattgca ataacgagag atcatgcagc cgcacgctgg tctccacccg ggcatctaca
    15301 gctcccggtt tggggagcag gagccccgca gtaaggatca gcatcgcaca actgttggca
    15361 gccagaacac taaagtgcgc tcgcagctcc gtcaggacgg acgtagaaag gatagcatgc
    15421 ggtagagggc ccaggttcag gatgtaaatg gccgcgtcac ggacgcgctg tgggccgccc
    15481 agctctcgga tttgcacgct gcggacgtcc tggtgcagcg cagcatgggt actcccgttc
    15541 gggattctcg cttcctggac gataaagtga agcatcgggt gcagctggtc gagcatcatg
    15601 gtgacactct gggattgcgg tccaagtacc tgcgagtcgg tcagtttata cccactgcga
    15661 ccacatcccg gctgtattca cctcaacgac gcaagcattg ttcagattga accagtccac
    15721 gcggctgagc acctgctggg tgaggtcgcg ggcatcgcct cctgtatgtt gcaggtacgc
    15781 cgaccagcgc cgttgcaact tcggccgctg ctcgcatgca aagtaaaagg ggtctcgatg
    15841 gtcaaaggca atgttgtagg cggtgtcagt ctcgctggcc accgtatcgc caaatcgacc
    15901 ggtcgcagag gccatctgca gcgccgtggg ggcagccgaa tctgccagaa acatcaccgc
    15961 gtctcgtagg gatggtcggc tgacgaacaa gcttgacagc gggctgtgcg caacatgccc
    16021 tcgctggggc tcctgaagga acccgatggt gattgtgaag cggatgatcc gggctagctg
    16081 cgcctcgggg acgccggaga ggcgtgcgag gtctgcgatg ctgacggtgt cggtgagagg
    16141 cagacaggcc agcacctgaa actcccctag ccattgaaga cacgagagaa gttgcgactg
    16201 caccgccagt cgctgcacca ggtctgccgg ctccgtaaga agtatctgca ggtgatcgac
    16261 attgctcagc agcaaccgtt ggatctcgcg gatggcccga ggcgcctctg acgggacgac
    16321 ggctggtaga catgccccat ccactctggc attgcggcag tattcggcta gccttctggc
    16381 cgcagcggcg acctcgttgg cccgggcttc cagctgggtg atactatcca tctggttgtc
    16441 cagaccgtct ctcttcgcaa gacgctcagt ggaattcgta cgatggacct ttcttataaa
    16501 gtccaccaca gcggcgtacg cagagtttca ccgtgccaac catatttact ccgtgagtgt
    16561 ctgatctcac acgctgggaa tacaaccatg gatcgcccta cgtgtaatcg ctggcgtgaa
    16621 agctatatcc ggcgaatgcc gcttatcgtt cgtgatgagc gcgatctatg gataaaatta
    16681 agaagaaaaa cagaaaagta agagaagccg acaaaatcga agacagcagc ctgtaatcag
    16741 ctgtaatact ccagtagcca gctcttcaaa tcccctacag tcggatactc caagaacagg
    16801 ctgcccgtca ctgtcacccc cagcgtctcc cggaacttct cggaaatcac cagactcatc
    16861 agactgtcga tccctaggct agagaaactg gcactgtcct tgaggtcact cagcccgagt
    16921 ccggcctccg tagccaccag agcgatcgct ttggcggcgg tactgttggc gtcgggctca
    16981 gcggctgcct tcactccgtt ggtggtcggc gcatcggctg atgctggagc ggccggagta
    17041 ctggccggtg ccgctttggg ctgcagggcc tctgatccag caggaggtgc aggtgcaggc
    17101 gcggaggtag caggcgtaga ctttctggca tccgcatccg gggcggagaa gaatcgattg
    17161 agcaggatac gaggatacct gcggaatttg attcccccga ccatgccgac aatcgtctcg
    17221 tcctggagga tgtagacgtc acccagatag atattgttgt cttcaaccgt cgggatcatc
    17281 ttgacataag agcggtattt gctccccgga aggaggggcg ccgcaaaccg catcgagctc
