BGC0001409: dutomycin biosynthetic gene cluster from Streptomyces minoensis
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Location: 1 - 59,215 nt. (total: 59,215 nt).
This entry is originally from NCBI GenBank KP710956.1.

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core biosynthetic genes
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General
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NRPS/PKS domains
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General information about the BGC
MIBiG accession BGC0001409
Short description dutomycin biosynthetic gene cluster from Streptomyces minoensis
Status Minimal annotation: yes
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Polyketide
Loci NCBI GenBank: KP710956.1
Compounds
  • dutomycin
Species Streptomyces minoensis [taxonomy]
References
Chemical products information
dutomycin
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C44H54O17
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AKD43489.1
 426 - 827 (-) hypothetical protein
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  • AKD43490.1
 824 - 1861 (-) NADPH-quinone reductase
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  • AKD43491.1
 1879 - 2820 (+) LysR family transcriptional regulator
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  • AKD43492.1
 3060 - 4250 (-) acyl-CoA dehydrogenase
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  • AKD43493.1
  • dutS9
 4377 - 5309 (-) NAD-dependent epimerase/dehydratase
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  • AKD43494.1
  • dutS7
 5306 - 5911 (-) dTDP-4-dehydrorhamnose 3,5-epimerase
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  • AKD43495.1
  • dutO4
 5917 - 7440 (-) Monooxygenase
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  • AKD43496.1
  • dutO2
 7781 - 9409 (+) Monooxygenase
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  • AKD43498.1
  • dutJ
 9419 - 10174 (+) 3-Ketoacyl-(acyl-carrier-protein) reductase
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  • AKD43497.1
  • dutD
 10239 - 11168 (+) Aromatase
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  • AKD43499.1
  • dutL
 11161 - 12648 (+) Acyl-CoA ligase
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  • AKD43500.1
  • dutO3
 12686 - 12973 (+) Monooxygenase
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  • AKD43501.1
  • dutE
 13034 - 13486 (-) Cyclase
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  • AKD43502.1
  • dutMT2
 13593 - 14645 (-) O-Methyltransferase
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  • AKD43503.1
  • dutF
 14651 - 15436 (-) Cyclase
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  • AKD43504.1
  • dutO1
 15443 - 16666 (-) Monooxygenase
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  • AKD43505.1
  • dutI
 16679 - 17458 (-) Ketoreductase
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  • AKD43506.1
  • dutMT1
 17739 - 18752 (+) Methtyltransferase
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  • AKD43507.1
  • dutK
 18910 - 19722 (-) SARP family regulator
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  • AKD43508.1
  • dutS2
 19926 - 20906 (-) NDP-glucose 4,6-dehydratase
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  • AKD43509.1
  • dutS1
 20903 - 21967 (-) NDP-glucose synthase
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  • AKD43510.1
  • dutP
 21982 - 23394 (-) Biotin carboxylase
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  • AKD43511.1
  • dutN
 23401 - 23928 (-) Acetyl-CoA carboxylase
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  • AKD43537.1
  • dutM
 23933 - 25630 (-) acetyl-CoA carboxylase
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  • AKD43512.1
  • dutC
 25627 - 25884 (-) Acyl carrier protein
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  • AKD43513.1
  • dutB
 25922 - 27145 (-) Chain length factor
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  • AKD43514.1
  • dutA
 27142 - 28395 (-) Ketoacyl synthase
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  • AKD43515.1
  • dutS3
 28624 - 30054 (+) NDP-hexose 2,3-dehydratase
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  • AKD43516.1
  • dutS4
 30051 - 31049 (+) NDP-hexose 3-ketoreductase
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  • AKD43517.1
  • dutQ
 31046 - 31648 (+) Flavin reductase
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  • AKD43518.1
  • dutR
 31578 - 32732 (+) Acyl-CoA dehydrogenase
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  • AKD43519.1
  • dutS5
 32792 - 34087 (-) NDP-hexose 3,4-dehydratase
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  • AKD43520.1
  • dutS6
 34092 - 35042 (-) NDP-4-keto-6-deoxyhexose reductase
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  • AKD43521.1
  • dutGT1
 35039 - 36223 (-) Glycosyltransferase
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  • AKD43522.1
  • dutG
 36246 - 42776 (-) Type I polyketide synthase
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  • AKD43523.1
  • dutH
 42844 - 43881 (-) ACP shuttle-type acyltransferase
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  • AKD43524.1
  • dutT
 44100 - 45029 (+) ABC transporter
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  • AKD43525.1
  • dutU
 45026 - 45832 (+) ABC transporter
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  • AKD43526.1
  • dutGT2
 45845 - 46993 (+) Glycosyltransferase
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  • AKD43527.1
  • dutV
 47024 - 50218 (-) SARP family transcriptional regulator
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  • AKD43528.1
  • dutS8
 50278 - 51510 (-) NDP-hexose 3-C-methyltransferase
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  • AKD43529.1
  • dutW
 51507 - 52487 (-) Carbohydrate kinase
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  • AKD43530.1
  • dutX
 52525 - 53688 (-) S-Adenosylmethionine synthase
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  • AKD43531.1
 53834 - 55390 (-) Copper oxidase
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  • AKD43532.1
 55387 - 55836 (-) Hypothetical protein
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  • AKD43533.1
 55940 - 56872 (+) Acetyltransferase
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  • AKD43534.1
 56869 - 57522 (+) TetR family transcriptional regulator
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  • AKD43535.1
 57575 - 58300 (-) Membrane protein
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  • AKD43536.1
 58365 - 58586 (-) Cobalt transporter
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Annotation changelog
MIBiG version Submitter Notes
1.3
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Updated bioactivity data
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
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