BGC0001403 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001403 (Aspergillus fumigatus Af293)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T1PKS	1	45,531	High	trypacidin	PKS

BGC0001403 - Region 1 - T1PKS

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Location: 1 - 45,531 nt. (total: 45,531 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 45,532
Label		BGC0001403

Tailoring functions

Transferases: methyltransferase sulfotransferase

AFUA_4G14510: methyltransferase

smcogs: SMCOG1089: methyltransferase

AFUA_4G14530: glutathione S-transferase

smcogs: SMCOG1193: glutathione S-transferase

AFUA_4G14550: O-methyltransferase

smcogs: SMCOG1042: O-methyltransferase

AFUA_4G14580: O-methyltransferase

smcogs: SMCOG1042: O-methyltransferase

Hydrolases: hydrolase

AFUA_4G14570: Decarboxylation

MITE: MITE0000163Decarboxylation (identity: 63.60%)
smcogs: SMCOG1170: metallo-beta-lactamase family protein

Lyases: hydrolase

AFUA_4G14570: Decarboxylation

MITE: MITE0000163Decarboxylation (identity: 63.60%)
smcogs: SMCOG1170: metallo-beta-lactamase family protein

Ligases: synthase

AFUA_4G14560: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001403.3	1.00	PKS	trypacidin	Aspergillus fumigatus Af293
BGC0001284.4	0.79	PKS	alternariol	Parastagonospora nodorum SN15
BGC0001258.3	0.76	PKS	1,3,6,8-tetrahydroxynaphthalene	Glarea lozoyensis
BGC0001257.3	0.76	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0002154.2	0.76	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0002175.3	0.75	PKS	YWA1	Aspergillus oryzae RIB40
BGC0000107.3	0.75	PKS	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0002592.2	0.64	PKS	geodin	Aspergillus terreus NIH2624
BGC0000156.5	0.63	PKS	TAN-1612, 1-(2,3,5,10-tetrahydroxy-7-methoxy-4-oxo-1,2,3,4-tetrahydroanthracen-2-yl)pentane-2,4-dione, desmethyl TAN-1612	Aspergillus niger
BGC0001276.3	0.63	PKS	6-methylsalicyclic acid	Aspergillus terreus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001403.3	1.00	PKS	trypacidin	Aspergillus fumigatus Af293
BGC0001284.4	0.79	PKS	alternariol	Parastagonospora nodorum SN15
BGC0001258.3	0.76	PKS	1,3,6,8-tetrahydroxynaphthalene	Glarea lozoyensis
BGC0001257.3	0.76	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0002154.2	0.76	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0002175.3	0.75	PKS	YWA1	Aspergillus oryzae RIB40
BGC0000107.3	0.75	PKS	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0002592.2	0.64	PKS	geodin	Aspergillus terreus NIH2624
BGC0000156.5	0.63	PKS	TAN-1612, 1-(2,3,5,10-tetrahydroxy-7-methoxy-4-oxo-1,2,3,4-tetrahydroanthracen-2-yl)pentane-2,4-dione, desmethyl TAN-1612	Aspergillus niger
BGC0001276.3	0.63	PKS	6-methylsalicyclic acid	Aspergillus terreus

Similar known clusters from MIBiG 4.0

Module view

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Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 45531:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (mal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

AFUA_4G14560: mal

PKS_AT (947..1245): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 75.0%; inactive: 62.5%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 96.1
inactive: 61.9
Methylmalonyl-CoA: 52.5
Methoxymalonyl-CoA: 48.4
Propionyl-CoA: 41.6
CHC-CoA: 27.5
fatty_acid: 26.5
Benzoyl-CoA: 23.2
2-Methylbutyryl-CoA: 21.3
Isobutyryl-CoA: 20.6
Ethylmalonyl-CoA: 18.5
Acetyl-CoA: 14.6
trans-1,2-CPDA: 14.3
3-Methylbutyryl-CoA: 6.5

Link to PARAS substrate predictor