    17341 cagccgggag tgacgcagaa attggcattc gtatcgttcg catcggagac attcattatg
    17401 aagccggcca gatgggccac actgtcaatg aagtacgggg gaacggtcca ggtgccgcct
    17461 ttctcggtgg tgaggacgac atctgcaaat gcctcgagct cgtgcagcac cactgactgc
    17521 atgccgcggt acttatcagc atagtcgacc aggctgctgg caaacagtcc gtaggccatg
    17581 cgccgggtga agcggttggc cacgccgtct tctgcgagct gctcaagcgc atggatccgg
    17641 ccctgcacga gatgggtcgc aggacgccag gacgccagcc agtcgctcgc ttcctcgtag
    17701 tagacagtcg cactggcaaa aggttcctca atagatccgt tgatcacgtt gtgccatttc
    17761 agatgtgcct gtctggatcg gatattgtca gtgctcgcag acacttggat gagctgtggt
    17821 gacttggtgt tctcctgcgc caccagagcc ttgacgactt ccaggttggc gatattcatg
    17881 tgtggttcct gattgggatt gagcttctta tagagatatt cacccagcgt gaacgcaata
    17941 tcggcatgga tcgactactg aggttagtca tgcgggatac aaagggagag ggcgcttacc
    18001 gaggtgacaa ctccccgtcc attcatcttg tggccatacg ctgccgctag gaaatccggc
    18061 tgcatgagat ccgactgcat gacgaccgac ccagctgcac cgtcgtactg ctcgtggatg
    18121 atctgctgga cggtggacgt cctcagctcc gatgccagcc ccgcaagggc cttggtttgc
    18181 ggggcctcgt catcgtagaa cgtgtttccc ttggtgaggg cccaatttcc ctggtactgg
    18241 atccagtatg tcttttcatt ccagctgtat gtcggcagat ccaatagccg gagggcccgt
    18301 tcgaacggct gatggaactc attccagtcc acaggcaccc cggcgcagtg gaggatccct
    18361 aaactgctcg tgagcgttac ccagttatcc tccccgcggc ggaacgacgg cacggtcacg
    18421 ctggtcgagg ggagggagga tcggacgaag ttgacacaga cagggtgtgg gccgatttca
    18481 acccacacgg tggcatcgtc aatggtggaa atcttgtgcg ccatcttcat cgcagagagg
    18541 aagtggacgg tctcgcgcgt cgcccgccgc atgtataccg aatctatcgt atgctcatcg
    18601 aagaccactt tactcagtaa tggtgagatc accggcaagt tcggcgcctg gaagacgacg
    18661 cccgatgccg ccagcgcctc aaactcgtcc aggatgggat ccatctgcgc cgagtgaaag
    18721 gcaaaggcta cctctaacac aatacacttg aatccctcgg cttccaggag cctggccacc
    18781 gccgccatct cctcgcgggt gccgctgagg accatttccc tgggtccatt gacacaagca
    18841 atttcatagg gcaggctccc tgcgaactgc tcaatttgct cgagagacgc ccggaccgcc
    18901 atcatctgat ggctactggg ctggcaccgc tcttgaagca ggcacgcacg ctgtccgaca
    18961 agaaagatgg catcgctagc agacagaacg ccagcgatgt gcagggccgc atactcaccc
    19021 agactatggc ccaccaccac atccggcgtc acgcctagcg agacccagta ctttgcaaga
    19081 gctatctcgg tgcagaccag tgctagctgt gtgatgacgg gacaatgggc atggtcccgg
    19141 ggataggagc cgtcaatggc agggacaaag gaagggaacc cttgcccctg cgccagggtg
    19201 tctaaatgca ggatctgcga gcgaaagtac ggcgagtgct ggaagagctg gaggtcccat
    19261 gatttatatg aggatccctg accggtaaag gcaaaggcaa tggggggcgg gcccgtggca
    19321 gaaatcggtt gaagggtatt gaccgagtcg gattcgaggg ttttgcacag ctgagccttg
    19381 agatccgcaa tatccgaagt ggccacggcg actcgatgat tatggtgatg acgccgtgcc
