BGC0001406: telomycin biosynthetic gene cluster from Streptomyces canus
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Location: 1 - 82,135 nt. (total: 82,135 nt).
This entry is originally from NCBI GenBank KT881498.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001406
Short description telomycin biosynthetic gene cluster from Streptomyces canus
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
Loci NCBI GenBank: KT881498.1
Compounds
  • telomycin
Species Streptomyces canus [taxonomy]
References
Chemical products information
telomycin
Copy SMILES
C59H77N13O19
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ALV86847.1
  • tlo1
 40 - 3189 (-) Tlo1
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  • ALV86848.1
  • tlo2
 3241 - 4446 (-) Tlo2
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  • ALV86849.1
  • tlo3
 4494 - 5309 (-) Tlo3
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  • ALV86850.1
  • tlo4
 5312 - 6136 (-) Tlo4
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  • ALV86851.1
  • tlo5
 6268 - 7581 (-) Tlo5
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  • ALV86852.1
  • tlo6
 7873 - 9591 (+) Tlo6
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  • ALV86853.1
  • tlo7
 9588 - 10523 (+) Tlo7
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  • ALV86854.1
  • tlo8
 10568 - 11611 (+) Tlo8
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  • ALV86855.1
  • tlo9
 11673 - 12977 (+) Tlo9
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  • ALV86856.1
  • tlo10
 13130 - 14833 (+) Tlo10
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  • ALV86857.1
  • tlo11
 14830 - 15669 (+) Tlo11
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  • ALV86858.1
  • tlo12
 15706 - 16650 (-) Tlo12
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  • ALV86859.1
  • tlo13
 16799 - 17740 (-) Tlo13
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  • ALV86860.1
  • tlo14
 17891 - 19324 (-) Tlo14
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  • ALV86861.1
  • tlo15
 19475 - 20533 (+) Tlo15
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  • ALV86862.1
  • tlo16
 20921 - 21403 (+) Tlo16
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  • ALV86863.1
  • tlo17
 21491 - 22456 (+) Tlo17
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  • ALV86864.1
  • tlo18
 22716 - 24464 (+) Tlo18
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  • ALV86865.1
  • tlo19
 24461 - 24730 (+) Tlo19
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  • ALV86866.1
  • tlo20
 24834 - 39140 (+) Tlo20
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  • ALV86867.1
  • tlo21
 39122 - 56611 (+) Tlo21
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  • ALV86868.1
  • tlo22
 56611 - 63810 (+) Tlo22
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  • ALV86869.1
  • tlo23
 63998 - 65245 (+) Tlo23
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  • ALV86870.1
  • tlo24
 65274 - 65498 (+) Tlo24
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  • ALV86871.1
  • tlo25
 65568 - 68042 (+) Tlo25
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  • ALV86872.1
  • tlo26
 68944 - 69750 (+) Tlo26
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  • ALV86873.1
  • tlo27
 69823 - 71940 (-) Tlo27
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  • ALV86874.1
  • tlo28
 72005 - 74755 (-) Tlo28
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  • ALV86875.1
  • tlo29
 74779 - 75996 (-) Tlo29
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  • ALV86876.1
  • tlo30
 76272 - 77090 (-) Tlo30
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  • ALV86877.1
  • tlo31
 77087 - 78031 (-) Tlo31
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  • ALV86878.1
  • tlo32
 78306 - 79169 (+) Tlo32
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  • ALV86879.1
  • tlo33
 79166 - 80056 (+) Tlo33
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  • ALV86880.1
  • tlo34
 80079 - 82088 (+) Tlo34
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NRP-specific information
Subclass N/A
Cyclic? no
NRP-synthases
Gene Modules
tlo20
Module ?
Specificity: aspartic acid branched
Evidence for specificity:
  • Structure-based inference
Module ?
Specificity: serine
Evidence for specificity:
  • Structure-based inference
Module ?
Specificity: threonine
Evidence for specificity:
  • Structure-based inference
Module ?
Specificity: allo-threonine / threonine
Evidence for specificity:
tlo21
Module ?
Specificity: alanine
Evidence for specificity:
  • Structure-based inference
Module ?
Specificity: glycine
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
Module ?
Specificity: proline
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
Module ?
Specificity: dehydrotryptophan
Evidence for specificity:
  • Structure-based inference
Module ?
Specificity: R-beta-methyltryptophan
Evidence for specificity:
  • Structure-based inference
tlo22
Module ?
Specificity: leucine
Evidence for specificity:
  • Structure-based inference
Module ?
Specificity: proline
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
Annotation changelog
MIBiG version Submitter Notes
1.3
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Updated bioactivity data
  • Added NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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