BGC0001422: myxochromide A biosynthetic gene cluster from Myxococcus fulvus HW-1
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Location: 1 - 42,748 nt. (total: 42,748 nt).
This entry is originally from NCBI GenBank KX622592.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001422
Short description myxochromide A biosynthetic gene cluster from Myxococcus fulvus HW-1
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Iterative type I)
Loci
KX622592.1
via
Compounds
  • myxochromide A
Species Myxococcus fulvus HW-1 [taxonomy]
References
Chemical products information
myxochromide A Evidence: Mass spectrometry
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C44H63N7O9
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • APZ78736.1
 1 - 1272 (-) glycosyl hydrolase
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    • APZ78737.1
    		 1339 - 2220 (+) multidrug ABC transporter ATP-binding protein
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      • APZ78738.1
      		 2230 - 5832 (+) membrane protein
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        • APZ78739.1
        		 5838 - 6374 (-) uncharacterized protein
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          • APZ78740.1
          		 6455 - 6931 (-) uncharacterized protein
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            • APZ78741.1
            		 7012 - 7827 (-) AraC family transcriptional regulator
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              • APZ78742.1
              • mchA
              		 8153 - 14608 (+) polyketide synthase
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                • APZ78743.1
                • mchB
                		 14605 - 23757 (+) nonribosomal peptide synthetase
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                  • APZ78744.1
                  • mchC
                  		 23790 - 37175 (+) nonribosomal peptide synthetase
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                    • APZ78745.1
                    • mchD
                    		 37172 - 37636 (+) membrane protein
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                      • APZ78746.1
                      		 37686 - 39236 (-) ATP-dependent RNA helicase RhlE
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                        • APZ78747.1
                        		 39603 - 40772 (-) cyclic nucleotide-binding protein
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                          • APZ78748.1
                          		 40896 - 41372 (-) peptidyl-prolyl cis-trans isomerase
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                            • APZ78749.1
                            		 41543 - 42748 (+) metallophosphatase
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                              Biosynthesis information

                              Biosynthetic modules

                              Name
                              2
                              Type
                              nrps-type1
                              Genes
                              mchB
                              Substrates
                              threonine (evidence: Sequence-based prediction)
                              Integrated Monomers
                              Domains
                              condensation (LCL), adenylation, methyltransferase
                              Name
                              3
                              Type
                              nrps-type1
                              Genes
                              mchB
                              Substrates
                              alanine (evidence: Sequence-based prediction)
                              Integrated Monomers
                              Domains
                              condensation (LCL), adenylation, epimerase
                              Name
                              4
                              Type
                              nrps-type1
                              Genes
                              mchC
                              Substrates
                              leucine (evidence: Sequence-based prediction)
                              Integrated Monomers
                              Domains
                              condensation (DCL), adenylation
                              Name
                              5
                              Type
                              nrps-type1
                              Genes
                              mchC
                              Substrates
                              proline (evidence: Sequence-based prediction)
                              Integrated Monomers
                              Domains
                              condensation (LCL), adenylation
                              Name
                              6
                              Type
                              nrps-type1
                              Genes
                              mchC
                              Substrates
                              alanine (evidence: Sequence-based prediction)
                              Integrated Monomers
                              Domains
                              condensation (LCL), adenylation
                              Name
                              7
                              Type
                              nrps-type1
                              Genes
                              mchC
                              Substrates
                              glutamine (evidence: Sequence-based prediction)
                              Integrated Monomers
                              Domains
                              condensation (LCL), adenylation
                              Name
                              1
                              Type
                              pks-modular
                              Genes
                              mchA
                              Substrates
                              Integrated Monomers
                              Domains
                              acyltransferase, ketosynthase, acyltransferase, dehydratase, enoylreductase, ketoreductase, carrier (ACP)
                              Annotation changelog

                              Entry version: 3

                              Date
                              Changes
                              Submitters
                              Reviewers
                              2022-09-15
                              Corrected NRP module activity
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              2022-09-15
                              Removed gene annotations, including 'extra' genes, which duplicated NCBI annotations
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              2022-09-15
                              Changed gene identifiers used to consistently be 'gene' names
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              2022-09-15
                              Changed amino acid substrates to lower case
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                              Entry version: 2

                              Date
                              Changes
                              Submitters
                              Reviewers
                              2019-10-16
                              Migrated from v1.4
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              2019-10-16
                              Updated compound(s) information (NPAtlas curation)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                              Entry version: 1

                              Date
                              Changes
                              Submitters
                              Reviewers
                              2018-08-06
                              Submitted
                              • (ID: W3AST4BMPVTIWZ3NNIXB2T6Y)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              Detailed domain annotation
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