BGC0001422: myxochromide A biosynthetic gene cluster from Myxococcus fulvus HW-1
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Location: 1 - 42,748 nt. (total: 42,748 nt).
This entry is originally from NCBI GenBank KX622592.1.

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core biosynthetic genes
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Gene details
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General
Compounds
Genes
Polyketide
NRP
History
KnownClusterBlast
NRPS/PKS domains
General information about the BGC
MIBiG accession BGC0001422
Short description myxochromide A biosynthetic gene cluster from Myxococcus fulvus HW-1
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP (Cyclic depsipeptide)
  • Polyketide (Polyene)
Loci NCBI GenBank: KX622592.1
Compounds
  • myxochromide A
Species Myxococcus fulvus HW-1 [taxonomy]
References
Chemical products information
myxochromide A
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C44H63N7O9
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • orf1
1 - 1272 (-) glycosyl hydrolase
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  • APZ78736.1
1 - 1272 (-) glycosyl hydrolase
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  • orf2
1339 - 2220 (+) multidrug ABC transporter ATP-binding protein
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  • APZ78737.1
1339 - 2220 (+) multidrug ABC transporter ATP-binding protein
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  • orf3
2230 - 5832 (+) membrane protein
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  • APZ78738.1
2230 - 5832 (+) membrane protein
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  • orf4
5838 - 6374 (-) uncharacterized protein
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  • APZ78739.1
5838 - 6374 (-) uncharacterized protein
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  • orf5
6455 - 6931 (-) uncharacterized protein
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  • APZ78740.1
6455 - 6931 (-) uncharacterized protein
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  • orf6
7012 - 7827 (-) AraC family transcriptional regulator
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  • APZ78741.1
7012 - 7827 (-) AraC family transcriptional regulator
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  • APZ78742.1
  • mchA
8153 - 14608 (+) polyketide synthase
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  • APZ78743.1
  • mchB
14605 - 23757 (+) nonribosomal peptide synthetase
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  • APZ78744.1
  • mchC
23790 - 37175 (+) nonribosomal peptide synthetase
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  • APZ78745.1
  • mchD
37172 - 37636 (+) membrane protein
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  • orf7
37686 - 39236 (-) ATP-dependent RNA helicase RhlE
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  • APZ78746.1
37686 - 39236 (-) ATP-dependent RNA helicase RhlE
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  • orf8
39603 - 40772 (-) cyclic nucleotide-binding protein
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  • APZ78747.1
39603 - 40772 (-) cyclic nucleotide-binding protein
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  • orf9
40896 - 41372 (-) peptidyl-prolyl cis-trans isomerase
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  • APZ78748.1
40896 - 41372 (-) peptidyl-prolyl cis-trans isomerase
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  • orf10
41543 - 42748 (+) metallophosphatase
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  • APZ78749.1
41543 - 42748 (+) metallophosphatase
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Polyketide-specific information
Subclass Polyene
Starter unit Acetyl-CoA
Cyclic? no
Polyketide-synthases
Genes Properties Modules
APZ78742.1
+
mchA
Synthase subclass: Iterative type I
Iterative PKS type: Partially reducing, Unknown
Iteration counts: 9
Module 1
Specificity: Malonyl-CoA
Evidence for specificity: Sequence-based prediction
Genes: APZ78742.1
Core domains: Ketosynthase, Acyltransferase, Dehydratase, Enoylreductase, Ketoreductase, Thiolation (ACP/PCP)
Non-canonical activity:
  • Iterated
Evidence for non-canonical activity:
  • Structure-based inference
NRP-specific information
Subclass Cyclic depsipeptide
Cyclic? yes
Release type
  • Macrolactonization
Thioesterase genes
  • mchC (Type I)
NRP-synthases
Gene Modules
APZ78743.1
Module 2
Specificity: Threonine
Evidence for specificity:
  • Sequence-based prediction
Condensation domain type: LCL
Modification domains: Methylation
Module 3
Specificity: Alanine
Evidence for specificity:
  • Sequence-based prediction
Condensation domain type: LCL
APZ78744.1
Module 4
Specificity: Leucine
Evidence for specificity:
  • Sequence-based prediction
Condensation domain type: DCL
Module 5
Specificity: Proline
Evidence for specificity:
  • Sequence-based prediction
Condensation domain type: LCL
Module 6
Specificity: Alanine
Evidence for specificity:
  • Sequence-based prediction
Condensation domain type: LCL
Module 7
Specificity: Glutamine
Evidence for specificity:
  • Sequence-based prediction
Condensation domain type: LCL
Annotation changelog
MIBiG version Submitter Notes
1.4
  • Hidden contributor (ID: W3AST4BMPVTIWZ3NNIXB2T6Y, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
Similar known gene clusters
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Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
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