BGC0001422: myxochromide A biosynthetic gene cluster from Myxococcus fulvus HW-1
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
Location: 1 - 42,748 nt. (total: 42,748 nt).
This entry is originally from NCBI GenBank KX622592.1.

Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset zoomreset view
zoomzoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
General
Compounds
Genes
Polyketide
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001422
Short description myxochromide A biosynthetic gene cluster from Myxococcus fulvus HW-1
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP (Cyclic depsipeptide)
  • Polyketide (Polyene)
Loci NCBI GenBank: KX622592.1
Compounds
  • myxochromide A
Species Myxococcus fulvus HW-1 [taxonomy]
References
Chemical products information
myxochromide A
Copy SMILES
C44H63N7O9
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • APZ78736.1
1 - 1272 (-) glycosyl hydrolase
copy AA seq
copy Nt seq
  • APZ78737.1
1339 - 2220 (+) multidrug ABC transporter ATP-binding protein
copy AA seq
copy Nt seq
  • APZ78738.1
2230 - 5832 (+) membrane protein
copy AA seq
copy Nt seq
  • APZ78739.1
5838 - 6374 (-) uncharacterized protein
copy AA seq
copy Nt seq
  • APZ78740.1
6455 - 6931 (-) uncharacterized protein
copy AA seq
copy Nt seq
  • APZ78741.1
7012 - 7827 (-) AraC family transcriptional regulator
copy AA seq
copy Nt seq
  • APZ78742.1
  • mchA
8153 - 14608 (+) polyketide synthase
copy AA seq
copy Nt seq
  • APZ78743.1
  • mchB
14605 - 23757 (+) nonribosomal peptide synthetase
copy AA seq
copy Nt seq
  • APZ78744.1
  • mchC
23790 - 37175 (+) nonribosomal peptide synthetase
copy AA seq
copy Nt seq
  • APZ78745.1
  • mchD
37172 - 37636 (+) membrane protein
copy AA seq
copy Nt seq
  • APZ78746.1
37686 - 39236 (-) ATP-dependent RNA helicase RhlE
copy AA seq
copy Nt seq
  • APZ78747.1
39603 - 40772 (-) cyclic nucleotide-binding protein
copy AA seq
copy Nt seq
  • APZ78748.1
40896 - 41372 (-) peptidyl-prolyl cis-trans isomerase
copy AA seq
copy Nt seq
  • APZ78749.1
41543 - 42748 (+) metallophosphatase
copy AA seq
copy Nt seq
Polyketide-specific information
Subclass Polyene
Starter unit Acetyl-CoA
Cyclic? no
Polyketide-synthases
Genes Properties Modules
mchA Synthase subclass: Iterative type I
Iterative PKS type: Partially reducing, Unknown
Iteration counts: 9
Module 1
Specificity: Malonyl-CoA
Evidence for specificity: Sequence-based prediction
Genes: mchA
Core domains: Ketosynthase, Acyltransferase, Dehydratase, Enoylreductase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Non-canonical activity:
  • Iterated
Evidence for non-canonical activity:
  • Structure-based inference
NRP-specific information
Subclass Cyclic depsipeptide
Cyclic? yes
Release type
  • Macrolactonization
Thioesterase genes
  • mchC (Type I)
NRP-synthases
Gene Modules
mchB
Module 2
Specificity: threonine
Evidence for specificity:
  • Sequence-based prediction
Condensation domain type: LCL
Modification domains: Methylation
Module 3
Specificity: alanine
Evidence for specificity:
  • Sequence-based prediction
Condensation domain type: LCL
mchC
Module 4
Specificity: leucine
Evidence for specificity:
  • Sequence-based prediction
Condensation domain type: DCL
Module 5
Specificity: proline
Evidence for specificity:
  • Sequence-based prediction
Condensation domain type: LCL
Module 6
Specificity: alanine
Evidence for specificity:
  • Sequence-based prediction
Condensation domain type: LCL
Module 7
Specificity: glutamine
Evidence for specificity:
  • Sequence-based prediction
Condensation domain type: LCL
Annotation changelog
MIBiG version Submitter Notes
1.4
  • Hidden contributor (ID: W3AST4BMPVTIWZ3NNIXB2T6Y, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Corrected NRP module activity
  • Removed gene annotations, including 'extra' genes, which duplicated NCBI annotations
  • Changed gene identifiers used to consistently be 'gene' names
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Changed amino acid substrates to lower case
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.