BGC0001413: cystobactamid 919-1 biosynthetic gene cluster from Cystobacter sp. Cbv34
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Location: 1 - 52,081 nt. (total: 52,081 nt).
This entry is originally from NCBI GenBank KP836244.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001413
Short description cystobactamid 919-1 biosynthetic gene cluster from Cystobacter sp. Cbv34
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
KP836244.1
via
Compounds
  • cystobactamid 919-1
  • cystobactamid 919-2
  • cystobactamid 919-3
Species Cystobacter sp. Cbv34 [taxonomy]
References
Chemical products information
cystobactamid 919-1 Evidence:
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C46H45N7O14
Chemical database entries
PubCHEM
cystobactamid 919-2 Evidence:
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C46H45N7O14
Chemical database entries
PubCHEM
cystobactamid 919-3 Evidence:
(no structure information available)
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AKP45383.1
  • cysT
 7 - 3810 (-) CysT
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    • AKP45384.1
    • cysS
    		 4021 - 5949 (-) CysS
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      • AKP45385.1
      • cysR
      		 6058 - 7059 (-) CysR
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        • AKP45386.1
        • cysQ
        		 7134 - 7928 (-) CysQ
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          • AKP45388.1
          • cysP
          		 8001 - 8702 (-) CysP
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            • AKP45389.1
            • cysO
            		 8736 - 9347 (-) CysO
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              • AKP45387.1
              • cysA
              		 9687 - 9899 (+) CysA
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                • AKP45390.1
                • cysB
                		 9968 - 10921 (+) CysB
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                  • AKP45391.1
                  • cysC
                  		 10931 - 12310 (+) CysC
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                    • AKP45392.1
                    • cysD
                    		 12436 - 14634 (+) CysD
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                      • AKP45393.1
                      • cysE
                      		 14721 - 15452 (+) CysE
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                        • AKP45394.1
                        • cysF
                        		 15475 - 16512 (+) CysF
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                          • AKP45395.1
                          • cysG
                          		 16552 - 22530 (+) CysG
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                            • AKP45396.1
                            • cysH
                            		 22598 - 25525 (+) CysH
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                              • AKP45397.1
                              • cysI
                              		 25527 - 26345 (+) CysI
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                                • AKP45398.1
                                • cysJ
                                		 26364 - 27347 (+) CysJ
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                                  • AKP45399.1
                                  • cysK
                                  		 27422 - 41059 (+) CysK
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                                    • AKP45400.1
                                    • cysL
                                    		 41056 - 44127 (+) CysL
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                                      • AKP45401.1
                                      • cysN
                                      		 44252 - 45325 (+) CysN
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                                        • AKP45402.1
                                        		 45462 - 47039 (-) nucleoporin
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                                          • AKP45403.1
                                          		 47036 - 47821 (-) hypothetical protein
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                                            • AKP45404.1
                                            		 47827 - 49128 (-) efflux ABC transporter
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                                              • AKP45405.1
                                              		 49133 - 51238 (-) ABC transporter permease
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                                                • AKP45406.1
                                                		 51238 - 51999 (-) ABC transporter ATP-binding protein
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                                                  Biosynthesis information

                                                  Biosynthetic modules

                                                  Name
                                                  Unk01
                                                  Type
                                                  nrps-type1
                                                  Genes
                                                  cysG
                                                  Substrates
                                                  3-hydroxy-para-aminobenzoic acid (evidence: Structure-based inference, Knock-out studies)
                                                  Integrated Monomers
                                                  Domains
                                                  adenylation
                                                  Name
                                                  Unk02
                                                  Type
                                                  nrps-type1
                                                  Genes
                                                  cysG
                                                  Substrates
                                                  2,3-dihydroxy-para-aminobenzoic acid (evidence: Structure-based inference, Knock-out studies)
                                                  Integrated Monomers
                                                  Domains
                                                  adenylation
                                                  Name
                                                  Unk03
                                                  Type
                                                  nrps-type1
                                                  Genes
                                                  cysH
                                                  Substrates
                                                  asparagine (evidence: Structure-based inference, Mass spectrometry)
                                                  Integrated Monomers
                                                  Domains
                                                  adenylation
                                                  Name
                                                  Unk04
                                                  Type
                                                  nrps-type1
                                                  Genes
                                                  cysK
                                                  Substrates
                                                  para-aminobenzoic acid (evidence: Structure-based inference [1], [2])
                                                  Integrated Monomers
                                                  Domains
                                                  adenylation
                                                  Name
                                                  Unk05
                                                  Type
                                                  nrps-type1
                                                  Genes
                                                  cysK
                                                  Substrates
                                                  para-aminobenzoic acid (evidence: Structure-based inference [1], [2])
                                                  Integrated Monomers
                                                  Domains
                                                  adenylation
                                                  Name
                                                  Unk06
                                                  Type
                                                  nrps-type1
                                                  Genes
                                                  cysK
                                                  Substrates
                                                  Integrated Monomers
                                                  Domains
                                                  adenylation
                                                  Name
                                                  Unk07
                                                  Type
                                                  nrps-type1
                                                  Genes
                                                  cysK
                                                  Substrates
                                                  para-aminobenzoic acid (evidence: Structure-based inference [1], [2])
                                                  Integrated Monomers
                                                  Domains
                                                  adenylation
                                                  Name
                                                  Unk08
                                                  Type
                                                  nrps-type1
                                                  Genes
                                                  cysL
                                                  Substrates
                                                  para-aminobenzoic acid (evidence: )
                                                  Integrated Monomers
                                                  Domains
                                                  adenylation
                                                  Annotation changelog

                                                  Entry version: 4

                                                  Date
                                                  Changes
                                                  Submitters
                                                  Reviewers
                                                  2022-10-07
                                                  Update chemical activity to schema version 2.11
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                  Entry version: 3

                                                  Date
                                                  Changes
                                                  Submitters
                                                  Reviewers
                                                  2022-09-15
                                                  Add product details
                                                  • (ID: SJG3CBEHSM6A3I74YXLH6GLA)
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                  2022-09-15
                                                  Updated bioactivity data
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                  2022-09-15
                                                  Added NRP substrate specificities
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                  Entry version: 2

                                                  Date
                                                  Changes
                                                  Submitters
                                                  Reviewers
                                                  2019-10-16
                                                  Migrated from v1.4
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                  Entry version: 1

                                                  Date
                                                  Changes
                                                  Submitters
                                                  Reviewers
                                                  2016-09-03
                                                  Submitted
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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