BGC0001418: myxochromide D biosynthetic gene cluster from Hyalangium minutum
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Location: 1 - 40,460 nt. (total: 40,460 nt).
This entry is originally from NCBI GenBank KX622588.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Polyketide
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001418
Short description myxochromide D biosynthetic gene cluster from Hyalangium minutum
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP (Cyclic depsipeptide)
  • Polyketide (Polyene)
Loci NCBI GenBank: KX622588.1
Compounds
  • myxochromide D
Species Hyalangium minutum [taxonomy]
References
Chemical products information
myxochromide D
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C39H56N6O8
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • APZ78686.1
 1 - 2661 (+) uncharacterized protein
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  • APZ78687.1
 2671 - 3312 (-) uncharacterized protein
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  • APZ78688.1
 3478 - 3825 (+) pilus assembly protein PilZ
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  • APZ78689.1
 3900 - 5450 (-) amino acid dehydrogenase
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  • APZ78690.1
  • mchA
 6179 - 12679 (+) polyketide synthase
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  • APZ78691.1
  • mchB
 12676 - 21825 (+) nonribosomal peptide synthetase
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  • APZ78692.1
  • mchC
 21860 - 35260 (+) nonribosomal peptide synthetase
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  • APZ78693.1
  • mchD
 35257 - 35730 (+) membrane protein
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  • APZ78694.1
 35872 - 37188 (+) uncharacterized protein
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  • APZ78695.1
 37494 - 38243 (+) ABC transporter ATP-binding protein
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  • APZ78696.1
 38240 - 39631 (+) ABC transporter permease
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  • APZ78697.1
 39657 - 40460 (+) uncharacterized protein
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Polyketide-specific information
Subclass Polyene
Starter unit Acetyl-CoA
Cyclic? no
Polyketide-synthases
Genes Properties Modules
mchA Synthase subclass: Iterative type I
Iterative PKS type: Partially reducing, Unknown
Iteration counts: 9
Module 1
Specificity: Malonyl-CoA
Evidence for specificity: Sequence-based prediction
Genes: mchA
Core domains: Ketosynthase, Acyltransferase, Dehydratase, Enoylreductase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Non-canonical activity:
  • Iterated
Evidence for non-canonical activity:
  • Structure-based inference
NRP-specific information
Subclass Cyclic depsipeptide
Cyclic? yes
Release type
  • Macrolactonization
Thioesterase genes
  • mchC (Type I)
NRP-synthases
Gene Modules
mchB
Module 2
Specificity: threonine
Evidence for specificity:
  • Sequence-based prediction
Condensation domain type: LCL
Modification domains: Methylation
Module 3
Specificity: alanine
Evidence for specificity:
  • Sequence-based prediction
Condensation domain type: LCL
mchC
Module 4
Specificity: leucine
Evidence for specificity:
  • Sequence-based prediction
Condensation domain type: DCL
Module 5 [inactive]
Condensation domain type: LCL
Non-canonical activity:
  • Other
Evidence for non-canonical activity:
  • Sequence-based prediction
Module 6
Specificity: alanine
Evidence for specificity:
  • Sequence-based prediction
Condensation domain type: LCL
Module 7
Specificity: glutamine
Evidence for specificity:
  • Sequence-based prediction
Condensation domain type: LCL
Annotation changelog
MIBiG version Submitter Notes
1.4
  • Hidden contributor (ID: W3AST4BMPVTIWZ3NNIXB2T6Y, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Corrected NRP module activity
  • Removed gene annotations, including 'extra' genes, which duplicated NCBI annotations
  • Changed gene identifiers used to consistently be 'gene' names
  • Changed amino acid substrates to lower case
Detailed domain annotation
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