BGC0001420: myxochromide D biosynthetic gene cluster from Hyalangium minutum
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Location: 1 - 43,282 nt. (total: 43,282 nt).
This entry is originally from NCBI GenBank KX622590.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001420
Short description myxochromide D biosynthetic gene cluster from Hyalangium minutum
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Iterative type I)
Loci
KX622590.1
via
Compounds
  • myxochromide D
Species Hyalangium minutum [taxonomy]
References
Chemical products information
myxochromide D Evidence: Mass spectrometry
Copy SMILES
C39H56N6O8
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • APZ78710.1
 1 - 2661 (+) uncharacterized protein
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    • APZ78711.1
    		 2671 - 3312 (-) uncharacterized protein
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      • APZ78712.1
      		 3478 - 3825 (+) pilus assembly protein PilZ
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        • APZ78713.1
        		 3901 - 5451 (-) amino acid dehydrogenase
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          • APZ78714.1
          • mchA
          		 6179 - 12679 (+) polyketide synthase
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            • APZ78715.1
            • mchB
            		 12676 - 21819 (+) nonribosomal peptide synthetase
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              • APZ78716.1
              • mchC
              		 21854 - 35254 (+) nonribosomal peptide synthetase
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                • APZ78717.1
                • mchD
                		 35251 - 35724 (+) membrane protein
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                  • APZ78718.1
                  		 35810 - 37360 (-) benzoate-CoA ligase family protein
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                    • APZ78719.1
                    		 37391 - 39658 (-) 8-amino-7-oxononanoate synthase
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                      • APZ78720.1
                      		 39658 - 39978 (-) phosphopantetheine-binding protein
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                        • APZ78721.1
                        		 39984 - 41585 (-) acyl-CoA dehydrogenase
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                          • APZ78722.1
                          		 41582 - 43282 (-) acyl-CoA synthetase
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                            Biosynthesis information

                            Biosynthetic modules

                            Name
                            2
                            Type
                            nrps-type1
                            Genes
                            mchB
                            Substrates
                            threonine (evidence: Sequence-based prediction)
                            Integrated Monomers
                            Domains
                            condensation (LCL), adenylation, methyltransferase
                            Name
                            3
                            Type
                            nrps-type1
                            Genes
                            mchB
                            Substrates
                            alanine (evidence: Sequence-based prediction)
                            Integrated Monomers
                            Domains
                            condensation (LCL), adenylation, epimerase
                            Name
                            4
                            Type
                            nrps-type1
                            Genes
                            mchC
                            Substrates
                            leucine (evidence: Sequence-based prediction)
                            Integrated Monomers
                            Domains
                            condensation (DCL), adenylation
                            Name
                            6
                            Type
                            nrps-type1
                            Genes
                            mchC
                            Substrates
                            alanine (evidence: Sequence-based prediction)
                            Integrated Monomers
                            Domains
                            condensation (LCL), adenylation
                            Name
                            7
                            Type
                            nrps-type1
                            Genes
                            mchC
                            Substrates
                            glutamine (evidence: Sequence-based prediction)
                            Integrated Monomers
                            Domains
                            condensation (LCL), adenylation
                            Name
                            1
                            Type
                            pks-modular
                            Genes
                            mchA
                            Substrates
                            Integrated Monomers
                            Domains
                            acyltransferase, ketosynthase, acyltransferase, dehydratase, enoylreductase, ketoreductase, carrier (ACP)
                            Annotation changelog

                            Entry version: 3

                            Date
                            Changes
                            Submitters
                            Reviewers
                            2022-09-15
                            Corrected NRP module activity
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            2022-09-15
                            Removed gene annotations, including 'extra' genes, which duplicated NCBI annotations
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            2022-09-15
                            Changed gene identifiers used to consistently be 'gene' names
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            2022-09-15
                            Changed amino acid substrates to lower case
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                            Entry version: 2

                            Date
                            Changes
                            Submitters
                            Reviewers
                            2019-10-16
                            Migrated from v1.4
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                            Entry version: 1

                            Date
                            Changes
                            Submitters
                            Reviewers
                            2018-08-06
                            Submitted
                            • (ID: W3AST4BMPVTIWZ3NNIXB2T6Y)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            Detailed domain annotation
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