Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0001425.1:
Cluster 1NRP / Polyketide144135

BGC0001425, myxochromide A biosynthetic gene cluster from Myxococcus xanthus. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: Myxochromide A
SMILES string: Copy to clipboard
Molecular formula: C45H63N7O9
Exact molecular mass: 846.476 Da ([M+H]+)
Molecular activity: Unknown

Class-specific details

Biosynthetic class(es):
NRP / Polyketide
Cyclic depsipeptide (cyclic)
Thioesterase type:
Type I
Release / cyclization type:
Macrolactonization

Nonribosomal peptide synthetases:
mchB (APZ78768.1)
Module 2
A specificity: Threonine
Evidence for specificity: Structure-based inference
C domain subtype: LCL
Scaffold-modifying domain: Methylation
Module 3
A specificity: Alanine
Evidence for specificity: Structure-based inference
AA is epimerized
C domain subtype: LCL
mchC (APZ78769.1)
Module 4
A specificity: Leucine
Evidence for specificity: Structure-based inference
C domain subtype: DCL
Module 5
A specificity: Proline
Evidence for specificity: Structure-based inference
C domain subtype: LCL
Module 6
A specificity: Alanine
Evidence for specificity: Structure-based inference
C domain subtype: LCL
Module 7
A specificity: Glutamine
Evidence for specificity: Structure-based inference
C domain subtype: LCL
Polyketide subclass:
Polyene (linear)
Polyketide synthase subclass:
Iterative type I
Starter unit:
Acetyl-CoA
Polyketide synthase / ketosynthase-encoding genes:
MCHA
Iterative PKS subtype:
Partially reducing
9
Thioesterase type:
None
Release / cyclization type:
Other

Modular polyketide synthases:
mchA (APZ78767.1)
Module 1
AT specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
KR stereochemistry: Unknown
Scaffold-modifying domain: None
Module is iterated
Evidence for iteration: Unknown

Gene cluster description

myxochromide A (BGC0001425). Gene Cluster 1. Biosynthetic class = NRP/Polyketide. GenBank KX622595, positions 6374-36584. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Knock-out studies, Sequence-based prediction
MIxS-compliance:Unknown
Contact for this cluster:Silke Wenzel (Helmholtz Institute for Pharmaceutical Research Saarland)

Literature references

1. Burgard C et al. (2017) Genomics-Guided Exploitation of Lipopeptide Diversity in Myxobacteria. ACS Chem Biol 12(3):779-786. doi: 10.1021/acschembio.6b00953. Epub