BGC0001406: telomycin biosynthetic gene cluster from Streptomyces canus
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Location: 1 - 82,135 nt. (total: 82,135 nt).
This entry is originally from NCBI GenBank KT881498.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001406
Short description telomycin biosynthetic gene cluster from Streptomyces canus
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
KT881498.1
via
Compounds
  • telomycin
Species Streptomyces canus [taxonomy]
References
Chemical products information
telomycin Evidence:
Copy SMILES
C59H77N13O19
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ALV86847.1
  • tlo1
 40 - 3189 (-) Tlo1
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    • ALV86848.1
    • tlo2
    		 3241 - 4446 (-) Tlo2
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      • ALV86849.1
      • tlo3
      		 4494 - 5309 (-) Tlo3
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        • ALV86850.1
        • tlo4
        		 5312 - 6136 (-) Tlo4
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          • ALV86851.1
          • tlo5
          		 6268 - 7581 (-) Tlo5
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            • ALV86852.1
            • tlo6
            		 7873 - 9591 (+) Tlo6
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              • ALV86853.1
              • tlo7
              		 9588 - 10523 (+) Tlo7
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                • ALV86854.1
                • tlo8
                		 10568 - 11611 (+) Tlo8
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                  • ALV86855.1
                  • tlo9
                  		 11673 - 12977 (+) Tlo9
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                    • ALV86856.1
                    • tlo10
                    		 13130 - 14833 (+) Tlo10
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                      • ALV86857.1
                      • tlo11
                      		 14830 - 15669 (+) Tlo11
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                        • ALV86858.1
                        • tlo12
                        		 15706 - 16650 (-) Tlo12
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                          • ALV86859.1
                          • tlo13
                          		 16799 - 17740 (-) Tlo13
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                            • ALV86860.1
                            • tlo14
                            		 17891 - 19324 (-) Tlo14
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                              • ALV86861.1
                              • tlo15
                              		 19475 - 20533 (+) Tlo15
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                                • ALV86862.1
                                • tlo16
                                		 20921 - 21403 (+) Tlo16
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                                  • ALV86863.1
                                  • tlo17
                                  		 21491 - 22456 (+) Tlo17
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                                    • ALV86864.1
                                    • tlo18
                                    		 22716 - 24464 (+) Tlo18
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                                      • ALV86865.1
                                      • tlo19
                                      		 24461 - 24730 (+) Tlo19
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                                        • ALV86866.1
                                        • tlo20
                                        		 24834 - 39140 (+) Tlo20
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                                          • ALV86867.1
                                          • tlo21
                                          		 39122 - 56611 (+) Tlo21
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                                            • ALV86868.1
                                            • tlo22
                                            		 56611 - 63810 (+) Tlo22
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                                              • ALV86869.1
                                              • tlo23
                                              		 63998 - 65245 (+) Tlo23
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                                                • ALV86870.1
                                                • tlo24
                                                		 65274 - 65498 (+) Tlo24
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                                                  • ALV86871.1
                                                  • tlo25
                                                  		 65568 - 68042 (+) Tlo25
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                                                    • ALV86872.1
                                                    • tlo26
                                                    		 68944 - 69750 (+) Tlo26
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                                                      • ALV86873.1
                                                      • tlo27
                                                      		 69823 - 71940 (-) Tlo27
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                                                        • ALV86874.1
                                                        • tlo28
                                                        		 72005 - 74755 (-) Tlo28
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                                                          • ALV86875.1
                                                          • tlo29
                                                          		 74779 - 75996 (-) Tlo29
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                                                            • ALV86876.1
                                                            • tlo30
                                                            		 76272 - 77090 (-) Tlo30
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                                                              • ALV86877.1
                                                              • tlo31
                                                              		 77087 - 78031 (-) Tlo31
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                                                                • ALV86878.1
                                                                • tlo32
                                                                		 78306 - 79169 (+) Tlo32
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                                                                  • ALV86879.1
                                                                  • tlo33
                                                                  		 79166 - 80056 (+) Tlo33
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                                                                    • ALV86880.1
                                                                    • tlo34
                                                                    		 80079 - 82088 (+) Tlo34
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                                                                      Biosynthesis information

