BGC0001409: dutomycin biosynthetic gene cluster from Streptomyces minoensis
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Location: 1 - 59,215 nt. (total: 59,215 nt).
This entry is originally from NCBI GenBank KP710956.1.

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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001409
Short description dutomycin biosynthetic gene cluster from Streptomyces minoensis
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Unknown)
Loci
KP710956.1
via
Compounds
  • dutomycin
Species Streptomyces minoensis [taxonomy]
References
Chemical products information
dutomycin Evidence:
Copy SMILES
C44H54O17
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AKD43489.1
 426 - 827 (-) hypothetical protein
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    • AKD43490.1
    		 824 - 1861 (-) NADPH-quinone reductase
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      • AKD43491.1
      		 1879 - 2820 (+) LysR family transcriptional regulator
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        • AKD43492.1
        		 3060 - 4250 (-) acyl-CoA dehydrogenase
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          • AKD43493.1
          • dutS9
          		 4377 - 5309 (-) NAD-dependent epimerase/dehydratase
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            • AKD43494.1
            • dutS7
            		 5306 - 5911 (-) dTDP-4-dehydrorhamnose 3,5-epimerase
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              • AKD43495.1
              • dutO4
              		 5917 - 7440 (-) Monooxygenase
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                • AKD43496.1
                • dutO2
                		 7781 - 9409 (+) Monooxygenase
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                  • AKD43498.1
                  • dutJ
                  		 9419 - 10174 (+) 3-Ketoacyl-(acyl-carrier-protein) reductase
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                    • AKD43497.1
                    • dutD
                    		 10239 - 11168 (+) Aromatase
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                      • AKD43499.1
                      • dutL
                      		 11161 - 12648 (+) Acyl-CoA ligase
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                        • AKD43500.1
                        • dutO3
                        		 12686 - 12973 (+) Monooxygenase
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                          • AKD43501.1
                          • dutE
                          		 13034 - 13486 (-) Cyclase
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                            • AKD43502.1
                            • dutMT2
                            		 13593 - 14645 (-) O-Methyltransferase
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                              • AKD43503.1
                              • dutF
                              		 14651 - 15436 (-) Cyclase
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                                • AKD43504.1
                                • dutO1
                                		 15443 - 16666 (-) Monooxygenase
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                                  • AKD43505.1
                                  • dutI
                                  		 16679 - 17458 (-) Ketoreductase
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                                    • AKD43506.1
                                    • dutMT1
                                    		 17739 - 18752 (+) Methtyltransferase
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                                      • AKD43507.1
                                      • dutK
                                      		 18910 - 19722 (-) SARP family regulator
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                                        • AKD43508.1
                                        • dutS2
                                        		 19926 - 20906 (-) NDP-glucose 4,6-dehydratase
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                                          • AKD43509.1
                                          • dutS1
                                          		 20903 - 21967 (-) NDP-glucose synthase
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                                            • AKD43510.1
                                            • dutP
                                            		 21982 - 23394 (-) Biotin carboxylase
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                                              • AKD43511.1
                                              • dutN
                                              		 23401 - 23928 (-) Acetyl-CoA carboxylase
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                                                • AKD43537.1
                                                • dutM
                                                		 23933 - 25630 (-) acetyl-CoA carboxylase
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                                                  • AKD43512.1
                                                  • dutC
                                                  		 25627 - 25884 (-) Acyl carrier protein
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                                                    • AKD43513.1
                                                    • dutB
                                                    		 25922 - 27145 (-) Chain length factor
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                                                      • AKD43514.1
                                                      • dutA
                                                      		 27142 - 28395 (-) Ketoacyl synthase
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                                                        • AKD43515.1
                                                        • dutS3
                                                        		 28624 - 30054 (+) NDP-hexose 2,3-dehydratase
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                                                          • AKD43516.1
                                                          • dutS4
                                                          		 30051 - 31049 (+) NDP-hexose 3-ketoreductase
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                                                            • AKD43517.1
                                                            • dutQ
                                                            		 31046 - 31648 (+) Flavin reductase
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                                                              • AKD43518.1
                                                              • dutR
                                                              		 31578 - 32732 (+) Acyl-CoA dehydrogenase
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                                                                • AKD43519.1
                                                                • dutS5
                                                                		 32792 - 34087 (-) NDP-hexose 3,4-dehydratase
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                                                                  • AKD43520.1
                                                                  • dutS6
                                                                  		 34092 - 35042 (-) NDP-4-keto-6-deoxyhexose reductase
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                                                                    • AKD43521.1
                                                                    • dutGT1
                                                                    		 35039 - 36223 (-) Glycosyltransferase
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                                                                      • AKD43522.1
                                                                      • dutG
                                                                      		 36246 - 42776 (-) Type I polyketide synthase
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                                                                        • AKD43523.1