    19441 gtggtcgtgt acgccaggtc agacaacgcg acgtccggat gggcgtccag gaagctcagc
    19501 agccgttcga ggttcccttt gagggagatc ttgctctttg ccgagacggt gaccaggtga
    19561 gaagaacggg ggtcgatcgc gccagccggc tttggtcgaa gcggcccttc ttctatagcc
    19621 aaggtcgaat tgcccccggc ggcactgaag ttgttgacca tcgcgatgcg cttcctgccg
    19681 gggcgtcggg gccagggctt cttttcatag ggaatacgca aatttcgctg atccaggtct
    19741 ttcgggaacc ccggattgat gctattcttg atgccgacat gcggggggat ggcctccttc
    19801 tggaacatga gaagcacctt caccagcgca gtgacacccg cgacagcttc cccgtggccg
    19861 acgtttgcct tgaccgcacc aatgaacacg ggctgctggg aactgcgccg cttaacagca
    19921 ggggcaaaga catcactgac tgacttgatt tcttccgcgt ccccggcctg ggtcccagtt
    19981 ccatgcatct cgacgtaact gacgtccatt ggatcgatgc cggcgctgcg gaggacctgt
    20041 cggctgagac aggactgggc gccggcatgt ggatgagtga tggagatggc ctccgcagag
    20101 tggtttgtcg cggccccaag aatcactccc aagatgttgt cattgtctgc ttccgcgtct
    20161 tccagacgct tcattacaat ggaggccact ccgtccgcac ggcaatagcc atctgcctca
    20221 cagtcccagg ttttgcacgc attgggagtc ttggtcagga aatgcccgtg gctgaggccg
    20281 gcgaaggcat ccgagtttgt cagaacattc attcctccgg ccaccaccgt gtccgtgtcg
    20341 ccgttccaga gagccgtaca ggctgcctag gaaaggttag tcagggggcg atgatcaaga
    20401 cgtccgacat acctggatgg tggccagact ggaggagcag gctgtatcga tactgaagct
    20461 cggcccccag agtttgaaaa agtagttgat ccgtcccggc ccgaatgcac gacagccgcc
    20521 ggggatgaag taggtgctaa tctcctgtgc cgagttgacc tcgcggtaat cgtcactggc
    20581 ttggccgtag aacgtgccca tgcggtgttt gttggacgat cgggtgcggt tcgccacgta
    20641 tcctgcccgc tccagggctt cgtaggccgt cacaatggcg agacgctgca ttggatcggt
    20701 ctgttgagct tcccgggggg acatgttgaa gaagggggca tcgaacaggc ctggttcgtc
    20761 aatgaagcaa ccatacggtg tgtggctcgc gttgacccgt ttccccgcgg gatcatagtg
    20821 actgtccacg tcgaatcggt ccggagggat cttgcgatgg acatccagcc cctgttccag
    20881 aatgtcccag aatttctccg tatcggtcgc tccactgggc atgcgacagg acatgccgac
    20941 gatggcgatt ttagattgag ccgtaccgcg cggtggaggc cgctcctcgt ctcgcgtcct
    21001 tgtgatccat gggccgaggt ccttgatagc cacctcgact ccttccctta gggaggtttc
    21061 caaggcggac aggaggtcgt gaaccggatg tgagttgcgg aagacctgga cctggacctc
    21121 ggacacggag agcagcttgg cccgttctac tactccctgg atgacatttt cccactcaat
    21181 ggcttgggtg aggatttcag tcatgacatg ttcgaacagc tccgtcgccg tcgtggctgt
    21241 cgggaagggc tcgccgctgc cagtcgagag gatcgggtat cgggcgataa agcgcgtatc
    21301 caacgccgct attgacgggc cttgaaccac tgaccgggca tgctgcgaat tgtagatgtg
    21361 ttttgcatga cacagccccc catacacggg aagcgcaacg aaggtgcggt cacggaagaa
    21421 atcagacatt cggaagaggc gccggagtcg agccggtggc ccactgatgg tcactgacgt
    21481 ccgactaatt gcgctgatga agatccggct cgcctcggga gtattctacg gctattagct
