BGC0001421: myxochromide B biosynthetic gene cluster from Myxococcus sp.
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Location: 1 - 47,099 nt. (total: 47,099 nt).
This entry is originally from NCBI GenBank KX622591.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Polyketide
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001421
Short description myxochromide B biosynthetic gene cluster from Myxococcus sp.
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP (Cyclic depsipeptide)
  • Polyketide (Polyene)
Loci NCBI GenBank: KX622591.1
Compounds
  • myxochromide B
Species Myxococcus sp. [taxonomy]
References
Chemical products information
myxochromide B
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C49H72N8O10
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • APZ78723.1
 1 - 1266 (-) glycosyl hydrolase
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  • APZ78724.1
 1334 - 2215 (+) multidrug ABC transporter ATP-binding protein
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  • APZ78725.1
 2226 - 5828 (+) membrane protein
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  • APZ78726.1
 5834 - 6370 (-) uncharacterized protein
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  • APZ78727.1
  • mchA
 6886 - 13338 (+) polyketide synthase
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  • APZ78728.1
  • mchB
 13335 - 22475 (+) nonribosomal peptide synthetase
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  • APZ78729.1
  • mchC
 22508 - 39013 (+) nonribosomal peptide synthetase
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  • APZ78730.1
  • mchD
 39010 - 39474 (+) membrane protein
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  • APZ78731.1
 39541 - 41064 (-) ATP-dependent RNA helicase RhlE
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  • APZ78732.1
 41424 - 43526 (-) elongation factor G
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  • APZ78733.1
 43960 - 45150 (-) cyclic nucleotide-binding protein
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  • APZ78734.1
 45263 - 45739 (-) peptidyl-prolyl cis-trans isomerase
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  • APZ78735.1
 45897 - 47099 (+) metallophosphatase
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Polyketide-specific information
Subclass Polyene
Starter unit Acetyl-CoA
Cyclic? no
Polyketide-synthases
Genes Properties Modules
mchA Synthase subclass: Iterative type I
Iterative PKS type: Partially reducing, Unknown
Iteration counts: 9
Module 1
Specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
Genes: mchA
Core domains: Ketosynthase, Acyltransferase, Dehydratase, Enoylreductase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Non-canonical activity:
  • Iterated
Evidence for non-canonical activity:
  • Structure-based inference
NRP-specific information
Subclass Cyclic depsipeptide
Cyclic? yes
Release type
  • Macrolactonization
Thioesterase genes
  • mchC (Type I)
NRP-synthases
Gene Modules
mchB
Module 2
Specificity: threonine
Evidence for specificity:
  • Mass spectrometry
  • Structure-based inference
  • Sequence-based prediction
Condensation domain type: LCL
Modification domains: Methylation
Module 3
Specificity: alanine
Evidence for specificity:
  • Mass spectrometry
  • Structure-based inference
  • Sequence-based prediction
Condensation domain type: LCL
mchC
Module 4
Specificity: leucine
Evidence for specificity:
  • Mass spectrometry
  • Structure-based inference
  • Sequence-based prediction
Condensation domain type: DCL
Module 5
Specificity: leucine
Evidence for specificity:
  • Mass spectrometry
  • Structure-based inference
  • Sequence-based prediction
Condensation domain type: LCL
Module 6
Specificity: proline
Evidence for specificity:
  • Mass spectrometry
  • Structure-based inference
  • Sequence-based prediction
Condensation domain type: LCL
Module 7
Specificity: alanine
Evidence for specificity:
  • Mass spectrometry
  • Structure-based inference
  • Sequence-based prediction
Condensation domain type: LCL
Module 8
Specificity: glutamine
Evidence for specificity:
  • Mass spectrometry
  • Structure-based inference
  • Sequence-based prediction
Condensation domain type: LCL
Annotation changelog
MIBiG version Submitter Notes
1.4
  • Hidden contributor (ID: W3AST4BMPVTIWZ3NNIXB2T6Y, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Corrected NRP module activity
  • Removed gene annotations, including 'extra' genes, which duplicated NCBI annotations
  • Changed gene identifiers used to consistently be 'gene' names
  • Corrected NRP gene names
  • Updated NRP substrate specificities
Detailed domain annotation
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