BGC0001425: myxochromide A biosynthetic gene cluster from Myxococcus xanthus DK 1622
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Location: 1 - 44,135 nt. (total: 44,135 nt).
This entry is originally from NCBI GenBank KX622595.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001425
Short description myxochromide A biosynthetic gene cluster from Myxococcus xanthus DK 1622
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Iterative type I)
Loci
KX622595.1
via Knock-out studies
Compounds
  • myxochromide A
Species Myxococcus xanthus DK 1622 [taxonomy]
References
Chemical products information
myxochromide A Evidence: NMR, Mass spectrometry, Chemical derivatisation
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C45H63N7O9
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • APZ78763.1
 1 - 1272 (-) glycosyl hydrolase
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    • APZ78764.1
    		 1279 - 2220 (+) multidrug ABC transporter ATP-binding protein
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      • APZ78765.1
      		 2230 - 5832 (+) membrane protein
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        • APZ78766.1
        		 5837 - 6373 (-) uncharacterized protein
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          • APZ78767.1
          • mchA
          		 7007 - 13465 (+) polyketide synthase
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            • APZ78768.1
            • mchB
            		 13462 - 22608 (+) nonribosomal peptide synthetase
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              • APZ78769.1
              • mchC
              		 22641 - 36038 (+) nonribosomal peptide synthetase
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                • APZ78770.1
                • mchD
                		 36035 - 36499 (+) membrane protein
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                  • APZ78771.1
                  		 36585 - 38090 (-) ATP-dependent RNA helicase RhlE
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                    • APZ78772.1
                    		 38440 - 40548 (-) elongation factor G
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                      • APZ78773.1
                      		 40983 - 42173 (-) cyclic nucleotide-binding protein
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                        • APZ78774.1
                        		 42292 - 42768 (-) peptidyl-prolyl cis-trans isomerase
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                          • APZ78775.1
                          		 42939 - 44135 (+) metallophosphatase
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                            Biosynthesis information

                            Biosynthetic modules

                            Name
                            2
                            Type
                            nrps-type1
                            Genes
                            mchB
                            Substrates
                            threonine (evidence: Structure-based inference)
                            Integrated Monomers
                            Domains
                            condensation (LCL), adenylation, methyltransferase
                            Name
                            3
                            Type
                            nrps-type1
                            Genes
                            mchB
                            Substrates
                            alanine (evidence: Structure-based inference)
                            Integrated Monomers
                            Domains
                            condensation (LCL), adenylation, epimerase
                            Name
                            4
                            Type
                            nrps-type1
                            Genes
                            mchC
                            Substrates
                            leucine (evidence: Structure-based inference)
                            Integrated Monomers
                            Domains
                            condensation (DCL), adenylation
                            Name
                            5
                            Type
                            nrps-type1
                            Genes
                            mchC
                            Substrates
                            proline (evidence: Structure-based inference)
                            Integrated Monomers
                            Domains
                            condensation (LCL), adenylation
                            Name
                            6
                            Type
                            nrps-type1
                            Genes
                            mchC
                            Substrates
                            alanine (evidence: Structure-based inference)
                            Integrated Monomers
                            Domains
                            condensation (LCL), adenylation
                            Name
                            7
                            Type
                            nrps-type1
                            Genes
                            mchC
                            Substrates
                            glutamine (evidence: Structure-based inference)
                            Integrated Monomers
                            Domains
                            condensation (LCL), adenylation
                            Name
                            1
                            Type
                            pks-modular
                            Genes
                            mchA
                            Substrates
                            Integrated Monomers
                            Domains
                            acyltransferase, ketosynthase, acyltransferase, dehydratase, enoylreductase, ketoreductase, carrier (ACP)
                            Annotation changelog

                            Entry version: 3

                            Date
                            Changes
                            Submitters
                            Reviewers
                            2022-09-15
                            Corrected NRP module activity
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            2022-09-15
                            Removed gene annotations, including 'extra' genes, which duplicated NCBI annotations
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            2022-09-15
                            Changed gene identifiers used to consistently be 'gene' names
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            2022-09-15
                            Changed amino acid substrates to lower case
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                            Entry version: 2

                            Date
                            Changes
                            Submitters
                            Reviewers
                            2019-10-16
                            Migrated from v1.4
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                            Entry version: 1

                            Date
                            Changes
                            Submitters
                            Reviewers
                            2018-08-06
                            Submitted
                            • (ID: W3AST4BMPVTIWZ3NNIXB2T6Y)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            Detailed domain annotation
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