    21541 ggtatacggt aacactccag tggaactcac ttcgcgcgtg tggataacag ccagctcctc
    21601 ttcggcttcc ttaggagcga cattgggaat cacataggcc catgagtctc gttcgcctgt
    21661 cgcatcagcg ggttgaagat tctgagagac atcggcaacc agcactccaa gacggaaagc
    21721 cacgcgcacg acctctgccc cggccaaggg aaggtccgcc agcgtcgggg agagagagac
    21781 agccgtcgac gccaacaggc caagtcccag gcctgtgaga taggtgtttg cggagtcgaa
    21841 ggtgtactca ttcggtgagt cttcgtagta actgatgccg tgagtactag ctactgttct
    21901 gagccggttc cacgtacccg ataaacgttc ccaactggat aacacaaaga agaacgccct
    21961 cgatcgaccc gcagagaggt cctctgcaca gctcgggctg ctcggcaaga tgtagaacgc
    22021 tctcgaacgg actcaccaag gctttttgcg cggcatgtag ttgtcgaact tcatcgtgca
    22081 ctgcccaggt gctctcctcg atgaatcggg cgaggagcgg gtatcgccgg tctttggtgt
    22141 aggtgtgtag tcgtcgacag atgccttgga tgccatcttg aggaagctcg ttaccaaagt
    22201 agacgacctt cattcctttc tctgctgtgg gagattcaga cgagggggta aagtctactg
    22261 gcctcatcgt cgctgctata gacctcagtc tctcaacaga tacgggaagt cggagaggga
    22321 tctttgctaa ccccagatac taatttcgta gagcaaagag gctgttgtgt agtcagtgta
    22381 ggtttttgcg tacggacatg tctatatgct ggccctccat caaacccaac gggacgtgcc
    22441 gtgttcggaa gtccatgatg ctctcgggct acagggagct cggtcgatat actttggacg
    22501 tccgactggt cggtcaattc tctcagatcc aattaggccg aggccgatgc ccactgtaac
    22561 agtgatcatt tactctgaca ttcgcttcct attagaattt ccctcggtat ttctttgcgc
    22621 atatgtcctc ccagtccaga gaacagtaat catggccaat gagaaacgag gaggatatcg
    22681 acaaatcaac caagcgctga atatatgtgc ctgggagggc tatttgaatg agcagcacgc
    22741 acggctgccc actcttgagg atgtcgaaca aatcagcccc cgcgtgctgc gtgtcctggg
    22801 tcagaatgaa ggcaaggtac gcagagccga cggctactat acatgtagtt cccggctgat
    22861 cgaaggacct cagttcacgc tccaaggaac aaacacttat atcgtgggca ccggccgtca
    22921 ccgtctgctc atcgacacgg gacaggggat tcccgagtgg gccagcctga tctcgtctac
    22981 cttggcaggc tcctcgatcg agctgtctca tgttctgctc actcactggc atggtgatca
    23041 tactgggggc gttccggacc ttctccggat gtatcccgac ttgtccgatt cgatctacaa
    23101 gcatacccct ggcaagggcc agaagcctat ctcagacgga cagaccttcc gtgtggaagg
    23161 cgctactgtc cgtgccgtac acacccccgg ccactcgcat gaccatatgt gtttcatcct
    23221 cgaggaggaa aatgccatgt tcaccgggga caacgtcctg ggccatggga gcagcgcggt
    23281 cgaggtgctt agtacctgga tgtcttcatt acggatgatg cagtcgcttc gctgtgcggt
    23341 ggggtatccg gcccacggcg cagtgatacg cgacctgcca agcaagctgg acctagagct
    23401 cacgcagaag gcccgtcggg aggacagggt cgtcgagacg ttgaagcaga tgaagacaga
    23461 gacccaacgg aacggagcac gggggaaagg cagcgtcacc gtccagcaac tggtgacggc
    23521 catgcatgga catgatttgg atgagcaggt gcggacaatg gccttggagc cgtttgtgga
    23581 cgaggttctg cggaagctgg cgcaggatga ccgggtggcg tttgaggtta gaggaggcca
