BGC0001403 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001403 (Aspergillus fumigatus Af293)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	25,711	RES-1214-2	Polyketide	50%

BGC0001403 - Region 1 - T1PKS

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Location: 1 - 25,711 nt. (total: 25,711 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 25,712
Label		BGC0001403

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001403.1	0.67	Polyketide	trypacidin	Aspergillus fumigatus Af293
BGC0000013.1	0.27	Polyketide	alternariol	Aspergillus nidulans FGSC A4
BGC0001858.1	0.24	Polyketide	alternapyrone B, alternapyrone C, alternapyrone D, alternapyrone E, alternapyrone F	Parastagonospora nodorum SN15
BGC0001068.1	0.24	Terpene, Polyketide	pyripyropene A	unidentified unclassified sequences.
BGC0001284.1	0.24	Terpene	alternariol	Parastagonospora nodorum SN15
BGC0001258.1	0.23	Polyketide	1,3,6,8-tetrahydroxynaphthalene	Glarea lozoyensis
BGC0001265.1	0.23	Polyketide	melanin	Bipolaris oryzae
BGC0001257.1	0.23	Polyketide	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0001906.1	0.23	Polyketide	naphthalene	Daldinia eschscholzii IFB-TL01
BGC0000107.1	0.23	Polyketide	naphthopyrone	Aspergillus nidulans FGSC A4

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001403.1	0.87	Polyketide	trypacidin	Aspergillus fumigatus Af293
BGC0000013.1	0.60	Polyketide	alternariol	Aspergillus nidulans FGSC A4
BGC0001858.1	0.58	Polyketide	alternapyrone B, alternapyrone C, alternapyrone D, alternapyrone E, alternapyrone F	Parastagonospora nodorum SN15
BGC0001068.1	0.57	Terpene, Polyketide	pyripyropene A	unidentified unclassified sequences.
BGC0001284.1	0.57	Terpene	alternariol	Parastagonospora nodorum SN15
BGC0001258.1	0.57	Polyketide	1,3,6,8-tetrahydroxynaphthalene	Glarea lozoyensis
BGC0001265.1	0.57	Polyketide	melanin	Bipolaris oryzae
BGC0001257.1	0.56	Polyketide	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0001906.1	0.56	Polyketide	naphthalene	Daldinia eschscholzii IFB-TL01
BGC0000107.1	0.56	Polyketide	naphthopyrone	Aspergillus nidulans FGSC A4

Similar known gene clusters

Module view

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NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 25711:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (mal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

AFUA_4G14560

PKS_AT (947..1245): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 75.0%; inactive: 62.5%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 96.1
inactive: 61.9
Methylmalonyl-CoA: 52.5
Methoxymalonyl-CoA: 48.4
Propionyl-CoA: 41.6
CHC-CoA: 27.5
fatty_acid: 26.5
Benzoyl-CoA: 23.2
2-Methylbutyryl-CoA: 21.3
Isobutyryl-CoA: 20.6
Ethylmalonyl-CoA: 18.5
Acetyl-CoA: 14.6
trans-1,2-CPDA: 14.3
3-Methylbutyryl-CoA: 6.5