BGC0001414: griselimycin biosynthetic gene cluster from Streptomyces muensis
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Location: 1 - 66,865 nt. (total: 66,865 nt).
This entry is originally from NCBI GenBank KP211414.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001414
Short description griselimycin biosynthetic gene cluster from Streptomyces muensis
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
Loci NCBI GenBank: KP211414.1
Compounds
  • griselimycin
Species Streptomyces muensis [taxonomy]
References
Chemical products information
griselimycin
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C57H96N10O12
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AKC91842.1
 837 - 2075 (+) XRE family transcriptional regulator
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  • AKC91843.1
 2185 - 2625 (+) hypothetical protein
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  • AKC91844.1
 2625 - 2819 (+) hypothetical protein
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  • AKC91845.1
 3033 - 4037 (+) hypothetical protein
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  • AKC91846.1
 4110 - 5630 (+) amino acid permease
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  • AKC91847.1
 5627 - 7066 (+) glutamin synthetase
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  • AKC91848.1
 7240 - 8133 (+) phosphotransferase enzyme family
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  • AKC91849.1
  • griA
 8501 - 31885 (-) nonribosomal peptide synthetase
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  • AKC91850.1
  • int1
 32770 - 33102 (-) integrase catalytic region
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  • AKC91851.1
  • tnp1
 33187 - 33726 (+) transposase
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  • AKC91852.1
  • int2
 33567 - 34127 (-) integrase catalytic region
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  • AKC91853.1
  • tnp2
 34648 - 36300 (-) transposase
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  • AKC91854.1
  • tnp3
 36283 - 37314 (+) transposase
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  • AKC91855.1
  • griR
 37743 - 38864 (-) DNA polymerase III beta subunit
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  • AKC91856.1
  • griB
 39640 - 52146 (+) nonribosomal peptide synthetase
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  • AKC91857.1
  • griC
 52143 - 56117 (+) nonribosomal peptide synthetase
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  • AKC91858.1
  • griD
 56114 - 56332 (+) mbtH-like protein
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  • AKC91859.1
  • griE
 56431 - 57243 (+) leucine hydroxylase
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  • AKC91860.1
  • griF
 57240 - 58415 (+) alcohol dehydrogenase
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  • AKC91861.1
  • griG
 58442 - 59242 (+) alpha/beta hydrolase
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  • AKC91862.1
  • griH
 59239 - 60138 (+) oxidoreductase
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  • AKC91863.1
 61141 - 61581 (-) pyridoxamine 5'-phosphate oxidase family protein
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  • AKC91864.1
 62167 - 62817 (+) hypothetical protein
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  • AKC91865.1
 62821 - 63936 (+) hypothetical protein
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  • AKC91866.1
 63966 - 65162 (+) amidohydrolase family protein
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  • AKC91867.1
 65203 - 66105 (-) XRE family transcriptional regulator
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NRP-specific information
Subclass N/A
Cyclic? no
NRP-synthases
Gene Modules
griA
Module ?
Specificity: valine
Evidence for specificity:
  • Structure-based inference
Module ?
Specificity: 4R-methylproline
Evidence for specificity:
  • Structure-based inference
  • Heterologous expression
Module ?
Specificity: threonine
Evidence for specificity:
  • Structure-based inference
Module ?
Specificity: leucine
Evidence for specificity:
  • Structure-based inference
Module ?
Specificity: 4R-methylproline
Evidence for specificity:
  • Structure-based inference
  • Heterologous expression
Module ?
Specificity: leucine
Evidence for specificity:
  • Structure-based inference
griB
Module ?
Specificity: valine
Evidence for specificity:
  • Structure-based inference
Module ?
Specificity: proline / 4R-methylproline
Evidence for specificity:
  • Structure-based inference
  • Heterologous expression
Module ?
Specificity: leucine
Evidence for specificity:
  • Structure-based inference
griC
Module ?
Specificity: glycine
Evidence for specificity:
  • Structure-based inference
Annotation changelog
MIBiG version Submitter Notes
1.3
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Updated bioactivity data
  • Added NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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