BGC0001422 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001422 (Myxococcus fulvus HW-1)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS,T1PKS	1	42,748	myxochromide A	NRP:Cyclic depsipeptide + Polyketide:Iterative type I	91%

BGC0001422 - Region 1 - NRPS,T1PKS

Download region GenBank file

Download region SVG

Location: 1 - 42,748 nt. (total: 42,748 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 42,749
Label		BGC0001422

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001422.1	0.89	NRP, Polyketide	myxochromide A	Myxococcus fulvus HW-1
BGC0001023.1	0.76	NRP, Polyketide	myxochromide S1	Stigmatella aurantiaca
BGC0001424.1	0.63	NRP, Polyketide	myxochromide C	Myxococcus virescens
BGC0001428.1	0.62	NRP, Polyketide	myxochromide A	Myxococcus xanthus
BGC0002071.1	0.56	NRP	Virginiafactin	Pseudomonas sp. QS1027
BGC0000426.1	0.55	NRP	sevadicin	Paenibacillus larvae
BGC0001426.1	0.55	NRP, Polyketide	myxochromide A	Myxococcus xanthus
BGC0001425.1	0.55	NRP, Polyketide	myxochromide A	Myxococcus xanthus DK 1622
BGC0000389.1	0.55	NRP	massetolide A	Pseudomonas fluorescens SS101
BGC0001427.1	0.55	NRP, Polyketide	myxochromide A	Myxococcus xanthus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001422.1	0.81	NRP, Polyketide	myxochromide A	Myxococcus fulvus HW-1
BGC0001023.1	0.79	NRP, Polyketide	myxochromide S1	Stigmatella aurantiaca
BGC0002071.1	0.72	NRP	Virginiafactin	Pseudomonas sp. QS1027
BGC0000389.1	0.71	NRP	massetolide A	Pseudomonas fluorescens SS101
BGC0001428.1	0.70	NRP, Polyketide	myxochromide A	Myxococcus xanthus
BGC0000426.1	0.70	NRP	sevadicin	Paenibacillus larvae
BGC0001424.1	0.69	NRP, Polyketide	myxochromide C	Myxococcus virescens
BGC0001426.1	0.67	NRP, Polyketide	myxochromide A	Myxococcus xanthus
BGC0001425.1	0.67	NRP, Polyketide	myxochromide A	Myxococcus xanthus DK 1622
BGC0001833.1	0.67	NRP	icosalide A, icosalide B	Burkholderia gladioli

Similar known gene clusters

Module view

Legend

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 42748:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (pk) + (NMe-thr - D-pro) + (leu - pro - phe - gln)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

mchA

PKS_AT (544..840): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; CE-Malonyl-CoA: 58.3%; Methoxymalonyl-CoA: 54.2%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 109.8
Isobutyryl-CoA: 95.2
Malonyl-CoA: 93.6
Methoxymalonyl-CoA: 91.2
Ethylmalonyl-CoA: 78.6
Propionyl-CoA: 47.4
2-Methylbutyryl-CoA: 46.2
Benzoyl-CoA: 42.1
CHC-CoA: 38.3
trans-1,2-CPDA: 32.0
Acetyl-CoA: 27.8
inactive: 23.1
3-Methylbutyryl-CoA: 22.2
fatty_acid: 19.2

mchB

Search NORINE for peptide: strict or relaxed

AMP-binding (510..914): thr

NRPSPredictor2: thr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: ser, thr, dhpg, hpg
Small clusters prediction:: thr
Single AA prediction:: thr

Stachelhaus prediction details:

Stachelhaus sequence:: DFWNIGMVHK
Nearest Stachelhaus code:: thr
Stachelhaus code match:: 100% (strong)

AMP-binding (2009..2399): pro

NRPSPredictor2: pro

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: phe, trp
Single AA prediction:: pro

Stachelhaus prediction details:

Stachelhaus sequence:: DvWvIAAViK
Nearest Stachelhaus code:: phe
Stachelhaus code match:: 70% (weak)

mchC

Search NORINE for peptide: strict or relaxed

AMP-binding (467..853): leu

NRPSPredictor2: leu

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: val, leu, ile, abu, iva
Single AA prediction:: leu

Stachelhaus prediction details:

Stachelhaus sequence:: DAWFLGNVVK
Nearest Stachelhaus code:: leu
Stachelhaus code match:: 100% (strong)

AMP-binding (1502..1897): pro

NRPSPredictor2: pro

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: pro, pip
Small clusters prediction:: pro
Single AA prediction:: pro

Stachelhaus prediction details:

Stachelhaus sequence:: DVQFIAHVVK
Nearest Stachelhaus code:: pro
Stachelhaus code match:: 100% (strong)

AMP-binding (2551..2941): phe

NRPSPredictor2: phe

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: phe, trp
Single AA prediction:: phe

Stachelhaus prediction details:

Stachelhaus sequence:: DVWvtAAIiK
Nearest Stachelhaus code:: ala
Stachelhaus code match:: 70% (weak)

AMP-binding (3594..3985): gln

NRPSPredictor2: gln

SVM prediction details:

Predicted physicochemical class:: hydrophilic
Large clusters prediction:: asp, asn, glu, gln, aad
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DAWQcGLIDK
Nearest Stachelhaus code:: gln
Stachelhaus code match:: 90% (moderate)