BGC0001416: nunapeptin biosynthetic gene cluster from Pseudomonas sp. In5
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Location: 764,645 - 879,715 nt. (total: 115,071 nt).
This entry is originally from NCBI GenBank LIRD01000002.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001416
Short description nunapeptin biosynthetic gene cluster from Pseudomonas sp. In5
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
LIRD01000002.1
764645 - 879715
via
Compounds
  • nunapeptin
  • nunamycin
Species Pseudomonas sp. In5 [taxonomy]
References
Chemical products information
nunapeptin Evidence:
(no structure information available)
nunamycin Evidence:
(no structure information available)
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AL066_08450
  • KPN90367.1
 764645 - 766063 (-) NunG
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    • AL066_08455
    • KPN90368.1
    		 766121 - 766954 (-) NunF
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      • AL066_08460
      • KPN90369.1
      		 767366 - 780931 (-) NunE
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        • AL066_08465
        • KPN93065.1
        		 780935 - 795769 (-) NunD
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          • AL066_08470
          • KPN90370.1
          		 796180 - 797169 (+) transcription factor
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            • AL066_08475
            • KPN90371.1
            		 797166 - 798530 (+) class III aminotransferase
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              • AL066_08480
              • KPN90372.1
              		 798919 - 800121 (-) NunC
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                • AL066_08485
                • KPN90373.1
                		 800163 - 801107 (-) NunB2
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                  • AL066_08490
                  • KPN90374.1
                  		 801100 - 802959 (-) NunB1
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                    • AL066_08495
                    • KPN90375.1
                    		 803399 - 804442 (+) NupP
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                      • AL066_08500
                      • KPN92955.1
                      		 804557 - 806287 (+) NupD
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                        • AL066_08505
                        • KPN93063.1
                        		 806512 - 835419 (+) NupA
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                          • AL066_08510
                          • KPN93064.1
                          		 835416 - 848543 (+) NupB
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                            • AL066_08515
                            • KPN90376.1
                            		 848882 - 879715 (+) NupC
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                              Biosynthesis information