                                                                        • dutH
                                                                        		 42844 - 43881 (-) ACP shuttle-type acyltransferase
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                                                                          • AKD43524.1
                                                                          • dutT
                                                                          		 44100 - 45029 (+) ABC transporter
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                                                                            • AKD43525.1
                                                                            • dutU
                                                                            		 45026 - 45832 (+) ABC transporter
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                                                                              • AKD43526.1
                                                                              • dutGT2
                                                                              		 45845 - 46993 (+) Glycosyltransferase
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                                                                                • AKD43527.1
                                                                                • dutV
                                                                                		 47024 - 50218 (-) SARP family transcriptional regulator
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                                                                                  • AKD43528.1
                                                                                  • dutS8
                                                                                  		 50278 - 51510 (-) NDP-hexose 3-C-methyltransferase
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                                                                                    • AKD43529.1
                                                                                    • dutW
                                                                                    		 51507 - 52487 (-) Carbohydrate kinase
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                                                                                      • AKD43530.1
                                                                                      • dutX
                                                                                      		 52525 - 53688 (-) S-Adenosylmethionine synthase
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                                                                                        • AKD43531.1
                                                                                        		 53834 - 55390 (-) Copper oxidase
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                                                                                          • AKD43532.1
                                                                                          		 55387 - 55836 (-) Hypothetical protein
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                                                                                            • AKD43533.1
                                                                                            		 55940 - 56872 (+) Acetyltransferase
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                                                                                              • AKD43534.1
                                                                                              		 56869 - 57522 (+) TetR family transcriptional regulator
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                                                                                                • AKD43535.1
                                                                                                		 57575 - 58300 (-) Membrane protein
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                                                                                                  • AKD43536.1
                                                                                                  		 58365 - 58586 (-) Cobalt transporter
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                                                                                                    Biosynthesis information
                                                                                                    Annotation changelog

                                                                                                    Entry version: 4

                                                                                                    Date
                                                                                                    Changes
                                                                                                    Submitters
                                                                                                    Reviewers
                                                                                                    2022-10-07
                                                                                                    Update chemical activity to schema version 2.11
                                                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                                    Entry version: 3

                                                                                                    Date
                                                                                                    Changes
                                                                                                    Submitters
                                                                                                    Reviewers
                                                                                                    2022-09-15
                                                                                                    Updated bioactivity data
                                                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                                    Entry version: 2

                                                                                                    Date
                                                                                                    Changes
                                                                                                    Submitters
                                                                                                    Reviewers
                                                                                                    2019-10-16
                                                                                                    Migrated from v1.4
                                                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                    2019-10-16
                                                                                                    Updated compound(s) information (NPAtlas curation)
                                                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                                    Entry version: 1

                                                                                                    Date
                                                                                                    Changes
                                                                                                    Submitters
                                                                                                    Reviewers
                                                                                                    2016-09-03
                                                                                                    Submitted
                                                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                    Detailed domain annotation
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