BGC0001414: griselimycin biosynthetic gene cluster from Streptomyces muensis
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Location: 1 - 66,865 nt. (total: 66,865 nt).
This entry is originally from NCBI GenBank KP211414.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001414
Short description griselimycin biosynthetic gene cluster from Streptomyces muensis
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
KP211414.1
via
Compounds
  • griselimycin
Species Streptomyces muensis [taxonomy]
References
Chemical products information
griselimycin Evidence:
Copy SMILES
C57H96N10O12
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AKC91842.1
 837 - 2075 (+) XRE family transcriptional regulator
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    • AKC91843.1
    		 2185 - 2625 (+) hypothetical protein
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      • AKC91844.1
      		 2625 - 2819 (+) hypothetical protein
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        • AKC91845.1
        		 3033 - 4037 (+) hypothetical protein
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          • AKC91846.1
          		 4110 - 5630 (+) amino acid permease
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            • AKC91847.1
            		 5627 - 7066 (+) glutamin synthetase
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              • AKC91848.1
              		 7240 - 8133 (+) phosphotransferase enzyme family
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                • AKC91849.1
                • griA
                		 8501 - 31885 (-) nonribosomal peptide synthetase
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                  • AKC91850.1
                  • int1
                  		 32770 - 33102 (-) integrase catalytic region
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                    • AKC91851.1
                    • tnp1
                    		 33187 - 33726 (+) transposase
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                      • AKC91852.1
                      • int2
                      		 33567 - 34127 (-) integrase catalytic region
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                        • AKC91853.1
                        • tnp2
                        		 34648 - 36300 (-) transposase
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                          • AKC91854.1
                          • tnp3
                          		 36283 - 37314 (+) transposase
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                            • AKC91855.1
                            • griR
                            		 37743 - 38864 (-) DNA polymerase III beta subunit
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                              • AKC91856.1
                              • griB
                              		 39640 - 52146 (+) nonribosomal peptide synthetase
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                                • AKC91857.1
                                • griC
                                		 52143 - 56117 (+) nonribosomal peptide synthetase
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                                  • AKC91858.1
                                  • griD
                                  		 56114 - 56332 (+) mbtH-like protein
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                                    • AKC91859.1
                                    • griE
                                    		 56431 - 57243 (+) leucine hydroxylase
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                                      • AKC91860.1
                                      • griF
                                      		 57240 - 58415 (+) alcohol dehydrogenase
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                                        • AKC91861.1
                                        • griG
                                        		 58442 - 59242 (+) alpha/beta hydrolase
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                                          • AKC91862.1
                                          • griH
                                          		 59239 - 60138 (+) oxidoreductase
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                                            • AKC91863.1
                                            		 61141 - 61581 (-) pyridoxamine 5'-phosphate oxidase family protein
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                                              • AKC91864.1
                                              		 62167 - 62817 (+) hypothetical protein
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                                                • AKC91865.1
                                                		 62821 - 63936 (+) hypothetical protein
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                                                  • AKC91866.1
                                                  		 63966 - 65162 (+) amidohydrolase family protein
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                                                    • AKC91867.1
                                                    		 65203 - 66105 (-) XRE family transcriptional regulator
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                                                      Biosynthesis information

                                                      Biosynthetic modules

                                                      Name
                                                      Unk01
                                                      Type
                                                      nrps-type1
                                                      Genes
                                                      griA
                                                      Substrates
                                                      valine (evidence: Structure-based inference [1])
                                                      Integrated Monomers
                                                      Domains
                                                      adenylation
                                                      Name
                                                      Unk02
                                                      Type
                                                      nrps-type1
                                                      Genes
                                                      griA
                                                      Substrates
                                                      4R-methylproline (evidence: Structure-based inference, Heterologous expression)
                                                      Integrated Monomers
                                                      Domains
                                                      adenylation
                                                      Name
                                                      Unk03
                                                      Type
                                                      nrps-type1
                                                      Genes
                                                      griA
                                                      Substrates
                                                      threonine (evidence: Structure-based inference [1])
                                                      Integrated Monomers
                                                      Domains
                                                      adenylation
                                                      Name
                                                      Unk04
                                                      Type
                                                      nrps-type1
                                                      Genes
                                                      griA
                                                      Substrates
                                                      leucine (evidence: Structure-based inference [1])
                                                      Integrated Monomers
                                                      Domains
                                                      adenylation
                                                      Name
                                                      Unk05
                                                      Type
                                                      nrps-type1
                                                      Genes
                                                      griA
                                                      Substrates
                                                      4R-methylproline (evidence: Structure-based inference, Heterologous expression)
                                                      Integrated Monomers
                                                      Domains
                                                      adenylation
                                                      Name
                                                      Unk06
                                                      Type
                                                      nrps-type1
                                                      Genes
                                                      griA
                                                      Substrates
                                                      leucine (evidence: Structure-based inference [1])
                                                      Integrated Monomers
                                                      Domains
                                                      adenylation
                                                      Name
                                                      Unk07
                                                      Type
                                                      nrps-type1
                                                      Genes
                                                      griB
                                                      Substrates
                                                      valine (evidence: Structure-based inference [1])
                                                      Integrated Monomers
                                                      Domains
                                                      adenylation
                                                      Name
                                                      Unk08
                                                      Type
                                                      nrps-type1
                                                      Genes
                                                      griB
                                                      Substrates
                                                      proline, 4R-methylproline (evidence: Structure-based inference, Heterologous expression)
                                                      Integrated Monomers
                                                      Domains
                                                      adenylation
                                                      Name
                                                      Unk09
                                                      Type
                                                      nrps-type1
                                                      Genes
                                                      griB
                                                      Substrates
                                                      leucine (evidence: Structure-based inference [1])
                                                      Integrated Monomers
                                                      Domains
                                                      adenylation
                                                      Name
                                                      Unk10
                                                      Type
                                                      nrps-type1
                                                      Genes
                                                      griC
                                                      Substrates
                                                      glycine (evidence: Structure-based inference [1])
                                                      Integrated Monomers
                                                      Domains
                                                      adenylation
                                                      Annotation changelog

                                                      Entry version: 4

                                                      Date
                                                      Changes
                                                      Submitters
                                                      Reviewers
                                                      2022-10-07
                                                      Update chemical activity to schema version 2.11
                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                      Entry version: 3

                                                      Date
                                                      Changes
                                                      Submitters
                                                      Reviewers
                                                      2022-09-15
                                                      Updated bioactivity data
                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                      2022-09-15
                                                      Added NRP substrate specificities
                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                      Entry version: 2

                                                      Date
                                                      Changes
                                                      Submitters
                                                      Reviewers
                                                      2019-10-16
                                                      Migrated from v1.4
                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                      2019-10-16
                                                      Updated compound(s) information (NPAtlas curation)
                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                      Entry version: 1

                                                      Date
                                                      Changes
                                                      Submitters
                                                      Reviewers
                                                      2016-09-03
                                                      Submitted
                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                      Detailed domain annotation
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