BGC0001417: myxochromide D biosynthetic gene cluster from Cystobacterineae bacterium
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Location: 1 - 34,448 nt. (total: 34,448 nt).
This entry is originally from NCBI GenBank KX622587.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001417
Short description myxochromide D biosynthetic gene cluster from Cystobacterineae bacterium
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Iterative type I)
Loci
KX622587.1
via
Compounds
  • myxochromide D
Species Cystobacterineae bacterium [taxonomy]
References
Chemical products information
myxochromide D Evidence: Mass spectrometry
Copy SMILES
C39H56N6O8
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • APZ78674.1
 1 - 1521 (+) two-component sensor histidine kinase
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    • APZ78675.1
    		 1576 - 2064 (-) membrane protein
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      • APZ78676.1
      		 2489 - 3118 (+) uncharacterized protein
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        • APZ78677.1
        		 3078 - 3563 (+) uncharacterized protein
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          • APZ78678.1
          • mchA
          		 4086 - 10586 (+) polyketide synthase
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            • APZ78679.1
            • mchB
            		 10583 - 19729 (+) nonribosomal peptide synthetase
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              • APZ78680.1
              • mchC
              		 19762 - 31347 (+) nonribosomal peptide synthetase
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                • APZ78681.1
                • mchD
                		 31344 - 31826 (+) membrane protein
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                  • APZ78682.1
                  		 31848 - 32108 (+) uncharacterized protein
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                    • APZ78683.1
                    		 32129 - 32938 (-) aldo/keto reductase
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                      • APZ78684.1
                      		 33347 - 34105 (-) uncharacterized protein
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                        • APZ78685.1
                        		 34107 - 34448 (-) uncharacterized protein
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                          Biosynthesis information

                          Biosynthetic modules

                          Name
                          2
                          Type
                          nrps-type1
                          Genes
                          mchB
                          Substrates
                          threonine (evidence: Sequence-based prediction)
                          Integrated Monomers
                          Domains
                          condensation (LCL), adenylation, methyltransferase
                          Name
                          3
                          Type
                          nrps-type1
                          Genes
                          mchB
                          Substrates
                          alanine (evidence: Sequence-based prediction)
                          Integrated Monomers
                          Domains
                          condensation (LCL), adenylation, epimerase
                          Name
                          4
                          Type
                          nrps-type1
                          Genes
                          mchC
                          Substrates
                          leucine (evidence: Sequence-based prediction)
                          Integrated Monomers
                          Domains
                          condensation (DCL), adenylation
                          Name
                          6
                          Type
                          nrps-type1
                          Genes
                          mchC
                          Substrates
                          alanine (evidence: Sequence-based prediction)
                          Integrated Monomers
                          Domains
                          condensation (LCL), adenylation
                          Name
                          7
                          Type
                          nrps-type1
                          Genes
                          mchC
                          Substrates
                          glutamine (evidence: Sequence-based prediction)
                          Integrated Monomers
                          Domains
                          condensation (LCL), adenylation
                          Name
                          1
                          Type
                          pks-modular
                          Genes
                          mchA
                          Substrates
                          Integrated Monomers
                          Domains
                          acyltransferase, ketosynthase, acyltransferase, dehydratase, enoylreductase, ketoreductase, carrier (ACP)
                          Annotation changelog

                          Entry version: 3

                          Date
                          Changes
                          Submitters
                          Reviewers
                          2022-09-15
                          Corrected NRP module activity
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          2022-09-15
                          Removed gene annotations, including 'extra' genes, which duplicated NCBI annotations
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          2022-09-15
                          Changed gene identifiers used to consistently be 'gene' names
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          2022-09-15
                          Changed amino acid substrates to lower case
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                          Entry version: 2

                          Date
                          Changes
                          Submitters
                          Reviewers
                          2019-10-16
                          Migrated from v1.4
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                          Entry version: 1

                          Date
                          Changes
                          Submitters
                          Reviewers
                          2018-08-06
                          Submitted
                          • (ID: W3AST4BMPVTIWZ3NNIXB2T6Y)
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          Detailed domain annotation
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