                                                                      Biosynthetic modules

                                                                      Name
                                                                      Unk01
                                                                      Type
                                                                      nrps-type1
                                                                      Genes
                                                                      tlo20
                                                                      Substrates
                                                                      aspartic acid branched (evidence: Structure-based inference [1])
                                                                      Integrated Monomers
                                                                      Domains
                                                                      adenylation
                                                                      Name
                                                                      Unk02
                                                                      Type
                                                                      nrps-type1
                                                                      Genes
                                                                      tlo20
                                                                      Substrates
                                                                      serine (evidence: Structure-based inference [1])
                                                                      Integrated Monomers
                                                                      Domains
                                                                      adenylation
                                                                      Name
                                                                      Unk03
                                                                      Type
                                                                      nrps-type1
                                                                      Genes
                                                                      tlo20
                                                                      Substrates
                                                                      threonine (evidence: Structure-based inference [1])
                                                                      Integrated Monomers
                                                                      Domains
                                                                      adenylation
                                                                      Name
                                                                      Unk04
                                                                      Type
                                                                      nrps-type1
                                                                      Genes
                                                                      tlo20
                                                                      Substrates
                                                                      allo-threonine, threonine (evidence: )
                                                                      Integrated Monomers
                                                                      Domains
                                                                      adenylation
                                                                      Name
                                                                      Unk05
                                                                      Type
                                                                      nrps-type1
                                                                      Genes
                                                                      tlo21
                                                                      Substrates
                                                                      alanine (evidence: Structure-based inference [1])
                                                                      Integrated Monomers
                                                                      Domains
                                                                      adenylation
                                                                      Name
                                                                      Unk06
                                                                      Type
                                                                      nrps-type1
                                                                      Genes
                                                                      tlo21
                                                                      Substrates
                                                                      glycine (evidence: Structure-based inference, Sequence-based prediction)
                                                                      Integrated Monomers
                                                                      Domains
                                                                      adenylation
                                                                      Name
                                                                      Unk07
                                                                      Type
                                                                      nrps-type1
                                                                      Genes
                                                                      tlo21
                                                                      Substrates
                                                                      proline (evidence: Structure-based inference, Sequence-based prediction)
                                                                      Integrated Monomers
                                                                      Domains
                                                                      adenylation
                                                                      Name
                                                                      Unk08
                                                                      Type
                                                                      nrps-type1
                                                                      Genes
                                                                      tlo21
                                                                      Substrates
                                                                      dehydrotryptophan (evidence: Structure-based inference [1])
                                                                      Integrated Monomers
                                                                      Domains
                                                                      adenylation
                                                                      Name
                                                                      Unk09
                                                                      Type
                                                                      nrps-type1
                                                                      Genes
                                                                      tlo21
                                                                      Substrates
                                                                      R-beta-methyltryptophan (evidence: Structure-based inference [1])
                                                                      Integrated Monomers
                                                                      Domains
                                                                      adenylation
                                                                      Name
                                                                      Unk10
                                                                      Type
                                                                      nrps-type1
                                                                      Genes
                                                                      tlo22
                                                                      Substrates
                                                                      leucine (evidence: Structure-based inference [1])
                                                                      Integrated Monomers
                                                                      Domains
                                                                      adenylation
                                                                      Name
                                                                      Unk11
                                                                      Type
                                                                      nrps-type1
                                                                      Genes
                                                                      tlo22
                                                                      Substrates
                                                                      proline (evidence: Structure-based inference, Sequence-based prediction)
                                                                      Integrated Monomers
                                                                      Domains
                                                                      adenylation
                                                                      Annotation changelog

                                                                      Entry version: 4

                                                                      Date
                                                                      Changes
                                                                      Submitters
                                                                      Reviewers
                                                                      2022-10-07
                                                                      Update chemical activity to schema version 2.11
                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                      Entry version: 3

                                                                      Date
                                                                      Changes
                                                                      Submitters
                                                                      Reviewers
                                                                      2022-09-15
                                                                      Updated bioactivity data
                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                      2022-09-15
                                                                      Added NRP substrate specificities
                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                      Entry version: 2

                                                                      Date
                                                                      Changes
                                                                      Submitters
                                                                      Reviewers
                                                                      2019-10-16
                                                                      Migrated from v1.4
                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                      Entry version: 1

                                                                      Date
                                                                      Changes
                                                                      Submitters
                                                                      Reviewers
                                                                      2016-09-03
                                                                      Submitted
                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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