                              Biosynthetic modules

                              Name
                              Unk01
                              Type
                              nrps-type1
                              Genes
                              AL066_08460
                              Substrates
                              threonine (evidence: Structure-based inference, Mass spectrometry, Homology)
                              Integrated Monomers
                              Domains
                              adenylation
                              Name
                              Unk02
                              Type
                              nrps-type1
                              Genes
                              AL066_08460
                              Substrates
                              threonine (evidence: Structure-based inference, Mass spectrometry, Homology)
                              Integrated Monomers
                              Domains
                              adenylation
                              Name
                              Unk03
                              Type
                              nrps-type1
                              Genes
                              AL066_08460
                              Substrates
                              aspartic acid (evidence: Structure-based inference, Mass spectrometry, Homology)
                              Integrated Monomers
                              Domains
                              adenylation
                              Name
                              Unk04
                              Type
                              nrps-type1
                              Genes
                              AL066_08490
                              Substrates
                              threonine (evidence: Structure-based inference, Mass spectrometry, Homology)
                              Integrated Monomers
                              Domains
                              adenylation
                              Name
                              Unk05
                              Type
                              nrps-type1
                              Genes
                              AL066_08515
                              Substrates
                              valine (evidence: Structure-based inference, Mass spectrometry, Homology)
                              Integrated Monomers
                              Domains
                              adenylation
                              Name
                              Unk06
                              Type
                              nrps-type1
                              Genes
                              AL066_08515
                              Substrates
                              alanine (evidence: Structure-based inference, Mass spectrometry, Homology)
                              Integrated Monomers
                              Domains
                              adenylation
                              Name
                              Unk07
                              Type
                              nrps-type1
                              Genes
                              AL066_08515
                              Substrates
                              valine (evidence: Structure-based inference, Mass spectrometry, Homology)
                              Integrated Monomers
                              Domains
                              adenylation
                              Name
                              Unk08
                              Type
                              nrps-type1
                              Genes
                              AL066_08515
                              Substrates
                              threonine (evidence: Structure-based inference, Mass spectrometry, Homology)
                              Integrated Monomers
                              Domains
                              adenylation
                              Name
                              Unk09
                              Type
                              nrps-type1
                              Genes
                              AL066_08515
                              Substrates
                              threonine (evidence: Structure-based inference, Mass spectrometry, Homology)
                              Integrated Monomers
                              Domains
                              adenylation
                              Name
                              Unk10
                              Type
                              nrps-type1
                              Genes
                              AL066_08515
                              Substrates
                              alanine (evidence: Structure-based inference, Mass spectrometry, Homology)
                              Integrated Monomers
                              Domains
                              adenylation
                              Name
                              Unk11
                              Type
                              nrps-type1
                              Genes
                              AL066_08515
                              Substrates
                              2,4-diaminobutyric acid (evidence: Structure-based inference, Mass spectrometry, Homology)
                              Integrated Monomers
                              Domains
                              adenylation
                              Name
                              Unk12
                              Type
                              nrps-type1
                              Genes
                              AL066_08515
                              Substrates
                              serine (evidence: Structure-based inference, Mass spectrometry, Homology)
                              Integrated Monomers
                              Domains
                              adenylation
                              Name
                              Unk13
                              Type
                              nrps-type1
                              Genes
                              AL066_08515
                              Substrates
                              isoleucine (evidence: Structure-based inference, Mass spectrometry, Homology)
                              Integrated Monomers
                              Domains
                              adenylation
                              Name
                              Unk14
                              Type
                              nrps-type1
                              Genes
                              AL066_08505
                              Substrates
                              threonine (evidence: Structure-based inference, Mass spectrometry, Homology)
                              Integrated Monomers
                              Domains
                              adenylation
                              Name
                              Unk15
                              Type
                              nrps-type1
                              Genes
                              AL066_08505
                              Substrates
                              proline (evidence: Structure-based inference, Mass spectrometry, Homology)
                              Integrated Monomers
                              Domains
                              adenylation
                              Name
                              Unk16
                              Type
                              nrps-type1
                              Genes
                              AL066_08505
                              Substrates
                              alanine (evidence: Structure-based inference, Mass spectrometry, Homology)
                              Integrated Monomers
                              Domains
                              adenylation
                              Name
                              Unk17
                              Type
                              nrps-type1
                              Genes
                              AL066_08505
                              Substrates
                              alanine (evidence: Structure-based inference, Mass spectrometry, Homology)
                              Integrated Monomers
                              Domains
                              adenylation
                              Name
                              Unk18
                              Type
                              nrps-type1
                              Genes
                              AL066_08505
                              Substrates
                              alanine (evidence: Structure-based inference, Mass spectrometry, Homology)
                              Integrated Monomers
                              Domains
                              adenylation
                              Name
                              Unk19
                              Type
                              nrps-type1
                              Genes
                              AL066_08505
                              Substrates
                              valine (evidence: Structure-based inference, Mass spectrometry, Homology)
                              Integrated Monomers
                              Domains
                              adenylation
                              Name
                              Unk20
                              Type
                              nrps-type1
                              Genes
                              AL066_08505
                              Substrates
                              alanine (evidence: Structure-based inference, Mass spectrometry, Homology)
                              Integrated Monomers
                              Domains
                              adenylation
                              Name
                              Unk21
                              Type
                              nrps-type1
                              Genes
                              AL066_08505
                              Substrates
                              threonine (evidence: Structure-based inference, Mass spectrometry, Homology)
                              Integrated Monomers
                              Domains
                              adenylation
                              Name
                              Unk22
                              Type
                              nrps-type1
                              Genes
                              AL066_08505
                              Substrates
                              serine (evidence: Structure-based inference, Mass spectrometry, Homology)
                              Integrated Monomers
                              Domains
                              adenylation
                              Name
                              Unk23
                              Type
                              nrps-type1
                              Genes
                              AL066_08510
                              Substrates
                              valine (evidence: Structure-based inference, Mass spectrometry, Homology)
                              Integrated Monomers
                              Domains
                              adenylation
                              Name
                              Unk24
                              Type
                              nrps-type1
                              Genes
                              AL066_08510
                              Substrates
                              isoleucine (evidence: Structure-based inference, Mass spectrometry, Homology)
                              Integrated Monomers
                              Domains
                              adenylation
                              Name
                              Unk25
                              Type
                              nrps-type1
                              Genes
                              AL066_08510
                              Substrates
                              serine (evidence: Structure-based inference, Mass spectrometry, Homology)
                              Integrated Monomers
                              Domains
                              adenylation
                              Name
                              Unk26
                              Type
                              nrps-type1
                              Genes
                              AL066_08510
                              Substrates
                              alanine (evidence: Structure-based inference, Mass spectrometry, Homology)
                              Integrated Monomers
                              Domains
                              adenylation
                              Name
                              Unk27
                              Type
                              nrps-type1
                              Genes
                              AL066_08465
                              Substrates
                              serine (evidence: Structure-based inference, Mass spectrometry, Homology)
                              Integrated Monomers
                              Domains
                              adenylation
                              Name
                              Unk28
                              Type
                              nrps-type1
                              Genes
                              AL066_08465
                              Substrates
                              2,4-diaminobutyric acid (evidence: Structure-based inference, Mass spectrometry, Homology)
                              Integrated Monomers
                              Domains
                              adenylation
                              Name
                              Unk29
                              Type
                              nrps-type1
                              Genes
                              AL066_08465
                              Substrates
                              glycine (evidence: Structure-based inference, Mass spectrometry, Homology)
                              Integrated Monomers
                              Domains
                              adenylation
                              Name
                              Unk30
                              Type
                              nrps-type1
                              Genes
                              AL066_08465
                              Substrates
                              homoserine (evidence: Structure-based inference, Mass spectrometry, Homology)
                              Integrated Monomers
                              Domains
                              adenylation
                              Annotation changelog

                              Entry version: 4

                              Date
                              Changes
                              Submitters
                              Reviewers
                              2022-10-07
                              Update chemical activity to schema version 2.11
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                              Entry version: 3

                              Date
                              Changes
                              Submitters
                              Reviewers
                              2022-09-15
                              Updated bioactivity data
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              2022-09-15
                              Added NRP substrate specificities
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                              Entry version: 2

                              Date
                              Changes
                              Submitters
                              Reviewers
                              2019-10-16
                              Migrated from v1.4
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                              Entry version: 1

                              Date
                              Changes
                              Submitters
                              Reviewers
                              2016-09-03
                              Submitted
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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