BGC0001404 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001404 (Penicillium rubens Wisconsin 54-1255)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T1PKS	1	57,354	High	sorbicillin	PKS

BGC0001404 - Region 1 - T1PKS

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Location: 1 - 57,354 nt. (total: 57,354 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 57,355
Label		BGC0001404

Tailoring functions

Oxidoreductases: oxidase

PCH_Pc21g05110: FAD linked oxidase domain protein

smcogs: SMCOG1138: FAD linked oxidase domain protein

Ligases: synthase

PCH_Pc21g05070: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

PCH_Pc21g05080: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001404.3	1.00	PKS	sorbicillin	Penicillium rubens Wisconsin 54-1255
BGC0002191.2	0.75	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0002190.2	0.74	PKS	sorbicillin, 2'3'-dihydrosorbicillin, sorbicillinol, oxosorbicillinol, bisvertinolone (spelled bisvertinolon in paper), dihydrobisvertinolone, tetrahydrobisvertinolone, bisorbicillinol, 2'3'-dihydrosorbicillinol	Acremonium chrysogenum ATCC 11550
BGC0001244.3	0.66	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001273.3	0.66	PKS	asperlactone	Aspergillus ochraceus
BGC0001284.4	0.66	PKS	alternariol	Parastagonospora nodorum SN15
BGC0001254.3	0.64	PKS	ACT-Toxin II	Alternaria alternata
BGC0000037.4	0.64	PKS	cichorine	Aspergillus nidulans FGSC A4
BGC0002192.3	0.64	PKS	FR901512	fungal sp. No.14919
BGC0000107.3	0.63	PKS	naphthopyrone	Aspergillus nidulans FGSC A4

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001404.3	1.00	PKS	sorbicillin	Penicillium rubens Wisconsin 54-1255
BGC0002191.2	0.75	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0002190.2	0.74	PKS	sorbicillin, 2'3'-dihydrosorbicillin, sorbicillinol, oxosorbicillinol, bisvertinolone (spelled bisvertinolon in paper), dihydrobisvertinolone, tetrahydrobisvertinolone, bisorbicillinol, 2'3'-dihydrosorbicillinol	Acremonium chrysogenum ATCC 11550
BGC0001244.3	0.66	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001273.3	0.66	PKS	asperlactone	Aspergillus ochraceus
BGC0001284.4	0.66	PKS	alternariol	Parastagonospora nodorum SN15
BGC0001254.3	0.64	PKS	ACT-Toxin II	Alternaria alternata
BGC0000037.4	0.64	PKS	cichorine	Aspergillus nidulans FGSC A4
BGC0002192.3	0.64	PKS	FR901512	fungal sp. No.14919
BGC0000107.3	0.63	PKS	naphthopyrone	Aspergillus nidulans FGSC A4

Similar known clusters from MIBiG 4.0

Module view

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Detailed domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 57354:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (pk) + (Me-pk)
Non-colinear ordering:: PCH_Pc21g05070 + PCH_Pc21g05080

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

PCH_Pc21g05070: pk

PKS_AT (960..1255): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 66.7%; Methylmalonyl-CoA: 58.3%; Methoxymalonyl-CoA: 54.2%

minowa: Methoxymalonyl-CoA

Prediction, score:

Methoxymalonyl-CoA: 65.8
Methylmalonyl-CoA: 53.4
Malonyl-CoA: 48.6
inactive: 37.7
Ethylmalonyl-CoA: 27.5
Propionyl-CoA: 27.1
CHC-CoA: 25.0
2-Methylbutyryl-CoA: 21.2
trans-1,2-CPDA: 17.2
Isobutyryl-CoA: 14.7
3-Methylbutyryl-CoA: 13.8
Benzoyl-CoA: 12.8
Acetyl-CoA: 12.1
fatty_acid: 0.0

PCH_Pc21g05080: pk

PKS_AT (573..895): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 58.3%; Ethylmalonyl-CoA: 54.2%; Methylmalonyl-CoA: 54.2%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 71.8
Methoxymalonyl-CoA: 63.3
Ethylmalonyl-CoA: 44.6
Isobutyryl-CoA: 38.5
Malonyl-CoA: 32.7
Propionyl-CoA: 25.0
trans-1,2-CPDA: 20.3
Benzoyl-CoA: 18.0
2-Methylbutyryl-CoA: 12.1
fatty_acid: 11.6
CHC-CoA: 10.8
inactive: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

Link to PARAS substrate predictor