    23641 gaaaaagtgg tttgcaatcg aatacaccta agtccatata tctgtggtac tgcactattt
    23701 ctgacttcta tggggctctg taatcccagc taaagacaac gaggaaagca ttccactccg
    23761 taaccattgc ttctccttgt agacacgggc cttcaattgc aatgaacatc agcgtattta
    23821 caactccggc tcctggcgaa tgcccagccc tgtttgacca gacttttggt gctttaagct
    23881 cggtggtttt cctcgggtcg ttttctcggg cgtgctccat atccaccaga tgtcaccccg
    23941 aatgcggcat cagtggaatg cttgtgttac aatgcctgtg ctcccatctg gataagtatc
    24001 tcgacactgc tgtatttgag caagtgtccc ttgaccaacc ctcgtagcgg acacgaataa
    24061 aacaccacaa gatggaacgg caaccaaagt ctctctgcga cgcgacgcaa cttcttgaga
    24121 ctgccaacat tatctctgac accgtccaga ccatcattgc ggaatggtcg gcggaggcga
    24181 aggcaccaca aggctctggc aagcaaaatg ctccaatgct tcctagtcgg gaactgtttg
    24241 atgctcagcg gaccatccta gccgcggttg gcaagctgac cgagttggtg tcggatccga
    24301 gcgcacggat cctggaagta gcaacgcagt ttcaggaatc ccgatcgttg tatatcgctg
    24361 ctgagcggcg cattccggac ctccttgccg ccggggatga gggcggcgtg cacatcgacc
    24421 agatcagcca gaaggccaaa atcgaacccc gaaagctggg tgagtctgca cctgagatga
    24481 gggttacgag caaggtctct ctctcctggc gataacaggc aactgacggt gatctgcagc
    24541 tcgcattttg agatacctgt gttcgatcgg tattttcaag caaaccgggc cggatacctt
    24601 tgcaaacaat aggatttcgg cggcactggt gtcgaatgag cccttgcgcg cctacgttca
    24661 gctggtgaat agtgagggct tcacggcctc cgatcgtctg ccacacaccc tcctgcatcc
    24721 agacactggg ccctcgtacg acgttgcaaa gacagcttgg caaaatgccg tctgcaccaa
    24781 aaagacccga tgggagtggc tcgaggaacg cgtggctcca gagcagttgt tggagtctgg
    24841 aggccattat ccggggattc caagtctggt tatgggactc ccgccaaggg aggatgatgg
    24901 actggtcgcg agaccggagc tggagatcat gggtttgtcc atggttggcg gcggacgagt
    24961 atttgggacc gcccatgttt acggtagctc tcgcccttga catcatcgga tcggctgttc
    25021 tcgctaacgt cacgcagatt tcccatgggc gtccctgggg gatgccctgg tagttgatgt
    25081 cgggggaggc gttggcggat tccccctgca actgagcaag gtataccccc agctgcggtt
    25141 cattgtgcag gaccgtggtc cggtcgtcaa gcaggggctg gagaaggtct ggccccggga
    25201 gaaccctgag gccttgcatc agggacgagt gcagttcgtc gagcatagct tcttcgatac
    25261 aaaccccact gagggcgccg acatttactt tctgcgatat gtcctgtaag gctgtccttt
    25321 cccattgtcg acggttgctg accttggcac cctacacagt catgactggt cggacgacta
    25381 ttgcgtgcgc attctggccg ccattcgctc gagtatggcg gcacactctc gcttgttgat
    25441 ctgcgatcag gtcatgaata cgaccatcgg agatcctgac ttggactcag ccccgagccc
    25501 gttgccggcc aactacggct accacacgcg gttcagccat agccgggata tcaccatgat
    25561 gtcgtgtatt aacgggattg aacggacgcc agcggagttc aagggtcttc tccaggccgc
    25621 cgggttgaag ctgaagaaga tttgggactg caggagccag gtgtcgttga ttgaagcagt
    25681 cttgccggag atgaacgggt tcagatagta t
//
